Signaling pathways involving adenosine A2A and A2B receptors in wound healing and fibrosis

Involvement of cAMP-PKA pathway in adenosine A1 and A2A receptor-mediated regulation of acetaldehyde-induced activation of HSCs

(2015) Yaru Yang et al.   BIOCHIMIE

Caffeine protects against alcohol-induced liver fibrosis by dampening the cAMP/PKA/CREB pathway in rat hepatic stellate cells

(2015) Qi Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The peripheral cannabinoid receptor 1 antagonist VD60 efficiently inhibits carbon tetrachloride-intoxicated hepatic fibrosis progression

(2014) Yan Wei et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Adenosine stimulates angiogenesis by up-regulating production of thrombospondin-1 by macrophages

(2014) Isabelle Ernens et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Caffeine Inhibits the Activation of Hepatic Stellate Cells Induced by Acetaldehyde via Adenosine A2A Receptor Mediated by the cAMP/PKA/SRC/ERK1/2/P38 MAPK Signal Pathway

(2014) He Wang et al.   PLoS One

Activation of adenosine receptor A2A increases HSC proliferation and inhibits death and senescence by down-regulation of p53 and Rb

(2014) Md. Kaimul Ahsan et al.   Frontiers in Pharmacology

Activation of adenosine A2Areceptor reduces osteoclast formation via PKA- and ERK1/2-mediated suppression of NFκB nuclear translocation

(2013) Aránzazu Mediero et al.   BRITISH JOURNAL OF PHARMACOLOGY

Elevated Ecto-5'-nucleotidase-Mediated Increased Renal Adenosine Signaling Via A2B Adenosine Receptor Contributes to Chronic Hypertension

(2013) Weiru Zhang et al.   CIRCULATION RESEARCH

Adenosine 2A receptor promotes collagen production by human fibroblasts via pathways involving cyclic AMP and AKT but independent of Smad2/3

(2013) Miguel Perez-Aso et al.   FASEB JOURNAL

Retracted: Equilibrative nucleoside transporter (ENT)-1-dependent elevation of extracellular adenosine protects the liver during ischemia and reperfusion

(2013) Michael A. Zimmerman et al.   HEPATOLOGY

Adenosine A2A receptor (A2AR) is a fine-tune regulator of the collagen1:collagen3 balance

(2013) Miguel Perez-Aso et al.   Purinergic Signalling

Adenosine A2A receptors promote collagen production by a Fli1- and CTGF-mediated mechanism

(2013) Edwin SL Chan et al.   ARTHRITIS RESEARCH & THERAPY

Regulation of Neutrophil Function by Adenosine

(2012) Kathryn E. Barletta et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

CD73 and adenosine generation in the creation of regulatory microenvironments

(2012) F. S. Regateiro et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Pharmacological blockade of adenosine A2A receptors diminishes scarring

(2012) Miguel Perez-Aso et al.   FASEB JOURNAL

The A2B adenosine receptor modulates pulmonary hypertension associated with interstitial lung disease

(2012) Harry Karmouty-Quintana et al.   FASEB JOURNAL

Beginnings of a Good Apoptotic Meal: The Find-Me and Eat-Me Signaling Pathways

(2011) Kodi S. Ravichandran   IMMUNITY

Adenosine A2A receptor activation stimulates collagen production in sclerodermic dermal fibroblasts either directly and through a cross-talk with the cannabinoid system

(2011) Pietro Enea Lazzerini et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Ischemia and reperfusion—from mechanism to translation

(2011) Holger K Eltzschig et al.   NATURE MEDICINE

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors--An Update

(2011) B. B. Fredholm et al.   PHARMACOLOGICAL REVIEWS

Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis

(2010) Sonali Sonnylal et al.   ARTHRITIS AND RHEUMATISM

Adenosine A2A receptors induced on iNKT and NK cells reduce pulmonary inflammation and injury in mice with sickle cell disease

(2010) K. L. Wallace et al.   BLOOD

Cyclic AMP Suppresses Matrix Metalloproteinase-1 Expression through Inhibition of MAPK and GSK-3β

(2010) Chi-Hyun Park et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Regulation of cardiac fibroblast collagen synthesis by adenosine: roles for Epac and PI3K

(2009) Francisco Villarreal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Increased adenosine contributes to penile fibrosis, a dangerous feature of priapism, via A2B adenosine receptor signaling

(2009) Jiaming Wen et al.   FASEB JOURNAL

Pharmacological Blockade of A2A Receptors Prevents Dermal Fibrosis in a Model of Elevated Tissue Adenosine

(2008) Patricia Fernández et al.   AMERICAN JOURNAL OF PATHOLOGY

Adenosine receptors: therapeutic aspects for inflammatory and immune diseases

(2008) György Haskó et al.   NATURE REVIEWS DRUG DISCOVERY

ATP Release from Vascular Endothelia Occurs Across Cx43 Hemichannels and Is Attenuated during Hypoxia

(2008) Marion Faigle et al.   PLoS One

The cyclic AMP effector Epac integrates pro- and anti-fibrotic signals

(2008) U. Yokoyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophils as Sources of Extracellular Nucleotides: Functional Consequences at the Vascular Interface

(2008) Holger K. Eltzschig et al.   TRENDS IN CARDIOVASCULAR MEDICINE

The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without affecting blood pressure

(2007) P Kalk et al.   BRITISH JOURNAL OF PHARMACOLOGY