标题
Purinergic Signalling: Therapeutic Developments
作者
关键词
-
出版物
Frontiers in Pharmacology
Volume 8, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2017-09-25
DOI
10.3389/fphar.2017.00661
参考文献
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- P2X4 receptors (P2X4Rs) represent a novel target for the development of drugs to prevent and/or treat alcohol use disorders
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- Impaired adenosine-mediated angiogenesis in preeclampsia: potential implications for fetal programming
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- Activation of adenosine receptor A2A increases HSC proliferation and inhibits death and senescence by down-regulation of p53 and Rb
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- Effects of Brilliant Blue G on Serum Tumor Necrosis Factor-α Levels and Depression-like Behavior in Mice after Lipopolysaccharide Administration
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- The role of p2x7 receptor in infectious inflammatory diseases and the influence of ectonucleotidases
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- Protective effects of the novel adenosine derivative WS0701 in a mouse model of posttraumatic stress disorder
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- The adenosine A2A receptor agonist CGS 21680 decreases ethanol self-administration in both non-dependent and dependent animals
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- Epithelial Wounds Induce Differential Phosphorylation Changes in Response to Purinergic and EGF Receptor Activation
- (2013) Amanuel Kehasse et al. AMERICAN JOURNAL OF PATHOLOGY
- Exhaled breath condensate adenosine tracks lung function changes in cystic fibrosis
- (2013) Charles R. Esther et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- A new rodent model for obstructive sleep apnea: effects on ATP-mediated dilations in cerebral arteries
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- P2X7Blockade Attenuates Murine Lupus Nephritis by Inhibiting Activation of the NLRP3/ASC/Caspase 1 Pathway
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- Neural regulation of inflammation in the airways and lungs
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- Potential roles of adenosine deaminase-2 in diabetic retinopathy
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- Adenosine, adenosine receptors and glaucoma: An updated overview
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- Regulation of Fear Responses by Striatal and Extrastriatal Adenosine A2A Receptors in Forebrain
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- Antagonism of adenosine A2A receptor expressed by lung adenocarcinoma tumor cells and cancer associated fibroblasts inhibits their growth
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- Anthraquinone emodin inhibits human cancer cell invasiveness by antagonizing P2X7 receptors
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- Altered responsiveness to extracellular ATP enhances acetaminophen hepatotoxicity
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- Adiponectin Receptor as a Key Player in Healthy Longevity and Obesity-Related Diseases
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- Targeting Adenosine Signaling to Treatment of Diabetic Nephropathy
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- From Mechanosensitivity to Inflammatory Responses: New Players in the Pathology of Glaucoma
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- Effect of the Purinergic Inhibitor Oxidized ATP in a Model of Islet Allograft Rejection
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- Targeting Purinergic Receptors in Islet Transplantation
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- The elevated gene expression level of the A2Badenosine receptor is associated with hyperglycemia in women with gestational diabetes mellitus
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- ATP and arterial calcification
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- The complex P2X7receptor/inflammasome in perivascular fat tissue of heavy smokers
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- Involvement of P2Y11 receptor in IFN-γ-induced IL-6 production in human keratinocytes
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- Adenosine signaling in airways: Toward a promising antiasthmatic approach
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- Antidepressant- and anticompulsive-like effects of purinergic receptor blockade: Involvement of nitric oxide
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- Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma
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- Extracellular UDP enhances P2X-mediated bladder smooth muscle contractility via P2Y6 activation of the phospholipase C/inositol trisphosphate pathway
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- The P2Y13receptor regulates extracellular ATP metabolism and the osteogenic response to mechanical loading
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- Signaling through Purinergic Receptors for ATP Induces Human Cutaneous Innate and Adaptive Th17 Responses: Implications in the Pathogenesis of Psoriasis
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- Adenosine A2A Receptor as a Drug Discovery Target
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- P2X7 receptor-induced death of motor neurons by a peroxynitrite/FAS-dependent pathway
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- The purinergic 2X7receptor participates in renal inflammation and injury induced by high-fat diet: possible role of NLRP3 inflammasome activation
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- CD73-Dependent Generation of Adenosine and Endothelial Adora2b Signaling Attenuate Diabetic Nephropathy
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- 284 UROTHELIUM-RELEASED ATP CONTRIBUTES TO BLADDER DYSFUNCTION IN TYPE 2 DIABETES
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- ABT-702, an adenosine kinase inhibitor, attenuates inflammation in diabetic retinopathy
- (2013) Nehal M. Elsherbiny et al. LIFE SCIENCES
- Purinergic signalling during sterile liver injury
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- Physiological Roles and Potential Therapeutic Applications of the P2X7 Receptor in Inflammation and Pain
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- Adenosine signaling in striatal circuits and alcohol use disorders
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- Astrocyte-derived ATP modulates depressive-like behaviors
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- Adenosine receptors as drug targets — what are the challenges?
