SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration
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Title
SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration
Authors
Keywords
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Journal
NEURON
Volume -, Issue -, Pages -
Publisher
Elsevier BV
Online
2021-03-03
DOI
10.1016/j.neuron.2021.02.009
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Note: Only part of the references are listed.- Multiple domain interfaces mediate SARM1 autoinhibition
- (2021) Chen Shen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Small Molecule SARM1 Inhibitors Recapitulate the SARM1−/− Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate
- (2021) Robert O. Hughes et al. Cell Reports
- cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons
- (2020) Yo Sasaki et al. EXPERIMENTAL NEUROLOGY
- Axons Matter: The Promise of Treating Neurodegenerative Disorders by Targeting SARM1-Mediated Axonal Degeneration
- (2020) Raul Krauss et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Sarm1 loss reduces axonal damage and improves cognitive outcome after repetitive mild closed head injury
- (2020) Mark E. Maynard et al. EXPERIMENTAL NEUROLOGY
- Programmed axon degeneration: from mouse to mechanism to medicine
- (2020) Michael P. Coleman et al. NATURE REVIEWS NEUROSCIENCE
- Nicotinamide Riboside—The Current State of Research and Therapeutic Uses
- (2020) Mario Mehmel et al. Nutrients
- The SARM1 axon degeneration pathway: control of the NAD+ metabolome regulates axon survival in health and disease
- (2020) Matthew D Figley et al. CURRENT OPINION IN NEUROBIOLOGY
- SARM1 acts downstream of neuroinflammatory and necroptotic signaling to induce axon degeneration
- (2020) Kwang Woo Ko et al. JOURNAL OF CELL BIOLOGY
- Structural and Mechanistic Regulation of the Pro-degenerative NAD Hydrolase SARM1
- (2020) Matthew Bratkowski et al. Cell Reports
- The NAD+-mediated self-inhibition mechanism of pro-neurodegenerative Sarm1
- (2020) Yuefeng Jiang et al. NATURE
- Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme
- (2020) Shoucai Ma et al. SCIENCE
- Structure of the activated ROQ1 resistosome directly recognizing the pathogen effector XopQ
- (2020) Raoul Martin et al. SCIENCE
- Gene therapy targeting SARM1 blocks pathological axon degeneration in mice
- (2019) Stefanie Geisler et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Structural Evidence for an Octameric Ring Arrangement of SARM1
- (2019) Michael Sporny et al. JOURNAL OF MOLECULAR BIOLOGY
- Namdinator – automatic molecular dynamics flexible fitting of structural models into cryo-EM and crystallography experimental maps
- (2019) Rune Thomas Kidmose et al. IUCrJ
- Quaternary structures of Vac8 differentially regulate the Cvt and PMN pathways
- (2019) Jumi Park et al. Autophagy
- TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death
- (2019) Li Wan et al. SCIENCE
- NAD+ cleavage activity by animal and plant TIR domains in cell death pathways
- (2019) Shane Horsefield et al. SCIENCE
- Axon death signalling in Wallerian degeneration among species and in disease
- (2019) Arnau Llobet Rosell et al. Open Biology
- Sarm1 deletion reduces axon damage, demyelination, and white matter atrophy after experimental traumatic brain injury
- (2019) Christina M. Marion et al. EXPERIMENTAL NEUROLOGY
- Positive-unlabeled convolutional neural networks for particle picking in cryo-electron micrographs
- (2019) Tristan Bepler et al. NATURE METHODS
- Rigid fusions of designed helical repeat binding proteins efficiently protect a binding surface from crystal contacts
- (2019) Patrick Ernst et al. Scientific Reports
- TIR Domain Proteins Are an Ancient Family of NAD + -Consuming Enzymes
- (2018) Kow Essuman et al. CURRENT BIOLOGY
- Primary Traumatic Axonopathy in Mice Subjected to Impact Acceleration: A Reappraisal of Pathology and Mechanisms with High-Resolution Anatomical Methods
- (2018) Nikolaos K. Ziogas et al. JOURNAL OF NEUROSCIENCE
- Pharmacological bypass of NAD+ salvage pathway protects neurons from chemotherapy-induced degeneration
- (2018) Hui-wen Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- New tools for the analysis and validation of cryo-EM maps and atomic models
- (2018) Pavel V. Afonine et al. Acta Crystallographica Section D-Structural Biology
- The tuberculosis necrotizing toxin is an NAD+ and NADP+ glycohydrolase with distinct enzymatic properties
- (2018) Uday Tak et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Automated Topology Builder Version 3.0: Prediction of Solvation Free Enthalpies in Water and Hexane
- (2018) Martin Stroet et al. Journal of Chemical Theory and Computation
- Structure-based analysis of the guanine nucleotide exchange factor SmgGDS reveals armadillo-repeat motifs and key regions for activity and GTPase binding
- (2017) Hikaru Shimizu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Deletion of Sarm1 gene is neuroprotective in two models of peripheral neuropathy
- (2017) Elliot Turkiew et al. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
- cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
- (2017) Ali Punjani et al. NATURE METHODS
- The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD + Cleavage Activity that Promotes Pathological Axonal Degeneration
- (2017) Kow Essuman et al. NEURON
- UCSF ChimeraX: Meeting modern challenges in visualization and analysis
- (2017) Thomas D. Goddard et al. PROTEIN SCIENCE
- PDBsum: Structural summaries of PDB entries
- (2017) Roman A. Laskowski et al. PROTEIN SCIENCE
- MolProbity: More and better reference data for improved all-atom structure validation
- (2017) Christopher J. Williams et al. PROTEIN SCIENCE
- Sarm1 Deletion, but Not Wld S , Confers Lifelong Rescue in a Mouse Model of Severe Axonopathy
- (2017) Jonathan Gilley et al. Cell Reports
- Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice
- (2016) Stefanie Geisler et al. BRAIN
- Attenuated traumatic axonal injury and improved functional outcome after traumatic brain injury in mice lackingSarm1
- (2016) Nils Henninger et al. BRAIN
- SARM1-specific motifs in the TIR domain enable NAD+loss and regulate injury-induced SARM1 activation
- (2016) Daniel W. Summers et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion
- (2016) Yo Sasaki et al. eLife
- The tuberculosis necrotizing toxin kills macrophages by hydrolyzing NAD
- (2015) Jim Sun et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- SARM1 activation triggers axon degeneration locally via NAD+ destruction
- (2015) J. Gerdts et al. SCIENCE
- The tuberculosis necrotizing toxin kills macrophages by hydrolyzing NAD
- (2015) Jim Sun et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Absence of SARM1 Rescues Development and Survival of NMNAT2-Deficient Axons
- (2015) Jonathan Gilley et al. Cell Reports
- Wallerian Degeneration Is Executed by an NMN-SARM1-Dependent Late Ca 2+ Influx but Only Modestly Influenced by Mitochondria
- (2015) Andrea Loreto et al. Cell Reports
- A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration
- (2014) M Di Stefano et al. CELL DEATH AND DIFFERENTIATION
- Deficiency of Nicotinamide Mononucleotide Adenylyltransferase 3 (Nmnat3) Causes Hemolytic Anemia by Altering the Glycolytic Flow in Mature Erythrocytes
- (2014) Keisuke Hikosaka et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Testing and validation of the Automated Topology Builder (ATB) version 2.0: prediction of hydration free enthalpies
- (2014) Katarzyna B. Koziara et al. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
- Deciphering key features in protein structures with the new ENDscript server
- (2014) Xavier Robert et al. NUCLEIC ACIDS RESEARCH
- How good are my data and what is the resolution?
- (2013) Philip R. Evans et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Routine Microsecond Molecular Dynamics Simulations with AMBER on GPUs. 2. Explicit Solvent Particle Mesh Ewald
- (2013) Romelia Salomon-Ferrer et al. Journal of Chemical Theory and Computation
- Sarm1-Mediated Axon Degeneration Requires Both SAM and TIR Interactions
- (2013) J. Gerdts et al. JOURNAL OF NEUROSCIENCE
- High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy
- (2013) Shaoxia Chen et al. ULTRAMICROSCOPY
- Towards automated crystallographic structure refinement withphenix.refine
- (2012) Pavel V. Afonine et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Prevention of overfitting in cryo-EM structure determination
- (2012) Sjors H W Scheres et al. NATURE METHODS
- dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway
- (2012) J. M. Osterloh et al. SCIENCE
- Data processing and analysis with theautoPROCtoolbox
- (2011) Clemens Vonrhein et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Architecture, implementation and parallelisation of the GROMOS software for biomolecular simulation
- (2011) Nathan Schmid et al. COMPUTER PHYSICS COMMUNICATIONS
- Definition and testing of the GROMOS force-field versions 54A7 and 54B7
- (2011) Nathan Schmid et al. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
- Image-based Screening Identifies Novel Roles for IκB Kinase and Glycogen Synthase Kinase 3 in Axonal Degeneration
- (2011) Josiah Gerdts et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- An Automated Force Field Topology Builder (ATB) and Repository: Version 1.0
- (2011) Alpeshkumar K. Malde et al. Journal of Chemical Theory and Computation
- New functionalities in the GROMOS biomolecular simulation software
- (2011) Anna-Pitschna E. Kunz et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- Quantitative analysis of cryo-EM density map segmentation by watershed and scale-space filtering, and fitting of structures by alignment to regions
- (2010) Grigore D. Pintilie et al. JOURNAL OF STRUCTURAL BIOLOGY
- Armadillo-repeat protein functions: questions for little creatures
- (2010) Rita Tewari et al. TRENDS IN CELL BIOLOGY
- Endogenous Nmnat2 Is an Essential Survival Factor for Maintenance of Healthy Axons
- (2010) Jonathan Gilley et al. PLOS BIOLOGY
- Detection and pharmacological modulation of nicotinamide mononucleotide (NMN) in vitro and in vivo
- (2009) Laura Formentini et al. BIOCHEMICAL PHARMACOLOGY
- Nicotinamide Mononucleotide Adenylyl Transferase-Mediated Axonal Protection Requires Enzymatic Activity But Not Increased Levels of Neuronal Nicotinamide Adenine Dinucleotide
- (2009) Y. Sasaki et al. JOURNAL OF NEUROSCIENCE
- The Immune Adaptor Molecule SARM Modulates Tumor Necrosis Factor Alpha Production and Microglia Activation in the Brainstem and Restricts West Nile Virus Pathogenesis
- (2009) K. J. Szretter et al. JOURNAL OF VIROLOGY
- Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD+ Precursor Vitamins in Human Nutrition
- (2008) Katrina L Bogan et al. Annual Review of Nutrition
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