Autophagy and Rheumatoid Arthritis: Current Knowledges and Future Perspectives

The Autophagy Level Is Increased in the Synovial Tissues of Patients with Active Rheumatoid Arthritis and Is Correlated with Disease Severity

(2017) Li Zhu et al.   MEDIATORS OF INFLAMMATION

Autoantibodies in inflammatory arthritis

(2016) P. Conigliaro et al.   AUTOIMMUNITY REVIEWS

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Increased autophagy in CD4+T cells of rheumatoid arthritis patients results in T-cell hyperactivation and apoptosis resistance

(2016) Jorg van Loosdregt et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Autophagy generates citrullinated peptides in human synoviocytes: a possible trigger for anti-citrullinated peptide antibodies

(2016) Maurizio Sorice et al.   RHEUMATOLOGY

Systemic application of 3-methyladenine markedly inhibited atherosclerotic lesion in ApoE−/− mice by modulating autophagy, foam cell formation and immune-negative molecules

(2016) Shen Dai et al.   Cell Death & Disease

mTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer, obesity, and aging

(2015) Andras Perl   Annals of the New York Academy of Sciences

Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss

(2015) Akilan Krishnamurthy et al.   ANNALS OF THE RHEUMATIC DISEASES

Autophagy protects meniscal cells from glucocorticoids-induced apoptosis via inositol trisphosphate receptor signaling

(2015) Chao Shen et al.   APOPTOSIS

Citrullination and autoimmunity

(2015) Guido Valesini et al.   AUTOIMMUNITY REVIEWS

Autophagy in malignant transformation and cancer progression

(2015) L. Galluzzi et al.   EMBO JOURNAL

Autoantibodies specific to D4GDI modulate Rho GTPase mediated cytoskeleton remodeling and induce autophagy in T lymphocytes

(2015) Cristiana Barbati et al.   JOURNAL OF AUTOIMMUNITY

Essential role for autophagy in life span extension

(2015) Frank Madeo et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy protects chondrocytes from glucocorticoids-induced apoptosis via ROS/Akt/FOXO3 signaling

(2015) C. Shen et al.   OSTEOARTHRITIS AND CARTILAGE

Safety of synthetic and biological DMARDs: a systematic literature review informing the 2013 update of the EULAR recommendations for management of rheumatoid arthritis

(2014) Sofia Ramiro et al.   ANNALS OF THE RHEUMATIC DISEASES

The autophagy geneATG5plays an essential role in B lymphocyte development

(2014) Brian C. Miller et al.   Autophagy

Bcl-2 family members: Dual regulators of apoptosis and autophagy

(2014) Beth Levine et al.   Autophagy

The Adaptor Protein p62 Is Involved in RANKL-induced Autophagy and Osteoclastogenesis

(2014) Rui-Fang Li et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Autophagy, a new determinant of plasma cell differentiation and antibody responses

(2014) Simone Cenci   MOLECULAR IMMUNOLOGY

Glucocorticoids induce autophagy in rat bone marrow mesenchymal stem cells

(2014) LONG WANG et al.   Molecular Medicine Reports

Autophagy—a key player in cellular and body metabolism

(2014) Kook Hwan Kim et al.   Nature Reviews Endocrinology

Role of alpha-synuclein in autophagy modulation of primary human T lymphocytes

(2014) T Colasanti et al.   Cell Death & Disease

Autophagy Inhibition Improves Chemosensitivity in BRAFV600E Brain Tumors

(2014) J. M. M. Levy et al.   Cancer Discovery

Autophagy in Plasma Cell Pathophysiology

(2014) Laura Oliva et al.   Frontiers in Immunology

Recent insights on the putative role of autophagy in autoimmune diseases

(2013) Elena Gianchecchi et al.   AUTOIMMUNITY REVIEWS

ATG5 regulates plasma cell differentiation

(2013) Kara L. Conway et al.   Autophagy

Historical landmarks of autophagy research

(2013) Yoshinori Ohsumi   CELL RESEARCH

A current perspective of autophagosome biogenesis

(2013) Shusaku T Shibutani et al.   CELL RESEARCH

Phosphoinositide 3-kinases as accelerators and brakes of autophagy

(2013) Fergal O′Farrell et al.   FEBS Journal

Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation

(2013) Yan Xiu et al.   JOURNAL OF CLINICAL INVESTIGATION

Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells

(2013) Zhen Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macroautophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central tolerance

(2013) Martin Aichinger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Plasma cells require autophagy for sustainable immunoglobulin production

(2013) Niccolò Pengo et al.   NATURE IMMUNOLOGY

Overexpression of Atg5 in mice activates autophagy and extends lifespan

(2013) Jong-Ok Pyo et al.   Nature Communications

Dual Role of Autophagy in Stress-Induced Cell Death in Rheumatoid Arthritis Synovial Fibroblasts

(2013) Masaru Kato et al.   Arthritis & Rheumatology

Autophagy regulates TNFα-mediated joint destruction in experimental arthritis

(2012) Neng-Yu Lin et al.   ANNALS OF THE RHEUMATIC DISEASES

Processing of proteins in autophagy vesicles of antigen-presenting cells generates citrullinated peptides recognized by the immune system

(2012) Jamie M. Ireland et al.   Autophagy

Autophagy proteins LC3B, ATG5 and ATG12 participate in quality control after mitochondrial damage and influence lifespan

(2012) Sören Mai et al.   Autophagy

Role of autophagy in immunity and autoimmunity, with a special focus on systemic lupus erythematosus

(2012) Marina Pierdominici et al.   FASEB JOURNAL

T lymphocytes from patients with systemic lupus erythematosus are resistant to induction of autophagy

(2012) Cristiano Alessandri et al.   FASEB JOURNAL

Oxidative stress as a potential biomarker for determining disease activity in patients with Rheumatoid Arthritis

(2012) Sunanda Kundu et al.   FREE RADICAL RESEARCH

Reduced apoptosis correlates with enhanced autophagy in synovial tissues of rheumatoid arthritis

(2012) Ke Xu et al.   INFLAMMATION RESEARCH

Autophagy in the Thymic Epithelium Is Dispensable for the Development of Self-Tolerance in a Novel Mouse Model

(2012) Supawadee Sukseree et al.   PLoS One

TNFα modulates protein degradation pathways in rheumatoid arthritis synovial fibroblasts

(2012) Alison M Connor et al.   ARTHRITIS RESEARCH & THERAPY

Autophagy in immunity and cell-autonomous defense against intracellular microbes

(2011) Vojo Deretic   IMMUNOLOGICAL REVIEWS

Autophagy regulates hypoxia-induced osteoclastogenesis through the HIF-1α/BNIP3 signaling pathway

(2011) Yi Zhao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Autophagy in antigen-presenting cells results in presentation of citrullinated peptides to CD4 T cells

(2011) Jamie M. Ireland et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Role for Autophagic Protein Beclin 1 Early in Lymphocyte Development

(2011) I. Arsov et al.   JOURNAL OF IMMUNOLOGY

Autophagy as a target for anticancer therapy

(2011) Filip Janku et al.   Nature Reviews Clinical Oncology

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mammalian target of rapamycin signaling is crucial for joint destruction in experimental arthritis and is activated in osteoclasts from patients with rheumatoid arthritis

(2010) Daniel Cejka et al.   ARTHRITIS AND RHEUMATISM

Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy

(2010) Yoshinori Takahashi et al.   Autophagy

Overview of macroautophagy regulation in mammalian cells

(2010) Maryam Mehrpour et al.   CELL RESEARCH

Crosstalk of reactive oxygen species and NF-κB signaling

(2010) Michael J Morgan et al.   CELL RESEARCH

TNF-α Induces Macroautophagy and Regulates MHC Class II Expression in Human Skeletal Muscle Cells

(2010) Christian W. Keller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy

(2010) Sabrina Di Bartolomeo et al.   JOURNAL OF CELL BIOLOGY

Macroautophagy Regulates Energy Metabolism during Effector T Cell Activation

(2010) V. M. Hubbard et al.   JOURNAL OF IMMUNOLOGY

Rheumatoid arthritis

(2010) David L Scott et al.   LANCET

Plasma membrane contributes to the formation of pre-autophagosomal structures

(2010) Brinda Ravikumar et al.   NATURE CELL BIOLOGY

Autophagy induction and CHOP under-expression promotes survival of fibroblasts from rheumatoid arthritis patients under endoplasmic reticulum stress

(2010) Yong-Joo Shin et al.   ARTHRITIS RESEARCH & THERAPY

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria

(2010) E Wirawan et al.   Cell Death & Disease

Cell death in rheumatoid arthritis

(2009) Adelheid Korb et al.   APOPTOSIS

3D tomography reveals connections between the phagophore and endoplasmic reticulum

(2009) Päivi Ylä-Anttila et al.   Autophagy

Life and death partners: apoptosis, autophagy and the cross-talk between them

(2009) A Eisenberg-Lerner et al.   CELL DEATH AND DIFFERENTIATION

Autophagic Compartments Gain Access to the MHC Class II Compartments in Thymic Epithelium

(2009) M. Kasai et al.   JOURNAL OF IMMUNOLOGY

Acute hypoxia and osteoclast activity: a balance between enhanced resorption and increased apoptosis

(2009) Helen J Knowles et al.   JOURNAL OF PATHOLOGY

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

Dynamics and diversity in autophagy mechanisms: lessons from yeast

(2009) Hitoshi Nakatogawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Interleukin-17 and Type 17 Helper T Cells

(2009) Pierre Miossec et al.   NEW ENGLAND JOURNAL OF MEDICINE

Differential effects of anti-TNF-  drugs on fibroblast-like synoviocyte apoptosis

(2009) L. Pattacini et al.   RHEUMATOLOGY

Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance

(2008) Jelena Nedjic et al.   NATURE

Everolimus in patients with rheumatoid arthritis receiving concomitant methotrexate: a 3-month, double-blind, randomised, placebo-controlled, parallel-group, proof-of-concept study

(2007) G A W Bruyn et al.   ANNALS OF THE RHEUMATIC DISEASES