Emerging regulators of the inflammatory process in osteoarthritis

The Search for Antiaging Interventions: From Elixirs to Fasting Regimens

(2014) Rafael de Cabo et al.   CELL

Regulation of the Catabolic Cascade in Osteoarthritis by the Zinc-ZIP8-MTF1 Axis

(2014) Jin-Hong Kim et al.   CELL

The interplay between mitochondria and autophagy and its role in the aging process

(2014) Alfonso Schiavi et al.   EXPERIMENTAL GERONTOLOGY

Dispensable role of myeloid differentiation primary response gene 88 (MyD88) and MyD88-dependent toll-like receptors (TLRs) in a murine model of osteoarthritis

(2014) Sonia Nasi et al.   JOINT BONE SPINE

Synovitis in Knee Osteoarthritis Assessed by Contrast-enhanced Magnetic Resonance Imaging (MRI) is Associated with Radiographic Tibiofemoral Osteoarthritis and MRI-detected Widespread Cartilage Damage: The MOST Study

(2014) A. Guermazi et al.   JOURNAL OF RHEUMATOLOGY

Endoplasmic reticulum stress-induced apoptosis contributes to articular cartilage degeneration via C/EBP homologous protein

(2014) Y. Uehara et al.   OSTEOARTHRITIS AND CARTILAGE

Endoplasmic Reticulum Stress-Unfolding Protein Response-Apoptosis Cascade Causes Chondrodysplasia in a col2a1 p.Gly1170Ser Mutated Mouse Model

(2014) Guoyan Liang et al.   PLoS One

Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice

(2013) Tokio Matsuzaki et al.   ANNALS OF THE RHEUMATIC DISEASES

The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments?

(2013) M A Karsdal et al.   ANNALS OF THE RHEUMATIC DISEASES

Hypoxia Promotes the Production and Inhibits the Destruction of Human Articular Cartilage

(2013) Brendan L. Thoms et al.   ARTHRITIS AND RHEUMATISM

Glucosamine Activates Autophagy In Vitro and In Vivo

(2013) Beatriz Caramés et al.   ARTHRITIS AND RHEUMATISM

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock

(2013) Kairui Mao et al.   CELL RESEARCH

ATF6 upregulates XBP1S and inhibits ER stress-mediated apoptosis in osteoarthritis cartilage

(2013) Feng-Jin Guo et al.   CELLULAR SIGNALLING

Haem oxygenase-1 induction reverses the actions of interleukin-1β on hypoxia-inducible transcription factors and human chondrocyte metabolism in hypoxia

(2013) Victoria Clérigues et al.   CLINICAL SCIENCE

A novel transgenic mouse model of growth plate dysplasia reveals that decreased chondrocyte proliferation due to chronic ER stress is a key factor in reduced bone growth

(2013) B. Gualeni et al.   Disease Models & Mechanisms

Mapping the crossroads of immune activation and cellular stress response pathways

(2013) Nuno Cláudio et al.   EMBO JOURNAL

Towards elucidating the role of SirT1 in osteoarthritis

(2013) Mona Dvir-Ginzberg   Frontiers in Bioscience-Landmark

Autophagy in inflammation, infection, neurodegeneration and cancer

(2013) Daniela S. Arroyo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Nutraceuticals: Potential for Chondroprotection and Molecular Targeting of Osteoarthritis

(2013) Daniel Leong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of Intensive Diet and Exercise on Knee Joint Loads, Inflammation, and Clinical Outcomes Among Overweight and Obese Adults With Knee Osteoarthritis

(2013) Stephen P. Messier et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

HLA-B27 misfolding and ankylosing spondylitis

(2013) Robert A. Colbert et al.   MOLECULAR IMMUNOLOGY

Metabolism of inflammation limited by AMPK and pseudo-starvation

(2013) Luke A. J. O'Neill et al.   NATURE

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

(2013) Takuma Misawa et al.   NATURE IMMUNOLOGY

Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis

(2013) Gehua Zhen et al.   NATURE MEDICINE

Biologic agents in osteoarthritis: hopes and disappointments

(2013) Xavier Chevalier et al.   Nature Reviews Rheumatology

Towards a mechanism-based approach to pain management in osteoarthritis

(2013) Anne-Marie Malfait et al.   Nature Reviews Rheumatology

Consequences of chondrocyte hypertrophy on osteoarthritic cartilage: potential effect on angiogenesis

(2013) L. Pesesse et al.   OSTEOARTHRITIS AND CARTILAGE

Importance of synovitis in osteoarthritis: Evidence for the use of glycosaminoglycans against synovial inflammation

