Role of the Inflammation-Autophagy-Senescence Integrative Network in Osteoarthritis
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Title
Role of the Inflammation-Autophagy-Senescence Integrative Network in Osteoarthritis
Authors
Keywords
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Journal
Frontiers in Physiology
Volume 9, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2018-06-25
DOI
10.3389/fphys.2018.00706
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Note: Only part of the references are listed.- SIRT7 is an important regulator of cartilage homeostasis and osteoarthritis development
- (2018) Wataru Korogi et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Inhibition of miR-20 promotes proliferation and autophagy in articular chondrocytes by PI3K/AKT/mTOR signaling pathway
- (2018) Weidong He et al. BIOMEDICINE & PHARMACOTHERAPY
- Antagonism of cysteinyl leukotriene receptor 1 (cysLTR1) by montelukast suppresses cell senescence of chondrocytes
- (2018) Wei Song et al. CYTOKINE
- Parathyroid hormone-(1–34) ameliorated knee osteoarthritis in rats via autophagy
- (2018) Chung-Hwan Chen et al. JOURNAL OF APPLIED PHYSIOLOGY
- Parkin clearance of dysfunctional mitochondria regulates ROS levels and increases survival of human chondrocytes
- (2018) M.Y. Ansari et al. OSTEOARTHRITIS AND CARTILAGE
- FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis
- (2018) Tokio Matsuzaki et al. Science Translational Medicine
- Platelet rich plasma (PRP) induces chondroprotection via increasing autophagy, anti-inflammatory markers, and decreasing apoptosis in human osteoarthritic cartilage
- (2017) Mayssam Moussa et al. EXPERIMENTAL CELL RESEARCH
- Different roles of Akt and mechanistic target of rapamycin in serum‑dependent chondroprotection of human osteoarthritic chondrocytes
- (2017) Tongen Zhang et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Local intra-articular injection of resveratrol delays cartilage degeneration in C57BL/6 mice by inducing autophagy via AMPK/mTOR pathway
- (2017) Na Qin et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
- (2017) Simon I Hay et al. LANCET
- Hydroxytyrosol inhibits the inflammatory response of osteoarthritis chondrocytes via SIRT6-mediated autophagy
- (2017) Li‑Qiang Zhi et al. Molecular Medicine Reports
- Cytoplasmic chromatin triggers inflammation in senescence and cancer
- (2017) Zhixun Dou et al. NATURE
- Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence
- (2017) Selene Glück et al. NATURE CELL BIOLOGY
- Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment
- (2017) Ok Hee Jeon et al. NATURE MEDICINE
- Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles
- (2017) Lorenzo Galluzzi et al. NATURE REVIEWS DRUG DISCOVERY
- Suppression of Sestrins in aging and osteoarthritic cartilage: dysfunction of an important stress defense mechanism
- (2017) T. Shen et al. OSTEOARTHRITIS AND CARTILAGE
- Selective interference of mTORC1/RAPTOR protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism with Akt and autophagy induction
- (2017) M. Ito et al. OSTEOARTHRITIS AND CARTILAGE
- Dysregulated circadian rhythm pathway in human osteoarthritis: NR1D1 and BMAL1 suppression alters TGF-β signaling in chondrocytes
- (2017) R. Akagi et al. OSTEOARTHRITIS AND CARTILAGE
- mTORC1 activation downregulates FGFR3 and PTH/PTHrP receptor in articular chondrocytes to initiate osteoarthritis
- (2017) H. Zhang et al. OSTEOARTHRITIS AND CARTILAGE
- Compromised autophagy precedes meniscus degeneration and cartilage damage in mice
- (2017) J.K. Meckes et al. OSTEOARTHRITIS AND CARTILAGE
- SIRT6: Novel Mechanisms and Links to Aging and Disease
