Autophagy Activation and Protection From Mitochondrial Dysfunction in Human Chondrocytes

The role of autophagy in Parkinson's disease: rotenone-based modeling

(2013) Nian Xiong et al.   Behavioral and Brain Functions

Mitochondrial respiratory chain dysfunction modulates metalloproteases -1, -3 and -13 in human normal chondrocytes in culture

(2013) Berta Cillero-Pastor et al.   BMC MUSCULOSKELETAL DISORDERS

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Autophagy activation by rapamycin reduces severity of experimental osteoarthritis

(2011) Beatriz Caramés et al.   ANNALS OF THE RHEUMATIC DISEASES

Mechanical injury suppresses autophagy regulators and pharmacologic activation of autophagy results in chondroprotection

(2011) Beatriz Caramés et al.   ARTHRITIS AND RHEUMATISM

Autophagy modulates osteoarthritis-related gene expression in human chondrocytes

(2011) Hiroshi Sasaki et al.   ARTHRITIS AND RHEUMATISM

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

The role of mitochondria in osteoarthritis

(2011) Francisco J. Blanco et al.   Nature Reviews Rheumatology

Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis

(2010) Beatriz Caramés et al.   ARTHRITIS AND RHEUMATISM

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

(2010) Joo-Yong Lee et al.   JOURNAL OF CELL BIOLOGY

The molecular mechanism of mitochondria autophagy in yeast

(2010) Tomotake Kanki et al.   MOLECULAR MICROBIOLOGY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Protein Targets of Oxidative Damage in Human Neurodegenerative Diseases with Abnormal Protein Aggregates

(2009) Anna Martínez et al.   BRAIN PATHOLOGY

Rapamycin protects against rotenone-induced apoptosis through autophagy induction

(2009) T. Pan et al.   NEUROSCIENCE

Aging-related loss of the chromatin protein HMGB2 in articular cartilage is linked to reduced cellularity and osteoarthritis

(2009) N. Taniguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial dysfunction activates cyclooxygenase 2 expression in cultured normal human chondrocytes

(2008) Berta Cillero-Pastor et al.   ARTHRITIS AND RHEUMATISM

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Mitochondrial Dysregulation of Osteoarthritic Human Articular Chondrocytes Analyzed by Proteomics

(2008) Cristina Ruiz-Romero et al.   MOLECULAR & CELLULAR PROTEOMICS

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE