Functional up-regulation of the M-current by retigabine contrasts hyperexcitability and excitotoxicity on rat hypoglossal motoneurons

KCNQ-Encoded Potassium Channels as Therapeutic Targets

(2018) Vincenzo Barrese et al.   Annual Review of Pharmacology and Toxicology

Hypoexcitability precedes denervation in the large fast-contracting motor units in two unrelated mouse models of ALS

(2018) María de Lourdes Martínez-Silva et al.   eLife

Fasciculation in amyotrophic lateral sclerosis: origin and pathophysiological relevance

(2017) Mamede de Carvalho et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Cortical influences drive amyotrophic lateral sclerosis

(2017) Andrew Eisen et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Changes in the Excitability of Neocortical Neurons in a Mouse Model of Amyotrophic Lateral Sclerosis Are Not Specific to Corticospinal Neurons and Are Modulated by Advancing Disease

(2017) Juhyun Kim et al.   JOURNAL OF NEUROSCIENCE

Specificity of M-channel activators: binding or effect?

(2017) Rene Barro-Soria et al.   JOURNAL OF PHYSIOLOGY-LONDON

Electrophysiological characterization of the M-current in rat hypoglossal motoneurons

(2017) Filippo Ghezzi et al.   NEUROSCIENCE

Propofol Protects Rat Hypoglossal Motoneurons in an In Vitro Model of Excitotoxicity by Boosting GABAergic Inhibition and Reducing Oxidative Stress

(2017) Filippo Ghezzi et al.   NEUROSCIENCE

The neuropathological signature of bulbar-onset ALS: A systematic review

(2017) S. Shellikeri et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Neurotoxicity of propofol on rat hypoglossal motoneurons in vitro

(2017) Laura Monni et al.   NEUROSCIENCE LETTERS

Nicotinic receptors modulate the onset of reactive oxygen species production and mitochondrial dysfunction evoked by glutamate uptake block in the rat hypoglossal nucleus

(2017) Maria Tortora et al.   NEUROSCIENCE LETTERS

Nicotine protects rat hypoglossal motoneurons from excitotoxic death via downregulation of connexin 36

(2017) Silvia Corsini et al.   Cell Death & Disease

Amyotrophic lateral sclerosis

(2017) Orla Hardiman et al.   Nature Reviews Disease Primers

Excitotoxicity in ALS: Overstimulation, or overreaction?

(2016) Anna E. King et al.   EXPERIMENTAL NEUROLOGY

Nonreciprocal mechanisms in up- and downregulation of spinal motoneuron excitability by modulators of KCNQ/Kv7 channels

(2016) Joseph Lombardo et al.   JOURNAL OF NEUROPHYSIOLOGY

Sequence determinants of subtype-specific actions of KCNQ channel openers

(2016) Alice W. Wang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Nicotinic receptor activation contrasts pathophysiological bursting and neurodegeneration evoked by glutamate uptake block on rat hypoglossal motoneurons

(2016) Silvia Corsini et al.   JOURNAL OF PHYSIOLOGY-LONDON

Pathophysiological and diagnostic implications of cortical dysfunction in ALS

(2016) Nimeshan Geevasinga et al.   Nature Reviews Neurology

Axonal Excitability in Amyotrophic Lateral Sclerosis

(2016) Susanna B. Park et al.   Neurotherapeutics

Axonal Dysfunction Precedes Motor Neuronal Death in Amyotrophic Lateral Sclerosis

(2016) Yuta Iwai et al.   PLoS One

TDP-43/FUS in motor neuron disease: Complexity and challenges

(2016) Erika N. Guerrero et al.   PROGRESS IN NEUROBIOLOGY

Emerging Roles of Filopodia and Dendritic Spines in Motoneuron Plasticity during Development and Disease

(2016) Refik Kanjhan et al.   NEURAL PLASTICITY

Role of HSP70 in motoneuron survival after excitotoxic stress in a rat spinal cord injury modelin vitro

(2015) Ayisha Shabbir et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Homeostatic Dysregulation in Membrane Properties of Masticatory Motoneurons Compared with Oculomotor Neurons in a Mouse Model for Amyotrophic Lateral Sclerosis

(2015) S. Venugopal et al.   JOURNAL OF NEUROSCIENCE

Is hyperexcitability really guilty in amyotrophic lateral sclerosis?

