Neuroprotection in glaucoma: Mechanisms beyond intraocular pressure lowering

NAD salvage pathway machinery expression in normal and glaucomatous retina and optic nerve

(2023) James R. Tribble et al.   Acta Neuropathologica Communications

Mitophagy: A promising therapeutic target for neuroprotection during ageing and age‐related diseases

(2023) Ela Mishra et al.   BRITISH JOURNAL OF PHARMACOLOGY

Bax Contributes to Retinal Ganglion Cell Dendritic Degeneration During Glaucoma

(2022) Michael L. Risner et al.   MOLECULAR NEUROBIOLOGY

NMNAT2 is downregulated in glaucomatous RGCs, and RGC-specific gene therapy rescues neurodegeneration and visual function

(2022) Fang Fang et al.   MOLECULAR THERAPY

TRPV4 and TRPC1 channels mediate the response to tensile strain in mouse Müller cells

(2022) Andrew O. Jo et al.   CELL CALCIUM

Damage-Associated Molecular Patterns (DAMPs) in Retinal Disorders

(2022) Binapani Mahaling et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Role of Axonal Transport in Glaucoma

(2022) Mariana Santana Dias et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions

(2022) Eszter Császár et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules

(2022) Yun Shi et al.   MOLECULAR CELL

The physiological and pathophysiological roles of the autophagy lysosomal system in the conventional aqueous humor outflow pathway: More than cellular clean up

(2022) Myoung Sup Shim et al.   PROGRESS IN RETINAL AND EYE RESEARCH

P2X7/P2X4 Receptors Mediate Proliferation and Migration of Retinal Microglia in Experimental Glaucoma in Mice

(2022) Meng-Xi Xu et al.   Neuroscience Bulletin

Valproic Acid Reduces Neuroinflammation to Provide Retinal Ganglion Cell Neuroprotection in the Retina Axotomy Model

(2022) James R. Tribble et al.   Frontiers in Cell and Developmental Biology

Aquaporin 4 is not present in normal porcine and human lamina cribrosa

(2022) Elizabeth C. Kimball et al.   PLoS One

Microglia states and nomenclature: A field at its crossroads

(2022) Rosa C. Paolicelli et al.   NEURON

Selective inhibitors of SARM1 targeting an allosteric cysteine in the autoregulatory ARM domain

(2022) Hannah C. Feldman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restoration of mitochondria axonal transport by adaptor Disc1 supplementation prevents neurodegeneration and rescues visual function

(2022) Heberto Quintero et al.   Cell Reports

Widespread retina and optic nerve neuroinflammation in enucleated eyes from glaucoma patients

(2022) Carola Rutigliani et al.   Acta Neuropathologica Communications

Microglia depletion exacerbates retinal ganglion cell loss in a mouse model of glaucoma

(2022) Zizhu Tan et al.   EXPERIMENTAL EYE RESEARCH

Local neuroplasticity in adult glaucomatous visual cortex

(2022) Joana Carvalho et al.   Scientific Reports

Loss of Retinogeniculate Synaptic Function in the DBA/2J Mouse Model of Glaucoma

(2022) Jennie C. Smith et al.   eNeuro

Increased ratios of complement factors C3a to C3 in aqueous humor and serum mark glaucoma progression

(2021) W.H.G. Hubens et al.   EXPERIMENTAL EYE RESEARCH

When Is a Control Not a Control? Reactive Microglia Occur Throughout the Control Contralateral Pathway of Retinal Ganglion Cell Projections in Experimental Glaucoma

(2021) James R. Tribble et al.   Translational Vision Science & Technology

Retinal Ganglion Cell Degeneration in a Rat Magnetic Bead Model of Ocular Hypertensive Glaucoma

(2021) James R. Tribble et al.   Translational Vision Science & Technology

Reactive astrocyte nomenclature, definitions, and future directions

(2021) Carole Escartin et al.   NATURE NEUROSCIENCE

SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration

(2021) Matthew D. Figley et al.   NEURON

Regulation and metabolic functions of mTORC1 and mTORC2

(2021) Angelia Szwed et al.   PHYSIOLOGICAL REVIEWS

Neurodegeneration, Neuroprotection and Regeneration in the Zebrafish Retina

(2021) Salvatore L. Stella et al.   Cells

Pharmacological SARM1 inhibition protects axon structure and function in paclitaxel-induced peripheral neuropathy

