P2X7 Receptor Signaling Contributes to Sepsis-Associated Brain Dysfunction

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Inhibition of Signal Transducer and Activator of Transcription 3 (STAT3) reduces neonatal hypoxic-ischaemic brain damage

(2016) Mariya Hristova et al.   JOURNAL OF NEUROCHEMISTRY

The role of microglia activation in the development of sepsis-induced long-term cognitive impairment

(2015) Monique Michels et al.   BRAIN BEHAVIOR AND IMMUNITY

P2X7 Receptor Antagonism Attenuates the Intermittent Hypoxia-induced Spatial Deficits in a Murine Model of Sleep Apnea Via Inhibiting Neuroinflammation and Oxidative Stress

(2015) Hui-Guo Liu et al.   CHINESE MEDICAL JOURNAL

CD39 improves survival in microbial sepsis by attenuating systemic inflammation

(2015) Balázs Csóka et al.   FASEB JOURNAL

The P2X7 Receptor Contributes to the Development of the Exacerbated Inflammatory Response Associated with Sepsis

(2015) Patricia Texeira Santana et al.   Journal of Innate Immunity

Interleukin-1 and acute brain injury

(2015) Katie N. Murray et al.   Frontiers in Cellular Neuroscience

Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors

(2015) Ayumi Kawano et al.   PLoS One

Neuroinflammation: Microglial Activation During Sepsis

(2014) Monique Michels et al.   CURRENT NEUROVASCULAR RESEARCH

P2X7-dependent, but differentially regulated release of IL-6, CCL2, and TNF-α in cultured mouse microglia

(2014) Chu-Hsin Shieh et al.   GLIA

Activation of Human Alveolar Macrophages via P2 Receptors: Coupling to Intracellular Ca2+ Increases and Cytokine Secretion

(2014) D. Myrtek et al.   JOURNAL OF IMMUNOLOGY

Long-term cerebral consequences of sepsis

(2014) Catherine N Widmann et al.   LANCET NEUROLOGY

Activated Microglia-Induced Deficits in Excitatory Synapses Through IL-1β: Implications for Cognitive Impairment in Sepsis

(2014) Carolina A. Moraes et al.   MOLECULAR NEUROBIOLOGY

Inflammasomes in neuroinflammation and changes in brain function: a focused review

(2014) Gaurav Singhal et al.   Frontiers in Neuroscience

The role of p2x7 receptor in infectious inflammatory diseases and the influence of ectonucleotidases

(2014) Robson Coutinho-Silva et al.   Biomedical Journal

TLR stimulation initiates a CD39-based autoregulatory mechanism that limits macrophage inflammatory responses

(2013) H. B. Cohen et al.   BLOOD

A cytokine network involving brain-borne IL-1β, IL-1ra, IL-18, IL-6, and TNFα operates during long-term potentiation and learning

(2013) Adriana del Rey et al.   BRAIN BEHAVIOR AND IMMUNITY

Il1-β Involvement in Cognitive Impairment after Sepsis

(2013) Francielle Mina et al.   MOLECULAR NEUROBIOLOGY

Acute Brain Inflammation and Oxidative Damage Are Related to Long-Term Cognitive Deficits and Markers of Neurodegeneration in Sepsis-Survivor Rats

(2013) Mágada T. Schwalm et al.   MOLECULAR NEUROBIOLOGY

Disordered purinergic signaling and abnormal cellular metabolism are associated with development of liver cancer inCd39/Entpd1null Mice

(2012) Xiaofeng Sun et al.   HEPATOLOGY

Caspase-3 Mediates In Part Hippocampal Apoptosis in Sepsis

(2012) Clarissa M. Comim et al.   MOLECULAR NEUROBIOLOGY

Sepsis-associated encephalopathy

(2012) Teneille E. Gofton et al.   Nature Reviews Neurology

Sepsis-induced morbidity in mice: Effects on body temperature, body weight, cage activity, social behavior and cytokines in brain

(2012) Jill I. Granger et al.   PSYCHONEUROENDOCRINOLOGY

NTPDase1 activity attenuates microglial phagocytosis

(2012) Larisa Bulavina et al.   Purinergic Signalling

Sepsis-Associated Encephalopathy: Review of the Neuropsychiatric Manifestations and Cognitive Outcome

(2011) C. D. Lamar et al.   JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES

Cecal ligation and puncture: the gold standard model for polymicrobial sepsis?

(2011) Lien Dejager et al.   TRENDS IN MICROBIOLOGY

NTPDase1 governs P2X7-dependent functions in murine macrophages

(2010) Sébastien A. Lévesque et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Adenosine A2A receptor agonist (CGS-21680) prevents endotoxin-induced effects on nucleotidase activities in mouse lymphocytes

(2010) Fernanda Cenci Vuaden et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis

(2010) Theodore J. Iwashyna et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

(2010) B. McDonald et al.   SCIENCE

The P2X7 Receptor Drives Microglial Activation and Proliferation: A Trophic Role for P2X7R Pore

(2009) M. Monif et al.   JOURNAL OF NEUROSCIENCE

Oxidative Mechanisms of Brain Dysfunction During Sepsis

(2009) Felipe Dal-Pizzol et al.   NEUROCHEMICAL RESEARCH

Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury

(2009) W. Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Purinergic signalling in inflammation of the central nervous system

(2009) Francesco Di Virgilio et al.   TRENDS IN NEUROSCIENCES

Knockout Mice Reveal a Role for P2Y6 Receptor in Macrophages, Endothelial Cells, and Vascular Smooth Muscle Cells

(2008) I. Bar et al.   MOLECULAR PHARMACOLOGY

ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1  and IL-18 secretion in an autocrine way

(2008) A. Piccini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ectonucleotidasecd39/ENTPDase1 modulates purinergic-mediated microglial migration

(2007) Katrin Färber et al.   GLIA