Olive polyphenols: new promising agents to combat aging-associated neurodegeneration

Oleuropein aglycone and polyphenols from olive mill waste water ameliorate cognitive deficits and neuropathology

(2016) Daniela Pantano et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Nutraceutical Properties of Olive Oil Polyphenols. An Itinerary from Cultured Cells through Animal Models to Humans

(2016) Stefania Rigacci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The polyphenol Oleuropein aglycone hinders the growth of toxic transthyretin amyloid assemblies

(2016) Manuela Leri et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Hydroxytyrosol induces phase II detoxifying enzyme expression and effectively protects dopaminergic cells against dopamine- and 6-hydroxydopamine induced cytotoxicity

(2016) Guohua Yu et al.   NEUROCHEMISTRY INTERNATIONAL

The Reciprocal Interactions between Polyphenols and Gut Microbiota and Effects on Bioaccessibility

(2016) Tugba Ozdal et al.   Nutrients

Oleocanthal Enhances Amyloid-β Clearance from the Brains of TgSwDI Mice and in Vitro across a Human Blood-Brain Barrier Model

(2015) Hisham Qosa et al.   ACS Chemical Neuroscience

Fate of Microbial Metabolites of Dietary Polyphenols in Rats: Is the Brain Their Target Destination?

(2015) Mattia Gasperotti et al.   ACS Chemical Neuroscience

Oleuropein aglycone in lipid bilayer membranes. A molecular dynamics study

(2015) Vicente Galiano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Nutriepigenomics

(2015) Marlene Remely et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Dietary Polyphenols Promote Growth of the Gut BacteriumAkkermansia muciniphilaand Attenuate High-Fat Diet–Induced Metabolic Syndrome

(2015) Diana E. Roopchand et al.   DIABETES

Effect of virgin olive oil and thyme phenolic compounds on blood lipid profile: implications of human gut microbiota

(2015) Sandra Martín-Peláez et al.   EUROPEAN JOURNAL OF NUTRITION

Prediabetes and alzheimer's disease

(2015) Deepthi Rapaka et al.   INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES

Extra-virgin olive oil attenuates amyloid-β and tau pathologies in the brains of TgSwDI mice

(2015) Hisham Qosa et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Reshaping faecal gut microbiota composition by the intake of trans-resveratrol and quercetin in high-fat sucrose diet-fed rats

(2015) U. Etxeberria et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Role of intestinal microbiota in the generation of polyphenol-derived phenolic acid mediated attenuation of Alzheimer's disease β-amyloid oligomerization

(2015) Dongjie Wang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Oleuropein aglycone protects against pyroglutamylated-3 amyloid-ß toxicity: biochemical, epigenetic and functional correlates

(2015) Ilaria Luccarini et al.   NEUROBIOLOGY OF AGING

A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease

(2015) R. Scott Turner et al.   NEUROLOGY

A Survey of Modulation of Gut Microbiota by Dietary Polyphenols

(2015) Montserrat Dueñas et al.   Biomed Research International

A randomised controlled intervention trial evaluating the efficacy of a Mediterranean dietary pattern on cognitive function and psychological wellbeing in healthy older adults: the MedLey study

(2015) Alissa Knight et al.   BMC Geriatrics

Mediterranean Diet and Age-Related Cognitive Decline

(2015) Cinta Valls-Pedret et al.   JAMA Internal Medicine

Aberrant insulin signaling in Alzheimer's disease: current knowledge

(2015) Gaurav Bedse et al.   Frontiers in Neuroscience

Beneficial properties of natural phenols: Highlight on protection against pathological conditions associated with amyloid aggregation

(2014) Massimo Stefani et al.   BIOFACTORS

Type 3 diabetes is sporadic Alzheimer׳s disease: Mini-review

(2014) Suzanne M. de la Monte   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Nutraceuticals and amyloid neurodegenerative diseases: a focus on natural phenols

(2014) Stefania Rigacci et al.   Expert Review of Neurotherapeutics

Genotype patterns at CLU, CR1, PICALM and APOE, cognition and Mediterranean diet: the PREDIMED-NAVARRA trial

(2014) Elena H. Martínez-Lapiscina et al.   Genes and Nutrition

Faecal microbial metabolism of olive oil phenolic compounds: In vitro and in vivo approaches

(2014) Juana I. Mosele et al.   MOLECULAR NUTRITION & FOOD RESEARCH

3,4-Dihydroxyphenylethanol Attenuates Spatio-Cognitive Deficits in an Alzheimer’s Disease Mouse Model: Modulation of the Molecular Signals in Neuronal Survival-Apoptotic Programs

(2014) Mohanasundaram Arunsundar et al.   NEUROTOXICITY RESEARCH

Resveratrol Triggers Protective Autophagy Through the Ceramide/Akt/mTOR Pathway in Melanoma B16 Cells

(2014) Meng Wang et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Olive-Oil-Derived Oleocanthal Enhances β-Amyloid Clearance as a Potential Neuroprotective Mechanism against Alzheimer’s Disease: In Vitro and in Vivo Studies

(2013) Alaa H. Abuznait et al.   ACS Chemical Neuroscience

Inhibiting toxic aggregation of amyloidogenic proteins: A therapeutic strategy for protein misfolding diseases

(2013) Biao Cheng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The biotransformation of oleuropein in rats

(2013) Peiyan Lin et al.   BIOMEDICAL CHROMATOGRAPHY

Xenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil

(2013) Javier A. Menendez et al.   CELL CYCLE

Chemical proteomics-driven discovery of oleocanthal as an Hsp90 inhibitor

(2013) Luigi Margarucci et al.   CHEMICAL COMMUNICATIONS

Bioavailability of phenolics from an oleuropein-rich olive (Olea europaea) leaf extract and its acute effect on plasma antioxidant status: comparison between pre- and postmenopausal women

(2013) R. García-Villalba et al.   EUROPEAN JOURNAL OF NUTRITION

Coronary heart disease differences across Europe

(2013) Alessandro Menotti et al.   Journal of Cardiovascular Medicine

Virgin olive oil supplementation and long-term cognition: the Predimed-Navarra randomized, trial

(2013) Elena H. Martinez-Lapiscina et al.   Journal of Nutrition Health & Aging

Epigenetic effects of natural polyphenols: A focus on SIRT1-mediated mechanisms

(2013) Vincent B. Owona Ayissi et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Human absorption and metabolism of oleuropein and hydroxytyrosol ingested as olive (Olea europaeaL.) leaf extract

(2013) Martin de Bock et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Oleuropein aglycone counteracts Aβ42 toxicity in the rat brain

(2013) Ilaria Luccarini et al.   NEUROSCIENCE LETTERS

Epigenetics: A novel therapeutic approach for the treatment of Alzheimer's disease

(2013) Lina Adwan et al.   PHARMACOLOGY & THERAPEUTICS

Olive (Olea europaea L.) Leaf Polyphenols Improve Insulin Sensitivity in Middle-Aged Overweight Men: A Randomized, Placebo-Controlled, Crossover Trial

(2013) Martin de Bock et al.   PLoS One

Oleuropein Aglycone Protects Transgenic C. elegans Strains Expressing Aβ42 by Reducing Plaque Load and Motor Deficit

(2013) Luisa Diomede et al.   PLoS One

The Polyphenol Oleuropein Aglycone Protects TgCRND8 Mice against Aß Plaque Pathology

(2013) Cristina Grossi et al.   PLoS One

Highly Stabilized Curcumin Nanoparticles Tested in an In Vitro Blood–Brain Barrier Model and in Alzheimer’s Disease Tg2576 Mice

(2012) Kwok Kin Cheng et al.   AAPS Journal

Identification of the factors responsible for the in vitro pro-oxidant and cytotoxic activities of the olive polyphenols oleuropein and hydroxytyrosol

(2012) Elena M. Odiatou et al.   CANCER LETTERS

Oleuropein, an Anti-oxidant Polyphenol Constituent of Olive Promotes α-Secretase Cleavage of the Amyloid Precursor Protein (AβPP)

(2012) Myrta Kostomoiri et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Direct Measurement of Oleocanthal and Oleacein Levels in Olive Oil by Quantitative 1H NMR. Establishment of a New Index for the Characterization of Extra Virgin Olive Oils

(2012) Evangelia Karkoula et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Olive Leaf Extract as a Hypoglycemic Agent in Both Human Diabetic Subjects and in Rats

(2012) Julio Wainstein et al.   JOURNAL OF MEDICINAL FOOD

Modulation of Tau Protein Fibrillization by Oleocanthal

(2012) Maria Chiara Monti et al.   JOURNAL OF NATURAL PRODUCTS

A metabolite-profiling approach to assess the uptake and metabolism of phenolic compounds from olive leaves in SKBR3 cells by HPLC–ESI-QTOF-MS

(2012) R. Quirantes-Piné et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Tyrosol, a main phenol present in extra virgin olive oil, increases lifespan and stress resistance in Caenorhabditis elegans

(2012) Ana Cañuelo et al.   MECHANISMS OF AGEING AND DEVELOPMENT

An epigenetic blockade of cognitive functions in the neurodegenerating brain

(2012) Johannes Gräff et al.   NATURE

Potential benefits of adherence to the Mediterranean diet on cognitive health

(2012) Catherine Féart et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Structural features and cytotoxicity of amyloid oligomers: Implications in Alzheimer's disease and other diseases with amyloid deposits

(2012) Massimo Stefani   PROGRESS IN NEUROBIOLOGY

Long-Term Dietary Extra-Virgin Olive Oil Rich in Polyphenols Reverses Age-Related Dysfunctions in Motor Coordination and Contextual Memory in Mice: Role of Oxidative Stress

(2012) Vanessa Pitozzi et al.   REJUVENATION RESEARCH

Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study

(2012) John M Ringman et al.   Alzheimers Research & Therapy

MnSOD activity regulates hydroxytyrosol-induced extension of chronological lifespan

(2011) Ehab H. Sarsour et al.   AGE

A mechanistic approach for islet amyloid polypeptide aggregation to develop anti-amyloidogenic agents for type-2 diabetes

(2011) Ejaz Ahmad et al.   BIOCHIMIE

Polyphenolic Glycosides and Aglycones Utilize Opposing Pathways To Selectively Remodel and Inactivate Toxic Oligomers of Amyloid β

(2011) Ali Reza A. Ladiwala et al.   CHEMBIOCHEM

Naturally Occurring Iridoids and Secoiridoids. An Updated Review, Part 4

(2011) Biswanath Dinda et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Tyrosol and Hydroxytyrosol Two Main Components of Olive Oil, Protect N2a Cells Against Amyloid-β-Induced Toxicity. Involvement of the NF-κB Signaling

(2011) C. St-Laurent-Thibault et al.   Current Alzheimer Research

Aβ(1-42) Aggregates into Non-Toxic Amyloid Assemblies in the Presence of the Natural Polyphenol Oleuropein Aglycon

(2011) Stefania Rigacci et al.   Current Alzheimer Research

Inhibition and disaggregation of α-synuclein oligomers by natural polyphenolic compounds

(2011) Mario Caruana et al.   FEBS LETTERS

Unusual Pungency from Extra-Virgin Olive Oil Is Attributable to Restricted Spatial Expression of the Receptor of Oleocanthal

(2011) C. Peyrot des Gachons et al.   JOURNAL OF NEUROSCIENCE

First-Pass Metabolism via UDP-Glucuronosyltransferase: a Barrier to Oral Bioavailability of Phenolics

(2011) Baojian Wu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Olive oil intake is inversely related to cancer prevalence: a systematic review and a meta-analysis of 13800 patients and 23340 controls in 19 observational studies

(2011) Theodora Psaltopoulou et al.   Lipids in Health and Disease

Distribution of olive oil phenolic compounds in rat tissues after administration of a phenolic extract from olive cake

(2011) Aida Serra et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Oleuropein and derivatives from olives as Tau aggregation inhibitors

(2011) Anthony Daccache et al.   NEUROCHEMISTRY INTERNATIONAL

The chemistry and biotransformation of tea constituents

(2011) Shengmin Sang et al.   PHARMACOLOGICAL RESEARCH

Mediterranean diet pyramid today. Science and cultural updates

(2011) Anna Bach-Faig et al.   PUBLIC HEALTH NUTRITION

New insights on the interaction mechanism between tau protein and oleocanthal, an extra-virgin olive-oil bioactive component

(2011) Maria Chiara Monti et al.   Food & Function

Study of the interaction between the amyloid beta peptide (1-40) and antioxidant compounds by nuclear magnetic resonance spectroscopy

(2010) Petros A. Galanakis et al.   BIOPOLYMERS

Biological Activities of Phenolic Compounds Present in Virgin Olive Oil

(2010) Sara Cicerale et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Aromatic Small Molecules Remodel Toxic Soluble Oligomers of Amyloid β through Three Independent Pathways

(2010) Ali Reza A. Ladiwala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Olive oil and health: Summary of the II international conference on olive oil and health consensus report, Jaén and Córdoba (Spain) 2008

(2010) J. López-Miranda et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Mediterranean Diet and Mild Cognitive Impairment

(2009) Nikolaos Scarmeas et al.   ARCHIVES OF NEUROLOGY

Olive Oil and Cognition: Results from the Three-City Study

(2009) Claudine Berr et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Variations of iridoid oleuropein in Italian olive varieties during growth and maturation

(2009) Alfonso Ranalli et al.   EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY

Olive Oil and Cardiovascular Health

(2009) María-Isabel Covas et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Oleuropein aglycon prevents cytotoxic amyloid aggregation of human amylin☆

(2009) Stefania Rigacci et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Stability of oleuropein in the human proximal gut

(2009) Constantinos Markopoulos et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Alzheimer's-associated Aβ oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal

(2009) Jason Pitt et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: Parallels with Alzheimer's disease and correction by insulin

(2008) C.G. Jolivalt et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Biological and Pharmacological Activities of Iridoids: Recent Developments

(2008) Rosa Tundis et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Neuroprotective effect of hydroxytyrosol and hydroxytyrosol acetate in rat brain slices subjected to hypoxia–reoxygenation

(2008) José Antonio González-Correa et al.   NEUROSCIENCE LETTERS

Bioactive effects of olive oil phenolic compounds in humans: reduction of heart disease factors and oxidative damage

(2008) M.-I. Covas   INFLAMMOPHARMACOLOGY