Review
Medicine, General & Internal
Teresa Salvatore, Pia Clara Pafundi, Raffaele Galiero, Gaetana Albanese, Anna Di Martino, Alfredo Caturano, Erica Vetrano, Luca Rinaldi, Ferdinando Carlo Sasso
Summary: Research has shown that individuals with diabetes mellitus have a higher risk of heart failure compared to non-diabetic individuals, and diabetic cardiomyopathy may be a key factor. Metabolic abnormalities, mitochondrial damage, oxidative stress, and other factors may lead to extracellular remodeling and hypertrophy in the diabetic heart, resulting in left ventricular diastolic and systolic dysfunction.
FRONTIERS IN MEDICINE
(2021)
Article
Pathology
Aicha Saadane, Yunpeng Du, Wallace B. Thoreson, Masaru Miyagi, Emma M. Lessieur, Jianying Kiser, Xiangyi Wen, Bruce A. Berkowitz, Timothy S. Kern
Summary: This study demonstrated that diabetes increases cytosolic calcium level in rod cells, activating a Ca2+-sensitive protease called calpain, leading to oxidative stress and inflammation in the retina. Inhibiting calpain activity or reducing Wwox up-regulation could be novel therapeutic targets for early diabetic retinopathy.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yu-Han Chen, Albert P. Ta, Yumay Chen, Hsiao-Chen Lee, Wenjun Fan, Phang-Lang Chen, Maria C. Jordan, Kenneth P. Roos, Grant R. MacGregor, Qin Yang, Robert A. Edwards, Junfeng Li, Ping H. Wang
Summary: The study aimed to investigate the effect of mitochondrial AKT signaling on cardiac structure and function. The results showed that disrupted mitochondrial AKT signaling led to cardiomyopathy with cardiac fibrosis, left ventricular hypertrophy, and dysfunction. On the other hand, activation of mitochondrial AKT1 protected against diabetic cardiomyopathy and improved overall metabolism. These findings highlight the importance of mitochondrial AKT signaling in maintaining cardiac health.
CARDIOVASCULAR DIABETOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Claudia Richter, Rabea Hinkel
Summary: Research on diabetic cardiomyopathy relies heavily on animal models, particularly transgenic rodent models. While these models have advantages in terms of genetic traceability and direct measurable effects, they also face challenges in clinical relevance. Other spontaneous diabetes models in larger mammals like dogs and pigs could be more representative for testing translational approaches.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Endocrinology & Metabolism
Raffaele Marfella, Nunzia D'Onofrio, Maria Consiglia Trotta, Celestino Sardu, Lucia Scisciola, Cristiano Amarelli, Maria Luisa Balestrieri, Vincenzo Grimaldi, Gelsomina Mansueto, Salvatore Esposito, Michele D'Amico, Paolo Golino, Giuseppe Signoriello, Marisa De Feo, Ciro Maiello, Claudio Napoli, Giuseppe Paolisso
Summary: The early pathogenesis of human diabetic cardiomyopathy is associated with overexpression of JunD/PPAR-gamma and lipid accumulation, which can be attenuated by treatment with SGLT2 inhibitors in diabetic patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Cell Biology
Brad Ebanks, Gunjan Katyal, Chris Taylor, Adam Dowle, Chiara Papetti, Magnus Lucassen, Nicoleta Moisoi, Lisa Chakrabarti
Summary: This study investigated the interaction of mitochondrial haemoglobin with ATP synthase and its associated proteins, and found upregulated expression of mitochondrial haemoglobin in response to hypoxia. The results suggest that mitochondrial pH and ATP synthase activity are involved in the mitochondrial haemoglobin response to hypoxia.
Article
Cell Biology
Stefano Cagnin, Marco Brugnaro, Caterina Millino, Beniamina Pacchioni, Carmen Troiano, Moises Di Sante, Nina Kaludercic
Summary: This study reveals the link between MAO activity, transcriptomic changes, and activation of pro-survival signaling and autophagy in diabetic cardiomyopathy.
Article
Cell Biology
Xiaowei Liu, Yajun Liu, Lijiang Tang, Changqing Du
Summary: This study found that FPPS overexpression is associated with diabetic myocardial remodeling, and IBN inhibits myocardial tissue remodeling by suppressing the RhoA/ERK1/2 and RhoA/p38 MAPK pathways.
Article
Biochemistry & Molecular Biology
Lang Hu, Yanjie Guo, Liqiang Song, He Wen, Nan Sun, Ying Wang, Bingchao Qi, Qi Liang, Jing Geng, Xuteng Liu, Feng Fu, Yan Li
Summary: In patients with diabetes, myocardial dysfunction is associated with an imbalance in mitochondrial fusion/fission dynamics. Nicotinamide riboside (NR) supplementation can ameliorate mitochondrial dysfunction and oxidative stress by promoting mitochondrial fusion. This study suggests that promoting mitochondrial fusion through oral supplementation of NR could be a potential strategy for delaying cardiac complications in patients with diabetes.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Yan Xiong, Yu-Lian He, Xiao-Mei Li, Fan Nie, Xin-Ke Zhou
Summary: This study showed that endogenous ADMA accumulation contributes to cardiac and mitochondrial dysfunctions in diabetic rats, possibly through NOS uncoupling.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Mengyi Wang, Jingyuan Tang, Shiwu Zhang, Kemiao Pang, Yajun Zhao, Ning Liu, Jiayi Huang, Jiaxin Kang, Shiyun Dong, Hongxia Li, Zhen Tian, Binhong Duan, Fanghao Lu, Weihua Zhang
Summary: In this study, the researchers investigated the effects of hydrogen sulfide (H2S) on diabetic cardiomyopathy (DCM) in mice and cardiomyocytes. They found that exogenous H2S restored its levels in the hearts of diabetic mice and cardiomyocytes exposed to high glucose and palmitate. H2S activated the Nrf2/GPx4/GSH pathway, suppressed ferroptosis, and mitigated mitochondrial apoptosis in db/db mice. The researchers also discovered that H2S facilitated the sulfhydration of Syvn1, which increased the ubiquitination level of Keap1 and promoted Nrf2 nuclear translocation. Overall, exogenous H2S showed potential therapeutic effects on DCM.
CELL DEATH DISCOVERY
(2023)
Article
Endocrinology & Metabolism
Xin Huang, Kai-jie Zhang, Jun-jie Jiang, Shou-yin Jiang, Jia-bin Lin, Yi-jia Lou
Summary: This study explores the underlying mechanisms of acute cardiac injury in T2D hearts with SARS-CoV-2 infection. The researchers identified CAPNS1 as a crucial gene associated with JP2 hydrolysis and nuclear translocation. These findings suggest CAPNS1 as a potential target for adverse prognostics and comprehensive therapy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Raffaele Marfella, Nunzia D'Onofrio, Gelsomina Mansueto, Vincenzo Grimaldi, Maria Consiglia Trotta, Celestino Sardu, Ferdinando Carlo Sasso, Lucia Scisciola, Cristiano Amarelli, Salvatore Esposito, Michele D'Amico, Paolo Golino, Marisa De Feo, Giuseppe Signoriello, Pasquale Paolisso, Emanuele Gallinoro, Marc Vanderheyden, Ciro Maiello, Maria Luisa Balestrieri, Emanuele Barbato, Claudio Napoli, Giuseppe Paolisso
Summary: The study found that high glycated-hemoglobin (HbA1c) levels in type-2 diabetic (T2DM) patients with reduced ejection fraction were associated with an increased risk of adverse cardiovascular outcomes. The diabetic environment affects the levels of glycosylated ACE2 (GlycACE2) in cardiomyocytes, which weakens the anti-remodeling effects of renin-angiotensin system (RAS) inhibitors. Poor glycemic control increases the expression of GlycACE2, while achieving tight glycemic control restores the cardioprotective effects of RAS inhibition.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Cell Biology
Priyanka Gupta, Keehn Strange, Rahul Telange, Ailan Guo, Heather Hatch, Amin Sobh, Jonathan Elie, Angela M. Carter, John Totenhagen, Chunfeng Tan, Yogesh A. Sonawane, Jiri Neuzil, Amarnath Natarajan, Ashley J. Ovens, Jonathan S. Oakhill, Thorsten Wiederhold, Karel Pacak, Hans K. Ghayee, Laurent Meijer, Sushanth Reddy, James A. Bibb
Summary: Metabolic dysfunction mutations can lead to cancer. Loss of SDHB triggers a signaling cascade that disrupts energy sensing and promotes cancer progression.
Article
Multidisciplinary Sciences
Eslam M. F. Mehina, Stephanie Taylor, Roobina Boghozian, Emily White, Sun Eui Choi, Manjinder S. Cheema, Jakob Korbelin, Craig E. Brown
Summary: The study identified a unique population of Gal3-expressing infiltrative macrophages in diabetic mice that play a crucial role in promoting vessel elimination after brain injury. Depletion of these infiltrative macrophages attenuated phagocytic activity and prevented the loss of blood vessels after injury.
Article
Cardiac & Cardiovascular Systems
Yutian Li, Shan Deng, Xiaohong Wang, Wei Huang, Jing Chen, Nathan Robbins, Xingjiang Mu, Kobina Essandoh, Tianqing Peng, Anil G. Jegga, Jack Rubinstein, David E. Adams, Yigang Wang, Jiangtong Peng, Guo-Chang Fan
Summary: This study utilizing a global Sectm1a-knockout mouse model revealed that Sectm1a deficiency leads to increased accumulation of inflammatory macrophages in the heart, worsening cardiac injury in response to inflammatory stimuli. By modulating LXR alpha signaling in macrophages, Sectm1a was identified as a novel regulator of inflammation-induced cardiac dysfunction, suggesting its potential as a therapeutic target for resolving inflammation and associated cardiac dysfunction.
CARDIOVASCULAR RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Sandra K. Szlapinski, David J. Hill
Summary: Normal pregnancy is associated with increased insulin resistance which is normally compensated for by an adaptive increase in pancreatic beta-cell mass. Placenta-derived hormones and growth factors play a key role in altering pancreatic morphology and function. However, maternal obesity can disrupt this adaptive process, leading to an increased risk of gestational diabetes.
CURRENT VASCULAR PHARMACOLOGY
(2021)
Editorial Material
Medicine, Research & Experimental
E. Dale Abel
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Medicine, Research & Experimental
Maoxue Tang, Sarah H. Park, Sabrina Petri, Hang Yu, Carlos B. Rueda, E. Dale Abel, Carla Y. Kim, Elizabeth M. C. Hillman, Fanghua Li, Yeojin Lee, Lei Ding, Smitha Jagadish, Wayne N. Frankel, Darryl C. De Vivo, Umrao R. Monani
Summary: Glut1 plays a crucial role in brain angiogenesis through its cell-autonomous function in brain microvascular endothelial cells. Depletion of Glut1 leads to neuroinflammation, reduced BDNF levels, and disease manifestation, with the most severe effects observed when Glut1 scarcity is induced during neonatal brain angiogenesis. Targeting brain endothelial cells during early development is essential for maintaining proper brain angiogenesis and preventing neuroinflammation in Glut1 deficiency syndrome.
Article
Cardiac & Cardiovascular Systems
Kate L. Weeks, Yow Keat Tham, Suzan G. Yildiz, Yonali Alexander, Daniel G. Donner, Helen Kiriazis, Claudia A. Harmawan, Amy Hsu, Bianca C. Bernardo, Aya Matsumoto, Ronald A. DePinho, E. Dale Abel, Elizabeth A. Woodcock, Julie R. McMullen
Summary: This study found that the transcription factor FoxO1 is a critical mediator of exercise-induced cardiac hypertrophy, which has important implications when considering FoxO1 as a target for treating the diseased heart. Given that exercise-induced hypertrophy is protective, this finding is significant in the context of treating heart disease.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Immunology
Peng Wang, Xingjiang Mu, Hongyan Zhao, Yutian Li, Lu Wang, Vivian Wolfe, Shu-Nan Cui, Xiaohong Wang, Tianqing Peng, Basilia Zingarelli, Chunting Wang, Guo-Chang Fan
Summary: This study revealed that GDF3 may play a crucial role in controlling bacterial infection by enhancing macrophage phagocytosis and intracellular killing of bacteria through promoting LXR alpha activity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Pierre-Benoit Ancey, Caroline Contat, Gael Boivin, Silvia Sabatino, Justine Pascual, Nadine Zangger, Jean Yannis Perentes, Solange Peters, E. Dale Abel, David G. Kirsch, Jeffrey C. Rathmell, Marie-Catherine Vozenin, Etienne Meylan
Summary: The study highlights the importance of GLUT1 in tumor-associated neutrophils (TAN) within lung tumors, with increased glucose uptake mediated by GLUT1 impacting tumor growth and radiotherapy resistance. Targeting metabolic vulnerabilities to support anti-tumor neutrophils may be a promising strategy for cancer treatment.
