Inhibition of PIKfyve by YM-201636 Dysregulates Autophagy and Leads to Apoptosis-Independent Neuronal Cell Death

Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636

(2012) Diego Sbrissa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Modulation of synaptic function by VAC14, a protein that regulates the phosphoinositides PI(3,5)P2and PI(5)P

(2012) Yanling Zhang et al.   EMBO JOURNAL

Neuronal expression of Fig4 is both necessary and sufficient to prevent spongiform neurodegeneration

(2012) C. J. Ferguson et al.   HUMAN MOLECULAR GENETICS

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Dynamin Inhibition Blocks Botulinum Neurotoxin Type A Endocytosis in Neurons and Delays Botulism

(2011) Callista B. Harper et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Phosphoinositide Kinase PIKfyve Is Vital in Early Embryonic Development

(2011) Ognian C. Ikonomov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella

(2010) Markus C Kerr et al.   EMBO JOURNAL

Regioselective Approach to Phosphatidylinositol 3,5-Bisphosphates: Syntheses of the Native Phospholipid and Biotinylated Short-Chain Derivative

(2010) Regan J. Anderson et al.   JOURNAL OF ORGANIC CHEMISTRY

Autophagy gone awry in neurodegenerative diseases

(2010) Esther Wong et al.   NATURE NEUROSCIENCE

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dynamic control of neuroexocytosis by phosphoinositides in health and disease

(2010) P.J. Wen et al.   PROGRESS IN LIPID RESEARCH

Deleterious Variants of FIG4, a Phosphoinositide Phosphatase, in Patients with ALS

(2009) Clement Y. Chow et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2

(2009) Cole J. Ferguson et al.   HUMAN MOLECULAR GENETICS

PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell death

(2009) Fuminori Tsuruta et al.   JOURNAL OF CELL BIOLOGY

PIKfyve Regulation of Endosome-Linked Pathways

(2009) Jane de Lartigue et al.   TRAFFIC

Liaisons dangereuses: autophagy, neuronal survival and neurodegeneration

(2008) Sharon A Tooze et al.   CURRENT OPINION IN NEUROBIOLOGY

VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P2 in yeast and mouse

(2008) Natsuko Jin et al.   EMBO JOURNAL

A selective PIKfyve inhibitor blocks PtdIns(3,5)P2 production and disrupts endomembrane transport and retroviral budding

(2008) Harold B J Jefferies et al.   EMBO REPORTS

 -Amyloid1-42 Induces Neuronal Death through the p75 Neurotrophin Receptor

(2008) A. Sotthibundhu et al.   JOURNAL OF NEUROSCIENCE

Ca2+-regulated Pool of Phosphatidylinositol-3-phosphate Produced by Phosphatidylinositol 3-Kinase C2α on Neurosecretory Vesicles

(2008) Peter J. Wen et al.   MOLECULAR BIOLOGY OF THE CELL