Heat Shock Cognate 70 Inhibitor, VER-155008, Reduces Memory Deficits and Axonal Degeneration in a Mouse Model of Alzheimer’s Disease

A Systematic Strategy for Discovering a Therapeutic Drug for Alzheimer’s Disease and Its Target Molecule

(2017) Zhiyou Yang et al.   Frontiers in Pharmacology

Regrowth of Serotonin Axons in the Adult Mouse Brain Following Injury

(2016) Yunju Jin et al.   NEURON

β-Secretase 1’s Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice

(2016) Diego Piedrahita et al.   Frontiers in Cellular Neuroscience

Inhibition of clathrin-mediated endocytosis prevents amyloid β-induced axonal damage

(2015) Tomoharu Kuboyama et al.   NEUROBIOLOGY OF AGING

Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology

(2014) Virginie Stygelbout et al.   BRAIN

Antioxidant Signaling Involving the Microtubule Motor KIF12 Is an Intracellular Target of Nutrition Excess in Beta Cells

(2014) Wenxing Yang et al.   DEVELOPMENTAL CELL

HSPA8/HSC70 chaperone protein

(2013) François Stricher et al.   Autophagy

Allosteric Heat Shock Protein 70 Inhibitors Rapidly Rescue Synaptic Plasticity Deficits by Reducing Aberrant Tau

(2013) Jose Abisambra et al.   BIOLOGICAL PSYCHIATRY

Functional Analysis of Hsp70 Inhibitors

(2013) Rainer Schlecht et al.   PLoS One

Inhibition of HSP70: A challenging anti-cancer strategy

(2012) Anastasia R. Goloudina et al.   CANCER LETTERS

Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model

(2012) Siva Sundara Kumar Durairajan et al.   NEUROBIOLOGY OF AGING

Comprehensive review on the HSC70 functions, interactions with related molecules and involvement in clinical diseases and therapeutic potential

(2012) Tuoen Liu et al.   PHARMACOLOGY & THERAPEUTICS

Diosgenin is an exogenous activator of 1,25D3-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice

(2012) Chihiro Tohda et al.   Scientific Reports

Carboxyl-terminus of Hsc70 interacting protein mediates 2,5-hexanedione-induced neurofilament medium chain degradation

(2011) Qingshan Wang et al.   BIOCHEMICAL PHARMACOLOGY

Chaperone-mediated autophagy: Dice's 'wild' idea about lysosomal selectivity

(2011) Ana Maria Cuervo   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hsc70 Rapidly Engages Tau after Microtubule Destabilization

(2010) Umesh K. Jinwal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells

(2009) Andrew J. Massey et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

From hatching to dispatching: the multiple cellular roles of the Hsp70 molecular chaperone machinery

(2008) Eirini Meimaridou et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Transcription factor Sp1 dysregulation in Alzheimer's disease

(2008) Bruce A. Citron et al.   JOURNAL OF NEUROSCIENCE RESEARCH