Article
Biology
Aida Javan Balegh Marand, Cleo Baars, John Heesakkers, Ellen van den Munckhof, Morteza Ghojazadeh, Mohammad Sajjad Rahnama'i, Dick Janssen
Summary: Through the study, it was found that there are significant differences in the urinary microbiome between patients with OAB and those without OAB, with OAB patients having fewer and less diverse microbiomes, as well as a higher proportion of Lactobacillus, particularly Lactobacillus iners. These results suggest that the urinary microbiome may be involved in the pathogenesis of a specific phenotype of OAB and provide a new starting point for studying the causes and treatments of OAB.
Article
Biochemistry & Molecular Biology
Yuan-Hong Jiang, Jia-Fong Jhang, Ya-Hui Wu, Hann-Chorng Kuo
Summary: This study investigated the levels of urine inflammatory and oxidative stress biomarkers in patients with detrusor underactivity (DU) and detrusor overactivity with DU (DO-DU). The results showed that DU and DO-DU patients had different urine biomarker profiles compared to controls. Multivariate logistic-regression models revealed that 8-OHdG, PGE2, EGF, IL-5, IL-8, IL-10, and TAC were significant biomarkers for diagnosing DU.
Article
Medicine, General & Internal
Victor Nitti, Cornelia Haag-Molkenteller, Michael Kennelly, Michael Chancellor, Brenda Jenkins, Brigitte Schurch
Summary: Neurogenic detrusor overactivity (NDO) is a complication of various conditions, such as multiple sclerosis and spinal cord injury, which leads to high bladder pressure and urinary incontinence. OnabotulinumtoxinA has been proven to be an effective treatment option for both NDO and non-neurogenic overactive bladder (OAB), significantly improving quality of life in patients. Clinical trials have shown positive results in terms of reduced incontinence episodes, improved urodynamic parameters, and better quality of life for patients with NDO and OAB.
Article
Obstetrics & Gynecology
Matteo Frigerio, Marta Barba, Alice Cola, Federico Spelzini, Rodolfo Milani, Stefano Manodoro
Summary: This study aimed to evaluate the relationship between COUB and POP surgery, and to identify possible risk factors for postoperative COUB. The results showed that patients with more severe anterior compartment prolapse and more frequent overactive bladder were more likely to have COUB preoperatively. However, COUB symptoms decreased significantly after POP repair. In addition, preoperative opening detrusor pressure was identified as the only independent predictor for postoperative COUB.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Neurosciences
Rui Wang, Ming Hong, Jingyi Huang, Na Zhou, Yao Zhang, Siyuan Xu, Jiaye Liu, Junjie Yuan, Lusiqi Zhang, Linyuan Huang, Ping Huang, Bo Tan, Hong-ying Cao
Summary: This research explores the neurotoxicity of low-dose cyclophosphamide on the urinary bladder of rats through in vivo and in vitro studies. The results indicate that low-dose CYP treatment induces nerve injury, leading to bladder pain and overactive bladder in female rats. The up-regulation of Nlrp6 and Casp11 may contribute to these pathological changes.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biophysics
David P. Rosen, Douglas A. Husmann, Lance A. Mynderse, Troy F. Kelly, Azra Alizad, Mostafa Fatemi
Summary: This study investigated the feasibility of using ultrasound bladder vibrometry (UBV) for detecting detrusor overactivity (DO) and developed a processing approach to identify transient peaks in data series. By applying a DO index as a classifier, sensitivities and specificities of 0.70 and 0.75 were achieved for detecting DO using UBV measurements. The results show promising potential for noninvasive detection of DO with further refinement of the UBV measurement process.
