The curious case of vacuolar ATPase: regulation of signaling pathways

Molecular mechanisms of cutis laxa– and distal renal tubular acidosis–causing mutations in V-ATPaseasubunits, ATP6V0A2 and ATP6V0A4

(2018) Sally Esmail et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammary epithelium-specific inactivation of V-ATPase reduces stiffness of extracellular matrix and enhances metastasis of breast cancer

(2017) Gajendra K. Katara et al.   Molecular Oncology

Osteoclast proton pump regulator Atp6v1c1 enhances breast cancer growth by activating the mTORC1 pathway and bone metastasis by increasing V-ATPase activity

(2017) Matthew McConnell et al.   Oncotarget

The Function of V-ATPases in Cancer

(2016) Laura Stransky et al.   PHYSIOLOGICAL REVIEWS

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

The V-ATPase a2 isoform controls mammary gland development through Notch and TGF-β signaling

(2016) Sahithi Pamarthy et al.   Cell Death & Disease

Cancer derived peptide of vacuolar ATPase ‘a2’ isoform promotes neutrophil migration by autocrine secretion of IL-8

(2016) Safaa A. Ibrahim et al.   Scientific Reports

Role of vacuolar-type proton ATPase in signal transduction

(2015) Ge-Hong Sun-Wada et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Vacuolar ATPase in Phagosome-Lysosome Fusion

(2015) Sandra Kissing et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CERS2 Suppresses Tumor Cell Invasion and is Associated with Decreased V-ATPase and MMP-2/MMP-9 Activities in Breast Cancer

(2015) Shao-hua Fan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of Notch signaling during lipopolysaccharide-induced preterm labor

(2015) Varkha Agrawal et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Expression and role of a2 vacuolar-ATPase (a2V) in trafficking of human neutrophil granules and exocytosis

(2015) Alice Gilman-Sachs et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Male fertility and apoptosis in normal spermatogenesis are regulated by vacuolar-ATPase isoform a2

(2015) Mukesh K. Jaiswal et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Inhibition of vacuolar ATPase subunit in tumor cells delays tumor growth by decreasing the essential macrophage population in the tumor microenvironment

(2015) G K Katara et al.   ONCOGENE

Recent Insights into the Structure, Regulation, and Function of the V-ATPases

(2015) Kristina Cotter et al.   TRENDS IN BIOCHEMICAL SCIENCES

Autophagosome–lysosome fusion is independent of V-ATPase-mediated acidification

(2015) Caroline Mauvezin et al.   Nature Communications

The Vacuolar ATPase a2-subunit regulates Notch signaling in triple-negative breast cancer cells

(2015) Sahithi Pamarthy et al.   Oncotarget

Vacuolar ATPase 'a2' isoform exhibits distinct cell surface accumulation and modulates matrix metalloproteinase activity in ovarian cancer

(2015) Arpita Kulshrestha et al.   Oncotarget

Notch Signaling in Inflammation-Induced Preterm Labor

(2015) Mukesh K. Jaiswal et al.   Scientific Reports

Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification

(2015) Ju-Hyun Lee et al.   Cell Reports

Eukaryotic V-ATPase: Novel structural findings and functional insights

(2014) Vladimir Marshansky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Therapeutic targeting of the mTOR-signalling pathway in cancer: benefits and limitations

(2014) M Moschetta et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Four Faces of Autophagy: Implications for Cancer Therapy

(2014) D. A. Gewirtz   CANCER RESEARCH

Novel techniques in the development of osteoporosis drug therapy: the osteoclast ruffled-border vacuolar H+-ATPase as an emerging target

(2014) Norbert Kartner et al.   Expert Opinion on Drug Discovery

The potential of targeting Wnt/β-catenin in colon cancer

(2014) Ana Sebio et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Autophagy—a key player in cellular and body metabolism

(2014) Kook Hwan Kim et al.   Nature Reviews Endocrinology

ESCRT-0 Is Not Required for Ectopic Notch Activation and Tumor Suppression in Drosophila

(2014) Emiliana Tognon et al.   PLoS One

Regulation of mTORC1 by amino acids

(2014) Liron Bar-Peled et al.   TRENDS IN CELL BIOLOGY

How to Take Autophagy and Endocytosis Up a Notch

(2014) Julia M. I. Barth et al.   Biomed Research International

(Pro)renin receptor and V-ATPase: fromDrosophilato humans

(2013) Anthony Rousselle et al.   CLINICAL SCIENCE

Positive and negative regulation of developmental signaling by the endocytic pathway

(2013) Yoh Wada et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

V-ATPase inhibition by archazolid leads to lysosomal dysfunction resulting in impaired cathepsin B activationin vivo

(2013) Rebekka Kubisch et al.   INTERNATIONAL JOURNAL OF CANCER

The V-ATPase membrane domain is a sensor of granular pH that controls the exocytotic machinery

