The brain–joint axis in osteoarthritis: nerves, circadian clocks and beyond

Deficiency of circadian clock protein BMAL1 in mice results in a low bone mass phenotype

(2016) William E. Samsa et al.   BONE

Aging and Circadian Disruption: Causes and Effects

(2016) Steven A. Brown et al.   Aging-US

Parathyroid hormone resets the cartilage circadian clock of the organ-cultured murine femur

(2015) Naoki Okubo et al.   Acta Orthopaedica

Neural Control of Energy Balance: Translating Circuits to Therapies

(2015) Laurent Gautron et al.   CELL

Activation of a7 Nicotinic Acetylcholine Receptors Prevents Monosodium Iodoacetate-Induced Osteoarthritis in Rats

(2015) Yuan Liu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Emerging targets in osteoarthritis therapy

(2015) Mary B Goldring et al.   CURRENT OPINION IN PHARMACOLOGY

Environmental Disruption of Circadian Rhythm Predisposes Mice to Osteoarthritis-Like Changes in Knee Joint

(2015) Ranjan Kc et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity

(2015) Michal Dudek et al.   JOURNAL OF CLINICAL INVESTIGATION

Does lipopolysaccharide-mediated inflammation have a role in OA?

(2015) Zeyu Huang et al.   Nature Reviews Rheumatology

Metabolic stress-induced joint inflammation and osteoarthritis

(2015) A. Courties et al.   OSTEOARTHRITIS AND CARTILAGE

Catabolic cytokines disrupt the circadian clock and the expression of clock-controlled genes in cartilage via an NFкB-dependent pathway

(2015) B. Guo et al.   OSTEOARTHRITIS AND CARTILAGE

Reflecting on the global burden of musculoskeletal conditions: lessons learnt from the Global Burden of Disease 2010 Study and the next steps forward

(2014) Damian G Hoy et al.   ANNALS OF THE RHEUMATIC DISEASES

Sympathetic nervous system and inflammation: A conceptual view

(2014) Wilfrid Jänig   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

The interaction between nutrition and the brain and its consequences for body weight gain and metabolism; studies in rodents and men

(2014) Susanne E. la Fleur et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Running on time: the role of circadian clocks in the musculoskeletal system

(2014) Michal Dudek et al.   BIOCHEMICAL JOURNAL

Glucocorticoids mediate circadian timing in peripheral osteoclasts resulting in the circadian expression rhythm of osteoclast-related genes

(2014) Yuko Fujihara et al.   BONE

Circadian clock control of endocrine factors

(2014) Karen L. Gamble et al.   Nature Reviews Endocrinology

Neurostimulation of the Cholinergic Anti-Inflammatory Pathway Ameliorates Disease in Rat Collagen-Induced Arthritis

(2014) Yaakov A. Levine et al.   PLoS One

A circadian gene expression atlas in mammals: Implications for biology and medicine

(2014) Ray Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Mechanosensory Pathway to the Drosophila Circadian Clock

(2014) A. Simoni et al.   SCIENCE

Circadian rhythms in rheumatology - a glucocorticoid perspective

(2014) Cornelia M Spies et al.   ARTHRITIS RESEARCH & THERAPY

Gremlin-2 is a BMP antagonist that is regulated by the circadian clock

(2014) Ching-Yan Chloé Yeung et al.   Scientific Reports

Norepinephrine Inhibition of Mesenchymal Stem Cell and Chondrogenic Progenitor Cell Chondrogenesis and Acceleration of Chondrogenic Hypertrophy

(2014) Zsuzsa Jenei-Lanzl et al.   Arthritis & Rheumatology

Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice

(2013) Tokio Matsuzaki et al.   ANNALS OF THE RHEUMATIC DISEASES

The Circadian Clock in Murine Chondrocytes Regulates Genes Controlling Key Aspects of Cartilage Homeostasis

(2013) Nicole Gossan et al.   ARTHRITIS AND RHEUMATISM

SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging

(2013) Hung-Chun Chang et al.   CELL

Human Epidermal Stem Cell Function Is Regulated by Circadian Oscillations

(2013) Peggy Janich et al.   Cell Stem Cell

Circadian Disruption Leads to Insulin Resistance and Obesity

(2013) Shu-qun Shi et al.   CURRENT BIOLOGY

Hepatoselectivity and the evolution of insulin

(2013) R. Herring et al.   DIABETES OBESITY & METABOLISM

Different circadian expression of major matrix-related genes in various types of cartilage: modulation by light–dark conditions

(2013) Kiyomasa K. Honda et al.   JOURNAL OF BIOCHEMISTRY

Role of neuroendocrine and neuroimmune mechanisms in chronic inflammatory rheumatic diseases—The 10-year update

(2013) Rainer H. Straub et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Timing is important in medication administration: a timely review of chronotherapy research

(2013) Gagandeep Kaur et al.   International Journal of Clinical Pharmacy

Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice

(2012) Odile Gabay et al.   ANNALS OF THE RHEUMATIC DISEASES

Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse model

(2012) Odile Gabay et al.   ARTHRITIS AND RHEUMATISM

Comparison of β-Adrenergic and Glucocorticoid Signaling on Clock Gene and Osteoblast-Related Gene Expressions in Human Osteoblast

(2012) Shintaro Komoto et al.   CHRONOBIOLOGY INTERNATIONAL

Glucocorticoids as Entraining Signals for Peripheral Circadian Oscillators

(2012) Pınar Pezük et al.   ENDOCRINOLOGY

Aging Differentially Affects the Re-entrainment Response of Central and Peripheral Circadian Oscillators

(2012) M. T. Sellix et al.   JOURNAL OF NEUROSCIENCE

The overexpression of SIRT1 inhibited osteoarthritic gene expression changes induced by interleukin-1β in human chondrocytes

(2012) Takehiko Matsushita et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Theo Vos et al.   LANCET

Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists

(2012) Laura A. Solt et al.   NATURE

Circadian topology of metabolism

(2012) Joseph Bass   NATURE

Metabolic syndrome meets osteoarthritis

(2012) Qi Zhuo et al.   Nature Reviews Rheumatology

Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)

(2012) F. Berenbaum   OSTEOARTHRITIS AND CARTILAGE

Identification of Small Molecule Activators of Cryptochrome

(2012) T. Hirota et al.   SCIENCE

Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4

(2012) Dong Sohn et al.   ARTHRITIS RESEARCH & THERAPY

Treatment of chronic inflammatory diseases with implantable medical devices

(2011) R. J. Zitnik   ANNALS OF THE RHEUMATIC DISEASES

Substance P and norepinephrine modulate murine chondrocyte proliferation and apoptosis

(2011) Alfred Opolka et al.   ARTHRITIS AND RHEUMATISM

Circadian clock protein BMAL1 regulates cellular senescence in vivo

(2011) Rohini V. Khapre et al.   CELL CYCLE

Osteoarthritis accelerates and exacerbates Alzheimer's disease pathology in mice

(2011) Stephanos Kyrkanides et al.   Journal of Neuroinflammation

Osteoarthritis: an update with relevance for clinical practice

(2011) Johannes WJ Bijlsma et al.   LANCET

Circadian rhythms in the hypothalamo–pituitary–adrenal (HPA) axis

(2011) A. Kalsbeek et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Serum factors in older individuals change cellular clock properties

(2011) L. Pagani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β2-Adrenergic receptors inhibit the expression of collagen type II in growth plate chondrocytes by stimulating the AP-1 factor Jun-B

(2010) Jane Mitchell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

In search of autonomic balance: the good, the bad, and the ugly

(2010) François M. Abboud   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The cholinergic system, circadian rhythmicity, and time memory

(2010) R.A. Hut et al.   BEHAVIOURAL BRAIN RESEARCH

Why is osteoarthritis an age-related disease?

(2010) A. Shane Anderson et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Diurnal variation in serum markers of type I collagen synthesis and degradation in healthy premenopausal women

(2010) Christian Hassager et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Double disruption of α2A- and α2C -adrenoceptors results in sympathetic hyperactivity and high-bone-mass phenotype

(2010) Tatiana L Fonseca et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Mammalian circadian clock and metabolism - the epigenetic link

(2010) M. M. Bellet et al.   JOURNAL OF CELL SCIENCE

Tanezumab for the Treatment of Pain from Osteoarthritis of the Knee

(2010) Nancy E. Lane et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Clock Genes Period 2 and Cryptochrome 2 Differentially Balance Bone Formation

(2010) Erik Maronde et al.   PLoS One

Regulation of chick bone growth by leptin and catecholamines

(2010) L. J. Mauro et al.   POULTRY SCIENCE

Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes

(2010) Q.-J. Meng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temperature as a Universal Resetting Cue for Mammalian Circadian Oscillators

(2010) E. D. Buhr et al.   SCIENCE

Interactions of the circadian CLOCK system and the HPA axis

(2010) Nancy Nader et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Association between weight or body mass index and hand osteoarthritis: a systematic review

(2009) E. Yusuf et al.   ANNALS OF THE RHEUMATIC DISEASES

Interference by adrenaline with chondrogenic differentiation through suppression of gene transactivation mediated by Sox9 family members

(2009) Takeshi Takarada et al.   BONE

Cholinergic control of inflammation

(2009) M. Rosas-Ballina et al.   JOURNAL OF INTERNAL MEDICINE

Metabolism control by the circadian clock and vice versa

(2009) Kristin Eckel-Mahan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix

(2009) R.F. Loeser   OSTEOARTHRITIS AND CARTILAGE

Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1

(2009) Y. Nakahata et al.   SCIENCE

Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD+ Biosynthesis

(2009) K. M. Ramsey et al.   SCIENCE

Articular cartilage: structure, injuries and review of management

(2008) A. M. Bhosale et al.   BRITISH MEDICAL BULLETIN

The Meter of Metabolism

(2008) Carla B. Green et al.   CELL

The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control

(2008) Yasukazu Nakahata et al.   CELL

SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation

(2008) Gad Asher et al.   CELL

Adipose Tissue Macrophages, Low Grade Inflammation and Insulin Resistance in Human Obesity

(2008) Leonie Heilbronn et al.   CURRENT PHARMACEUTICAL DESIGN

Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis

(2008) Ingrid Meulenbelt et al.   HUMAN MOLECULAR GENETICS

Ligand modulation of REV-ERB  function resets the peripheral circadian clock in a phasic manner

(2008) Q. J. Meng et al.   JOURNAL OF CELL SCIENCE

The genetics of mammalian circadian order and disorder: implications for physiology and disease

(2008) Joseph S. Takahashi et al.   NATURE REVIEWS GENETICS

Systematic assessment of the human osteoblast transcriptome in resting and induced primary cells

(2008) Elin Grundberg et al.   PHYSIOLOGICAL GENOMICS

β2-adrenergic receptors expressed on murine chondrocytes stimulate cellular growth and inhibit the expression of Indian hedgehog and collagen type X

(2007) Lick Pui Lai et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Resetting of central and peripheral circadian oscillators in aged rats

(2006) Alec J. Davidson et al.   NEUROBIOLOGY OF AGING