- (2017) Luisa Tasselli et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Trehalose ameliorates oxidative stress-mediated mitochondrial dysfunction and ER stress via selective autophagy stimulation and autophagic flux restoration in osteoarthritis development
- (2017) Qian Tang et al. Cell Death & Disease
- MicroRNA-17-5p contributes to osteoarthritis progression by binding p62/SQSTM1
- (2017) Huihui Li et al. Experimental and Therapeutic Medicine
- miR-4262 regulates chondrocyte viability, apoptosis, autophagy by targeting SIRT1 and activating PI3K/AKT/mTOR signaling pathway in rats with osteoarthritis
- (2017) Wencai Sun et al. Experimental and Therapeutic Medicine
- Melatonin inhibits Sirt1-dependent NAMPT and NFAT5 signaling in chondrocytes to attenuate osteoarthritis
- (2017) Jia Yi Guo et al. Oncotarget
- Role of melatonin combined with exercise as a switch-like regulator for circadian behavior in advanced osteoarthritic knee
- (2017) Yunkyung Hong et al. Oncotarget
- The clock gene, brain and muscle Arnt-like 1, regulates autophagy in high glucose-induced cardiomyocyte injury
- (2017) Li Qiao et al. Oncotarget
- Characterisation of a divergent progenitor cell sub-populations in human osteoarthritic cartilage: the role of telomere erosion and replicative senescence
- (2017) Christopher R. Fellows et al. Scientific Reports
- Autophagy Protects Advanced Glycation End Product-Induced Apoptosis and Expression of MMP-3 and MMP-13 in Rat Chondrocytes
- (2017) Wenzhou Huang et al. Biomed Research International
- Regulated in Development and DNA Damage Response 1 Deficiency Impairs Autophagy and Mitochondrial Biogenesis in Articular Cartilage and Increases the Severity of Experimental Osteoarthritis
- (2017) Oscar Alvarez-Garcia et al. Arthritis & Rheumatology
- Regulation of Chondrocyte Survival in Mouse Articular Cartilage by p63
- (2017) Yuki Taniguchi et al. Arthritis & Rheumatology
- Redox control of senescence and age-related disease
- (2017) Akshaya Chandrasekaran et al. Redox Biology
- Ageing in the musculoskeletal system
- (2016) Sally Roberts et al. Acta Orthopaedica
- Ageing and the telomere connection: An intimate relationship with inflammation
- (2016) Jingwen Zhang et al. AGEING RESEARCH REVIEWS
- Robust, universal biomarker assay to detect senescent cells in biological specimens
- (2016) Konstantinos Evangelou et al. AGING CELL
- Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors
- (2016) Yi Zhu et al. AGING CELL
- Paracrine effects of human adipose-derived mesenchymal stem cells in inflammatory stress-induced senescence features of osteoarthritic chondrocytes
- (2016) Julia Platas et al. Aging-US
- The intervertebral disc contains intrinsic circadian clocks that are regulated by age and cytokines and linked to degeneration
- (2016) Michal Dudek et al. ANNALS OF THE RHEUMATIC DISEASES
- CCL2/CCR2, but not CCL5/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis
- (2016) Harini Raghu et al. ANNALS OF THE RHEUMATIC DISEASES
- Hydroxytyrosol prevents chondrocyte death under oxidative stress by inducing autophagy through sirtuin 1-dependent and -independent mechanisms
- (2016) Silvia Cetrullo et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- The protective role of autophagy in experimental osteoarthritis, and the therapeutic effects of Torin 1 on osteoarthritis by activating autophagy
- (2016) Ni-Tao Cheng et al. BMC MUSCULOSKELETAL DISORDERS
- Inflammatory mediators in osteoarthritis: A critical review of the state-of-the-art, current prospects, and future challenges
- (2016) Maryam Rahmati et al. BONE
- Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan
- (2016) Valter D. Longo et al. Cell Metabolism
