Journal
TRANSLATIONAL NEUROSCIENCE
Volume 3, Issue 4, Pages 355-372Publisher
SCIENDO
DOI: 10.2478/s13380-012-0044-7
Keywords
Axonal transport; Neurodegenerative diseases
Categories
Funding
- Alzheimer's Drug Discovery Foundation
- Margaret Q. Landenberger Research Foundation
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Gene products such as organelles, proteins and RNAs are actively transported to synaptic terminals for the remodeling of pre-existing neuronal connections and formation of new ones. Proteins described as molecular motors mediate this transport and utilize specialized cytoskeletal proteins that function as molecular tracks for the motor based transport of cargos. Molecular motors such as kinesins and dynein's move along microtubule tracks formed by tubulins whereas myosin motors utilize tracks formed by actin. Deficits in active transport of gene products have been implicated in a number of neurological disorders. We describe such disorders collectively as transportopathies. Here we review current knowledge of critical components of active transport and their relevance to neurodegenerative diseases.
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