(2021) Todd Bosanac et al.   BRAIN

Insulin Signaling as a Therapeutic Target in Glaucomatous Neurodegeneration

(2021) Sara Al Hussein Al Awamlh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Receptor-ligand supplementation via a self-cleaving 2A peptide–based gene therapy promotes CNS axonal transport with functional recovery

(2021) Tasneem Z. Khatib et al.   Science Advances

Citicoline in Ophthalmological Neurodegenerative Disease: A Comprehensive Review

(2021) Francesco Oddone et al.   Pharmaceuticals

AMPK hyperactivation promotes dendrite retraction, synaptic loss, and neuronal dysfunction in glaucoma

(2021) Nicolas Belforte et al.   Molecular Neurodegeneration

Neuroprotection by WldS depends on retinal ganglion cell type and age in glaucoma

(2021) Michael L. Risner et al.   Molecular Neurodegeneration

Detecting retinal cell stress and apoptosis with DARC: Progression from lab to clinic

(2021) Maria Francesca Cordeiro et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Molecular regulation of neuroinflammation in glaucoma: Current knowledge and the ongoing search for new treatment targets

(2021) Gülgün Tezel   PROGRESS IN RETINAL AND EYE RESEARCH

Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction

(2021) James R. Tribble et al.   Redox Biology

Retinal Ganglion Cell Transplantation: Approaches for Overcoming Challenges to Functional Integration

(2021) Kevin Y. Zhang et al.   Cells

Immune Responses in the Glaucomatous Retina: Regulation and Dynamics

(2021) Valery I. Shestopalov et al.   Cells

Targeting the NLRP3 Inflammasome in Glaucoma

(2021) Sophie Coyle et al.   Biomolecules

Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection

(2021) Yo Sasaki et al.   EXPERIMENTAL NEUROLOGY

Interplay between Müller cells and microglia aggravates retinal inflammatory response in experimental glaucoma

(2021) Xin Hu et al.   Journal of Neuroinflammation

New insights into the role of autophagy in retinal and eye diseases

(2021) Beatriz Villarejo-Zori et al.   MOLECULAR ASPECTS OF MEDICINE

CD82 protects against glaucomatous axonal transport deficits via mTORC1 activation in mice

(2021) Meng Ye et al.   Cell Death & Disease

Neurotoxins subvert the allosteric activation mechanism of SARM1 to induce neuronal loss

(2021) Tong Wu et al.   Cell Reports

Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1

(2021) Andrea Loreto et al.   eLife

Nicotinamide and Pyruvate for Neuroenhancement in Open-Angle Glaucoma

(2021) Carlos Gustavo De Moraes et al.   JAMA Ophthalmology

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Programmed axon degeneration: from mouse to mechanism to medicine

(2020) Michael P. Coleman et al.   NATURE REVIEWS NEUROSCIENCE

BDNF improves axon transportation and rescues visual function in a rodent model of acute elevation of intraocular pressure

(2020) Rui Du et al.   Science China-Life Sciences

mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges

(2020) Zhilin Zou et al.   Cell and Bioscience

Ocular hypertension suppresses homeostatic gene expression in optic nerve head microglia of DBA/2 J mice

(2020) James R. Tribble et al.   Molecular Brain

Improvement in inner retinal function in glaucoma with nicotinamide (vitamin B3 ) supplementation: A crossover randomized clinical trial

(2020) Flora Hui et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

SARM1 acts downstream of neuroinflammatory and necroptotic signaling to induce axon degeneration

(2020) Kwang Woo Ko et al.   JOURNAL OF CELL BIOLOGY

Retinal energy metabolism in health and glaucoma

(2020) Robert J. Casson et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Neurotoxic Reactive Astrocytes Drive Neuronal Death after Retinal Injury

(2020) Kevin A. Guttenplan et al.   Cell Reports

Age related retinal Ganglion cell susceptibility in context of autophagy deficiency

(2020) Katharina Bell et al.   Cell Death Discovery

Microautophagy – distinct molecular mechanisms handle cargoes of many sizes

(2020) Sebastian Schuck   JOURNAL OF CELL SCIENCE

Transgenic inhibition of astroglial NF-κB restrains the neuroinflammatory and neurodegenerative outcomes of experimental mouse glaucoma

(2020) Xiangjun Yang et al.   Journal of Neuroinflammation

CNS axonal degeneration and transport deficits at the optic nerve head precede structural and functional loss of retinal ganglion cells in a mouse model of glaucoma

(2020) Prabhavathi Maddineni et al.   Molecular Neurodegeneration

Inflammation in Glaucoma: From the back to the front of the eye, and beyond

(2020) Christophe Baudouin et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Anterograde Axonal Transport in Neuronal Homeostasis and Disease

(2020) Laurent Guillaud et al.   Frontiers in Molecular Neuroscience

Retinal ganglion cell degeneration correlates with hippocampal spine loss in experimental Alzheimer’s disease

(2020) Ryan J. Bevan et al.   Acta Neuropathologica Communications

Optogenetic stimulation of the superior colliculus confers retinal neuroprotection in a mouse glaucoma model

(2019) E. Geeraerts et al.   JOURNAL OF NEUROSCIENCE

Inhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA/2J glaucoma

(2019) Pete A. Williams et al.   Molecular Neurodegeneration

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

(2019) Rumani Singh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms for the maintenance and regulation of axonal energy supply

(2019) Kelly Anne Chamberlain et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Microglial Function Is Distinct in Different Anatomical Locations during Retinal Homeostasis and Degeneration

(2019) Emily G. O’Koren et al.   IMMUNITY

Axon injury signaling and compartmentalized injury response in glaucoma

(2019) Stephanie B. Syc-Mazurek et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Microglial subtypes: diversity within the microglial community

(2019) Vassilis Stratoulias et al.   EMBO JOURNAL

mTORC2 activation protects retinal ganglion cells via Akt signaling after autophagy induction in traumatic optic nerve injury

(2019) Yao-Tseng Wen et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Axonal transport and neurological disease

(2019) James N. Sleigh et al.   Nature Reviews Neurology

Axonal transport defects and neurodegeneration: Molecular mechanisms and therapeutic implications

(2019) Wenting Guo et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Morphological and Functional Evaluation of Oral Citicoline Therapy in Chronic Open-Angle Glaucoma Patients: A Pilot Study With a 2-Year Follow-Up

(2019) Michele Lanza et al.   Frontiers in Pharmacology

A small peptide antagonist of the Fas receptor inhibits neuroinflammation and prevents axon degeneration and retinal ganglion cell death in an inducible mouse model of glaucoma

(2019) Anitha Krishnan et al.   Journal of Neuroinflammation

Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration

(2019) Andrea Loreto et al.   NEUROBIOLOGY OF DISEASE

Microglia monitor and protect neuronal function through specialized somatic purinergic junctions

(2019) Csaba Cserép et al.   SCIENCE

Insulin signalling promotes dendrite and synapse regeneration and restores circuit function after axonal injury

(2018) Jessica Agostinone et al.   BRAIN

Glaucoma Pathogenesis and Neurotrophins: Focus on the Molecular and Genetic Basis for Therapeutic Prospects

(2018) Nitin Chitranshi et al.   Current Neuropharmacology

Role of SARM1 and DR6 in retinal ganglion cell axonal and somal degeneration following axonal injury

(2018) Kimberly A. Fernandes et al.   EXPERIMENTAL EYE RESEARCH

Role of mTOR in Glucose and Lipid Metabolism

(2018) Zhuo Mao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Decreased Serum Levels of Complement C3 Reflect Complement System Dysregulation in Patients with Primary Open-angle Glaucoma

(2018) Shengjie Li et al.   JOURNAL OF GLAUCOMA

Structural and Functional Rescue of Chronic Metabolically Stressed Optic Nerves through Respiration