(2013) Yves Henrotin et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

C/EBP homologous protein drives pro-catabolic responses in chondrocytes

(2013) Matt Husa et al.   ARTHRITIS RESEARCH & THERAPY

Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes

(2013) Freyr Petursson et al.   ARTHRITIS RESEARCH & THERAPY

Brief Report: Carboxypeptidase B Serves as a Protective Mediator in Osteoarthritis

(2013) Christin M. Lepus et al.   Arthritis & Rheumatology

The Interplay between NLRs and Autophagy in Immunity and Inflammation

(2013) Leticia A. M. Carneiro et al.   Frontiers in Immunology

Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice

(2012) Odile Gabay et al.   ANNALS OF THE RHEUMATIC DISEASES

The growing array of innate inflammatory ignition switches in osteoarthritis

(2012) Ru Liu-Bryan et al.   ARTHRITIS AND RHEUMATISM

Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse model

(2012) Odile Gabay et al.   ARTHRITIS AND RHEUMATISM

Stress-induced cartilage degradation does not depend on the NLRP3 inflammasome in human osteoarthritis and mouse models

(2012) Carole Bougault et al.   ARTHRITIS AND RHEUMATISM

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Mitochondrial dysfunction increases inflammatory responsiveness to cytokines in normal human chondrocytes

(2012) Carlos Vaamonde-García et al.   ARTHRITIS AND RHEUMATISM

β-catenin regulates parathyroid hormone/parathyroid hormone-related protein receptor signals and chondrocyte hypertrophy through binding to the intracellular C-terminal region of the receptor

(2012) Fumiko Yano et al.   ARTHRITIS AND RHEUMATISM

Mitochondrial dysfunction in osteoarthritis is associated with down-regulation of superoxide dismutase 2

(2012) Christos Gavriilidis et al.   ARTHRITIS AND RHEUMATISM

The role of synovitis in osteoarthritis pathogenesis

(2012) Carla R. Scanzello et al.   BONE

Osteoarthritis, inflammation and obesity

(2012) Francis Berenbaum et al.   CURRENT OPINION IN RHEUMATOLOGY

XBP1S Associates with RUNX2 and Regulates Chondrocyte Hypertrophy

(2012) Yanna Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Nitric Oxide Inhibits the NLRP3 Inflammasome

(2012) E. Hernandez-Cuellar et al.   JOURNAL OF IMMUNOLOGY

Fueling the flame: bioenergy couples metabolism and inflammation

(2012) T. F. Liu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The overexpression of SIRT1 inhibited osteoarthritic gene expression changes induced by interleukin-1β in human chondrocytes

(2012) Takehiko Matsushita et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Autophagy: A New Therapeutic Target in Cartilage Injury and Osteoarthritis

(2012) Martin Lotz et al.   JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS

Hypoxia—a key regulator of angiogenesis and inflammation in rheumatoid arthritis

(2012) Sofia Konisti et al.   Nature Reviews Rheumatology

Syndecans in cartilage breakdown and synovial inflammation

(2012) Thomas Pap et al.   Nature Reviews Rheumatology

SIRT1, a class III histone deacetylase, regulates TNF-α-induced inflammation in human chondrocytes

(2012) M.-H. Moon et al.   OSTEOARTHRITIS AND CARTILAGE

CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis

(2012) R. E. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER stress-induced inflammation: does it aid or impede disease progression?

(2012) Abhishek D. Garg et al.   TRENDS IN MOLECULAR MEDICINE

Biomechanical factors and physical examination findings in osteoarthritis of the knee: associations with tissue abnormalities assessed by conventional radiography and high-resolution 3.0 Tesla magnetic resonance imaging

(2012) Jesper Knoop et al.   ARTHRITIS RESEARCH & THERAPY

Hyaluronan injection in murine osteoarthritis prevents TGFbeta 1-induced synovial neovascularization and fibrosis and maintains articular cartilage integrity by a CD44-dependent mechanism

(2012) Jun Li et al.   ARTHRITIS RESEARCH & THERAPY

Prevalence of abnormalities in knees detected by MRI in adults without knee osteoarthritis: population based observational study (Framingham Osteoarthritis Study)

(2012) A. Guermazi et al.   BMJ-British Medical Journal

AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network

(2011) Antero Salminen et al.   AGEING RESEARCH REVIEWS

Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1β and tumor necrosis factor α

(2011) Robert Terkeltaub et al.   ARTHRITIS AND RHEUMATISM

Lack of a chondroprotective effect of cyclooxygenase 2 inhibition in a surgically induced model of osteoarthritis in mice

(2011) Atsushi Fukai et al.   ARTHRITIS AND RHEUMATISM

Alarmins S100A8 and S100A9 elicit a catabolic effect in human osteoarthritic chondrocytes that is dependent on Toll-like receptor 4

(2011) Rik F. P. Schelbergen et al.   ARTHRITIS AND RHEUMATISM

Mitochondria: Sovereign of inflammation?

