4.7 Article

Chemical proteomics-driven discovery of oleocanthal as an Hsp90 inhibitor

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 52, Pages 5844-5846

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc41858h

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Hsp90, a key target in cancer therapy, has been identified as the main partner of oleocanthal, an olive oil bioactive compound. A combination of chemical and biological assays disclosed its mechanism of action at the molecular level.

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