(2018) Mohammad Harun-Or-Rashid et al.   JOURNAL OF NEUROSCIENCE

Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma

(2018) Anthony P. Khawaja et al.   NATURE GENETICS

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

(2018) Steven E. Arnold et al.   Nature Reviews Neurology

Reduced brain insulin signaling: A seminal process in Alzheimer's disease pathogenesis

(2018) George S. Bloom et al.   NEUROPHARMACOLOGY

The coma in glaucoma: Retinal ganglion cell dysfunction and recovery

(2018) Lewis E. Fry et al.   PROGRESS IN RETINAL AND EYE RESEARCH

CD163+ macrophages infiltrate axon bundles of postmortem optic nerves with glaucoma

(2018) Milica A. Margeta et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Oral Memantine for the Treatment of Glaucoma

(2018) Robert N. Weinreb et al.   OPHTHALMOLOGY

Neuroprotection of retinal ganglion cells by a novel gene therapy construct that achieves sustained enhancement of brain-derived neurotrophic factor/tropomyosin-related kinase receptor-B signaling

(2018) Andrew Osborne et al.   Cell Death & Disease

Amyloid precursor protein-mediated mitochondrial regulation and Alzheimer's disease

(2018) M Isabel G Lopez Sanchez et al.   BRITISH JOURNAL OF PHARMACOLOGY

Low levels of NMNAT2 compromise axon development and survival

(2018) Jonathan Gilley et al.   HUMAN MOLECULAR GENETICS

Monocyte infiltration rather than microglia proliferation dominates the early immune response to rapid photoreceptor degeneration

(2018) Sarah J. Karlen et al.   Journal of Neuroinflammation

Reduced AMPK activation and increased HCAR activation drive anti-inflammatory response and neuroprotection in glaucoma

(2018) Mohammad Harun-Or-Rashid et al.   Journal of Neuroinflammation

Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells

(2018) Harald Lund et al.   Nature Communications

Who’s lost first? Susceptibility of retinal ganglion cell types in experimental glaucoma

(2017) Luca Della Santina et al.   EXPERIMENTAL EYE RESEARCH

Glaucoma as a Metabolic Optic Neuropathy

(2017) Pete A. Williams et al.   JOURNAL OF GLAUCOMA

Involvement of microglia in early axoglial alterations of the optic nerve induced by experimental glaucoma

(2017) Melina P. Bordone et al.   JOURNAL OF NEUROCHEMISTRY

GlyCAM1 negatively regulates monocyte entry into the optic nerve head and contributes to radiation-based protection in glaucoma

(2017) Pete A. Williams et al.   Journal of Neuroinflammation

Topical Coenzyme Q10 demonstrates mitochondrial-mediated neuroprotection in a rodent model of ocular hypertension

(2017) Benjamin Michael Davis et al.   MITOCHONDRION

Mitochondrial dynamics, transport, and quality control: A bottleneck for retinal ganglion cell viability in optic neuropathies

(2017) Yoko A. Ito et al.   MITOCHONDRION

The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD + Cleavage Activity that Promotes Pathological Axonal Degeneration

(2017) Kow Essuman et al.   NEURON

Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective

(2017) Jeffrey M. Harder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BAX to basics: How the BCL2 gene family controls the death of retinal ganglion cells

(2017) Margaret E. Maes et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Vitamin B 3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice

(2017) Pete A. Williams et al.   SCIENCE

The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain

(2017) Farraj Albalawi et al.   Frontiers in Cellular Neuroscience

HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients

(2017) Wenting Guo et al.   Nature Communications

Sarm1 Deletion, but Not Wld S , Confers Lifelong Rescue in a Mouse Model of Severe Axonopathy

(2017) Jonathan Gilley et al.   Cell Reports

Oral Delivery of a Synthetic Sterol Reduces Axonopathy and Inflammation in a Rodent Model of Glaucoma

(2017) Wendi S. Lambert et al.   Frontiers in Neuroscience

Metabolic Vulnerability in the Neurodegenerative Disease Glaucoma

(2017) Denise M. Inman et al.   Frontiers in Neuroscience

Nicotinamide and WLDS Act Together to Prevent Neurodegeneration in Glaucoma

(2017) Pete A. Williams et al.   Frontiers in Neuroscience

Interleukin-6 Deficiency Attenuates Retinal Ganglion Cell Axonopathy and Glaucoma-Related Vision Loss

(2017) Franklin D. Echevarria et al.   Frontiers in Neuroscience

Visual Impairment in Alzheimer's Disease: A Critical Review

(2017) Elizabeth Kirby et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid precursor protein drives down-regulation of mitochondrial oxidative phosphorylation independent of amyloid beta

(2017) M. Isabel G. Lopez Sanchez et al.   Scientific Reports

Age-related neurodegenerative disease associated pathways identified in retinal and vitreous proteome from human glaucoma eyes

(2017) Mehdi Mirzaei et al.   Scientific Reports

Presence and Risk Factors for Glaucoma in Patients with Diabetes

(2016) Brian J. Song et al.   Current Diabetes Reports

Elevated Regulatory T Cell Levels in Glaucoma Patients in Comparison to Healthy Controls

(2016) Katharina Bell et al.   CURRENT EYE RESEARCH

Brain-derived neurotrophic factor prevents dendritic retraction of adult mouse retinal ganglion cells

(2016) Kate E. Binley et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Glaucoma: Focus on mitochondria in relation to pathogenesis and neuroprotection

(2016) Neville N. Osborne et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Overexpression of Soluble Fas Ligand following Adeno-Associated Virus Gene Therapy Prevents Retinal Ganglion Cell Death in Chronic and Acute Murine Models of Glaucoma

(2016) Anitha Krishnan et al.   JOURNAL OF IMMUNOLOGY

Novel Roles for the Insulin-Regulated Glucose Transporter-4 in Hippocampally Dependent Memory

(2016) Jiah Pearson-Leary et al.   JOURNAL OF NEUROSCIENCE

Corticothalamic Axons Are Essential for Retinal Ganglion Cell Axon Targeting to the Mouse Dorsal Lateral Geniculate Nucleus

(2016) James A. Shanks et al.   JOURNAL OF NEUROSCIENCE

Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma

(2016) Pete A. Williams et al.   Molecular Neurodegeneration

Virus-mediated EpoR76E Therapy Slows Optic Nerve Axonopathy in Experimental Glaucoma

(2016) Wesley S Bond et al.   MOLECULAR THERAPY

Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma

(2016) Jessica N Cooke Bailey et al.   NATURE GENETICS

Insulin resistance and Parkinson’s disease: A new target for disease modification?

(2016) D. Athauda et al.   PROGRESS IN NEUROBIOLOGY

Glia–neuron interactions in the mammalian retina

(2016) Elena Vecino et al.   PROGRESS IN RETINAL AND EYE RESEARCH

NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies

(2016) Yousuf O. Ali et al.   PLOS BIOLOGY

NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion

(2016) Yo Sasaki et al.   eLife

Loss of Fractalkine Signaling Exacerbates Axon Transport Dysfunction in a Chronic Model of Glaucoma

(2016) Kevin T. Breen et al.   Frontiers in Neuroscience

Riluzole- and Resveratrol-Induced Delay of Retinal Ganglion Cell Death in an Experimental Model of Glaucoma

(2015) Dilara Pirhan et al.   CURRENT EYE RESEARCH

Assessment of retinal ganglion cell damage in glaucomatous optic neuropathy: Axon transport, injury and soma loss

(2015) Andrea C. Nuschke et al.   EXPERIMENTAL EYE RESEARCH

Dendrite pathology and neurodegeneration: focus on mTOR

(2015) AdrianaDi Polo   Neural Regeneration Research

Impairment of insulin receptor substrate 1 signaling by insulin resistance inhibits neurite outgrowth and aggravates neuronal cell death

(2015) J. Song et al.   NEUROSCIENCE

Local axonal protection by WldS as revealed by conditional regulation of protein stability

(2015) Jack T. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo imaging of axonal transport of mitochondria in the diseased and aged mammalian CNS

(2015) Yuji Takihara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SARM1 activation triggers axon degeneration locally via NAD+ destruction