- AntimiR-30b Inhibits TNF-α Mediated Apoptosis and Attenuated Cartilage Degradation through Enhancing Autophagy
- (2016) Zhe Chen et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- The chondrocyte-intrinsic circadian clock is disrupted in human osteoarthritis
- (2016) Sarah J. B. Snelling et al. CHRONOBIOLOGY INTERNATIONAL
- Clock GeneBmal1Modulates Human Cartilage Gene Expression by Crosstalk With Sirt1
- (2016) Wei Yang et al. ENDOCRINOLOGY
- Overexpression of HMGB1 A-box reduced IL-1β-induced MMP expression and the production of inflammatory mediators in human chondrocytes
- (2016) Yahui Fu et al. EXPERIMENTAL CELL RESEARCH
- Critical role of lysosomes in the dysfunction of human Cardiac Stem Cells obtained from failing hearts
- (2016) Giuseppe Gianfranceschi et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Sucrose, But Not Glucose, Blocks IL1-β-Induced Inflammatory Response in Human Chondrocytes by Inducing Autophagy via AKT/mTOR Pathway
- (2016) Nazir M. Khan et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Effects of SIRT1 gene knock-out via activation of SREBP2 protein-mediated PI3K/AKT signaling on osteoarthritis in mice
- (2016) Fei Yu et al. Journal of Huazhong University of Science and Technology-Medical Sciences
- Regulation of Autophagy By Signaling Through the Atg1/ULK1 Complex
- (2016) Daniel Papinski et al. JOURNAL OF MOLECULAR BIOLOGY
- Fis1 depletion in osteoarthritis impairs chondrocyte survival and peroxisomal and lysosomal function
- (2016) Dongkyun Kim et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Inhibition of senescence and promotion of the proliferation of chondrocytes from articular cartilage by CsA and FK506 involves inhibition of p38MAPK
- (2016) Seok-Won Kang et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Autophagy maintains stemness by preventing senescence
- (2016) Laura García-Prat et al. NATURE
- Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
- (2016) Darren J. Baker et al. NATURE
- The brain–joint axis in osteoarthritis: nerves, circadian clocks and beyond
- (2016) Francis Berenbaum et al. Nature Reviews Rheumatology
- Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis
- (2016) William H. Robinson et al. Nature Reviews Rheumatology
- The danger from within: alarmins in arthritis
- (2016) Meriam Nefla et al. Nature Reviews Rheumatology
- MicroRNA-155 suppresses autophagy in chondrocytes by modulating expression of autophagy proteins
- (2016) S. D'Adamo et al. OSTEOARTHRITIS AND CARTILAGE
- Insulin decreases autophagy and leads to cartilage degradation
- (2016) M. Ribeiro et al. OSTEOARTHRITIS AND CARTILAGE
- Diabetes-accelerated experimental osteoarthritis is prevented by autophagy activation
- (2016) M. Ribeiro et al. OSTEOARTHRITIS AND CARTILAGE
- Suppression of REDD1 in osteoarthritis cartilage, a novel mechanism for dysregulated mTOR signaling and defective autophagy
- (2016) O. Alvarez-Garcia et al. OSTEOARTHRITIS AND CARTILAGE
- Adipose-derived stem cells induce autophagic activation and inhibit catabolic response to pro-inflammatory cytokines in rat chondrocytes
- (2016) Li-Bo Jiang et al. OSTEOARTHRITIS AND CARTILAGE
- Suppression of NF-κB activity via nanoparticle-based siRNA delivery alters early cartilage responses to injury
- (2016) Huimin Yan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer
- (2016) Diletta Di Mitri et al. TRENDS IN CELL BIOLOGY
- Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL
- (2016) Reut Yosef et al. Nature Communications
- Inhibition of the Mechanistic Target of Rapamycin (mTOR)–Rapamycin and Beyond
- (2016) Dudley W. Lamming Cold Spring Harbor Perspectives in Medicine
- The Role of Sirtuins in Cartilage Homeostasis and Osteoarthritis
