Cathepsin S inhibition suppresses systemic lupus erythematosus and lupus nephritis because cathepsin S is essential for MHC class II-mediated CD4 T cell and B cell priming

The Pathogenesis of Lupus Nephritis

(2013) M. Lech et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Germinal Centers

(2012) Gabriel D. Victora et al.   Annual Review of Immunology

Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas

(2012) G. D. Victora et al.   BLOOD

Lupus nephritis. How latest insights into its pathogenesis promote novel therapies

(2012) Onkar P. Kulkarni et al.   CURRENT OPINION IN RHEUMATOLOGY

Quantitative Expression of C-Type Lectin Receptors in Humans and Mice

(2012) Maciej Lech et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cathepsin S dominates autoantigen processing in human thymic dendritic cells

(2012) Christina Stoeckle et al.   JOURNAL OF AUTOIMMUNITY

Taming lupus—a new understanding of pathogenesis is leading to clinical advances

(2012) Zheng Liu et al.   NATURE MEDICINE

Therapeutic dosing of an orally active, selective cathepsin S inhibitor suppresses disease in models of autoimmunity

(2011) Mark Baugh et al.   JOURNAL OF AUTOIMMUNITY

Genetic and Pharmacological Evaluation of Cathepsin S in a Mouse Model of Asthma

(2010) Kathleen Deschamps et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Toll-Like Receptors and Danger Signaling in Kidney Injury

(2010) H.-J. Anders   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Lack of SIGIRR/TIR8 aggravates hydrocarbon oil-induced lupus nephritis

(2009) Maciej Lech et al.   JOURNAL OF PATHOLOGY

Human Idiopathic Membranous Nephropathy — A Mystery Solved?

(2009) Richard J. Glassock   NEW ENGLAND JOURNAL OF MEDICINE

Viral 5′-triphosphate RNA and non-CpG DNA aggravate autoimmunity and lupus nephritis via distinct TLR-independent immune responses

(2008) Ramanjaneyulu Allam et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cysteine cathepsin S as an immunomodulatory target: present and future trends

(2008) Suman Gupta et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Systemic Lupus Erythematosus

(2008) Anisur Rahman et al.   NEW ENGLAND JOURNAL OF MEDICINE