Ageing in the musculoskeletal system

Does Defective Bone Lead to Defective Muscle?

(2015) Lynda F. Bonewald   JOURNAL OF BONE AND MINERAL RESEARCH

Defining the phenotype of young healthy nucleus pulposus cells: Recommendations of the Spine Research Interest Group at the 2014 annual ORS meeting

(2015) Makarand V. Risbud et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Aging-related inflammation in osteoarthritis

(2015) M.A. Greene et al.   OSTEOARTHRITIS AND CARTILAGE

Soluble factors from the notochordal-rich intervertebral disc inhibit endothelial cell invasion and vessel formation in the presence and absence of pro-inflammatory cytokines

(2015) M.C. Cornejo et al.   OSTEOARTHRITIS AND CARTILAGE

Intact glycosaminoglycans from intervertebral disc-derived notochordal cell-conditioned media inhibit neurite growth while maintaining neuronal cell viability

(2015) Devina Purmessur et al.   Spine Journal

Regulation of tissue morphogenesis by endothelial cell-derived signals

(2015) Saravana K. Ramasamy et al.   TRENDS IN CELL BIOLOGY

The effect of erythropoietin on bone

(2014) Jan Hendrik Duedal Rölfing   Acta Orthopaedica

Tumor Necrosis Factor-α– and Interleukin-1β–Dependent Matrix Metalloproteinase-3 Expression in Nucleus Pulposus Cells Requires Cooperative Signaling via Syndecan 4 and Mitogen-Activated Protein Kinase–NF-κB Axis

(2014) Xin Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

Sirtuin1 (Sirt1) Promotes Cortical Bone Formation by Preventing β-Catenin Sequestration by FoxO Transcription Factors in Osteoblast Progenitors

(2014) Srividhya Iyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resident mesenchymal progenitors of articular cartilage

(2014) Maria Elena Candela et al.   MATRIX BIOLOGY

Vessels of rejuvenation

(2014) Ferdinand le Noble et al.   NATURE

Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone

(2014) Anjali P. Kusumbe et al.   NATURE

Endothelial Notch activity promotes angiogenesis and osteogenesis in bone

(2014) Saravana K. Ramasamy et al.   NATURE

Intervertebral disc regeneration: a great challenge for tissue engineers

(2014) Pauline Colombier et al.   TRENDS IN BIOTECHNOLOGY

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Interactions between VEGFR and Notch signaling pathways in endothelial and neural cells

(2013) Jean-Leon Thomas et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Hypoxia-inducible Factor (HIF)-1α and CCN2 Form a Regulatory Circuit in Hypoxic Nucleus Pulposus Cells

(2013) Cassie M. Tran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sclerostin is expressed in osteoclasts from aged mice and reduces osteoclast-mediated stimulation of mineralization

(2013) Kuniaki Ota et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

FOXOs attenuate bone formation by suppressing Wnt signaling

(2013) Srividhya Iyer et al.   JOURNAL OF CLINICAL INVESTIGATION

Mineralization and collagen orientation throughout aging at the vertebral endplate in the human lumbar spine

(2013) Rachel C. Paietta et al.   JOURNAL OF STRUCTURAL BIOLOGY

Molecular regulation of CCN2 in the intervertebral disc: Lessons learned from other connective tissues

(2013) Cassie M. Tran et al.   MATRIX BIOLOGY

Homeostatic Mechanisms in Articular Cartilage and Role of Inflammation in Osteoarthritis

(2013) Xavier Houard et al.   Current Rheumatology Reports

BMP-2 and TGF-β3 do not prevent spontaneous degeneration in rabbit disc explants but induce ossification of the annulus fibrosus

(2012) Daniel Haschtmann et al.   EUROPEAN SPINE JOURNAL

Silent information regulator (Sir)T1 inhibits NF-κB signaling to maintain normal skeletal remodeling

(2012) James R Edwards et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Shh Signaling from the Nucleus Pulposus Is Required for the Postnatal Growth and Differentiation of the Mouse Intervertebral Disc

(2012) Chitra Lekha Dahia et al.   PLoS One

Increased type II collagen cleavage by cathepsin K and collagenase activities with aging and osteoarthritis in human articular cartilage

(2012) Valeria M Dejica et al.   ARTHRITIS RESEARCH & THERAPY

Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc

(2012) Daisuke Sakai et al.   Nature Communications

Interleukin-7 levels in synovial fluid increase with age and MMP-1 levels decrease with progression of osteoarthritis

(2011) René Rübenhagen et al.   Acta Orthopaedica

Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice

(2011) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Age-dependent alteration of TGF-β signalling in osteoarthritis

