Article
Neurosciences
Xiangjun Yang, Qun Zeng, Gulgun Tezel
Summary: This study investigated the importance of caspase-8 in different fates of glaucomatous RGCs and astroglia, revealing cell type-specific distinct processes that regulate caspase-8 functions in experimental glaucoma. Deletion of caspase-8 in astroglia protected RGCs against glia-driven inflammatory injury, while inhibition of caspase-8 cleavage inhibited apoptosis in RGCs themselves, suggesting the multi-target potential of caspase-8 regulation in providing neuroprotection and immunomodulation in glaucoma.
NEUROBIOLOGY OF DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Maja Jazvinscak Jembrek, Nada Orsolic, Lucija Mandic, Anja Sadzak, Suzana Segota
Summary: Neurodegenerative diseases are a major cause of disability and death worldwide, with pathways involving transcription factors playing a critical role in the pathological changes associated with oxidative stress and neuroinflammation. This review focuses on the role of transcription factor p53 in coordinating cellular response and potential therapeutic interventions using natural polyphenolic compounds with anti-oxidative, anti-inflammatory and anti-apoptotic effects. Further research is needed to fully understand the cellular and molecular mechanisms of these compounds for potential new treatments for neurodegenerative diseases.
Review
Biochemistry & Molecular Biology
Bhagavathi Sundaram Sivamaruthi, Neha Raghani, Mehul Chorawala, Sankha Bhattacharya, Bhupendra G. Prajapati, Gehan M. Elossaily, Chaiyavat Chaiyasut
Summary: The NF-kappa B pathway plays a crucial role in various diseases, including Alzheimer's disease. It has the potential to mitigate neuroinflammation, modulate amyloid beta production, and promote neuronal survival in the progression of Alzheimer's disease. However, there are limitations and challenges associated with this approach, as balancing inflammation inhibition and preserving physiological immune responses is critical.
Article
Microbiology
Zheng Chen, Zikai Zhao, Yixin Liu, Muhammad Imran, Jing Rao, Ning Cai, Jing Ye, Shengbo Cao
Summary: This study revealed the role of NOD1 in Japanese encephalitis virus (JEV)-induced neuroinflammation. Activation of NOD1 enhanced the neuroinflammatory response in both in vivo and in vitro models of JEV infection. Inhibition of NOD1 significantly abrogated the inflammatory response triggered by JEV infection. Moreover, NOD1 knockout mice showed resistance to JEV infection. The NOD1-mediated neuroinflammatory response was associated with the activation/phosphorylation of downstream signaling molecules.
MICROBIOLOGY SPECTRUM
(2022)
Article
Food Science & Technology
Zhipeng Li, Qingchen Wang, Zhonghong Zhang, Yaping Guo, Mingna Sun, Li Li, Wenbin He
Summary: This study found that chrysin, a natural flavonoid compound, can alleviate neuroinflammation and depressive-like behaviors induced by chronic stress by inhibiting the activation of Fyn and NF-κB pathway.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Chemistry, Medicinal
Shiquan Chang, Xin Li, Yachun Zheng, Huimei Shi, Di Zhang, Bei Jing, Zhenni Chen, Guoqiang Qian, Guoping Zhao
Summary: This research demonstrates that kaempferol has anti-inflammatory and analgesic effects, potentially through modulating microglial polarization and inhibiting the TLR4/NF-kappa B signaling pathway.
PHYTOTHERAPY RESEARCH
(2022)
Article
Chemistry, Medicinal
Yuyan Bai, Jin Zhou, Han Zhu, Yanlin Tao, Lupeng Wang, Liu Yang, Hui Wu, Fei Huang, Hailian Shi, Xiaojun Wu
Summary: This study found that Isoliquiritigenin (ISL) can inhibit microglia-mediated neuroinflammation in Parkinson's disease (PD) by deactivating JNK/AKT/NFκB signaling pathways. These findings suggest the therapeutic potential of ISL for microglia-mediated neuroinflammation in PD.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biology
Dongyang Wang, Xiaojing Zheng, Lihong Chai, Junli Zhao, Jiuling Zhu, Yanqing Li, Peiyan Yang, Qinwen Mao, Haibin Xia
Summary: In this study, the role of FAM76B in regulating neuroinflammation was demonstrated for the first time. It was shown that FAM76B could regulate the NF-kappa B-mediated inflammatory pathway by affecting hnRNPA2B1 translocation. This provides new insights into the mechanism of inflammation regulation.