(2015) J. Gerdts et al.   SCIENCE

Absence of SARM1 Rescues Development and Survival of NMNAT2-Deficient Axons

(2015) Jonathan Gilley et al.   Cell Reports

Aberrant insulin signaling in Alzheimer's disease: current knowledge

(2015) Gaurav Bedse et al.   Frontiers in Neuroscience

Measurement of Systemic Mitochondrial Function in Advanced Primary Open-Angle Glaucoma and Leber Hereditary Optic Neuropathy

(2015) Nicole J Van Bergen et al.   PLoS One

REDD2-mediated inhibition of mTOR promotes dendrite retraction induced by axonal injury

(2014) B Morquette et al.   CELL DEATH AND DIFFERENTIATION

Whole-mitochondrial genome sequencing in primary open-angle glaucoma using massively parallel sequencing identifies novel and known pathogenic variants

(2014) Periasamy Sundaresan et al.   GENETICS IN MEDICINE

Radiation Pretreatment Does Not Protect the Rat Optic Nerve From Elevated Intraocular Pressure-Induced Injury

(2014) E. C. Johnson et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Unique Function of Kinesin Kif5A in Localization of Mitochondria in Axons

(2014) P. D. Campbell et al.   JOURNAL OF NEUROSCIENCE

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040

(2014) Yih-Chung Tham et al.   OPHTHALMOLOGY

Rapamycin Is Neuroprotective in a Rat Chronic Hypertensive Glaucoma Model

(2014) Wenru Su et al.   PLoS One

Loss of Miro1-directed mitochondrial movement results in a novel murine model for neuron disease

(2014) T. T. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1  production in acute glaucoma

(2014) W. Chi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations

(2014) Vinay K. Godena et al.   Nature Communications

The mTORC1 effectors S6K1 and 4E-BP play different roles in CNS axon regeneration

(2014) Liu Yang et al.   Nature Communications

Anterograde transport blockade precedes deficits in retrograde transport in the visual projection of the DBA/2J mouse model of glaucoma

(2014) Christine M. Dengler-Crish et al.   Frontiers in Neuroscience

Expression of insulin-like growth factor 1 receptor in rat retina following optic nerve injury

(2013) Shu-yang Bu et al.   ACTA OPHTHALMOLOGICA

Factors associated with lifetime risk of open-angle glaucoma blindness

(2013) Dorothea Peters et al.   ACTA OPHTHALMOLOGICA

Balance between autophagic pathways preserves retinal homeostasis

(2013) Natalia Rodríguez-Muela et al.   AGING CELL

The ULK1 complex

(2013) Pui-Mun Wong et al.   Autophagy

Challenges in the development of glaucoma neuroprotection therapy

(2013) Yang Liu et al.   CELL AND TISSUE RESEARCH

Intranasal Insulin as a Treatment for Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

(2013) Jessica Freiherr et al.   CNS DRUGS

From Mechanosensitivity to Inflammatory Responses: New Players in the Pathology of Glaucoma

(2013) David Križaj et al.   CURRENT EYE RESEARCH

Retinal ganglion cell maps in the brain: implications for visual processing

(2013) Onkar S Dhande et al.   CURRENT OPINION IN NEUROBIOLOGY

DISC1 complexes with TRAK1 and Miro1 to modulate anterograde axonal mitochondrial trafficking

(2013) Fumiaki Ogawa et al.   HUMAN MOLECULAR GENETICS

Deficiency of complement component 5 ameliorates glaucoma in DBA/2J mice

(2013) Gareth R Howell et al.   Journal of Neuroinflammation

Differential Progression of Structural and Functional Alterations in Distinct Retinal Ganglion Cell Types in a Mouse Model of Glaucoma

(2013) L. Della Santina et al.   JOURNAL OF NEUROSCIENCE

Retinal ganglion cell dendritic degeneration in a mouse model of Alzheimer's disease

(2013) Pete A. Williams et al.   NEUROBIOLOGY OF AGING

Proximal inhibition of p38 MAPK stress signaling prevents distal axonopathy

(2013) Jason D. Dapper et al.   NEUROBIOLOGY OF DISEASE

TRAK/Milton Motor-Adaptor Proteins Steer Mitochondrial Trafficking to Axons and Dendrites

(2013) Myrrhe van Spronsen et al.   NEURON

How Does Glaucoma Look?