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- Blockade of peripheral P2Y1 receptors prevents the induction of thermal hyperalgesia via modulation of TRPV1 expression in carrageenan-induced inflammatory pain rats: Involvement of p38 MAPK phosphorylation in DRGs
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- Presynaptic adenosine A1 receptors modulate excitatory transmission in the rat basolateral amygdala
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- Targets for botulinum toxin in the lower urinary tract
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- CF102 for the Treatment of Hepatocellular Carcinoma: A Phase I/II, Open-Label, Dose-Escalation Study
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- Voltage-gated and ATP-sensitive K+ channels are associated with cell proliferation and tumorigenesis of human glioma
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- Upregulation of P2X3 receptors by neuronal calcium sensor protein VILIP-1 in dorsal root ganglions contributes to the bone cancer pain in rats
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- The role of the adenosinergic system in lung fibrosis
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- Cardiovascular adenosine receptors: Expression, actions and interactions
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- The role of purinergic pathways in the pathophysiology of gut diseases: Pharmacological modulation and potential therapeutic applications
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- A2A Adenosine Receptors Are Differentially Modulated by Pharmacological Treatments in Rheumatoid Arthritis Patients and Their Stimulation Ameliorates Adjuvant-Induced Arthritis in Rats
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- Urinary ATP May Be a Dynamic Biomarker of Detrusor Overactivity in Women with Overactive Bladder Syndrome
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- Adenosine 2A Receptor Antagonist Prevented and Reversed Liver Fibrosis in a Mouse Model of Ethanol-Exacerbated Liver Fibrosis
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- Male contraception via simultaneous knockout of 1A-adrenoceptors and P2X1-purinoceptors in mice
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- Role of the ectonucleotidase NTPDase2 in taste bud function
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- Mutation of the ATP-gated P2X2 receptor leads to progressive hearing loss and increased susceptibility to noise
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- Purinergic signalling in the urinary tract in health and disease
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- Purinergic signalling in endocrine organs
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- Purinergic signalling in the reproductive system in health and disease
- (2013) Geoffrey Burnstock Purinergic Signalling
- Purinergic signalling in the liver in health and disease
- (2013) Geoffrey Burnstock et al. Purinergic Signalling
- Purinergic signaling in inflammatory cells: P2 receptor expression, functional effects, and modulation of inflammatory responses
- (2013) Fenila Jacob et al. Purinergic Signalling
- Block of P2X7 receptors could partly reverse the delayed neuronal death in area CA1 of the hippocampus after transient global cerebral ischemia
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- Purinergic signalling in the kidney in health and disease
- (2013) Geoffrey Burnstock et al. Purinergic Signalling
- Purinergic signalling in the musculoskeletal system
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- Loss of P2X7 nucleotide receptor function leads to abnormal fat distribution in mice
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- Purinergic signalling and cancer
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- Purinergic signalling and diabetes
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- Endogenous A1 adenosine receptor protects mice from acute ethanol-induced hepatotoxicity
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- Ejaculatory Dysfunction
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- Desensitization properties of P2X3 receptors shaping pain signaling
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- A taste for ATP: neurotransmission in taste buds
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- The therapeutic promise of ATP antagonism at P2X3 receptors in respiratory and urological disorders
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- P2X7 receptors in cerebral ischemia
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- P2Y1 purinoceptor inhibition reduces extracellular signal-regulated protein kinase 1/2 phosphorylation in spinal cord and dorsal root ganglia: implications for cancer-induced bone pain
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- The effects of adenosine A2A receptor knockout on renal interstitial fibrosis in a mouse model of unilateral ureteral obstruction
- (2012) Hang Xiao et al. ACTA HISTOCHEMICA
- Pannexin1 contributes to pathophysiological ATP release in lipoapoptosis induced by saturated free fatty acids in liver cells
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- Activated hepatic stellate cells upregulate transcription of ecto-5′-nucleotidase/CD73 via specific SP1 and SMAD promoter elements
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- P2X7 receptor-mediated purinergic signaling promotes liver injury in acetaminophen hepatotoxicity in mice
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- Clinical evaluation of the efficacy of the P2X7purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine
- (2012) Edward C Keystone et al. ANNALS OF THE RHEUMATIC DISEASES
- Adenosine Signaling
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- Regulation of Foam Cells by Adenosine
- (2012) Allison B. Reiss et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Adenosine receptor antagonism suppresses functional and histological inflammatory changes in the rat urinary bladder
- (2012) Patrik Aronsson et al. AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
- ATP activates P2X receptors to mediate gap junctional coupling in the cochlea
- (2012) Yan Zhu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Discovery of P2X3 selective antagonists for the treatment of chronic pain
- (2012) Louis-David Cantin et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Expression and electrophysiological characteristics of P2X3receptors in interstitial cells of Cajal in rats with partial bladder outlet obstruction
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- Modulation of bladder afferent signals in normal and spinal cord-injured rats by purinergic P2X3 and P2X2/3 receptors
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- Antitumor activity of zoledronic acid in primary breast cancer cells determined by the ATP tumor chemosensitivity assay
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- Mechanisms of constitutive and ATP-evoked ATP release in neonatal mouse olfactory epithelium
- (2012) Sébastien Hayoz et al. BMC NEUROSCIENCE
- CD73-Deficient Mice Are Resistant to Carcinogenesis
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- Expression of P2X7 Receptor Increases In Vivo Tumor Growth
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- The His155Tyr (489C>T) single nucleotide polymorphism of P2RX7 gene confers an enhanced function of P2X7 receptor in immune cells from patients with rheumatoid arthritis
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- Adenosine A2areceptor stimulation prevents hepatocyte lipotoxicity and non-alcoholic steatohepatitis (NASH) in rats
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- Clinical Use of Clopidogrel
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- The stimulation of A3 adenosine receptors reduces bone-residing breast cancer in a rat preclinical model
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- Functional up-regulation of P2X3 receptors in dorsal root ganglion in a rat model of bone cancer pain
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- Chronic administration of the selective P2X3, P2X2/3 receptor antagonist, A-317491, transiently attenuates cancer-induced bone pain in mice
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- Feasibility study of B16 melanoma therapy using oxidized ATP to target purinergic receptor P2X7
- (2012) Fumie Hattori et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Botulinum Neurotoxin Serotype A Suppresses Neurotransmitter Release from Afferent as Well as Efferent Nerves in the Urinary Bladder
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- Purinergic P2Y2 Receptors Promote Neutrophil Infiltration and Hepatocyte Death in Mice With Acute Liver Injury
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- Promotion of liver regeneration by natural killer cells in a murine model is dependent on extracellular adenosine triphosphate phosphohydrolysis
- (2012) Nadine Graubardt et al. HEPATOLOGY
- Disordered purinergic signaling and abnormal cellular metabolism are associated with development of liver cancer inCd39/Entpd1null Mice
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- Effects of nucleotides adenosine monophosphate and adenosine triphosphate in combination with L-arginine on male rabbit corpus cavernosum tissue
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- Dendritic cells tolerized with adenosine A2AR agonist attenuate acute kidney injury
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- Influence of pressure on adenosine triphosphate function as a sympathetic neurotransmitter in small mesenteric arteries from the spontaneously hypertensive rat
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- Adora2b Adenosine Receptor Signaling Protects during Acute Kidney Injury via Inhibition of Neutrophil-Dependent TNF-α Release
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- Clopidogrel and the risk of osteoporotic fractures: a nationwide cohort study
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- P2X7 receptor-mediated Nlrp3-inflammasome activation is a genetic determinant of macrophage-dependent crescentic glomerulonephritis
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- Identification of a Promising Drug Candidate for the Treatment of Type 2 Diabetes Based on a P2Y1 Receptor Agonist
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- ATP acts as a survival signal and prevents the mineralization of aortic valve
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- Spontaneous firing and evoked responses of spinal nociceptive neurons are attenuated by blockade of P2X3 and P2X2/3 receptors in inflamed rats
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- Suppression of Bladder Overactivity by Adenosine A2A Receptor Antagonist in a Rat Model of Parkinson Disease
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- Decreased Intravesical Adenosine Triphosphate in Patients with Refractory Detrusor Overactivity and Bacteriuria
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- Adenosine increases nasal mucociliary clearance rate in mice through A2Aand A2Badenosine receptors
- (2012) Xiaoyang Hua et al. LARYNGOSCOPE
- The modulation of hepatic adenosine triphosphate and inflammation by eicosapentaenoic acid during severe fibrotic progression in the SHRSP5/Dmcr rat model
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- Purinoceptor signaling in malaria-infected erythrocytes
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- Assessment of peripheral blood CD4+ adenosine triphosphate activity in patients with rheumatoid arthritis
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- Adenosine and autism: A spectrum of opportunities
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- Opiate-induced changes in brain adenosine levels and narcotic drug responses
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- Correlation between cystometric volumes, ATP release, and pH inwomenwithoveractive bladderversus controls
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- Functional polymorphisms in the P2X7 receptor gene are associated with osteoporosis
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- Activation of P2X7 Receptor by ATP Plays an Important Role in Regulating Inflammatory Responses during Acute Viral Infection
- (2012) Benjamin H. Lee et al. PLoS One
- Activation of P2X7 Promotes Cerebral Edema and Neurological Injury after Traumatic Brain Injury in Mice
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- Protective Role of P2Y2 Receptor against Lung Infection Induced by Pneumonia Virus of Mice
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- Non-synonymous polymorphisms in the P2RX 4 are related to bone mineral density and osteoporosis risk in a cohort of Dutch fracture patients
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- Anti-inflammatory effects of purine nucleosides, adenosine and inosine, in a mouse model of pleurisy: evidence for the role of adenosine A2 receptors
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- The CD39-adenosinergic axis in the pathogenesis of renal ischemia–reperfusion injury
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- Purinergic Receptor Antagonist A438079 Protects Against Acetaminophen-Induced Liver Injury by Inhibiting P450 Isoenzymes, Not by Inflammasome Activation
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- Enhancement of Liver Regeneration by Adenosine Triphosphate-Sensitive K+ Channel Opener (Diazoxide) After Partial Hepatectomy
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- Adenosine receptor expression in rheumatoid synovium: a basis for methotrexate action
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- Adenosine and its receptors as therapeutic targets: An overview
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- Pathophysiology of Overactive Bladder
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- A2A Adenosine Receptor (A2AAR) as a Therapeutic Target in Diabetic Retinopathy
- (2011) Ahmed S. Ibrahim et al. AMERICAN JOURNAL OF PATHOLOGY
- CD73 protects kidney from ischemia-reperfusion injury through reduction of free radicals
- (2011) RONGRONG JIAN et al. APMIS
- Activation of the P2Y1 receptor induces apoptosis and inhibits proliferation of prostate cancer cells
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- Adenosine triphosphate-based chemotherapy response assay-guided chemotherapy in unresectable colorectal liver metastasis
- (2011) H Hur et al. BRITISH JOURNAL OF CANCER
- The role of P2X7 purinergic receptors in inflammatory and nociceptive changes accompanying cyclophosphamide-induced haemorrhagic cystitis in mice
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- P2Y1 Transient Overexpression Induced Mineralization in Spinal Ligament Cells Derived from Patients with Ossification of the Posterior Longitudinal Ligament of the Cervical Spine
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- A novel fused 1,2,4-triazine aryl derivative as antioxidant and nonselective antagonist of adenosine A2A receptors in ethanol-activated liver stellate cells
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- Adenosine and protection from acute kidney injury
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- Altered purinergic signaling in CD73-deficient mice inhibits tumor progression
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- 973 ATP RELEASE FROM BLADDERS IS INCREASED IN-VIVO AND SUPPRESSED BY ALPHA-1 ADRENOCEPTOR BLOCKER IN A RAT MODEL OF BLADDER OUTLET OBSTRUCTION
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- A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases
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- Adenosine triphosphate-binding cassette transporter genes up-regulation in untreated hepatocellular carcinoma is mediated by cellular microRNAs
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- Platelet-derived adenosine 5′-triphosphate suppresses activation of human hepatic stellate cell: In vitro study
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- P2X7 receptor antagonism attenuates the hypertension and renal injury in Dahl salt-sensitive rats
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- Electromagnetic fields (EMFs) and adenosine receptors modulate prostaglandin E2and cytokine release in human osteoarthritic synovial fibroblasts
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- P2X7 receptor signaling contributes to tissue factor–dependent thrombosis in mice
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- Adenosine A2B Receptor Blockade Slows Growth of Bladder and Breast Tumors
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- Purinergic Signaling in Healthy and Diseased Skin
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- Tetanic failure due to decreased endogenous adenosine A2A tonus operating neuronal Cav1 (L-type) influx in Myasthenia gravis
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- Novel molecular targets for prevention of obesity and osteoporosis
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- UV-B induced alteration in purinergic receptors and signaling on HaCaT keratinocytes
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- CGS 21680, an Agonist of the Adenosine (A2A) Receptor, Reduces Progression of Murine Type II Collagen-induced Arthritis
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- Inhibition of the P2X7 Receptor Reduces Cystogenesis in PKD
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- Purinergic P2X7 Receptors Participate in Disturbed Intracellular Calcium Homeostasis in Peripheral Blood Mononuclear Cells of Patients with Chronic Kidney Disease
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- Adenosine abolishes MTX-induced suppression of osteoclastogenesis and inflammatory bone destruction in adjuvant-induced arthritis
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- P2Y2 receptor-mediated modulation of estrogen-induced proliferation of breast cancer cells
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- P2X7 receptor-deficient mice are susceptible to bone cancer pain
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- Purinergic signalling: From normal behaviour to pathological brain function
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- Adenosine induces cell-cycle arrest and apoptosis in androgen-dependent and -independent prostate cancer cell lines, LNcap-FGC-10, DU-145, and PC3
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- Effects of A2A adenosine receptor blockade or stimulation on alcohol intake in alcohol-preferring rats
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- Liver damage and systemic inflammatory responses are exacerbated by the genetic deletion of CD39 in total hepatic ischemia
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- Nucleotide receptors as targets in the pharmacological enhancement of dermal wound healing
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- European meeting “P2 receptors: new targets for the treatment of osteoporosis”
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- Effects of diadenosine tetraphosphate on FGF9-induced chloride flux changes in achondroplastic chondrocytes
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- P2Y1 receptor activation by photolysis of caged ATP enhances neuronal network activity in the developing olfactory bulb
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- Adenosine 2A receptor: a crucial neuromodulator with bidirectional effect in neuroinflammation and brain injury
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- ATP Mediates Neuroprotective and Neuroproliferative Effects in Mouse Olfactory Epithelium following Exposure to Satratoxin G In Vitro and In Vivo
- (2011) Cuihong Jia et al. TOXICOLOGICAL SCIENCES
- Alterations in the extracellular catabolism of nucleotides are involved in the antiproliferative effect of quercetin in human bladder cancer T24 cells
- (2011) Liliana Rockenbach et al. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
- Purinergic P2X Receptor Regulates N-Methyl-d-aspartate Receptor Expression and Synaptic Excitatory Amino Acid Concentration in Morphine-tolerant Rats
- (2010) Yueh-Hua Tai et al. ANESTHESIOLOGY
- The role of adenosine receptors in rheumatoid arthritis
- (2010) Katia Varani et al. AUTOIMMUNITY REVIEWS
- Functional and morphological examinations of P1A1 purinoceptors in the normal and inflamed urinary bladder of the rat
- (2010) Renata Vesela et al. AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
- Structure–activity relationships and in vivo activity of (1H-pyrazol-4-yl)acetamide antagonists of the P2X7 receptor
- (2010) Paul J. Beswick et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Systemic blockade of P2X3 and P2X2/3 receptors attenuates bone cancer pain behaviour in rats
- (2010) Timothy K. Y. Kaan et al. BRAIN
- Receptor localization, native tissue binding and ex vivo occupancy for centrally penetrant P2X7 antagonists in the rat
- (2010) SL Able et al. BRITISH JOURNAL OF PHARMACOLOGY
- Expression and functional role of adenosine receptors in regulating inflammatory responses in human synoviocytes
- (2010) K Varani et al. BRITISH JOURNAL OF PHARMACOLOGY
- Effect of Extracellular ATP on Cisplatin-Induced Cytotoxicity in Human Ovarian Carcinoma Cells
- (2010) Anand Rotte et al. CHEMOTHERAPY
- Adenosine deaminase in saliva as a diagnostic marker of squamous cell carcinoma of tongue
- (2010) Balwant Rai et al. Clinical Oral Investigations
- Parallel regulation of extracellular ATP and inorganic pyrophosphate: Roles of growth factors, transduction modulators, and ANK
- (2010) Jill C. Costello et al. CONNECTIVE TISSUE RESEARCH
- Expression and function of the P2X7 purinergic receptor in patients with systemic lupus erythematosus and rheumatoid arthritis
- (2010) Liliana Portales-Cervantes et al. HUMAN IMMUNOLOGY
- Hypoxia-inducible adenosine A2B receptor modulates proliferation of colon carcinoma cells
- (2010) De-Fu Ma et al. HUMAN PATHOLOGY
- Blocking P2X receptors can inhibit the injury-induced proliferation of olfactory epithelium progenitor cells in adult mouse
- (2010) Liang Gao et al. INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
- The P2Y2 Receptor Sensitizes Mouse Bladder Sensory Neurons and Facilitates Purinergic Currents
- (2010) X. Chen et al. JOURNAL OF NEUROSCIENCE
- Correlation of changes in pain intensity with synovial fluid adenosine triphosphate levels after treatment of patients with osteoarthritis of the knee with high-molecular-weight hyaluronic acid
- (2010) Nobuyuki Kumahashi et al. KNEE
- Common variants in P2RY11 are associated with narcolepsy
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- Polycystins and renovascular mechanosensory transduction
- (2010) Amanda Patel et al. Nature Reviews Nephrology
- A multi-scale view of skin thermal pain: from nociception to pain sensation
- (2010) Y. J. Zhu et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
- Purinergic Receptor Functionality Is Necessary for Infection of Human Hepatocytes by Hepatitis Delta Virus and Hepatitis B Virus
- (2010) John M. Taylor et al. PLoS One
- Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis
- (2010) J. Stagg et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The effects of P2X7 receptor antagonists on the formation and function of human osteoclasts in vitro
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- Involvement of P2Y6 Receptor in p38 MAPK-Mediated COX-2 Expression in Response to UVB Irradiation of Human Keratinocytes
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- (2010) M. J. L. Bours et al. RHEUMATOLOGY
- Butyl benzyl phthalate suppresses the ATP-induced cell proliferation in human osteosarcoma HOS cells
- (2010) Pei-Shan Liu et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- ADP-dependent platelet function prior to and in the early course of pediatric Liver transplantation and persisting thrombocytopenia are positively correlated with ischemia/reperfusion injury
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- (2010) L.-M. Tang et al. TRANSPLANTATION PROCEEDINGS
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- Synthesis of ATP derivatives of compounds of the mevalonate pathway (isopentenyl di- and triphosphate; geranyl di- and triphosphate, farnesyl di- and triphosphate, and dimethylallyl diphosphate) catalyzed by T4 RNA ligase, T4 DNA ligase and other ligases
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- Deficiency of polycystic kidney disease-1 gene (PKD1) expression increases A3 adenosine receptors in human renal cells: Implications for cAMP-dependent signalling and proliferation of PKD1-mutated cystic cells
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- Effects of ageing and streptozotocin-induced diabetes on connexin43 and P2 purinoceptor expression in the rat corpora cavernosa and urinary bladder
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- ADA-deficient SCID is associated with a specific microenvironment and bone phenotype characterized by RANKL/OPG imbalance and osteoblast insufficiency
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- P2X7-mediated chemoprevention of epithelial cancers
- (2009) George I Gorodeski EXPERT OPINION ON THERAPEUTIC TARGETS
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- Functional variants of the P2RX7 gene, aseptic osteolysis, and revision of the total hip arthroplasty: A preliminary study
- (2009) F. Mrazek et al. HUMAN IMMUNOLOGY
- In vivo infusion of UTP and uridine to the deafened guinea pig inner ear: Effects on response thresholds and neural survival
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- Adenosine Administration Accelerates Progression of the Cell Cycle during Rat Liver Regeneration Induced by One-Third Hepatectomy
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- Adenosine Signaling, Priapism and Novel Therapies
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- Management of Erectile Function by Penile Purinergic P2 Receptors in the Diabetic Rat