- (2016) Mona Dvir-Ginzberg et al. Current Rheumatology Reports
- Aging Promotes Sirtuin 3-Dependent Cartilage Superoxide Dismutase 2 Acetylation and Osteoarthritis
- (2016) Yao Fu et al. Arthritis & Rheumatology
- Intra-articular injection of Torin 1 reduces degeneration of articular cartilage in a rabbit osteoarthritis model
- (2016) N-T. Cheng et al. Bone & Joint Research
- Osteoarthritis
- (2016) Johanne Martel-Pelletier et al. Nature Reviews Disease Primers
- Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues
- (2016) EA Georgakopoulou et al. Aging-US
- Inflammaging: disturbed interplay between autophagy and inflammasomes
- (2016) Antero Salminen et al. Aging-US
- Loss of hepatic chaperone-mediated autophagy accelerates proteostasis failure in aging
- (2015) Jaime L. Schneider et al. AGING CELL
- PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage
- (2015) Faezeh Vasheghani et al. ANNALS OF THE RHEUMATIC DISEASES
- Targeted deletion of Atg5 in chondrocytes promotes age-related osteoarthritis
- (2015) Thibault Bouderlique et al. ANNALS OF THE RHEUMATIC DISEASES
- Autophagy protects meniscal cells from glucocorticoids-induced apoptosis via inositol trisphosphate receptor signaling
- (2015) Chao Shen et al. APOPTOSIS
- Autophagy protects endplate chondrocytes from intermittent cyclic mechanical tension induced calcification
- (2015) Hong-guang Xu BONE
- Autophagy signal transduction by ATG proteins: from hierarchies to networks
- (2015) Sebastian Wesselborg et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- MicroRNA-146a Induced by Hypoxia Promotes Chondrocyte Autophagy through Bcl-2
- (2015) Fei Zhang et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Synovial Fluid HMGB-1 Levels are Associated with Osteoarthritis Severity
- (2015) Xueru Ke et al. Clinical Laboratory
- Monosodium Urate Crystal-Induced Chondrocyte Death via Autophagic Process
- (2015) Hyun Hwang et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Biomarkers of Chondrocyte Apoptosis and Autophagy in Osteoarthritis
- (2015) Giuseppe Musumeci et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Autophagy Modulates Articular Cartilage Vesicle Formation in Primary Articular Chondrocytes
- (2015) Ann K. Rosenthal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity
- (2015) Michal Dudek et al. JOURNAL OF CLINICAL INVESTIGATION
- mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
- (2015) Nicolás Herranz et al. NATURE CELL BIOLOGY
- MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
- (2015) Remi-Martin Laberge et al. NATURE CELL BIOLOGY
- IL-6 as a keystone cytokine in health and disease
- (2015) Christopher A Hunter et al. NATURE IMMUNOLOGY
- Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
- (2015) Jianhui Chang et al. NATURE MEDICINE
- Autophagy protects chondrocytes from glucocorticoids-induced apoptosis via ROS/Akt/FOXO3 signaling
- (2015) C. Shen et al. OSTEOARTHRITIS AND CARTILAGE
- Epigenetic regulation of interleukin-8, an inflammatory chemokine, in osteoarthritis
- (2015) A. Takahashi et al. OSTEOARTHRITIS AND CARTILAGE
- Depletion of SIRT6 causes cellular senescence, DNA damage, and telomere dysfunction in human chondrocytes
- (2015) K. Nagai et al. OSTEOARTHRITIS AND CARTILAGE
- Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use
- (2015) V.B. Kraus et al. OSTEOARTHRITIS AND CARTILAGE
- The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4
- (2015) C. Kang et al. SCIENCE
- Bach1 deficiency reduces severity of osteoarthritis through upregulation of heme oxygenase-1
- (2015) Tsuyoshi Takada et al. ARTHRITIS RESEARCH & THERAPY
- Correlation between osteopontin and caveolin-1 in the pathogenesis and progression of osteoarthritis