(2013) David P. Crabb et al.   OPHTHALMOLOGY

Insights into the Genetic Architecture of Early Stage Age-Related Macular Degeneration: A Genome-Wide Association Study Meta-Analysis

(2013) Elizabeth G. Holliday et al.   PLoS One

Enhanced Insight into the Autoimmune Component of Glaucoma: IgG Autoantibody Accumulation and Pro-Inflammatory Conditions in Human Glaucomatous Retina

(2013) Oliver W. Gramlich et al.   PLoS One

Mitochondrial Genome Analysis of Primary Open Angle Glaucoma Patients

(2013) Deblina Banerjee et al.   PLoS One

Retinal Ganglion Cell Dendritic Atrophy in DBA/2J Glaucoma

(2013) Pete A. Williams et al.   PLoS One

Mitochondrial Sequence Variation in African-American Primary Open-Angle Glaucoma Patients

(2013) David W. Collins et al.   PLoS One

Insight into Molecular and Functional Properties of NMNAT3 Reveals New Hints of NAD Homeostasis within Human Mitochondria

(2013) Roberta Felici et al.   PLoS One

Axonal protection by Nmnat3 overexpression with involvement of autophagy in optic nerve degeneration

(2013) Y Kitaoka et al.   Cell Death & Disease

GABA and Glutamate Uptake and Metabolism in Retinal Glial (Müller) Cells

(2013) Andreas Bringmann et al.   Frontiers in Endocrinology

Apolipoprotein E Gene Associations in Age-related Macular Degeneration: The Melbourne Collaborative Cohort Study

(2012) M. K. M. Adams et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Under Pressure: Cellular and Molecular Responses During Glaucoma, a Common Neurodegeneration with Axonopathy

(2012) Robert W. Nickells et al.   Annual Review of Neuroscience

Opa1 is essential for retinal ganglion cell synaptic architecture and connectivity

(2012) Pete A. Williams et al.   BRAIN

Retina ganglion cell degeneration in glaucoma: an opportunity missed? A review

(2012) James E Morgan   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Definition of glaucoma: clinical and experimental concepts

(2012) Robert J Casson et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Intrinsic axonal degeneration pathways are critical for glaucomatous damage

(2012) Gareth R. Howell et al.   EXPERIMENTAL NEUROLOGY

Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma

(2012) Gareth R. Howell et al.   JOURNAL OF CLINICAL INVESTIGATION

Insulin in the Brain: Sources, Localization and Functions

(2012) Rasoul Ghasemi et al.   MOLECULAR NEUROBIOLOGY

The Neuronal Organization of the Retina

(2012) Richard H. Masland   NEURON

Synaptic Energy Use and Supply

(2012) Julia J. Harris et al.   NEURON

Etanercept, a Widely Used Inhibitor of Tumor Necrosis Factor-α (TNF- α), Prevents Retinal Ganglion Cell Loss in a Rat Model of Glaucoma

(2012) Miin Roh et al.   PLoS One

Early Reduction of Microglia Activation by Irradiation in a Model of Chronic Glaucoma

(2012) Alejandra Bosco et al.   PLoS One

Secondary Post-Geniculate Involvement in Leber’s Hereditary Optic Neuropathy

(2012) Giovanni Rizzo et al.   PLoS One

Activation of autophagy induces retinal ganglion cell death in a chronic hypertensive glaucoma model

(2012) H-Y Lopilly Park et al.   Cell Death & Disease

Pathologies of axonal transport in neurodegenerative diseases

(2012) Xin-An Liu et al.   Translational Neuroscience

The optic nerve head is the site of axonal transport disruption, axonal cytoskeleton damage and putative axonal regeneration failure in a rat model of glaucoma

(2011) Glyn Chidlow et al.   ACTA NEUROPATHOLOGICA

Autophagy promotes survival of retinal ganglion cells after optic nerve axotomy in mice

(2011) N Rodríguez-Muela et al.   CELL DEATH AND DIFFERENTIATION

Association of tumour necrosis factor-alpha -308 G/A polymorphism with primary open-angle glaucoma

(2011) Banu Bozkurt et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Ophthalmic features of Friedreich ataxia

(2011) S Noval et al.   EYE

Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma

(2011) Gareth R. Howell et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuroprotection and progenitor cell renewal in the injured adult murine retina requires healing monocyte-derived macrophages

(2011) Anat London et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Age-Related Alterations in Neurons of the Mouse Retina

(2011) M. A. Samuel et al.   JOURNAL OF NEUROSCIENCE

Plasma Citrate Levels as a Potential Biomarker for Glaucoma

(2011) Stephan A. Fraenkl et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

MFN2 mutations cause severe phenotypes in most patients with CMT2A

(2011) S. M. E. Feely et al.   NEUROLOGY

Mitochondrial Damage in the Trabecular Meshwork Occurs Only in Primary Open-Angle Glaucoma and in Pseudoexfoliative Glaucoma

(2011) Alberto Izzotti et al.   PLoS One

The molecular basis of retinal ganglion cell death in glaucoma

(2011) Mohammadali Almasieh et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Wallerian Degeneration, WldS, and Nmnat

(2010) Michael P. Coleman et al.   Annual Review of Neuroscience

A Single Nucleotide Polymorphism in the Bax Gene Promoter Affects Transcription and Influences Retinal Ganglion Cell Death

(2010) Sheila J Semaan et al.   ASN Neuro

Opa1 deficiency in a mouse model of dominant optic atrophy leads to retinal ganglion cell dendropathy

(2010) P. A. Williams et al.   BRAIN

Modulation of morphological changes of microglia and neuroprotection by monocyte chemoattractant protein-1 in experimental glaucoma

(2010) Kin Chiu et al.   Cellular & Molecular Immunology

Inhibitors of Lactate Dehydrogenase Isoforms and their Therapeutic Potentials

(2010) C. Granchi et al.   CURRENT MEDICINAL CHEMISTRY

Leber’s Hereditary Optic Neuropathy

(2010) Alfredo A. Sadun et al.   Current Treatment Options in Neurology

Mitochondrial dysfunction in glaucoma and emerging bioenergetic therapies

(2010) Shanjean Lee et al.   EXPERIMENTAL EYE RESEARCH

Early microglia activation in a mouse model of chronic glaucoma

(2010) Alejandra Bosco et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Targeting NMNAT1 to Axons and Synapses Transforms Its Neuroprotective Potency In Vivo

(2010) E. Babetto et al.   JOURNAL OF NEUROSCIENCE

Distal axonopathy with structural persistence in glaucomatous neurodegeneration

(2010) S. D. Crish et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endogenous Nmnat2 Is an Essential Survival Factor for Maintenance of Healthy Axons

(2010) Jonathan Gilley et al.   PLOS BIOLOGY

HISTOPATHOLOGY OF EYE, OPTIC NERVE AND BRAIN IN A CASE OF DOMINANT OPTIC ATROPHY

(2009) P. KJER et al.   ACTA OPHTHALMOLOGICA

Retinal ganglion cell neurodegeneration in mitochondrial inherited disorders

(2009) Valerio Carelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Regulation of neonatal development of retinal ganglion cell dendrites by neurotrophin-3 overexpression

(2009) Xiaorong Liu et al.   JOURNAL OF COMPARATIVE NEUROLOGY

OPA1 increases the risk of normal but not high tension glaucoma

(2009) P. Yu-Wai-Man et al.   JOURNAL OF MEDICAL GENETICS

Visual system involvement in patients with Friedreich's ataxia

(2008) Filippo Fortuna et al.   BRAIN

TheWldSgene delays axonal but not somatic degeneration in a rat glaucoma model

(2008) Bogdan Beirowski et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Resveratrol prevents the expression of glaucoma markers induced by chronic oxidative stress in trabecular meshwork cells

(2008) Coralia Luna et al.   FOOD AND CHEMICAL TOXICOLOGY

Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

(2008) K. K. Park et al.   SCIENCE