(2011) Peter M. van der Kraan et al.   CELL AND TISSUE RESEARCH

Cellular Senescence, Vascular Disease, and Aging

(2011) Jason C. Kovacic et al.   CIRCULATION

Age-Related Increases of Macroautophagy and Chaperone-Mediated Autophagy in Rat Nucleus Pulposus

(2011) Wei Ye et al.   CONNECTIVE TISSUE RESEARCH

Tracing notochord-derived cells using a Noto-cre mouse: implications for intervertebral disc development

(2011) M. R. McCann et al.   Disease Models & Mechanisms

Sirt1 Is a Regulator of Bone Mass and a Repressor ofSostEncoding for Sclerostin, a Bone Formation Inhibitor

(2011) Einav Cohen-Kfir et al.   ENDOCRINOLOGY

The role of mitochondria in osteoarthritis

(2011) Francisco J. Blanco et al.   Nature Reviews Rheumatology

Advanced glycation end products cause collagen II reduction by activating Janus kinase/signal transducer and activator of transcription 3 pathway in porcine chondrocytes

(2011) C.-Y. Huang et al.   RHEUMATOLOGY

Intervertebral Disc Development Is Regulated by Wnt/β-catenin Signaling

(2011) Naoki Kondo et al.   SPINE

Notochordal cells protect nucleus pulposus cells from degradation and apoptosis: implications for the mechanisms of intervertebral disc degeneration

(2011) W Erwin et al.   ARTHRITIS RESEARCH & THERAPY

Events in Articular Chondrocytes with Aging

(2011) Daniel J. Leong et al.   Current Osteoporosis Reports

FoxO-Mediated Defense against Oxidative Stress in Osteoblasts Is Indispensable for Skeletal Homeostasis in Mice

(2010) Elena Ambrogini et al.   Cell Metabolism

Age-Related Changes in the Musculoskeletal System and the Development of Osteoarthritis

(2010) Richard F. Loeser   CLINICS IN GERIATRIC MEDICINE

Mechanotransduction in bone repair and regeneration

(2010) Chenyu Huang et al.   FASEB JOURNAL

Regulation of circulating sclerostin levels by sex steroids in women and in men

(2010) Ulrike IL Mödder et al.   JOURNAL OF BONE AND MINERAL RESEARCH

An immunohistochemical study of mechanoreceptors in lumbar spine intervertebral discs

(2010) A. Dimitroulias et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Conversion of vascular endothelial cells into multipotent stem-like cells

(2010) Damian Medici et al.   NATURE MEDICINE

Vascularization and Morphological Changes of the Endplate After Axial Compression and Distraction of the Intervertebral Disc

(2010) Hwan Tak Hee et al.   SPINE

Inflammatory networks during cellular senescence: causes and consequences

(2010) Adam Freund et al.   TRENDS IN MOLECULAR MEDICINE

Effect of aging on cellular mechanotransduction

(2009) Miaozong Wu et al.   AGEING RESEARCH REVIEWS

Down-regulation of mTOR leads to up-regulation of osteoprotegerin in bone marrow cells

(2009) Makio Mogi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Comparison of growth factor and cytokine expression in patients with degenerated disc disease and herniated nucleus pulposus

(2009) Seungcheol Lee et al.   CLINICAL BIOCHEMISTRY

Lubricin Distribution in the Human Intervertebral Disc

(2009) Kristy M Shine et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Identification of phenotypic discriminating markers for intervertebral disc cells and articular chondrocytes

(2009) J. Clouet et al.   RHEUMATOLOGY

Intercellular Signaling Pathways Active During Intervertebral Disc Growth, Differentiation, and Aging

(2009) Chitra Lekha Dahia et al.   SPINE

Senescence mechanisms of nucleus pulposus chondrocytes in human intervertebral discs

(2009) Ki-Won Kim et al.   Spine Journal

Rapamycin Promotes the Osteoblastic Differentiation of Human Embryonic Stem Cells by Blocking the mTOR Pathway and Stimulating the BMP/Smad Pathway

(2009) Kyu-Won Lee et al.   STEM CELLS AND DEVELOPMENT

Vascular calcification and bone disease: the calcification paradox

(2009) Veerle Persy et al.   TRENDS IN MOLECULAR MEDICINE

Gene expression analysis of major lineage-defining factors in human bone marrow cells: Effect of aging, gender, and age-related disorders

(2008) Ying Jiang et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

TNF-α-induced NF-κB signaling reverses age-related declines in VEGF induction and angiogenic activity in intervertebral disc tissues

(2008) Tetsuro Ohba et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

The FoxO code

(2008) D R Calnan et al.   ONCOGENE

Age-related changes in human bone marrow-derived mesenchymal stem cells: Consequences for cell therapies

(2007) A. Stolzing et al.   MECHANISMS OF AGEING AND DEVELOPMENT