Trehalose ameliorates oxidative stress-mediated mitochondrial dysfunction and ER stress via selective autophagy stimulation and autophagic flux restoration in osteoarthritis development

Suppression of Sestrins in aging and osteoarthritic cartilage: dysfunction of an important stress defense mechanism

(2017) T. Shen et al.   OSTEOARTHRITIS AND CARTILAGE

Receptor-mediated reticulophagy: a novel promising therapy target for diseases

(2016) Lanfang Li et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD+elevation

(2016) Xiaojuan Han et al.   AGING CELL

Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence

(2016) Haoran Tai et al.   Autophagy

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DRP1-dependent apoptotic mitochondrial fission occurs independently of BAX, BAK and APAF1 to amplify cell death by BID and oxidative stress

(2016) Björn Oettinghaus et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Hydroxytyrosol prevents chondrocyte death under oxidative stress by inducing autophagy through sirtuin 1-dependent and -independent mechanisms

(2016) Silvia Cetrullo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

ROS/oxidative stress signaling in osteoarthritis

(2016) Panagiotis Lepetsos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Inhibition of autophagy sensitises cells to hydrogen peroxide-induced apoptosis: Protective effect of mild thermotolerance acquired at 40 °C

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AntimiR-30b Inhibits TNF-α Mediated Apoptosis and Attenuated Cartilage Degradation through Enhancing Autophagy

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(2016) Alexander M van der Bliek   EMBO JOURNAL

Advanced oxidation protein products induce apoptosis of human chondrocyte through reactive oxygen species-mediated mitochondrial dysfunction and endoplasmic reticulum stress pathways

(2016) Wenbin Ye et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Disease-modifying treatments for osteoarthritis (DMOADs) of the knee and hip: lessons learned from failures and opportunities for the future

(2016) M.A. Karsdal et al.   OSTEOARTHRITIS AND CARTILAGE

mTOR-Independent autophagy inducer trehalose rescues against insulin resistance-induced myocardial contractile anomalies: Role of p38 MAPK and Foxo1

(2016) Qiurong Wang et al.   PHARMACOLOGICAL RESEARCH

Mystery solved: Trehalose kickstarts autophagy by blocking glucose transport

(2016) Pablo Mardones et al.   Science Signaling

Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis

(2016) Brian J. DeBosch et al.   Science Signaling

Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo

(2016) Deheng Chen et al.   Cell Death & Disease

Resveratrol attenuated hydrogen peroxide-induced myocardial apoptosis by autophagic flux

(2016) Chih-Yang Huang et al.   Food & Nutrition Research

Mystery solved: Trehalose kickstarts autophagy by blocking glucose transport

(2016) Pablo Mardones et al.   Science Signaling

Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis

(2016) Brian J. DeBosch et al.   Science Signaling

Trehalose, sucrose and raffinose are novel activators of autophagy in human keratinocytes through an mTOR-independent pathway

(2016) Xu Chen et al.   Scientific Reports

Reticulophagy and nucleophagy: New findings and unsolved issues

(2015) Hitoshi Nakatogawa et al.   Autophagy

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(2015) S Glyn-Jones et al.   LANCET

Treatment with Trehalose Prevents Behavioral and Neurochemical Deficits Produced in an AAV α-Synuclein Rat Model of Parkinson’s Disease

(2015) Qing He et al.   MOLECULAR NEUROBIOLOGY

Autophagy protects chondrocytes from glucocorticoids-induced apoptosis via ROS/Akt/FOXO3 signaling

(2015) C. Shen et al.   OSTEOARTHRITIS AND CARTILAGE

Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD

(2014) Sayak K Mitter et al.   Autophagy

MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis

(2014) Xiaojie Zhang et al.   Autophagy

Mitochondrial Pathology in Osteoarthritic Chondrocytes

(2014) Longhuo Wu et al.   CURRENT DRUG TARGETS

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(2014) Thomas J. LaRocca et al.   EXPERIMENTAL GERONTOLOGY

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(2014) Alexandra Stolz et al.   NATURE CELL BIOLOGY

Endoplasmic reticulum stress-induced apoptosis contributes to articular cartilage degeneration via C/EBP homologous protein

(2014) Y. Uehara et al.   OSTEOARTHRITIS AND CARTILAGE

Local intra-articular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis

(2014) Koji Takayama et al.   ARTHRITIS RESEARCH & THERAPY

Brief Report: Stress-Inducible Nuclear Protein 1 Regulates Matrix Metalloproteinase 13 Expression in Human Articular Chondrocytes

(2014) Raghunatha R. Yammani et al.   Arthritis & Rheumatology

Trehalose prevents neural tube defects by correcting maternal diabetes-suppressed autophagy and neurogenesis

(2013) Cheng Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hydrogen peroxide impairs autophagic flux in a cell model of nonalcoholic fatty liver disease

(2013) Pengtao Jiang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

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(2013) Subhashini Bolisetty et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

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(2013)   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Comparison of biological processes induced in HepG2 cells by tert-butyl hydroperoxide (t-BHP) and hydroperoxide (H2O2): The influence of carvacrol

(2013) Darina Slamenova et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome

(2013) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

Reactive Oxygen Species: The 2-Edged Sword of Osteoarthritis

(2012) Ding Li et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Oxidative stress impairs autophagic flux in prion protein-deficient hippocampal cells

(2012) Jae-Min Oh et al.   Autophagy

Microtubule-associated Protein 1 Light Chain 3 (LC3) Interacts with Bnip3 Protein to Selectively Remove Endoplasmic Reticulum and Mitochondria via Autophagy

(2012) Rita A. Hanna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acute joint pathology and synovial inflammation is associated with increased intra-articular fracture severity in the mouse knee

(2011) J.S. Lewis et al.   OSTEOARTHRITIS AND CARTILAGE

Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis

(2010) Beatriz Caramés et al.   ARTHRITIS AND RHEUMATISM

Bnip3-mediated mitochondrial autophagy is independent of the mitochondrial permeability transition pore

(2010) Melissa N. Quinsay et al.   Autophagy

Eaten alive: a history of macroautophagy

(2010) Zhifen Yang et al.   NATURE CELL BIOLOGY

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

(2010) S.S. Glasson et al.   OSTEOARTHRITIS AND CARTILAGE