(2015) Felix Leroy et al.   Neural Regeneration Research

KCNQ5 K+ channels control hippocampal synaptic inhibition and fast network oscillations

(2015) Pawel Fidzinski et al.   Nature Communications

Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability

(2015) Anna-Claire Devlin et al.   Nature Communications

Axonal Ion Channel Dysfunction inC9orf72Familial Amyotrophic Lateral Sclerosis

(2015) Nimeshan Geevasinga et al.   JAMA Neurology

Adult spinal motoneurones are not hyperexcitable in a mouse model of inherited amyotrophic lateral sclerosis

(2014) Nicolas Delestrée et al.   JOURNAL OF PHYSIOLOGY-LONDON

Intrinsic Membrane Hyperexcitability of Amyotrophic Lateral Sclerosis Patient-Derived Motor Neurons

(2014) Brian J. Wainger et al.   Cell Reports

Early intrinsic hyperexcitability does not contribute to motoneuron degeneration in amyotrophic lateral sclerosis

(2014) Félix Leroy et al.   eLife

Safety profile of two novel antiepileptic agents approved for the treatment of refractory partial seizures: ezogabine (retigabine) and perampanel

(2013) Michele A Faulkner et al.   Expert Opinion On Drug Safety

Amyotrophic lateral sclerosis—a model of corticofugal axonal spread

(2013) Heiko Braak et al.   Nature Reviews Neurology

The genetics and neuropathology of amyotrophic lateral sclerosis

(2012) Ammar Al-Chalabi et al.   ACTA NEUROPATHOLOGICA

Early pathogenesis in the adult-onset neurodegenerative disease amyotrophic lateral sclerosis

(2012) Brigitte van Zundert et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

M-type potassium channels modulate Schaffer collateral-CA1 glutamatergic synaptic transmission

(2012) Jianli Sun et al.   JOURNAL OF PHYSIOLOGY-LONDON

Understanding the Rhythm of Breathing: So Near, Yet So Far

(2011) Jack L. Feldman et al.   Annual Review of Physiology

Postnatal developmental profile of neurons and glia in motor nuclei of the brainstem and spinal cord, and its comparison with organotypic slice cultures

(2011) Alessandra Cifra et al.   Developmental Neurobiology

Riluzole is a potent drug to protect neonatal rat hypoglossal motoneurons in vitro from excitotoxicity due to glutamate uptake block

(2011) Alessandra Cifra et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Markedly reduced axonal potassium channel expression in human sporadic amyotrophic lateral sclerosis: An immunohistochemical study

(2011) Kazumoto Shibuya et al.   EXPERIMENTAL NEUROLOGY

Synchronization of presynaptic input to motor units of tongue, inspiratory intercostal, and diaphragm muscles

(2011) Amber Rice et al.   JOURNAL OF NEUROPHYSIOLOGY

Amyotrophic lateral sclerosis

(2011) Matthew C Kiernan et al.   LANCET

KCNQ5 channels control resting properties and release probability of a synapse

(2011) Hai Huang et al.   NATURE NEUROSCIENCE

Respiratory motoneurons and pathological conditions: Lessons from hypoglossal motoneurons challenged by excitotoxic or oxidative stress

(2011) Alessandra Cifra et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Transient oxidative stress evokes early changes in the functional properties of neonatal rat hypoglossal motoneuronsin vitro

(2010) Francesca Nani et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

GAD67-GFP+ Neurons in the Nucleus of Roller: A Possible Source of Inhibitory Input to Hypoglossal Motoneurons. I. Morphology and Firing Properties

(2010) J.F.M. van Brederode et al.   JOURNAL OF NEUROPHYSIOLOGY

The C-terminal domain of βIV-spectrin is crucial for KCNQ2 aggregation and excitability at nodes of Ranvier

(2010) Jérôme J. Devaux   JOURNAL OF PHYSIOLOGY-LONDON

The KCNQ5 potassium channel mediates a component of the afterhyperpolarization current in mouse hippocampus

(2010) A. V. Tzingounis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neural KCNQ (Kv7) channels

(2009) David A Brown et al.   BRITISH JOURNAL OF PHARMACOLOGY

Neuroprotection in the Newborn Infant

(2009) Fernando F. Gonzalez et al.   CLINICS IN PERINATOLOGY

Inhibition of Apoptosome Activation Protects Injured Motor Neurons from Cell Death

(2008) Anish Kumar Kanungo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional significance of axonal Kv7 channels in hippocampal pyramidal neurons

(2008) M. M. Shah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA