Modulation of P2X3 and P2X2/3 Receptors by Monoclonal Antibodies

P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study

(2015) Rayid Abdulqawi et al.   LANCET

CaMKIIα and caveolin-1 cooperate to drive ATP-induced membrane delivery of the P2X3 receptor

(2014) Xu-Qiao Chen et al.   Journal of Molecular Cell Biology

Adenosine triphosphate drives head and neck cancer pain through P2X2/3 heterotrimers

(2014) Yi Ye et al.   Acta Neuropathologica Communications

Purinergic mechanisms and pain—An update

(2013) Geoffrey Burnstock   EUROPEAN JOURNAL OF PHARMACOLOGY

Purinergic signalling: from discovery to current developments

(2013) Geoffrey Burnstock   EXPERIMENTAL PHYSIOLOGY

The trafficking and targeting of P2X receptors

(2013) Lucy E. Robinson et al.   Frontiers in Cellular Neuroscience

The therapeutic promise of ATP antagonism at P2X3 receptors in respiratory and urological disorders

(2013) Anthony P. Ford et al.   Frontiers in Cellular Neuroscience

Clinical evaluation of the efficacy of the P2X7purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine

(2012) Edward C Keystone et al.   ANNALS OF THE RHEUMATIC DISEASES

Mechanism of action of therapeutic monoclonal antibodies: Promises and pitfalls of in vitro and in vivo assays

(2012) Josée Golay et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Efficacy and Safety of CE-224,535, an Antagonist of P2X7 Receptor, in Treatment of Patients with Rheumatoid Arthritis Inadequately Controlled by Methotrexate

(2012) T. C. STOCK et al.   JOURNAL OF RHEUMATOLOGY

Molecular mechanism of ATP binding and ion channel activation in P2X receptors

(2012) Motoyuki Hattori et al.   NATURE

Discovery of Potent Competitive Antagonists and Positive Modulators of the P2X2 Receptor

(2011) Younis Baqi et al.   JOURNAL OF MEDICINAL CHEMISTRY

In pursuit of P2X3 antagonists: novel therapeutics for chronic pain and afferent sensitization

(2011) Anthony P. Ford   Purinergic Signalling

Using antibodies against P2Y and P2X receptors in purinergic signaling research

(2011) Dovrat Brass et al.   Purinergic Signalling

P2X receptor antagonists for pain management: examination of binding and physicochemical properties

(2011) Rebecca J. Gum et al.   Purinergic Signalling

Systemic blockade of P2X3 and P2X2/3 receptors attenuates bone cancer pain behaviour in rats

(2010) Timothy K. Y. Kaan et al.   BRAIN

AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist

(2010) Joel R Gever et al.   BRITISH JOURNAL OF PHARMACOLOGY

P2X purinergic receptor ligands: recently patented compounds

(2010) Hendra Gunosewoyo et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Pain behavior in the formalin test persists after ablation of the great majority of C-fiber nociceptors

(2010) Shannon D. Shields et al.   PAIN

Rapid constitutive and ligand-activated endocytic trafficking of P2X3receptor

(2009) Fabrizio Vacca et al.   JOURNAL OF NEUROCHEMISTRY

Pore architecture and ion sites in acid-sensing ion channels and P2X receptors

(2009) Eric B. Gonzales et al.   NATURE

Crystal structure of the ATP-gated P2X4 ion channel in the closed state

(2009) Toshimitsu Kawate et al.   NATURE

Selective potentiation of homomeric P2X2 ionotropic ATP receptors by a fast non-genomic action of progesterone

(2009) Mathias De Roo et al.   NEUROPHARMACOLOGY

ATP-gated P2X cation-channels

(2008) Michael F. Jarvis et al.   NEUROPHARMACOLOGY