- (2015) TU MIN et al. Experimental and Therapeutic Medicine
- Overexpression of Sirtuin 6 suppresses cellular senescence and NF-κB mediated inflammatory responses in osteoarthritis development
- (2015) Yaosen Wu et al. Scientific Reports
- SIRTain regulators of premature senescence and accelerated aging
- (2015) Shrestha Ghosh et al. Protein & Cell
- Autophagy Activation and Protection From Mitochondrial Dysfunction in Human Chondrocytes
- (2015) Paloma López de Figueroa et al. Arthritis & Rheumatology
- Identification of aPrg4-Expressing Articular Cartilage Progenitor Cell Population in Mice
- (2015) Elena Kozhemyakina et al. Arthritis & Rheumatology
- Mitochondrial Biogenesis Is Impaired in Osteoarthritis Chondrocytes but Reversible via Peroxisome Proliferator-Activated Receptor γ Coactivator 1α
- (2015) Yun Wang et al. Arthritis & Rheumatology
- The Relationship of Autophagy Defects to Cartilage Damage During Joint Aging in a Mouse Model
- (2015) Beatriz Caramés et al. Arthritis & Rheumatology
- Serum and synovial fluid chemokine ligand 2/monocyte chemoattractant protein 1 concentrations correlates with symptomatic severity in patients with knee osteoarthritis
- (2015) Liang Li et al. ANNALS OF CLINICAL BIOCHEMISTRY
- Mechanical overloading causes mitochondrial superoxide and SOD2 imbalance in chondrocytes resulting in cartilage degeneration
- (2015) Masato Koike et al. Scientific Reports
- Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis
- (2014) Yue Zhang et al. ANNALS OF THE RHEUMATIC DISEASES
- Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage
- (2014) Wang Hui et al. ANNALS OF THE RHEUMATIC DISEASES
- Senescent cells: SASPected drivers of age-related pathologies
- (2014) Yossi Ovadya et al. BIOGERONTOLOGY
- Intra-articular administration of gelatin hydrogels incorporating rapamycin–micelles reduces the development of experimental osteoarthritis in a murine model
- (2014) Tokio Matsuzaki et al. BIOMATERIALS
- Autophagy protects end plate chondrocytes from intermittent cyclic mechanical tension induced calcification
- (2014) Hong-guang Xu et al. BONE
- An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
- (2014) Marco Demaria et al. DEVELOPMENTAL CELL
- Genomic Analysis and Differential Expression of HMG and S100A Family in Human Arthritis: Upregulated Expression of Chemokines, IL-8 and Nitric Oxide by HMGB1
- (2014) Ashok R. Amin et al. DNA AND CELL BIOLOGY
- Induction of heme oxygenase-1 expression protects articular chondrocytes against cilostazol-induced cellular senescence
- (2014) KANG MI KIM et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Oxidative Stress-induced Inhibition of Sirt1 by Caveolin-1 Promotes p53-dependent Premature Senescence and Stimulates the Secretion of Interleukin 6 (IL-6)
- (2014) Daniela Volonte et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Glucosamine protects nucleus pulposus cells and induces autophagy via the mTOR-dependent pathway
- (2014) LiBo Jiang et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Telomeres Shorten in Response to Oxidative Stress in Mouse Skeletal Muscle Fibers
- (2014) A. T. Ludlow et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Autophagy in human articular chondrocytes is cytoprotective following glucocorticoid stimulation
- (2014) NING LIU et al. Molecular Medicine Reports
- The role of senescent cells in ageing
- (2014) Jan M. van Deursen NATURE
- Emerging regulators of the inflammatory process in osteoarthritis
- (2014) Ru Liu-Bryan et al. Nature Reviews Rheumatology
- Defective autophagy in chondrocytes with Kashin-Beck disease but higher than osteoarthritis
- (2014) C. Wu et al. OSTEOARTHRITIS AND CARTILAGE