PHYSIOLOGICAL MEASUREMENT
(2021)
Article
Obstetrics & Gynecology
Ting-Xuan Huang, Tsia-Shu Lo, Hsiao-Jung Tseng, Yi-Hao Lin, Ching-Chung Liang, Wu-Chiao Hsieh
Summary: The primary objective of this study was to determine the prevalence of overactive bladder (OAB) and detrusor overactivity (DO) in female patients referred for urodynamic study (UDS) due to lower urinary tract symptoms (LUTS). The study found that patients with DO were associated with older age, increased parity, greater urine leakage, and worse storage and micturition functions on UDS.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2023)
Article
Medicine, General & Internal
Jessica Jay Fang, Ming-Ping Wu, Yu-Chun Yen, Jeng-Cheng Wu, Hung-Yen Chin
Summary: The study found that nulliparous women with OAB had a significantly higher prevalence of abnormal voiding patterns, DO, and MUCP compared to parous women. Especially in nulliparous women, abnormal voiding patterns were significantly associated with DO and MUCP.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2021)
Article
Urology & Nephrology
Taras Ptashnyk, Martin Hatzinger, Federico L. Zeller, Ruth Kirschner-Hermanns
Summary: In patients with overactive bladder (OAB), differences were found between those with detrusor overactivity and those without in terms of age, disease duration, frequency of urination, nocturia episodes, urgency episodes, incontinence episodes, and impact on quality of life. Patients with detrusor overactivity displayed more severe OAB symptoms and lower quality of life impact.
SCANDINAVIAN JOURNAL OF UROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wei-Hsin Chen, Yuan-Hong Jiang, Hann-Chorng Kuo
Summary: Urinary oxidative stress biomarkers can be used to diagnose and predict the occurrence of detrusor overactivity (DO) in women with urodynamic stress incontinence (USI). Combined with voided volume, the diagnostic accuracy can be improved.
Article
Urology & Nephrology
Hanieh Salehi-Pourmehr, Morteza Ghojazadeh, Elham Jahantabi, Sakineh Hajebrahimi
Summary: The study confirms the value of NGF as a diagnostic biomarker for detrusor overactivity in women with mixed urinary incontinence. Higher NGF levels can predict the diagnosis of DO, showing high sensitivity in the diagnostic process.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2021)
Article
Pharmacology & Pharmacy
Kuang-Ming Liao, Ka-Lok Lio, Yu-Ju Chou, Chen-Chun Kuo, Chung-Yu Chen
Summary: The study aimed to evaluate the relationship between OAB medication adherence and different types of medication with UTI risk. The study found that during the follow-up period, neither adherence nor different types of medication had an impact on UTI risk, regardless of UTI history or sex.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Zhipeng Zhou, Yifeng Qiu, Kun Li, Qi Sun, Ming Xie, Pengcheng Huang, Yao Yu, Benlin Wang, Jingwen Xue, Zhangrui Zhu, Zhengyuan Feng, Jie Zhao, Peng Wu
Summary: The results of this study indicate that urinary microbiota might influence the efficacy of mirabegron, and that Lactobacillus might be a potential marker for evaluating the therapeutic efficacy of mirabegron in OAB patients.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Food Science & Technology
Chung-Cheng Wang, Eric Chieh-Lung Chou, Yao-Chi Chuang, Chih-Chieh Lin, Yu-Chao Hsu, Chun-Hou Liao, Hann-Chorng Kuo
Summary: The results indicated that intradetrusor onabotulinumtoxinA injections were safe and significantly improved subjective measures related to neurogenic detrusor overactivity (NDO) or overactive bladder (OAB) in patients. The study showed positive outcomes in terms of efficacy and safety for both NDO and OAB patients, suggesting the potential benefits of onabotulinumtoxinA injection in treating these conditions.
Article
Cell Biology
Guang Wang, Tong-Xin Yang, Jiong-Ming Li, Zi-Ye Huang, Wen-Bo Yang, Pei Li, Da-Lin He
Summary: This study identifies BTK as a critical gene in IC/BPS and suggests its potential as a therapeutic target. Functional enrichment analysis indicates the involvement of innate immunity. Experimental results demonstrate increased mast cells in IC/BPS and the inhibitory effect of BTK knockdown on mast cell functions. These findings provide new insights into the molecular mechanisms of IC/BPS and offer potential avenues for treatment development.
