Cathepsin K Deficiency Ameliorates Systemic Lupus Erythematosus-like Manifestations inFaslprMice

Cathepsin K-mediated notch1 activation contributes to neovascularization in response to hypoxia

(2014) Haiying Jiang et al.   Nature Communications

Cathepsin K Is Involved in Development of Psoriasis-like Skin Lesions through TLR-Dependent Th17 Activation

(2013) T. Hirai et al.   JOURNAL OF IMMUNOLOGY

Effects of cathepsin K deficiency on intercellular junction proteins, luminal mucus layers, and extracellular matrix constituents in the mouse colon

(2012) Maria Arampatzidou et al.   BIOLOGICAL CHEMISTRY

Deficiency of cathepsin S attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice

(2012) Yanwen Qin et al.   CARDIOVASCULAR RESEARCH

Polyclonal CD4+Foxp3+ Treg cells induce TGFβ-dependent tolerogenic dendritic cells that suppress the murine lupus-like syndrome

(2012) Qin Lan et al.   Journal of Molecular Cell Biology

Cathepsin L Activity Is Essential to Elastase Perfusion–Induced Abdominal Aortic Aneurysms in Mice

(2011) Jiusong Sun et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cathepsin K Deficiency Reduces Elastase Perfusion–Induced Abdominal Aortic Aneurysms in Mice

(2011) Jiusong Sun et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficits

(2011) Stephanie Dauth et al.   BMC NEUROSCIENCE

Effector T-cell subsets in systemic lupus erythematosus

(2011) Min S. Shin et al.   CURRENT OPINION IN RHEUMATOLOGY

Activation of dendritic cells via TLR7 reduces Foxp3 expression and suppressive function in induced Tregs

(2011) Daniela Hackl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulatory T-cells in systemic lupus erythematosus and rheumatoid arthritis

(2011) Konstantia-Maria Chavele et al.   FEBS LETTERS

Transfer of Regulatory Properties from Tolerogenic to Proinflammatory Dendritic Cells via Induced Autoreactive Regulatory T Cells

(2011) F. S. Kleijwegt et al.   JOURNAL OF IMMUNOLOGY

Systemic Lupus Erythematosus

(2011) George C. Tsokos   NEW ENGLAND JOURNAL OF MEDICINE

Abnormalities of T cell signaling in systemic lupus erythematosus

(2011) Vaishali R Moulton et al.   ARTHRITIS RESEARCH & THERAPY

4SC-101, A Novel Small Molecule Dihydroorotate Dehydrogenase Inhibitor, Suppresses Systemic Lupus Erythematosus in MRL-(Fas)lpr Mice

(2010) Onkar P. Kulkarni et al.   AMERICAN JOURNAL OF PATHOLOGY

Detection of femtomole quantities of mature cathepsin K with zymography

(2010) Weiwei A. Li et al.   ANALYTICAL BIOCHEMISTRY

Cutting Edge: Critical Role of I B Kinase   in TLR7/9-Induced Type I IFN Production by Conventional Dendritic Cells

(2010) K. Hoshino et al.   JOURNAL OF IMMUNOLOGY

T cells as therapeutic targets in SLE

(2010) José C. Crispín et al.   Nature Reviews Rheumatology

Interleukin 17 acts in synergy with B cell–activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus

(2009) Agnès Doreau et al.   NATURE IMMUNOLOGY

Deficiency and Inhibition of Cathepsin K Reduce Body Weight Gain and Increase Glucose Metabolism in Mice

(2008) Min Yang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Function of CD4+,CD25+ Treg cells in MRL/lpr mice is compromised by intrinsic defects in antigen-presenting cells and effector T cells

(2008) Véronique Parietti et al.   ARTHRITIS AND RHEUMATISM

Role of cathepsin K in structural changes in brachiocephalic artery during progression of atherosclerosis in apoE-deficient mice

(2008) Andriy O. Samokhin et al.   ATHEROSCLEROSIS

Altered homeostasis of CD4+ FoxP3+regulatory T-cell subpopulations in systemic lupus erythematosus

(2008) Jau-Ling Suen et al.   IMMUNOLOGY

Quantitative and qualitative deficiencies of regulatory T cells in patients with systemic lupus erythematosus (SLE)

(2008) M. Bonelli et al.   INTERNATIONAL IMMUNOLOGY

Functional Regulation of MyD88-Activated Interferon Regulatory Factor 5 by K63-Linked Polyubiquitination

(2008) M. Y. Balkhi et al.   MOLECULAR AND CELLULAR BIOLOGY

The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor

(2008) Sarah E. Ewald et al.   NATURE

Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9

(2008) Boyoun Park et al.   NATURE IMMUNOLOGY

Systemic Lupus Erythematosus

(2008) Anisur Rahman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cathepsin K-Dependent Toll-Like Receptor 9 Signaling Revealed in Experimental Arthritis

(2008) M. Asagiri et al.   SCIENCE