- FOXO transcription factors: key regulators of cellular quality control
- (2014) Ashley E. Webb et al. TRENDS IN BIOCHEMICAL SCIENCES
- p16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodeling in osteoarthritis
- (2014) Didier Philipot et al. ARTHRITIS RESEARCH & THERAPY
- Local intra-articular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis
- (2014) Koji Takayama et al. ARTHRITIS RESEARCH & THERAPY
- FoxO Transcription Factors Support Oxidative Stress Resistance in Human Chondrocytes
- (2014) Yukio Akasaki et al. Arthritis & Rheumatology
- Adult Cartilage-Specific Peroxisome Proliferator–Activated Receptor Gamma Knockout Mice Exhibit the Spontaneous Osteoarthritis Phenotype
- (2013) Faezeh Vasheghani et al. AMERICAN JOURNAL OF PATHOLOGY
- Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice
- (2013) Tokio Matsuzaki et al. ANNALS OF THE RHEUMATIC DISEASES
- Enhancement of chondrocyte autophagy is an early response in the degenerative cartilage of the temporomandibular joint to biomechanical dental stimulation
- (2013) Mian Zhang et al. APOPTOSIS
- The Circadian Clock in Murine Chondrocytes Regulates Genes Controlling Key Aspects of Cartilage Homeostasis
- (2013) Nicole Gossan et al. ARTHRITIS AND RHEUMATISM
- Glucosamine Activates Autophagy In Vitro and In Vivo
- (2013) Beatriz Caramés et al. ARTHRITIS AND RHEUMATISM
- Signalling pathways regulating muscle mass in ageing skeletal muscle. The role of the IGF1-Akt-mTOR-FoxO pathway
- (2013) M. Sandri et al. BIOGERONTOLOGY
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- Programmed Cell Senescence during Mammalian Embryonic Development
- (2013) Daniel Muñoz-Espín et al. CELL
- Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning
- (2013) Mekayla Storer et al. CELL
- Immunopathogenesis of osteoarthritis
- (2013) Abdul Haseeb et al. CLINICAL IMMUNOLOGY
- Autophagy in inflammation, infection, neurodegeneration and cancer
- (2013) Daniela S. Arroyo et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- The dual role of autophagy in chondrocyte responses in the pathogenesis of articular cartilage degeneration in osteoarthritis
- (2013) JUN CHANG et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Correlation between senescence-associated beta-galactosidase expression in articular cartilage and disease severity of patients with knee osteoarthritis
- (2013) Shu-Guang Gao et al. International Journal of Rheumatic Diseases
- p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes
- (2013) Albert R. Davalos et al. JOURNAL OF CELL BIOLOGY
- Rapalogs and mTOR inhibitors as anti-aging therapeutics
- (2013) Dudley W. Lamming et al. JOURNAL OF CLINICAL INVESTIGATION
- The beginning of the end
- (2013) Judith Campisi NATURE
- mTOR is a key modulator of ageing and age-related disease
- (2013) Simon C. Johnson et al. NATURE
- Metabolism of inflammation limited by AMPK and pseudo-starvation
- (2013) Luke A. J. O'Neill et al. NATURE
- Transmitting senescence to the cell neighbourhood
- (2013) Matthew Hoare et al. NATURE CELL BIOLOGY
- A complex secretory program orchestrated by the inflammasome controls paracrine senescence
- (2013) Juan Carlos Acosta et al. NATURE CELL BIOLOGY
- Dysregulated FOXO transcription factors in articular cartilage in aging and osteoarthritis
- (2013) Y. Akasaki et al. OSTEOARTHRITIS AND CARTILAGE
- Effects of aging on articular cartilage homeostasis
- (2012) Martin Lotz et al. BONE
- mTOR Signaling in Growth Control and Disease
- (2012) Mathieu Laplante et al. CELL
- Vertical inhibition of the PI3K/Akt/mTOR pathway for the treatment of osteoarthritis
- (2012) Jiezhong Chen et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Cytoprotective and anti-inflammatory effects of melatonin in hydrogen peroxide-stimulated CHON-001 human chondrocyte cell line and rabbit model of osteoarthritis via the SIRT1 pathway
- (2012) Hyun-Dae Lim et al. JOURNAL OF PINEAL RESEARCH
- Lamin B1 loss is a senescence-associated biomarker
- (2012) Adam Freund et al. MOLECULAR BIOLOGY OF THE CELL
- The sirtuin SIRT6 regulates lifespan in male mice
- (2012) Yariv Kanfi et al. NATURE
- Sirtuins as regulators of metabolism and healthspan
- (2012) Riekelt H. Houtkooper et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis
- (2012) R. E. Miller et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Removal of Shelterin Reveals the Telomere End-Protection Problem
- (2012) A. Sfeir et al. SCIENCE
- Rapamycin Reverses Elevated mTORC1 Signaling in Lamin A/C-Deficient Mice, Rescues Cardiac and Skeletal Muscle Function, and Extends Survival
- (2012) F. J. Ramos et al. Science Translational Medicine
- Autophagy activation by rapamycin reduces severity of experimental osteoarthritis
- (2011) Beatriz Caramés et al. ANNALS OF THE RHEUMATIC DISEASES
- The Role of Atg Proteins in Autophagosome Formation
- (2011) Noboru Mizushima et al. Annual Review of Cell and Developmental Biology
- Mechanical injury suppresses autophagy regulators and pharmacologic activation of autophagy results in chondroprotection
- (2011) Beatriz Caramés et al. ARTHRITIS AND RHEUMATISM
- Autophagy modulates osteoarthritis-related gene expression in human chondrocytes
- (2011) Hiroshi Sasaki et al. ARTHRITIS AND RHEUMATISM
- Distinct Roles of Endothelial and Adipocyte Caveolin-1 in Macrophage Infiltration and Adipose Tissue Metabolic Activity
- (2011) N. Briand et al. DIABETES
- p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype
- (2011) Adam Freund et al. EMBO JOURNAL
- Control of the senescence-associated secretory phenotype by NF- B promotes senescence and enhances chemosensitivity
- (2011) Y. Chien et al. GENES & DEVELOPMENT
- Four faces of cellular senescence
- (2011) Francis Rodier et al. JOURNAL OF CELL BIOLOGY
- Oxidative stress induces senescence in chondrocytes
- (2011) Anita Brandl et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Autophagy and disease: always two sides to a problem
- (2011) Sunandini Sridhar et al. JOURNAL OF PATHOLOGY
- Caveolin-1, cellular senescence and age-related diseases
- (2011) Huafei Zou et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Autophagy, nutrition and immunology
- (2011) Ana Maria Cuervo et al. MOLECULAR ASPECTS OF MEDICINE
- Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
- (2011) Darren J. Baker et al. NATURE
- Klotho suppresses RIG-I-mediated senescence-associated inflammation
- (2011) Feng Liu et al. NATURE CELL BIOLOGY
- SIRT6 Promotes DNA Repair Under Stress by Activating PARP1
- (2011) Z. Mao et al. SCIENCE
- The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
- (2010) Jean-Philippe Coppé et al. Annual Review of Pathology-Mechanisms of Disease
- Cell death of chondrocytes is a combination between apoptosis and autophagy during the pathogenesis of Osteoarthritis within an experimental model
- (2010) M. Almonte-Becerril et al. APOPTOSIS
- Mammalian target of rapamycin signaling is crucial for joint destruction in experimental arthritis and is activated in osteoclasts from patients with rheumatoid arthritis
- (2010) Daniel Cejka et al. ARTHRITIS AND RHEUMATISM
- Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis
- (2010) Beatriz Caramés et al. ARTHRITIS AND RHEUMATISM
- Methods for detecting autophagy and determining autophagy-induced cell deathThis review is one of a selection of papers published in a Special Issue on Oxidative Stress in Health and Disease.