(2011) Jürg Tschopp   EUROPEAN JOURNAL OF IMMUNOLOGY

Resveratrol inhibits interleukin 1β-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-κB activity

(2011) Ming Lei et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mitochondria at the Interface Between Danger Signaling and Metabolism: Role of Unfolded Protein Responses in Chronic Inflammation

(2011) Eva Rath et al.   INFLAMMATORY BOWEL DISEASES

Enhanced apoptotic and reduced protective response in chondrocytes following endoplasmic reticulum stress in osteoarthritic cartilage

(2011) Koji Takada et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Identification of a central role for complement in osteoarthritis

(2011) Qian Wang et al.   NATURE MEDICINE

The role of mitochondria in osteoarthritis

(2011) Francisco J. Blanco et al.   Nature Reviews Rheumatology

NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy

(2011) C. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of resveratrol on cartilage protection and apoptosis inhibition in experimental osteoarthritis of rabbit

(2011) Jing Wang et al.   RHEUMATOLOGY INTERNATIONAL

Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis

(2010) Mary B. Goldring et al.   Annals of the New York Academy of Sciences

Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease

(2010) J. L. Scott et al.   ANNALS OF THE RHEUMATIC DISEASES

SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway

(2010) Viktoria Gagarina et al.   ARTHRITIS AND RHEUMATISM

Inflammatory osteoarthritis of the hand

(2010) Leonardo Punzi et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

HIF-2α - a mediator of osteoarthritis?

(2010) Christopher L Murphy   CELL RESEARCH

NF-κB Signaling: Multiple Angles to Target OA

(2010) Kenneth B. Marcu et al.   CURRENT DRUG TARGETS

Lubricin: a novel potential biotherapeutic approaches for the treatment of osteoarthritis

(2010) Jia-peng Bao et al.   MOLECULAR BIOLOGY REPORTS

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages

(2010) Fabio Martinon et al.   NATURE IMMUNOLOGY

Shifting HIFs in osteoarthritis

(2010) Matthew Husa et al.   NATURE MEDICINE

Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development

(2010) Taku Saito et al.   NATURE MEDICINE

Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction

(2010) Siyoung Yang et al.   NATURE MEDICINE

The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

(2010) Jérémie Sellam et al.   Nature Reviews Rheumatology

S100A8 and S100A9 in experimental osteoarthritis

(2010) Hala Zreiqat et al.   ARTHRITIS RESEARCH & THERAPY

SIRT1 regulation of apoptosis of human chondrocytes

(2009) Koji Takayama et al.   ARTHRITIS AND RHEUMATISM

Prevention of cartilage degeneration in a rat model of osteoarthritis by intraarticular treatment with recombinant lubricin

(2009) Carl R. Flannery et al.   ARTHRITIS AND RHEUMATISM

Ionizing Radiation Induces Cellular Senescence of Articular Chondrocytes via Negative Regulation of SIRT1 by p38 Kinase

(2009) Eun-Hee Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Pattern Recognition Receptor CD36 Is a Chondrocyte Hypertrophy Marker Associated with Suppression of Catabolic Responses and Promotion of Repair Responses to Inflammatory Stimuli

(2009) D. L. Cecil et al.   JOURNAL OF IMMUNOLOGY

Modulating hedgehog signaling can attenuate the severity of osteoarthritis

(2009) Alvin C Lin et al.   NATURE MEDICINE

Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis

(2009) Frank Echtermeyer et al.   NATURE MEDICINE

AMPK in Health and Disease

(2009) Gregory R. Steinberg et al.   PHYSIOLOGICAL REVIEWS

The antioxidant resveratrol protects against chondrocyte apoptosis via effects on mitochondrial polarization and ATP production

(2008) Mandar Dave et al.   ARTHRITIS AND RHEUMATISM

Resveratrol suppresses interleukin-1β-induced inflammatory signaling and apoptosis in human articular chondrocytes: Potential for use as a novel nutraceutical for the treatment of osteoarthritis

(2008) Mehdi Shakibaei et al.   BIOCHEMICAL PHARMACOLOGY

Autophagy: A New Phase in the Maturation of Growth Plate Chondrocytes Is Regulated by HIF, mTOR and AMP Kinase

(2008) Vickram Srinivas et al.   CELLS TISSUES ORGANS

AMP-activated protein kinase in skeletal muscle: From structure and localization to its role as a master regulator of cellular metabolism

(2008) C. A. Witczak et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Regulation of Cartilage-specific Gene Expression in Human Chondrocytes by SirT1 and Nicotinamide Phosphoribosyltransferase

(2008) Mona Dvir-Ginzberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of inflammation signalling by resveratrol in human chondrocytes in vitro

(2007) Constanze Csaki et al.   BIOCHEMICAL PHARMACOLOGY