Review
Biochemistry & Molecular Biology
David J. Hill
Summary: The development and plasticity of the endocrine pancreas are influenced by both intrauterine and postnatal factors. Perturbations in nutritional availability and metabolic requirements can lead to altered pancreatic function and increased risk of diabetes. Cellular pathways within the pancreas, especially paracrine interactions, play a crucial role in limiting the plasticity of insulin-producing cells.
MOLECULAR ASPECTS OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Sandra Szlapinski, Brenda Strutt, Madeline Deane, Edith Arany, Jamie Bennett, David J. Hill
Summary: The study found that artemisinin and acetone both improve glucose tolerance, mainly due to acetone. In non-pregnant mice, acetone treatment can promote α-cell to β-cell conversion. However, there was no significant change in β-cell mass during pregnancy or post-partum.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Lin Jiang, Jialiang Liang, Wei Huang, Jianyong Ma, Ki Ho Park, Zhichao Wu, Peng Chen, Hua Zhu, Jian-Jie Ma, Wenfeng Cai, Christian Paul, Liang Niu, Guo-Chang Fan, Hong-Sheng Wang, Onur Kanisicak, Meifeng Xu, Yigang Wang
Summary: Using the CRISPR activation system, fibroblasts were reprogrammed into CPCs by activating endogenous genes. These induced CPCs showed cardiac characteristics and were able to generate functional cardio-myocytes and vascular cells in vitro. The transcriptomic analysis revealed important gene regulatory mechanisms during the early stage of CPC formation.
Article
Cardiac & Cardiovascular Systems
Huili Li, Ting Cao, Weimin Ding, Liwen Liang, Guo-Chang Fan, Lina Qu, Tianqing Peng
Summary: Microgravity-induced myocardial abnormalities can be prevented and treated by inhibiting Rac1, which is associated with the inhibition of NADPH oxidase activation and reduction of oxidative stress. This finding may pave the way for future clinical trials using atorvastatin to prevent myocardial abnormalities under microgravity conditions.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Mengxiao Zhang, Huiting Zhong, Ting Cao, Yifan Huang, Xiaoyun Ji, Guo-Chang Fan, Tianqing Peng
Summary: Lipid overload contributes to cardiac complications of diabetes and obesity. This study reveals the protective role of gamma-aminobutyrate transaminase (ABAT) in lipid overload-induced cardiac injury through mechanisms independent of its GABA catabolic activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Lilian Cristina Mendoza, Juergen Harreiter, Gernot Desoye, David Simmons, Juan M. Adelantado, Alexandra Kautzky-Willer, Agnieszka Zawiejska, Ewa Wender-Ozegowska, Annunziata Lapolla, Maria G. Dalfra, Alessandra Bertolotto, Roland Devlieger, Fidelma Dunne, Elisabeth R. Mathiesen, Peter Damm, Lisse Lotte Andersen, Dorte Moller Jensen, David Hill, Mireille Nicoline Maria van Poppel, Rosa Corcoy
Summary: This study examines the relationship between vitamin D and glucose homeostasis in pregnant women with overweight/obesity. The results show no clear beneficial associations between vitamin D compounds and glucose homeostasis measures.
Article
Biochemistry & Molecular Biology
Shawna L. L. McMillin, Parker L. L. Evans, William M. M. Taylor, Luke A. A. Weyrauch, Tyler J. J. Sermersheim, Steven S. S. Welc, Monique R. R. Heitmeier, Richard C. C. Hresko, Paul W. W. Hruz, Francoise Koumanov, Geoffrey D. D. Holman, E. Dale Abel, Carol A. A. Witczak
Summary: The study found that GLUT1 does not mediate basal muscle glucose uptake and suggests the existence of a novel glucose transport mechanism for overload-stimulated glucose uptake.
Article
Biochemistry & Molecular Biology
Julia T. Stadler, Mireille N. M. van Poppel, Christian Wadsack, Michael Holzer, Anja Pammer, David Simmons, David Hill, Gernot Desoye, Gunther Marsche
Summary: Pregravid obesity is a major risk factor for pregnancy complications and cardiovascular events in children. However, the biological mechanisms underlying these adverse outcomes are not well understood. Impairment of HDL function in obese and GDM-complicated pregnancies may have long-term effects on maternal and offspring health.