- (2010) Yongqiang Chen et al. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
- The essence of senescence
- (2010) T. Kuilman et al. GENES & DEVELOPMENT
- Autophagy: cellular and molecular mechanisms
- (2010) Danielle Glick et al. JOURNAL OF PATHOLOGY
- Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress
- (2010) Shomit Sengupta et al. MOLECULAR CELL
- Role of proinflammatory cytokines in the pathophysiology of osteoarthritis
- (2010) Mohit Kapoor et al. Nature Reviews Rheumatology
- A Human-Like Senescence-Associated Secretory Phenotype Is Conserved in Mouse Cells Dependent on Physiological Oxygen
- (2010) Jean-Philippe Coppé et al. PLoS One
- Loss of Caveolin-1 Accelerates Neurodegeneration and Aging
- (2010) Brian P. Head et al. PLoS One
- The Beclin 1–VPS34 complex – at the crossroads of autophagy and beyond
- (2010) Sarah F. Funderburk et al. TRENDS IN CELL BIOLOGY
- Inflammatory networks during cellular senescence: causes and consequences
- (2010) Adam Freund et al. TRENDS IN MOLECULAR MEDICINE
- Mitochondrial Turnover and Aging of Long-Lived Postmitotic Cells: The Mitochondrial–Lysosomal Axis Theory of Aging
- (2009) Alexei Terman et al. ANTIOXIDANTS & REDOX SIGNALING
- Regulation of autophagy in human and murine cartilage: Hypoxia-inducible factor 2 suppresses chondrocyte autophagy
- (2009) Jolene Bohensky et al. ARTHRITIS AND RHEUMATISM
- Caveolin-1 Regulates the Antagonistic Pleiotropic Properties of Cellular Senescence through a Novel Mdm2/p53-Mediated Pathway
- (2009) J. N. Bartholomew et al. CANCER RESEARCH
- SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span
- (2009) Tiara L.A. Kawahara et al. CELL
- Autophagy: Regulation and role in disease
- (2009) Alfred J. Meijer et al. CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
- Autophagy mediates the mitotic senescence transition
- (2009) A. R.J. Young et al. GENES & DEVELOPMENT
- Angiogenic growth factors inhibit chondrocyte ageing in osteoarthritis: potential involvement of catabolic stress-induced overexpression of caveolin-1 in cellular ageing
- (2009) Kazuo YUDOH et al. International Journal of Rheumatic Diseases
- An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1
- (2009) Carson C. Thoreen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo
- (2009) Florence Debacq-Chainiaux et al. Nature Protocols
- Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix
- (2009) R.F. Loeser OSTEOARTHRITIS AND CARTILAGE
- Chromatin protein HMGB2 regulates articular cartilage surface maintenance via -catenin pathway
- (2009) N. Taniguchi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cell surface-bound IL-1 is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network
- (2009) A. V. Orjalo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cellular Senescence: Molecular Mechanisms, In Vivo Significance, and Redox Considerations
- (2008) Michael Muller ANTIOXIDANTS & REDOX SIGNALING
- SIRT1 regulates the ribosomal DNA locus: Epigenetic candles twinkle longevity in the Christmas tree
- (2008) Antero Salminen et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network
- (2008) Thomas Kuilman et al. CELL
- Oncogenic BRAF Induces Senescence and Apoptosis through Pathways Mediated by the Secreted Protein IGFBP7
- (2008) Narendra Wajapeyee et al. CELL
- Senescence of Activated Stellate Cells Limits Liver Fibrosis
- (2008) Valery Krizhanovsky et al. CELL
- The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series
- (2008) Jiefei Geng et al. EMBO REPORTS
- Premature aging in mice activates a systemic metabolic response involving autophagy induction
- (2008) Guillermo Mariño et al. HUMAN MOLECULAR GENETICS
- SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
- (2008) Eriko Michishita et al. NATURE
- Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency
- (2008) Darren J. Baker et al. NATURE CELL BIOLOGY
- Telomeres and Aging
- (2008) Geraldine Aubert et al. PHYSIOLOGICAL REVIEWS
- Autophagy and aging: keeping that old broom working
- (2008) Ana Maria Cuervo TRENDS IN GENETICS
- Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
- (2008) Jean-Philippe Coppé et al. PLOS BIOLOGY
- Differential effects of tumor necrosis factor-α and interleukin-1β on cell death in human articular chondrocytes
- (2007) B. Caramés et al. OSTEOARTHRITIS AND CARTILAGE
- Reactive nitrogen and oxygen species in interleukin-1-mediated DNA damage associated with osteoarthritis
- (2007) C.M. Davies et al. OSTEOARTHRITIS AND CARTILAGE
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