(2013) Sandrine Poëa-Guyon et al.   JOURNAL OF CELL BIOLOGY

The WNT signaling pathway from ligand secretion to gene transcription: Molecular mechanisms and pharmacological targets

(2013) Hoeke A. Baarsma et al.   PHARMACOLOGY & THERAPEUTICS

Regulation of Luminal Acidification by the V-ATPase

(2013) Sylvie Breton et al.   PHYSIOLOGY

Impaired endolysosomal function disrupts Notch signalling in optic nerve astrocytes

(2013) Mallika Valapala et al.   Nature Communications

The lack of autophagy triggers precocious activation of Notch signaling during Drosophila oogenesis

(2012) Julia MI Barth et al.   BMC DEVELOPMENTAL BIOLOGY

The V-ATPase-Inhibitor Archazolid Abrogates Tumor Metastasis via Inhibition of Endocytic Activation of the Rho-GTPase Rac1

(2012) R. M. Wiedmann et al.   CANCER RESEARCH

Further characterization of ATP6V0A2-related autosomal recessive cutis laxa

(2012) Björn Fischer et al.   HUMAN GENETICS

V-ATPases in osteoclasts: Structure, function and potential inhibitors of bone resorption

(2012) A. Qin et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Atp6v0a4 knockout mouse is a model of distal renal tubular acidosis with hearing loss, with additional extrarenal phenotype

(2012) E. E. Norgett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

V-ATPase upregulation during early pregnancy: a possible link to establishment of an inflammatory response during preimplantation period of pregnancy

(2012) Mukesh K Jaiswal et al.   REPRODUCTION

Endocytic routes to Notch activation

(2012) Martin Baron   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Wnt Signaling in Cancer

(2012) P. Polakis   Cold Spring Harbor Perspectives in Biology

V-ATPase engagement in autophagic processes

(2011) Dalibor Mijaljica et al.   Autophagy

The V-ATPase proteolipid cylinder promotes the lipid-mixing stage of SNARE-dependent fusion of yeast vacuoles

(2011) Bernd Strasser et al.   EMBO JOURNAL

Drug Resistance and Cellular Adaptation to Tumor Acidic pH Microenvironment

(2011) Jonathan W. Wojtkowiak et al.   MOLECULAR PHARMACEUTICS

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Ion flux and the function of endosomes and lysosomes: pH is just the start

(2010) Cameron C. Scott et al.   BIOESSAYS

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

Endocytic Internalization Routes Required for Delta/Notch Signaling

(2010) Sarah L. Windler et al.   CURRENT BIOLOGY

Rabconnectin-3 Is a Functional Regulator of Mammalian Notch Signaling

(2010) Nilay Sethi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor-Associated a2 Vacuolar ATPase Acts As a Key Mediator of Cancer-Related Inflammation by Inducing Pro-Tumorigenic Properties in Monocytes

(2010) C. Kwong et al.   JOURNAL OF IMMUNOLOGY

Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation

(2010) Chan Gao et al.   NATURE CELL BIOLOGY

Requirement of Prorenin Receptor and Vacuolar H+-ATPase-Mediated Acidification for Wnt Signaling

(2010) C.-M. Cruciat et al.   SCIENCE

The H+ Vacuolar ATPase Maintains Neural Stem Cells in the Developing Mouse Cortex

(2010) Christian Lange et al.   STEM CELLS AND DEVELOPMENT

γ-Secretase-Dependent Cleavage Initiates Notch Signaling from the Plasma Membrane

(2010) Erika B. Sorensen et al.   TRAFFIC

Vacuolar H+-ATPase meets glycosylation in patients with cutis laxa

(2009) Mailys Guillard et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Heme-binding Protein HRG-1 Is Induced by Insulin-like Growth Factor I and Associates with the Vacuolar H+-ATPase to Control Endosomal pH and Receptor Trafficking

(2009) Katie M. O'Callaghan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibitors of V-ATPases: old and new players

(2009) M. Huss et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Regulation of the V-ATPase in kidney epithelial cells: dual role in acid-base homeostasis and vesicle trafficking

(2009) D. Brown et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Bafilomycins Produced in Culture byStreptomycesspp. Isolated from Marine Habitats Are Potent Inhibitors of Autophagy†

(2009) Gavin Carr et al.   JOURNAL OF NATURAL PRODUCTS

Endocytosis and signalling: intertwining molecular networks

(2009) Alexander Sorkin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

(2009) Paul Saftig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

V-ATPase expression in the mouse olfactory epithelium

(2008) Teodor G. Păunescu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The V-type H+-ATPase in vesicular trafficking: targeting, regulation and function

(2008) Vladimir Marshansky et al.   CURRENT OPINION IN CELL BIOLOGY

Causes and Consequences of Increased Glucose Metabolism of Cancers

(2008) R. J. Gillies et al.   JOURNAL OF NUCLEAR MEDICINE