Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis

In vivo bone-specific EphB4 overexpression in mice protects both subchondral bone and cartilage during osteoarthritis

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Microtubule-associated Protein 1 Light Chain 3 (LC3) Interacts with Bnip3 Protein to Selectively Remove Endoplasmic Reticulum and Mitochondria via Autophagy

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Rapamycin Reverses Elevated mTORC1 Signaling in Lamin A/C-Deficient Mice, Rescues Cardiac and Skeletal Muscle Function, and Extends Survival

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Autophagy activation by rapamycin reduces severity of experimental osteoarthritis

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AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets

(2011) Ken Inoki et al.   Annual Review of Pharmacology and Toxicology

Association of cartilage-specific deletion of peroxisome proliferator-activated receptor γ with abnormal endochondral ossification and impaired cartilage growth and development in a murine model

(2011) Roxana Monemdjou et al.   ARTHRITIS AND RHEUMATISM

Autophagy modulates osteoarthritis-related gene expression in human chondrocytes

(2011) Hiroshi Sasaki et al.   ARTHRITIS AND RHEUMATISM

Glucosamine Sulfate Reduces Prostaglandin E2 Production in Osteoarthritic Chondrocytes Through Inhibition of Microsomal PGE Synthase-1

(2011) M. KAPOOR et al.   JOURNAL OF RHEUMATOLOGY

AMPK -> ULK1 -> Autophagy

(2011) P. J. Roach   MOLECULAR AND CELLULAR BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis

(2010) Beatriz Caramés et al.   ARTHRITIS AND RHEUMATISM

The role of the Atg1/ULK1 complex in autophagy regulation

(2010) Noboru Mizushima   CURRENT OPINION IN CELL BIOLOGY

The Autophagy Connection

(2010) Daniel J. Klionsky   DEVELOPMENTAL CELL

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

(2010) S.S. Glasson et al.   OSTEOARTHRITIS AND CARTILAGE

Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes

(2009) Ginette Tardif et al.   BMC MUSCULOSKELETAL DISORDERS

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

Cartilage in normal and osteoarthritis conditions

(2008) Johanne Martel-Pelletier et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE