Glucosamine protects nucleus pulposus cells and induces autophagy via the mTOR-dependent pathway

Glucosamine Activates Autophagy In Vitro and In Vivo

(2013) Beatriz Caramés et al.   ARTHRITIS AND RHEUMATISM

mTOR signaling for biological control and cancer

(2013) Anya Alayev et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Glucosamine Supplementation Demonstrates a Negative Effect on Intervertebral Disc Matrix in an Animal Model of Disc Degeneration

(2013) Lloydine Jacobs et al.   SPINE

Intermittent Cyclic Mechanical Tension-induced Down-regulation of Ectonucleotide Pyrophosphatase Phosphodiesterase 1 Gene Expression is Mainly Dependent on TGF-β1 in End-plate Chondrocytes

(2013) Hong-guang Xu et al.   Orthopaedic Surgery

Role of mitochondrial pathway in compression-induced apoptosis of nucleus pulposus cells

(2012) Fan Ding et al.   APOPTOSIS

Increased Macroautophagy in the Pathological Process of Intervertebral Disc Degeneration in Rats

(2012) Wei Ye et al.   CONNECTIVE TISSUE RESEARCH

The pathogenesis of degeneration of the intervertebral disc and emerging therapies in the management of back pain

(2012) S. P. F. Hughes et al.   JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME

Apoptosis, senescence, and autophagy in rat nucleus pulposus cells: Implications for diabetic intervertebral disc degeneration

(2012) Libo Jiang et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Evaluation of a novel poly N-acetyl glucosamine (pGlcNAc) hydrogel for treatment of the degenerating intervertebral disc

(2012) Deepthi Gorapalli et al.   LIFE SCIENCES

Autophagy modulates osteoarthritis-related gene expression in human chondrocytes

(2011) Hiroshi Sasaki et al.   ARTHRITIS AND RHEUMATISM

Autophagy in mineralizing tissues: Microenvironmental perspectives

(2011) Vickram Srinivas et al.   CELL CYCLE

Age-Related Increases of Macroautophagy and Chaperone-Mediated Autophagy in Rat Nucleus Pulposus

(2011) Wei Ye et al.   CONNECTIVE TISSUE RESEARCH

Oxidative stress induces senescence in chondrocytes

(2011) Anita Brandl et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Autophagy in rat annulus fibrosus cells: evidence and possible implications

(2011) Chao Shen et al.   ARTHRITIS RESEARCH & THERAPY

Glucosamine induces autophagy via an mTOR-independent pathway

(2010) Tomoya Shintani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Growth stimulation leads to cellular senescence when the cell cycle is blocked

(2010) Zoya N. Demidenko et al.   CELL CYCLE

Leg Amputation Accelerates Senescence of Rat Lumbar Intervertebral Discs

(2010) Qiu-Juan Xing et al.   SPINE

Autophagy in disease: a double-edged sword with therapeutic potential

(2009) Wim Martinet et al.   CLINICAL SCIENCE

Senescence, Apoptosis or Autophagy?

(2008) José Miguel Vicencio et al.   GERONTOLOGY

IGF-1 rescues human intervertebral annulus cells fromin vitrostress-induced premature senescence

(2008) Helen E. Gruber et al.   GROWTH FACTORS

Autophagic cell death: the story of a misnomer

(2008) Guido Kroemer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines

(2008) W. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

Investigation of the role of IL-1 and TNF in matrix degradation in the intervertebral disc

(2008) J. A. Hoyland et al.   RHEUMATOLOGY

Effect of a glucosamine derivative on impact-induced chondrocyte apoptosis in vitro. A preliminary report

(2007) C.A.M. Huser et al.   OSTEOARTHRITIS AND CARTILAGE