Role of mTOR in Glucose and Lipid Metabolism

mTORC1 Signaling: A Double-Edged Sword in Diabetic β Cells

(2018) Amin Ardestani et al.   Cell Metabolism

Kaempferol alleviates palmitic acid-induced lipid stores, endoplasmic reticulum stress and pancreatic β-cell dysfunction through AMPK/mTOR-mediated lipophagy

(2018) Ritu Varshney et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical Dyslamination

(2018) Sang Min Park et al.   NEURON

Liver Reptin/RUVBL2 controls glucose and lipid metabolism with opposite actions on mTORC1 and mTORC2 signalling

(2017) Joaquim Javary et al.   GUT

mTOR controls ChREBP transcriptional activity and pancreatic β cell survival under diabetic stress

(2017) Gia Cac Chau et al.   JOURNAL OF CELL BIOLOGY

Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion

(2017) Nadejda Bozadjieva et al.   JOURNAL OF CLINICAL INVESTIGATION

EPRS is a critical mTORC1–S6K1 effector that influences adiposity in mice

(2017) Abul Arif et al.   NATURE

Raptor regulates functional maturation of murine beta cells

(2017) Qicheng Ni et al.   Nature Communications

Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing

(2017) Manuel Blandino-Rosano et al.   Nature Communications

mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice

(2017) Luke K Burke et al.   eLife

Role of nutrients and mTOR signaling in the regulation of pancreatic progenitors development

(2017) Lynda Elghazi et al.   Molecular Metabolism

Rapamycin treatment benefits glucose metabolism in mouse models of type 2 diabetes

(2016) Peter C. Reifsnyder et al.   Aging-US

Hypothalamic roles of mTOR complex I: integration of nutrient and hormone signals to regulate energy homeostasis

(2016) Fang Hu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

DEPTOR in POMC neurons affects liver metabolism but is dispensable for the regulation of energy balance

(2016) Alexandre Caron et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Rapamycin Blocks Induction of the Thermogenic Program in White Adipose Tissue

(2016) Cassie M. Tran et al.   DIABETES

Adipocyte-specific deletion of mTOR inhibits adipose tissue development and causes insulin resistance in mice

(2016) Tizhong Shan et al.   DIABETOLOGIA

Pharmacological inhibition of S6K1 increases glucose metabolism and Akt signalling in vitro and in diet-induced obese mice

(2016) Michael Shum et al.   DIABETOLOGIA

Reciprocal regulation of mTOR complexes in pancreatic islets from humans with type 2 diabetes

(2016) Ting Yuan et al.   DIABETOLOGIA

mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue

(2016) V. Albert et al.   EMBO Molecular Medicine

The TORC1-activated Proteins, p70S6K and GRB10, Regulate IL-4 Signaling and M2 Macrophage Polarization by Modulating Phosphorylation of Insulin Receptor Substrate-2

(2016) Kristi J. Warren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning

(2016) Dianxin Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

TSC1-mTOR signaling determines the differentiation of islet cells

(2016) Li Ding et al.   JOURNAL OF ENDOCRINOLOGY

An evolutionarily conserved pathway controls proteasome homeostasis

(2016) Adrien Rousseau et al.   NATURE

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

(2016) I. Ben-Sahra et al.   SCIENCE

Is REDD1 a Metabolic Éminence Grise ?

(2016) Christopher Lipina et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism

(2016) Yuefeng Tang et al.   Nature Communications

mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2

(2016) KyeongJin Kim et al.   Nature Communications

mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3

(2016) Maximilian Kleinert et al.   Molecular Metabolism

Mediobasal hypothalamic overexpression of DEPTOR protects against high-fat diet-induced obesity

(2016) Alexandre Caron et al.   Molecular Metabolism

Alterations to mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolism

(2016) Maitea Guridi et al.   Skeletal Muscle

Aberrant REDD1-mTORC1 responses to insulin in skeletal muscle from Type 2 diabetics

(2015) David L. Williamson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Raptor ablation in skeletal muscle decreases Cav1.1 expression and affects the function of the excitation–contraction coupling supramolecular complex

(2015) Rubén J. Lopez et al.   BIOCHEMICAL JOURNAL

Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesity

(2015) Shihyin Tsai et al.   JOURNAL OF CLINICAL INVESTIGATION

The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1

(2015) Jinbo Han et al.   NATURE

Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy

(2015) Jae Seok Lim et al.   NATURE MEDICINE

mTOR in Brain Physiology and Pathologies

(2015) Joël Bockaert et al.   PHYSIOLOGICAL REVIEWS

mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy

(2015) Jinghui Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21

(2015) Maitea Guridi et al.   Science Signaling

Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice

(2015) Mark A. Smith et al.   Cell Reports

Glucagon Couples Hepatic Amino Acid Catabolism to mTOR-Dependent Regulation of α-Cell Mass

(2015) Mark J. Solloway et al.   Cell Reports

Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21

(2015) Maitea Guridi et al.   Science Signaling

Sestrin 3 Protein Enhances Hepatic Insulin Sensitivity by Direct Activation of the mTORC2-Akt Signaling

(2014) Rongya Tao et al.   DIABETES

Tuberous Sclerosis Complex 1–Mechanistic Target of Rapamycin Complex 1 Signaling Determines Brown-to-White Adipocyte Phenotypic Switch

(2014) Xinxin Xiang et al.   DIABETES

Pancreatic  -Cell Failure Mediated by mTORC1 Hyperactivity and Autophagic Impairment

(2014) A. Bartolome et al.   DIABETES

Altered nutrient response of mTORC1 as a result of changes in REDD1 expression: effect of obesity vs. REDD1 deficiency

(2014) David L. Williamson et al.   JOURNAL OF APPLIED PHYSIOLOGY

Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21

(2014) M. Cornu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ghrelin promotes hepatic lipogenesis by activation of mTOR-PPAR  signaling pathway

(2014) Z. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTORC1 Promotes Denervation-Induced Muscle Atrophy Through a Mechanism Involving the Activation of FoxO and E3 Ubiquitin Ligases

(2014) H. Tang et al.   Science Signaling

Hepatoprotective role of Sestrin2 against chronic ER stress

(2014) Hwan-Woo Park et al.   Nature Communications

Rictor/mTORC2 Loss in the Myf5 Lineage Reprograms Brown Fat Metabolism and Protects Mice against Obesity and Metabolic Disease

(2014) Chien-Min Hung et al.   Cell Reports

Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo

(2014) Maximilian Kleinert et al.   Molecular Metabolism

Rictor/mTORC2 facilitates central regulation of energy and glucose homeostasis

(2014) Heidi E. Kocalis et al.   Molecular Metabolism

Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset Myopathy

(2013) Perrine Castets et al.   Cell Metabolism

mTOR in aging, metabolism, and cancer

(2013) Marion Cornu et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Evidence for Rapamycin Toxicity in Pancreatic β-Cells and a Review of the Underlying Molecular Mechanisms

(2013) Adam D. Barlow et al.   DIABETES

Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology

(2013) Venus Thomanetz et al.   JOURNAL OF CELL BIOLOGY

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

(2013) Pengda Liu et al.   NATURE CELL BIOLOGY

mTORC1 Dependent Regulation of REDD1 Protein Stability

(2013) Chia Yee Tan et al.   PLoS One

BSTA Promotes mTORC2-Mediated Phosphorylation of Akt1 to Suppress Expression of FoxC2 and Stimulate Adipocyte Differentiation

(2013) Y. Yao et al.   Science Signaling

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c

(2012) Asami Hagiwara et al.   Cell Metabolism

Maintenance of Metabolic Homeostasis by Sestrin2 and Sestrin3

(2012) Jun Hee Lee et al.   Cell Metabolism

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Identification of Akt-independent Regulation of Hepatic Lipogenesis by Mammalian Target of Rapamycin (mTOR) Complex 2

(2012) Minsheng Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR inhibition with rapamycin causes impaired insulin signalling and glucose uptake in human subcutaneous and omental adipocytes

(2012) Maria J. Pereira et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Rapamycin Ameliorates Age-Dependent Obesity Associated with Increased mTOR Signaling in Hypothalamic POMC Neurons

(2012) Shi-Bing Yang et al.   NEURON

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2

(2012) Lan Ye et al.   Frontiers in Genetics

Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats

(2011) N Deblon et al.   BRITISH JOURNAL OF PHARMACOLOGY

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

(2011) Timothy R. Peterson et al.   CELL

Rictor/mTORC2 Is Essential for Maintaining a Balance Between β-Cell Proliferation and Cell Size

(2011) Yanyun Gu et al.   DIABETES

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)

(2010) Laura R. Pearce et al.   BIOCHEMICAL JOURNAL

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Fat Cell-Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism

(2010) A. Kumar et al.   DIABETES

Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue

(2010) V. P. Houde et al.   DIABETES

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

(2010) Shomit Sengupta et al.   NATURE

Critical Role for Hypothalamic mTOR Activity in Energy Balance

(2009) Hiroyuki Mori et al.   Cell Metabolism

mTORC1-Activated S6K1 Phosphorylates Rictor on Threonine 1135 and Regulates mTORC2 Signaling

(2009) L.-A. Julien et al.   MOLECULAR AND CELLULAR BIOLOGY

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

mTOR complex 2 in adipose tissue negatively controls whole-body growth

(2009) N. Cybulski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mediobasal Hypothalamic p70 S6 Kinase 1 Modulates the Control of Energy Homeostasis

(2008) Clémence Blouet et al.   Cell Metabolism

Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

(2008) C. Florian Bentzinger et al.   Cell Metabolism

Regulation of TORC1 by Rag GTPases in nutrient response

(2008) Eunjung Kim et al.   NATURE CELL BIOLOGY

Disruption of Tsc2 in pancreatic   cells induces   cell mass expansion and improved glucose tolerance in a TORC1-dependent manner

(2008) L. Rachdi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA