Molecular Mechanisms Involved in Schwann Cell Plasticity

Dual specificity phosphatase 15 regulates Erk activation in Schwann cells

(2017) José F. Rodríguez-Molina et al.   JOURNAL OF NEUROCHEMISTRY

The role of p38alpha in Schwann cells in regulating peripheral nerve myelination and repair

(2017) Sheridan L. Roberts et al.   JOURNAL OF NEUROCHEMISTRY

Irreversible changes occurring in long-term denervated Schwann cells affect delayed nerve repair

(2017) Giulia Ronchi et al.   JOURNAL OF NEUROSURGERY

Therapeutic implications of toll-like receptors in peripheral neuropathic pain

(2017) Krishan K. Thakur et al.   PHARMACOLOGICAL RESEARCH

Salidroside promotes peripheral nerve regeneration based on tissue engineering strategy using Schwann cells and PLGA: in vitro and in vivo

(2017) Hui Liu et al.   Scientific Reports

Sam68 promotes Schwann cell proliferation by enhancing the PI3K/Akt pathway and acts on regeneration after sciatic nerve crush

(2016) Weijie Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dixdc1 targets CyclinD1 and p21 via PI3K pathway activation to promote Schwann cell proliferation after sciatic nerve crush

(2016) Weijie Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Proteolytic processing of Neuregulin-1

(2016) Michael Willem   BRAIN RESEARCH BULLETIN

The multicellular complexity of peripheral nerve regeneration

(2016) Anne-Laure Cattin et al.   CURRENT OPINION IN NEUROBIOLOGY

Promoting peripheral myelin repair

(2016) Ye Zhou et al.   EXPERIMENTAL NEUROLOGY

Cadm3 (Necl-1) interferes with the activation of the PI3 kinase/Akt signaling cascade and inhibits Schwann cell myelinationin vitro

(2016) Ming-Shuo Chen et al.   GLIA

Loss of Schwann cell plasticity in chronic inflammatory demyelinating polyneuropathy (CIDP)

(2016) Abhijeet R. Joshi et al.   Journal of Neuroinflammation

Gpr126/Adgrg6 Has Schwann Cell Autonomous and Nonautonomous Functions in Peripheral Nerve Injury and Repair

(2016) Amit Mogha et al.   JOURNAL OF NEUROSCIENCE

The repair Schwann cell and its function in regenerating nerves

(2016) K. R. Jessen et al.   JOURNAL OF PHYSIOLOGY-LONDON

AMPK Negatively Regulates Peripheral Myelination via Activation of c-Jun

(2016) Xiaoyu Liu et al.   MOLECULAR NEUROBIOLOGY

Zeb2 recruits HDAC–NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination

(2016) Lai Man Natalie Wu et al.   NATURE NEUROSCIENCE

Zeb2 is essential for Schwann cell differentiation, myelination and nerve repair

(2016) Susanne Quintes et al.   NATURE NEUROSCIENCE

Transforming growth factor beta 1, a cytokine with regenerative functions

(2016) Wale Sulaiman et al.   Neural Regeneration Research

Neuregulin-1 promotes functional improvement by enhancing collateral sprouting in SOD1G93A ALS mice and after partial muscle denervation

(2016) Renzo Mancuso et al.   NEUROBIOLOGY OF DISEASE

Neuregulin1 displayed on motor axons regulates terminal Schwann cell-mediated synapse elimination at developing neuromuscular junctions

(2016) Young il Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intrathecal gene therapy rescues a model of demyelinating peripheral neuropathy

(2016) Alexia Kagiava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G Protein-Coupled Receptors in Myelinating Glia

(2016) Amit Mogha et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

BMP7 retards peripheral myelination by activating p38 MAPK in Schwann cells

(2016) Xiaoyu Liu et al.   Scientific Reports

17β-Estradiol Promotes Schwann Cell Proliferation and Differentiation, Accelerating Early Remyelination in a Mouse Peripheral Nerve Injury Model

(2016) Yan Chen et al.   Biomed Research International

Molecular signaling mechanisms of axon-glia communication in the peripheral nervous system

(2015) Tamara Grigoryan et al.   BIOESSAYS

Macrophage-Induced Blood Vessels Guide Schwann Cell-Mediated Regeneration of Peripheral Nerves

(2015) Anne-Laure Cattin et al.   CELL

Strategies to promote peripheral nerve regeneration: electrical stimulation and/or exercise

(2015) Tessa Gordon et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The Neuregulin1/ErbB system is selectively regulated during peripheral nerve degeneration and regeneration

(2015) Giulia Ronchi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Fingolimod induces the transition to a nerve regeneration promoting Schwann cell phenotype

(2015) André Heinen et al.   EXPERIMENTAL NEUROLOGY

Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves

(2015) Jose A. Gomez-Sanchez et al.   JOURNAL OF CELL BIOLOGY

Immunoglobulins stimulate cultured Schwann cell maturation and promote their potential to induce axonal outgrowth

(2015) Nevena Tzekova et al.   Journal of Neuroinflammation

Preclinical validation of anti-nuclear factor-kappa B therapy to inhibit human vestibular schwannoma growth

(2015) Sonam Dilwali et al.   Molecular Oncology

Synthetic and nature-derived lipid nanoparticles for neural regeneration

(2015) Qiaobing Xu et al.   Neural Regeneration Research

Schwann Cells: Development and Role in Nerve Repair

(2015) Kristján R. Jessen et al.   Cold Spring Harbor Perspectives in Biology

Gene therapy and peripheral nerve repair: a perspective

(2015) Stefan A. Hoyng et al.   Frontiers in Molecular Neuroscience

c-Jun activation in Schwann cells protects against loss of sensory axons in inherited neuropathy

(2014) Janina Hantke et al.   BRAIN

Nonuniform molecular features of myelinating Schwann cells in models for CMT1: Distinct disease patterns are associated with NCAM and c-Jun upregulation

(2014) Dennis Klein et al.   GLIA

miR-9 inhibits Schwann cell migration by targeting Cthrc1 following sciatic nerve injury

(2014) S. Zhou et al.   JOURNAL OF CELL SCIENCE

Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A

(2014) Robert Fledrich et al.   NATURE MEDICINE

Metabolic regulator LKB1 is crucial for Schwann cell–mediated axon maintenance

(2014) Bogdan Beirowski et al.   NATURE NEUROSCIENCE

Prostaglandin D2 synthase/GPR44: a signaling axis in PNS myelination

(2014) Amelia Trimarco et al.   NATURE NEUROSCIENCE

Diminished Schwann Cell Repair Responses Underlie Age-Associated Impaired Axonal Regeneration

(2014) Michio W. Painter et al.   NEURON

mTORC1 Controls PNS Myelination along the mTORC1-RXRγ-SREBP-Lipid Biosynthesis Axis in Schwann Cells

(2014) Camilla Norrmén et al.   Cell Reports

Effect of active Notch signaling system on the early repair of rat sciatic nerve injury

(2014) Jin Wang et al.   Artificial Cells Nanomedicine and Biotechnology

Mitogen Activated Protein Kinase Family Proteins and c-jun Signaling in Injury-induced Schwann Cell Plasticity

(2014) Hye Jeong Lee et al.   Experimental Neurobiology

Akt/mTOR signalling in myelination

(2013) Camilla Norrmén et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Axonal neuregulin 1 is a rate limiting but not essential factor for nerve remyelination

(2013) Florence R. Fricker et al.   BRAIN

Engineering peripheral nerve repair

(2013) Laura M Marquardt et al.   CURRENT OPINION IN BIOTECHNOLOGY

The Neuregulin-Rac-MKK7 pathway regulates antagonistic c-jun/Krox20 expression in Schwann cell dedifferentiation

(2013) Yoon Kyung Shin et al.   GLIA

Lysophosphatidic acid (LPA) and its receptor, LPA1, influence embryonic schwann cell migration, myelination, and cell-to-axon segregation

(2013) Brigitte Anliker et al.   GLIA

Activation of NF- B in Schwann Cells Is Dispensable for Myelination In Vivo

(2013) P. D. Morton et al.   JOURNAL OF NEUROSCIENCE

DDIT4/REDD1/RTP801 Is a Novel Negative Regulator of Schwann Cell Myelination

(2013) R. Noseda et al.   JOURNAL OF NEUROSCIENCE

Axl/Gas6/NFκB signalling in schwannoma pathological proliferation, adhesion and survival

(2013) S Ammoun et al.   ONCOGENE

Liposomes to Target Peripheral Neurons and Schwann Cells

(2013) Sooyeon Lee et al.   PLoS One

Wnt/Rspondin/ -catenin signals control axonal sorting and lineage progression in Schwann cell development

(2013) T. Grigoryan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plastic Fantastic: Schwann Cells and Repair of the Peripheral Nervous System

(2013) Haesun A. Kim et al.   Stem Cells Translational Medicine

Fingolimod Impedes Schwann Cell–Mediated Myelination

(2012) Angelika Köhne et al.   ARCHIVES OF NEUROLOGY

PTEN and NF1 Inactivation in Schwann Cells Produces a Severe Phenotype in the Peripheral Nervous System That Promotes the Development and Malignant Progression of Peripheral Nerve Sheath Tumors

(2012) V. W. Keng et al.   CANCER RESEARCH

Genetic disruption ofPtenin a novel mouse model of tomaculous neuropathy

(2012) Sandra Goebbels et al.   EMBO Molecular Medicine

Nuclear factor-κB activation in schwann cells regulates regeneration and remyelination

(2012) Paul D. Morton et al.   GLIA

Histone methyltransferase enhancer of zeste homolog 2 regulates Schwann cell differentiation

(2012) André Heinen et al.   GLIA

Regulation of Schwann cell differentiation and proliferation by the Pax-3 transcription factor

(2012) Robin D. S. Doddrell et al.   GLIA

Expression of c-Jun and Sox-2 in human schwannomas and traumatic neuromas

(2012) Aditya Shivane et al.   HISTOPATHOLOGY

c-Jun in Schwann cells promotes axonal regeneration and motoneuron survival via paracrine signaling

(2012) Xavier Fontana et al.   JOURNAL OF CELL BIOLOGY

Negative Regulators of Schwann Cell Differentiation—Novel Targets for Peripheral Nerve Therapies?

(2012) André Heinen et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Arrest of Myelination and Reduced Axon Growth When Schwann Cells Lack mTOR

(2012) D. L. Sherman et al.   JOURNAL OF NEUROSCIENCE

p38 MAPK Activation Promotes Denervated Schwann Cell Phenotype and Functions as a Negative Regulator of Schwann Cell Differentiation and Myelination

(2012) D. P. Yang et al.   JOURNAL OF NEUROSCIENCE

The challenges and beauty of peripheral nerve regrowth

(2012) Douglas W. Zochodne   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

A role for Schwann cell–derived neuregulin-1 in remyelination

(2012) Ruth M Stassart et al.   NATURE NEUROSCIENCE

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Bers-ERK Schwann Cells Coordinate Nerve Regeneration

(2012) Jason M. Newbern et al.   NEURON

A Central Role for the ERK-Signaling Pathway in Controlling Schwann Cell Plasticity and Peripheral Nerve Regeneration In Vivo

(2012) Ilaria Napoli et al.   NEURON

c-Jun Reprograms Schwann Cells of Injured Nerves to Generate a Repair Cell Essential for Regeneration

(2012) Peter J. Arthur-Farraj et al.   NEURON

Efficacy of glial growth factor and nerve growth factor on the recovery of traumatic facial paralysis

(2011) Mucahit Yildiz et al.   EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY

Cthrc1 is a negative regulator of myelination in schwann cells

(2011) Caroline Apra et al.   GLIA

Mouse schwann cells need both NRG1 and cyclic AMP to myelinate

(2011) Peter Arthur-Farraj et al.   GLIA

Wallerian degeneration: the innate-immune response to traumatic nerve injury

(2011) Shlomo Rotshenker   Journal of Neuroinflammation

Wallerian degeneration: gaining perspective on inflammatory events after peripheral nerve injury

(2011) Andrew D Gaudet et al.   Journal of Neuroinflammation

Actin Polymerization Is Essential for Myelin Sheath Fragmentation during Wallerian Degeneration

(2011) J. Jung et al.   JOURNAL OF NEUROSCIENCE

Reduced BACE1 Activity Enhances Clearance of Myelin Debris and Regeneration of Axons in the Injured Peripheral Nervous System

(2011) M. H. Farah et al.   JOURNAL OF NEUROSCIENCE

The Atypical Guanine-Nucleotide Exchange Factor, Dock7, Negatively Regulates Schwann Cell Differentiation and Myelination

(2011) J. Yamauchi et al.   JOURNAL OF NEUROSCIENCE

Interplay between LXR and Wnt/ -Catenin Signaling in the Negative Regulation of Peripheral Myelin Genes by Oxysterols

(2011) J. Makoukji et al.   JOURNAL OF NEUROSCIENCE

Axonally Derived Neuregulin-1 Is Required for Remyelination and Regeneration after Nerve Injury in Adulthood

(2011) F. R. Fricker et al.   JOURNAL OF NEUROSCIENCE

c-Jun expression in human neuropathies: a pilot study

(2011) Elspeth J. Hutton et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

TACE (ADAM17) inhibits Schwann cell myelination

(2011) Rosa La Marca et al.   NATURE NEUROSCIENCE

HDAC-mediated deacetylation of NF-κB is critical for Schwann cell myelination

(2011) Ying Chen et al.   NATURE NEUROSCIENCE

Specific Functions for ERK/MAPK Signaling during PNS Development

(2011) Jason M. Newbern et al.   NEURON

EphB Signaling Directs Peripheral Nerve Regeneration through Sox2-Dependent Schwann Cell Sorting

(2010) Simona Parrinello et al.   CELL

Involvement of placental growth factor in Wallerian degeneration

(2010) Linda Chaballe et al.   GLIA

Toll-like receptor expression in the peripheral nerve

(2010) Sofie Goethals et al.   GLIA

Axonal Neuregulin 1 Type III Activates NF-κB in Schwann Cells during Myelin Formation

(2010) Allison S. Limpert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Schwann Cell Dedifferentiation Is Independent of Mitogenic Signaling and Uncoupled to Proliferation

(2010) Paula V. Monje et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Soluble Neuregulin-1 Has Bifunctional, Concentration-Dependent Effects on Schwann Cell Myelination

(2010) N. Syed et al.   JOURNAL OF NEUROSCIENCE

Elevated Phosphatidylinositol 3,4,5-Trisphosphate in Glia Triggers Cell-Autonomous Membrane Wrapping and Myelination

(2010) S. Goebbels et al.   JOURNAL OF NEUROSCIENCE

Secretion of EGF-like domain of heregulinβ promotes axonal growth and functional recovery of injured sciatic nerve

(2010) Insil Joung et al.   MOLECULES AND CELLS

Yy1 as a molecular link between neuregulin and transcriptional modulation of peripheral myelination

(2010) Ye He et al.   NATURE NEUROSCIENCE

Transgenic inhibition of glial NF-kappa B reduces pain behavior and inflammation after peripheral nerve injury

(2010) Eugene S. Fu et al.   PAIN

Dlg1-PTEN Interaction Regulates Myelin Thickness to Prevent Damaging Peripheral Nerve Overmyelination

(2010) L. Cotter et al.   SCIENCE

Nrg1/ErbB signaling networks in Schwann cell development and myelination

(2010) Jason Newbern et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Nuclear Factor-κB Activation in Axons and Schwann Cells in Experimental Sciatic Nerve Injury and Its Role in Modulating Axon Regeneration: Studies With Etanercept

(2009) Darrell Smith et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity

(2009) Ashwin Woodhoo et al.   NATURE NEUROSCIENCE

SSeCKS is a Suppressor in Schwann Cell Differentiation and Myelination

(2009) Yuhong Ji et al.   NEUROCHEMICAL RESEARCH

Connexin 32 increases the proliferative response of Schwann cells to neuregulin-1 (Nrg1)

(2009) M. Freidin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The tyrosine phosphatase Shp2 (PTPN11) directs Neuregulin-1/ErbB signaling throughout Schwann cell development

(2009) K. S. Grossmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A G Protein-Coupled Receptor Is Essential for Schwann Cells to Initiate Myelination

(2009) K. R. Monk et al.   SCIENCE

Dissecting and Targeting the Growth Factor-Dependent and Growth Factor-Independent Extracellular Signal-Regulated Kinase Pathway in Human Schwannoma

(2008) S. Ammoun et al.   CANCER RESEARCH

Schwann Cell Transplantation for CNS Repair

(2008) R. Matsas et al.   CURRENT MEDICINAL CHEMISTRY

Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves

(2008) Xiangyou Hu et al.   FASEB JOURNAL

Interactions between Schwann cells and macrophages in injury and inherited demyelinating disease

(2008) Rudolf Martini et al.   GLIA

Negative regulation of myelination: Relevance for development, injury, and demyelinating disease

(2008) Kristján R. Jessen et al.   GLIA

Active Gene Repression by the Egr2·NAB Complex during Peripheral Nerve Myelination

(2008) Gennifer M. Mager et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration

(2008) Junji Yamauchi et al.   JOURNAL OF CELL BIOLOGY

c-Jun is a negative regulator of myelination

(2008) David B. Parkinson et al.   JOURNAL OF CELL BIOLOGY

Protein Kinase A-Induced Phosphorylation of the p65 Subunit of Nuclear Factor- B Promotes Schwann Cell Differentiation into a Myelinating Phenotype

(2008) C. Yoon et al.   JOURNAL OF NEUROSCIENCE

Requirement of Myeloid Cells for Axon Regeneration

(2008) B. Barrette et al.   JOURNAL OF NEUROSCIENCE

Constitutively Active Akt Induces Enhanced Myelination in the CNS

(2008) A. I. Flores et al.   JOURNAL OF NEUROSCIENCE

Essential Role of Src Suppressed C Kinase Substrates in Schwann Cells Adhesion, Spreading and Migration

(2008) Meijuan Yan et al.   NEUROCHEMICAL RESEARCH

The cyclin-dependent kinase inhibitor p57kip2 is a negative regulator of Schwann cell differentiation and in vitro myelination

(2008) A. Heinen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of N-cadherin and β-catenin function reduces axon-induced Schwann cell proliferation

(2007) Burkhard Gess et al.   JOURNAL OF NEUROSCIENCE RESEARCH