Article
Sport Sciences
Lucas Veras, Florencio Diniz-Sousa, Giorjines Boppre, Ana Resende-Coelho, Edgar Moutinho-Ribeiro, Vitor Devezas, Hugo Santos-Sousa, John Preto, Joao Paulo Vilas-Boas, Leandro Machado, Jose Oliveira, Helder Fonseca
Summary: This study developed accelerometry-based equations to predict pGRF and pLR during walking and running, and compared the predicted values with actual values, demonstrating high accuracy of these equations.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Review
Pharmacology & Pharmacy
Rui Pinto-Cardoso, Catarina Bessa-Andres, Paulo Correia-de-Sa, Jose Bernardo Noronha-Matos
Summary: The osteochondral unit consists of articular cartilage, subchondral bone, and calcified cartilage. Cells within this unit, such as chondrocytes and osteoblasts, release nucleotides to the local environment, which plays a role in tissue homeostasis. Hypoxic conditions can affect the expression and activity of purinergic signaling molecules, and the interplay between hypoxia and the purinergic signaling cascade contributes to osteochondral unit homeostasis. Understanding this relationship may lead to new therapeutic targets for osteochondral rehabilitation.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lucas Solla Mathias, Carina Herman-de-Sousa, Sarah Santiloni Cury, Celia Regina Nogueira, Paulo Correia-de-Sa, Miriane de Oliveira
Summary: The anti-obesity hormones T3 and irisin have been found to stimulate thermogenesis and energy consumption, while reducing lipid accumulation. This study investigated their effects on the purinergic signaling pathway in adipocytes, and found that T3 and irisin differentially regulate the transcription of purinergic signaling markers. These findings may offer new insights into the treatment of obesity and related metabolic disorders.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)
Article
Biochemistry & Molecular Biology
Ana Salome Correia, Isabel Silva, Henrique Reguengo, Jose Carlos Oliveira, Francisco Vasques-Novoa, Armando Cardoso, Nuno Vale
Summary: L-tryptophan is metabolized into important pathways, and the effects of oxidative stress and glucocorticoid-induced stress on serotonin pathway were studied. The metabolites showed different concentrations in response to different stress inducers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Carlos Sousa-Soares, Jose Bernardo Noronha-Matos, Paulo Correia-de-Sa
Summary: The vertebrate neuromuscular junction is a specialised synapse composed of a presynaptic region, a postsynaptic skeletal motor endplate area, and perisynaptic Schwann cells that play a significant role in maintaining neuromuscular integrity, transmission, and plasticity. Acetylcholine is the main neurotransmitter at this synapse and is modulated by purinergic neuromodulators. Adenine nucleotides and adenosine, released alongside acetylcholine, regulate transmitter release and expression of ACh receptors via P2Y and P2X receptors. Adenosine, through A1 and A2A receptors, also modulates ACh release by motor nerve terminals. Understanding the complex interplay between purines and neuromuscular transmission is essential for conditions like Myasthenia gravis.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Urology & Nephrology
Ricardo Pereira e Silva, Diana Aguiar Sousa, Filipe Abadesso Lopes, Miguel Silva-Ramos, Ana Verdelho
Summary: A systematic review of 14 studies found an association between age-related white matter hyperintensities (ARWMH) and lower urinary tract symptoms/dysfunction (LUTS/LUTD), particularly overactive bladder (OAB) and detrusor overactivity. However, high-quality data on the association between ARWMH and OAB is scarce.
NEUROUROLOGY AND URODYNAMICS
(2023)
Article
Chemistry, Analytical
Lucas Veras, Florencio Diniz-Sousa, Giorjines Boppre, Vitor Devezas, Hugo Santos-Sousa, John Preto, Joao Paulo Vilas-Boas, Leandro Machado, Jose Oliveira, Helder Fonseca
Summary: The purpose of this study was to develop prediction equations for peak ground reaction force (pGRF) and peak loading rate (pLR) in high-impact activities for adults with various body masses. Regression equations were developed using accelerometry data, with body mass and peak acceleration or acceleration rate as predictors. The equations had high accuracy for predicting pGRF, with a coefficient of determination (R-2) of at least 0.83 and a mean absolute percentage error (MAPE) below 14.5%. However, the accuracy of the pLR prediction equations was lower than that of the pGRF equations.
Article
Urology & Nephrology
Jorge Correia, Bernardo Teixeira, Goncalo Mendes, Avelino Fraga, Miguel Silva-Ramos
Summary: Kidney transplantation has little impact on the tumor progression risk of renal cell carcinoma. Kidney transplant recipients have similar tumor recurrence and overall survival rates as dialyzed patients. The only factor associated with worse survival is the duration of dialysis.