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- Comparison of the peripheral mediator background of heat injury- and plantar incision-induced drop of the noxious heat threshold in the rat
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- Adenosine in fibrosis
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- Purinergic Mechanosensory Transduction and Visceral Pain
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- Role of Extracellular Adenosine in Acute Lung Injury
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- (2009) F. von Versen-Höynck et al. PLACENTA
- Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury
- (2009) W. Peng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An in vivo model of melanoma: treatment with ATP
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- P2X7 receptor expression is decreased in epithelial cancer cells of ectodermal, uro-genital sinus, and distal paramesonephric duct origin
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- Genetics of the P2X7 receptor and human disease
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- An imbalance between apoptosis and proliferation contributes to follicular persistence in polycystic ovaries in rats
- (2009) Natalia R Salvetti et al. Reproductive Biology and Endocrinology
- Platelet hyper-reactivity in active inflammatory arthritis is unique to the adenosine diphosphate pathway: a novel finding and potential therapeutic target
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- Uridine-5′-triphosphate Protects Against Hepatic- Ischemic/Reperfusion Injury in Mice
- (2009) Ziv Ben-Ari et al. TRANSPLANTATION
- Purinergic signaling in special senses
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- MDA-MB-231 produces ATP-mediated ICAM-1-dependent facilitation of the attachment of carcinoma cells to human lymphatic endothelial cells
- (2008) Yoshiko Kawai et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Neuronally released sympathetic neurotransmitters stimulate splenic interferon-γ secretion from T cells in early type II collagen-induced arthritis
- (2008) Rainer H. Straub et al. ARTHRITIS AND RHEUMATISM
- Radioprotective effects of ATP in human blood ex vivo
- (2008) Els L.R. Swennen et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Change in acetylcholine release from rat bladder with partial outlet obstruction
- (2008) Shigetaka Murakami et al. BJU INTERNATIONAL
- A functional study of purinergic signalling in the normal and pathological rabbit corpus cavernosum
- (2008) Robert C. Calvert et al. BJU INTERNATIONAL
- Cell Death Induced by Uridine 5'-triphosphate (UTP) in Contrast to Adenosine 5'-triphosphate (ATP) in Human Epidermoid Carcinoma Cells (A-431)
- (2008) Thomas Völkl et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- ATP, calcium and magnesium levels in platelets of patients with primary fibromyalgia
- (2008) Laura Bazzichi et al. CLINICAL BIOCHEMISTRY
- Differential responses of cells from human skin keratinocyte and bovine mammary epithelium to attack by pore-forming Staphylococcus aureus α-toxin
- (2008) Gunnaporn Suriyaphol et al. COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
- The P2X7receptor as a therapeutic target
- (2008) Romeo Romagnoli et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Purinergic receptor-mediated effects of adenosine 5′-triphosphate in urological malignant diseases
- (2008) Majid Shabbir et al. INTERNATIONAL JOURNAL OF UROLOGY
- APT102, a novel adpase, cooperates with aspirin to disrupt bone metastasis in mice
- (2008) Özge Uluçkan et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Targeting Therapy for Breast Carcinoma by ATP Synthase Inhibitor Aurovertin B
- (2008) Tsui-Chin Huang et al. JOURNAL OF PROTEOME RESEARCH
- Unknown
- (2008) Alexander Chouker et al. MOLECULAR MEDICINE
- Purinergic signalling and disorders of the central nervous system
- (2008) Geoffrey Burnstock NATURE REVIEWS DRUG DISCOVERY
- Reg-2 expression in dorsal root ganglion neurons after adjuvant-induced monoarthritis
- (2008) S. Averill et al. NEUROSCIENCE
- Adenosine analogs and electromagnetic fields inhibit prostaglandin E2 release in bovine synovial fibroblasts
- (2008) M. De Mattei et al. OSTEOARTHRITIS AND CARTILAGE
- Human Equilibrative Nucleoside Transporters 1 and 2 may be Differentially Modulated by A2B Adenosine Receptors in Placenta Microvascular Endothelial Cells from Pre-eclampsia
- (2008) C. Escudero et al. PLACENTA
- ATP release from the human ureter on distension and P2X3 receptor expression on suburothelial sensory nerves
- (2008) R. C. Calvert et al. Purinergic Signalling
- Drug Insight: biological effects of botulinum toxin A in the lower urinary tract
- (2008) Michael B Chancellor et al. Nature clinical practice. Urology
- P2Y receptors activated by diadenosine polyphosphates reestablish Ca2+ transients in achondroplasic chondrocytes
- (2007) Ana Guzmán-Aránguez et al. BONE
- Contrasting effects of P2 receptor agonists on spontaneous contractility of human fallopian tubes with and without acute inflammation
- (2007) Airat U. Ziganshin et al. PHARMACOLOGICAL RESEARCH
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