Article
Microbiology
Shirin Sultana, Md. Nasir Khan, Muhammad Shahdat Hossain, Jingcheng Dai, Mohammad Shamsur Rahman, Md. Salimullah
Summary: This study investigated the skin microbiomes and their functional annotations in healthy and diseased stinging catfish using 16S rRNA metagenomics. The results revealed differences in the composition, richness, and functions of the skin microbiome between healthy and diseased fish. The findings suggest that the bacterial community can influence the health status of cultured stinging catfish.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Biochemical Research Methods
Howard J. Vindin, Brian G. G. Oliver, Anthony S. Weiss
Summary: Elastic fibers play a crucial role in lung function, and their damage has a profound impact on lung diseases. Therefore, the development of novel lung-specific imaging methods for high-resolution 3D visualization of the extracellular matrix (ECM) is necessary. Recent advances in lung tissue engineering have contributed to the progress in imaging and modeling of the lung for research and clinical application.
CURRENT OPINION IN BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Callum Stewart-McGuinness, Christopher Platt, Matiss Ozols, Brian Goh, Tamara W. Griffiths, Michael J. Sherratt
Summary: This study used proteomics approaches to comprehensively analyze proteases and protease inhibitors in human skin, identifying various types of P/PIs and their distribution in normal and diseased skin. The results showed significant differences in the characteristics of P/PIs in different skin disease groups, suggesting a potential role of P/PIs in disease progression and providing important information for further research on the pathogenesis of skin diseases.
Review
Plant Sciences
Daniel Ludke, Philipp F. W. Rohmann, Marcel Wiermer
Summary: Plant viability and responses to changing environments depend on spatial communication between the compartments separated by the nuclear envelope, involving bidirectional exchange of proteins and RNAs mediated by a sophisticated transport machinery.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Francesca Del Gaudio, Dongli Liu, Urban Lendahl
Summary: Notch signalling is a highly conserved mechanism that plays important roles in differentiation and homeostasis in various tissues. This review focuses on the recent advances in understanding the roles of Notch signalling in the vasculature. It discusses the regulation of blood vessel generation and remodelling, as well as the contribution of dysregulated Notch signalling to vascular diseases. Furthermore, it highlights the current gaps in knowledge and challenges in understanding the role of Notch in the vasculature.
Review
Biochemical Research Methods
Vahid Hosseini, Anna Mallone, Fatemeh Nasrollahi, Serge Ostrovidov, Rohollah Nasiri, Mahboobeh Mahmoodi, Reihaneh Haghniaz, Avijit Baidya, M. Mehdi Salek, Mohammad Ali Darabi, Gorka Orive, Amir Shamloo, Mehmet R. Dokmeci, Samad Ahadian, Ali Khademhosseini
Summary: Studies have shown that irregular hemodynamics affect the progression of various vascular diseases, but inter-species differences between animals and humans hinder the translation of findings. Recent advances have led to increased use of in vitro human vascular tissue models to better simulate disease hemodynamics. Researchers have proposed essential criteria for generating an ideal in vitro model of the vascular system.
Review
Cell Biology
Javier Duran, Lennart Nickel, Manuel Estrada, Johannes Backs, Maarten M. G. van den Hoogenhof
Summary: The study explores the role of RNA splicing in heart development and disease, focusing on the multifunctional Ca2+/calmodulin dependent protein kinase II delta (CaMKII delta) and its various splice variants. The review discusses the functions of different splice variants, particularly the involvement of CaMKII delta B, CaMKII delta C, CaMKII delta A, and CaMKII delta 9 in heart signaling. The translational perspective and future directions of CaMKII delta splicing research in healthy and diseased hearts are also examined.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Francisca Cornejo, Bastian I. Cortes, Greg M. Findlay, Gonzalo I. Cancino
Summary: Protein phosphatases are key regulators of signal transduction, with the LAR-RPTP subfamily playing an important role in neurobiology, from neurodevelopment to brain disorders. The LAR-RPTP subfamily consists of three members in vertebrates and is involved in various brain functions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Fisheries
Shuo Li, Tongtong Zhang, Yu Feng, Jinsheng Sun
Summary: Extracellular nucleotides, such as ATP and ADP, released during inflammation or infection, play a crucial role in regulating immune responses in fish by activating specific purinergic receptors on immune cells.
Article
Peripheral Vascular Disease
Gregory W. McGarr, Caroline M. Muia, Samah Saci, Naoto Fujii, Glen P. Kenny
Summary: In healthy older adults, K-Ca channels play a significant role in modulating ATP-induced cutaneous vasodilation, while the contribution of NOS to this response is minimal.
MICROVASCULAR RESEARCH
(2021)
Article
Dermatology
Zlatina Ivanova, Teodor Aleksiev, Hristo Dobrev, Nikolay Atanasov
Summary: This study used a new measurement device based on indentometry to evaluate the mechanical properties of the skin in healthy individuals and patients with systemic sclerosis. The results showed that age, sex, and anatomical location significantly affected skin stiffness, while the use of moisturizers had no significant impact on epidermal water content. This method can successfully distinguish the changes in skin mechanical properties related to age, sex, and anatomical location, as well as in patients with systemic sclerosis.
SKIN RESEARCH AND TECHNOLOGY
(2023)
Review
Physiology
Christian Giaume, Christian C. Naus, Juan C. Saez, Luc Leybaert
Summary: Over the past few decades, research has shown that glial cells interact dynamically with neurons, impacting their activity and survival. Connexins and pannexins play a key role in these interactions, and understanding their function can provide insights into neuronal behavior and aid in the development of therapeutic strategies for brain diseases.
PHYSIOLOGICAL REVIEWS
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Erik Nutma, Kelly Ceyzeriat, Sandra Amor, Stergios Tsartsalis, Philippe Millet, David R. Owen, Vassilios Papadopoulos, Benjamin B. Tournier
Summary: TSPO, located in the outer mitochondrial membrane, is considered an in vivo marker of neuroinflammation as measured with PET. Changes in TSPO expression are observed in neurodegenerative, neuroinflammatory, and neuropsychiatric diseases, but further studies are needed to fully understand its cellular underpinnings and functional significance.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Review
Biochemistry & Molecular Biology
Hidetoshi Tozaki-Saitoh, Hiroshi Takeda, Kazuhide Inoue
Summary: Pain is an essential sensation in the body, and purinergic signaling plays a crucial role in its transmission. The communication between neuronal and non-neuronal cells relies on purinergic pathways. Microglia and astrocytes express various purinergic effectors, and different receptors are involved in the development of neuropathic pain.
Review
Immunology
Jacob J. E. Koopman, Mieke F. van Essen, Helmut G. Rennke, Aiko P. J. de Vries, Cees van Kooten
Summary: The membrane attack complex C5b-9, a key factor in the complement pathways, is implicated in various kidney diseases by causing cellular injury and inflammation. Understanding the deposition of C5b-9 in the kidney is crucial for predicting treatment outcomes and developing novel therapies targeting its formation.
FRONTIERS IN IMMUNOLOGY
(2021)
