Gain and Loss of Function of P2X7 Receptors: Mechanisms, Pharmacology and Relevance to Diabetic Neuropathic Pain

Sex differences in pain: a brief review of clinical and experimental findings

(2013) E.J. Bartley et al.   BRITISH JOURNAL OF ANAESTHESIA

P2X7 Receptor Channels Allow Direct Permeation of Nanometer-Sized Dyes

(2013) L. E. Browne et al.   JOURNAL OF NEUROSCIENCE

Motor neuron dysfunction in a mouse model of ALS: Gender-dependent effect of P2X7 antagonism

(2013) Chiara Cervetto et al.   TOXICOLOGY

The P2X7 loss-of-function Glu496Ala polymorphism affects ex vivo cytokine release and protects against the cytotoxic effects of high ATP-levels

(2012) Anke Wesselius et al.   BMC IMMUNOLOGY

Effects of genetic variation in the P2RX7 gene on pharmacodynamics of a P2X7 receptor antagonist: a prospective genotyping approach

(2012) Simon M. McHugh et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Single-nucleotide polymorphisms in the P2X7 receptor gene are associated with post-menopausal bone loss and vertebral fractures

(2012) Niklas R Jørgensen et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Polymorphisms in the P2X7 receptor gene are associated with low lumbar spine bone mineral density and accelerated bone loss in post-menopausal women

(2012) Alison Gartland et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

P2X7 receptor-stimulation causes fever via PGE2 and IL-1β release

(2012) Maria Barberà-Cremades et al.   FASEB JOURNAL

Crystallinity Segregation upon Selective Self-Assembling of Gold Colloidal Single Nanocrystals

(2012) Hervé Portalès et al.   NANO LETTERS

Molecular mechanism of ATP binding and ion channel activation in P2X receptors

(2012) Motoyuki Hattori et al.   NATURE

Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity

(2012) Robert E Sorge et al.   NATURE MEDICINE

Association of P2X7 receptor polymorphisms with bone mineral density and osteoporosis risk in a cohort of Dutch fracture patients

(2012) A. Wesselius et al.   OSTEOPOROSIS INTERNATIONAL

The Neuroprotective Effect of a Specific P2X7 Receptor Antagonist Derives from its Ability to Inhibit Assembly of the NLRP3 Inflammasome in Glial Cells

(2011) Niamh Murphy et al.   BRAIN PATHOLOGY

Residues 155 and 348 Contribute to the Determination of P2X7Receptor Function via Distinct Mechanisms Revealed by Single-nucleotide Polymorphisms

(2011) Helen J. Bradley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Duloxetine, Pregabalin, and Duloxetine Plus Gabapentin for Diabetic Peripheral Neuropathic Pain Management in Patients With Inadequate Pain Response to Gabapentin: An Open-Label, Randomized, Noninferiority Comparison

(2011) Robert J. Tanenberg et al.   MAYO CLINIC PROCEEDINGS

P2X7 Receptor Signaling Pathway as a Therapeutic Target for Neurodegenerative Diseases

(2010) Takato Takenouchi et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Two haplotypes of the P2X7 receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1β secretion

(2010) Leanne Stokes et al.   FASEB JOURNAL

Effect of P2X7receptor knockout on exocrine secretion of pancreas, salivary glands and lacrimal glands

(2010) Ivana Novak et al.   JOURNAL OF PHYSIOLOGY-LONDON

Sex, Gender, and Pain: A Review of Recent Clinical and Experimental Findings

(2009) Roger B. Fillingim et al.   JOURNAL OF PAIN

Single nucleotide polymorphisms that were identified in affective mood disorders affect ATP-activated P2X7 receptor functions

(2009) Sébastien Roger et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Identification and characterization of a novel variant of the human P2X7 receptor resulting in gain of function

(2009) Chengqun Sun et al.   Purinergic Signalling

Genetics of the P2X7 receptor and human disease

(2009) Stephen J. Fuller et al.   Purinergic Signalling

Altered cytokine levels in the blood and cerebrospinal fluid of chronic pain patients

(2008) Miroslav “Misha” Backonja et al.   JOURNAL OF NEUROIMMUNOLOGY

[3H]A-804598 ([3H]2-cyano-1-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine) is a novel, potent, and selective antagonist radioligand for P2X7 receptors

(2008) Diana L. Donnelly-Roberts et al.   NEUROPHARMACOLOGY