The ATP-Gated P2X7 Receptor As a Target for the Treatment of Drug-Resistant Epilepsy

The evolution of P2X7 antagonists with a focus on CNS indications

(2016) Jason C. Rech et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pilocarpine-Induced Status Epilepticus Increases the Sensitivity of P2X7 and P2Y1 Receptors to Nucleotides at Neural Progenitor Cells of the Juvenile Rodent Hippocampus

(2016) Katalin Rozmer et al.   CEREBRAL CORTEX

Neurodevelopmental alterations and seizures developed by mouse model of infantile hypophosphatasia are associated with purinergic signalling deregulation

(2016) Álvaro Sebastián-Serrano et al.   HUMAN MOLECULAR GENETICS

Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy

(2016) Alba Jimenez-Pacheco et al.   JOURNAL OF NEUROSCIENCE

Purinergic signaling in epilepsy

(2016) François Rassendren et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Classic antiepileptic drugs under fire and new options emerge

(2016) Christian E. Elger   Nature Reviews Neurology

Assessment of Treatment Side Effects and Quality of Life in People with Epilepsy

(2016) Benjamin N. Blond et al.   NEUROLOGIC CLINICS

P2X7 receptor antagonism reduces the severity of spontaneous seizures in a chronic model of temporal lobe epilepsy

(2016) Halima Amhaoul et al.   NEUROPHARMACOLOGY

ATPergic signalling during seizures and epilepsy

(2016) Tobias Engel et al.   NEUROPHARMACOLOGY

Purinergic mechanisms in neuroinflammation: An update from molecules to behavior

(2016) Edward Beamer et al.   NEUROPHARMACOLOGY

Variations of ATP and its metabolites in the hippocampus of rats subjected to pilocarpine-induced temporal lobe epilepsy

(2016) Flávia Doná et al.   Purinergic Signalling

Lack of functional P2X7 receptor aggravates brain edema development after middle cerebral artery occlusion

(2016) Melanie Kaiser et al.   Purinergic Signalling

P2X ion channel receptors and inflammation

(2016) Geoffrey Burnstock   Purinergic Signalling

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

Critical Evaluation of P2X7 Receptor Antagonists in Selected Seizure Models

(2016) Wolfgang Fischer et al.   PLoS One

The blood–brain barrier endothelium: a target for pro-inflammatory cytokines: Figure 1

(2015) Keith D. Rochfort et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Astrocyte uncoupling as a cause of human temporal lobe epilepsy

(2015) Peter Bedner et al.   BRAIN

Up-regulation of P2X7 receptor-mediated inhibition of GABA uptake by nerve terminals of the human epileptic neocortex

(2015) Aurora R. Barros-Barbosa et al.   EPILEPSIA

Effect of GLT-1 modulator and P2X7 antagonists alone and in combination in the kindling model of epilepsy in rats

(2015) Neha Soni et al.   EPILEPSY & BEHAVIOR

Reactive Astrogliosis Causes the Development of Spontaneous Seizures

(2015) S. Robel et al.   JOURNAL OF NEUROSCIENCE

Epilepsy: new advances

(2015) Solomon L Moshé et al.   LANCET

Neuromodulatory properties of inflammatory cytokines and their impact on neuronal excitability

(2015) Annamaria Vezzani et al.   NEUROPHARMACOLOGY

Inter-individual variation in the effect of antiepileptic drugs in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice

(2015) Sabine Klein et al.   NEUROPHARMACOLOGY

microRNA targeting of the P2X7 purinoceptor opposes a contralateral epileptogenic focus in the hippocampus

(2015) Eva M. Jimenez-Mateos et al.   Scientific Reports

Immunity and Inflammation in Epilepsy

(2015) Annamaria Vezzani et al.   Cold Spring Harbor Perspectives in Medicine

ATP as a multi-target danger signal in the brain

(2015) Ricardo J. Rodrigues et al.   Frontiers in Neuroscience

Management of epilepsy during pregnancy: an update

(2015) Sima I. Patel et al.   Therapeutic Advances in Neurological Disorders

Extracellular nucleotide and nucleoside signaling in vascular and blood disease

(2014) M. Idzko et al.   BLOOD

ATP-P2X7 Receptor Modulates Axon Initial Segment Composition and Function in Physiological Conditions and Brain Injury

(2014) Ana del Puerto et al.   CEREBRAL CORTEX

Past and Present Definitions of Epileptogenesis and Its Biomarkers

(2014) Asla Pitkänen et al.   Neurotherapeutics

P2X7 receptor: an emerging target in central nervous system diseases

(2014) Beáta Sperlágh et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Neuronal mechanisms of epileptogenesis

(2014) Roberto Di Maio   Frontiers in Cellular Neuroscience

The two-hit hypothesis for neuroinflammation: role of exogenous ATP in modulating inflammation in the brain

(2014) Bernd L. Fiebich et al.   Frontiers in Cellular Neuroscience

Increased neocortical expression of the P2X7 receptor after status epilepticus and anticonvulsant effect of P2X7 receptor antagonist A-438079

(2013) Alba Jimenez-Pacheco et al.   EPILEPSIA

Ablation of P2X7 receptor exacerbates gliosis and motoneuron death in the SOD1-G93A mouse model of amyotrophic lateral sclerosis

(2013) S. Apolloni et al.   HUMAN MOLECULAR GENETICS

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Transcranial amelioration of inflammation and cell death after brain injury

(2013) Theodore L. Roth et al.   NATURE

Seizure-induced brain-borne inflammation sustains seizure recurrence and blood-brain barrier damage

(2012) Laura Librizzi et al.   ANNALS OF NEUROLOGY

P2X7 Receptors: Channels, Pores and More

(2012) C. Volonte et al.   CNS & Neurological Disorders-Drug Targets

Pharmacoresistance and the role of surgery in difficult to treat epilepsy

(2012) Samuel Wiebe et al.   Nature Reviews Neurology

Ion Channels on Microglia: Therapeutic Targets for Neuroprotection

(2011) Stephen D. Skaper   CNS & Neurological Disorders-Drug Targets

Molecular cascades that mediate the influence of inflammation on epilepsy

(2011) Alon Friedman et al.   EPILEPSIA

Seizure suppression and neuroprotection by targeting the purinergic P2X7 receptor during status epilepticus in mice

(2011) Tobias Engel et al.   FASEB JOURNAL

The P2X7 receptor–pannexin-1 complex decreases muscarinic acetylcholine receptor–mediated seizure susceptibility in mice

(2011) Ji-Eun Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms of epileptogenesis and potential treatment targets

(2011) Asla Pitkänen et al.   LANCET NEUROLOGY

The Role of ATP in Sleep Regulation

(2011) Sachiko Chikahisa et al.   Frontiers in Neurology

Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures

(2010) Mattia Maroso et al.   NATURE MEDICINE

The genetics of epilepsy—The past, the present and future

(2010) Mark I. Rees   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Release of Adenosine and ATP During Ischemia and Epilepsy

(2009) Nicholas Dale et al.   Current Neuropharmacology

Reduced hippocampal damage and epileptic seizures after status epilepticus in mice lacking proapoptotic Puma

(2009) Tobias Engel et al.   FASEB JOURNAL

The P2X7 Receptor Drives Microglial Activation and Proliferation: A Trophic Role for P2X7R Pore

(2009) M. Monif et al.   JOURNAL OF NEUROSCIENCE

Key factors in the discovery and development of new antiepileptic drugs

(2009) Meir Bialer et al.   NATURE REVIEWS DRUG DISCOVERY

A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1 

(2008) S. Balosso et al.   BRAIN

Alteration of purinergic P2X4 and P2X7 receptor expression in rats with temporal-lobe epilepsy induced by pilocarpine

(2008) Flavia Doná et al.   EPILEPSY RESEARCH

Inhibition of P2X7 receptors by divalent cations: old action and new insight

(2008) Lin-Hua Jiang   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Antagonism of peripheral inflammation reduces the severity of status epilepticus

(2008) Nicola Marchi et al.   NEUROBIOLOGY OF DISEASE

Purinergic signalling in the nervous system: an overview

(2008) Maria P. Abbracchio et al.   TRENDS IN NEUROSCIENCES