ARCHIVIO ITALIANO DI UROLOGIA E ANDROLOGIA
(2023)
Article
Oncology
Marta Wiszpolska, Ewa Lepiarczyk, Mateusz A. Mazdziarz, Lukasz Paukszto, Karol G. Makowczenko, Aleksandra Lipka, Elzbieta Lopienska-Biernat, Krystyna Makowska, Slawomir Gonkowski, Paulo Correia-de-Sa, Marta Majewska
Summary: This study investigated the changes in liver gene expression caused by oral exposure to BPA in mice. The findings suggest that BPA has a significant impact on gene expression in the liver, and this may be related to genes associated with important metabolism and malignant tumors in the liver.
Article
Surgery
Manuela Almeida, Goncalo Calheiros Cruz, Ciria Sousa, Catia Figueiredo, Sofia Ventura, Jose Silvano, Sofia Pedroso, La Salete Martins, Miguel Ramos, Jorge Malheiro
Summary: A predictive model was developed to estimate the eGFR and risk of CKD at 1-year post-donation, which showed a strong correlation with the observed eGFR. Retrospective analysis of living donor kidney transplants from 1998 to 2020 revealed a good agreement between predicted and observed eGFR at 1-year post-donation. The model demonstrated a good discriminative ability in predicting CKD at 1-year post-donation.
TRANSPLANT INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Suiane Cavalcante, Sofia Viamonte, Rui S. Cadilha, Ilda P. Ribeiro, Ana Cristina Goncalves, Joao Sousa-Venancio, Marisol Gouveia, Manuel Teixeira, Mario Santos, Jose Oliveira, Fernando Ribeiro
Summary: This study aims to evaluate the effects of a single exercise bout on the circulating levels of EPCs and CECs in heart failure patients. The results showed that a single exercise bout increased the levels of EPCs but didn't change the levels of CECs. Heart failure patients had lower levels of EPCs compared to the age-matched group, but the exercise bout restored their EPCs levels to a level similar to the age-matched group.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Biology
K. B. V. de Oliveira, J. S. Severo, A. C. A. da Silva, B. L. B. dos Santos, P. H. M. Mendes, J. P. J. Sabino, A. L. M. M. Filho, P. Correia-de-Sa, A. A. dos Santos, M. T. B. da Silva
Summary: This study aimed to investigate the involvement of the P2X7 receptor blocker Brilliant Blue G (BBG) in gastric emptying and oxidative stress changes in the gastrointestinal tract of spontaneously hypertensive rats (SHR), and to study its relationship with the renin-angiotensin system. The results showed that BBG improved gastric emptying delay and oxidative stress markers in SHR animals, and this preventive effect was abrogated by the renin-angiotensin system.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2023)
Article
Urology & Nephrology
Manuela Almeida, Pedro R. Pereira, Miguel Ramos, Diogo Carneiro, Mariana Mandaleno, Filipa Silva, Sofia Pedroso, Manuela Franca, La Salete Martins, Jorge Malheiro
Summary: This study compared nuclear renography and computerized tomography in evaluating split renal function, and found that computerized tomography performed better in predicting the remaining renal function of living kidney donors at 1-year.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Catarina Miranda-Lourenco, Jessica Rosa, Nadia Rei, Rita F. Belo, Ana Luisa Lopes, Diogo Silva, Catia Vieira, Teresa Magalhaes-Cardoso, Ricardo Viais, Paulo Correia-de-Sa, Ana M. Sebastiao, Maria J. Diogenes
Summary: This study reveals significant changes in the BDNF and adenosine signaling pathways in a milder phenotype model of Rett Syndrome, suggesting that enhancing adenosinergic activity may be an effective therapeutic strategy for RTT patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Jorge Correia, Goncalo Mendes, Bernardo Texeira, Mariana Madanelo, Avelino Fraga, Miguel Silva-Ramos
Summary: In this retrospective analysis of patients with advanced UTUC, laparoscopic radical nephroureterectomy (LNU) showed comparable oncological control to open radical nephroureterectomy (ONU), while offering advantages in perioperative outcomes.
CENTRAL EUROPEAN JOURNAL OF UROLOGY
(2022)