Article
Immunology
Hong-Ji Deng, QuZhen Deji, WangDui Zhaba, Jia-Qiang Liu, Sheng-Qing Gao, Yan-Ling Han, Meng-Liang Zhou, Chun-Xi Wang
Summary: The study showed that A20 can attenuate early brain injury after SAH by suppressing the NF-kappa B pathway and reducing inflammatory responses, thereby exerting neuroprotective effects.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
Philippa Malko, Xiaoling Jia, Ian Wood, Lin-Hua Jiang
Summary: Microglial cell function and inflammation are regulated by the activation of Piezo1 channel. This study found that the activation of Piezo1 channel can inhibit the pro-inflammatory activation and production of pro-inflammatory cytokines in microglial cells by initiating intracellular Ca2+ signaling to inhibit the NF-kappa B inflammatory signaling pathway.
Article
Biotechnology & Applied Microbiology
Xuejun He, Yimin Huang, Yuan Liu, Xincheng Zhang, Quanji Wang, Yanchao Liu, Xiaopeng Ma, Xiaobing Long, Yang Ruan, Hongxia Lei, Chao Gan, Xiaochuan Wang, Xin Zou, Bo Xiong, Kai Shu, Ting Lei, Huaqiu Zhang
Summary: This study revealed that an exosomal long non-coding RNA from astrocytes attenuates microglial activation after traumatic brain injury by up-regulating Smad7, providing a potential therapeutic target.
Article
Agriculture, Multidisciplinary
Qi Zhang, Guowan Su, Qing Yang, Zhengpeng Wei, Jinmei Wang, Lin Zheng, Mouming Zhao
Summary: The study revealed that WCPFSRSF could ameliorate oxidative stress, promote the Nrf2-mediated defense system, and potentially reduce ROS generation by inhibiting NF kappa B. Additionally, WCPFSRSF showed potential as a radical scavenger and Nrf2 activator, with its antioxidant and anti-inflammatory effects possibly related to the presence of Cys and Trp. Furthermore, WCPFSRSF exhibited memory-improving effects in sleep-deprived mice, highlighting its potential as a candidate against neurotoxicity and memory deficits.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Jesus Herrera-Imbroda, Maria Flores-Lopez, Paloma Ruiz-Sastre, Carlos Gomez-Sanchez-Lafuente, Antonio Bordallo-Aragon, Fernando Rodriguez de Fonseca, Fermin Mayoral-Cleries
Summary: Psychosis and substance use disorders have been associated with pro-inflammatory changes in the central nervous system, and multiple studies have found a link between these disorders. Inflammatory mediators such as cytokines, chemokines, endocannabinoids, eicosanoids, lysophospholipids, and bacterial products are involved in both psychosis and substance use disorders. The abnormal neurodevelopment caused by neuroinflammation may be a common origin for these disorders, and the transcriptional factors NF kappa B and PPAR gamma may play a role in this process.
Article
Immunology
Yingchun Su, Yanting Liu, Dewei He, Guiqiu Hu, Hefei Wang, Bojian Ye, Yuan He, Xiyu Gao, Dianfeng Liu
Summary: Parkinson's disease is a common disease caused by degeneration of the central nervous system, characterized by the death of dopaminergic neurons. Neuroinflammation, particularly the excessive activation of microglia, plays a significant role in its pathogenesis. Hordenine has been found to have anti-oxidant and anti-inflammatory properties, and this study reveals its potential in inhibiting neuroinflammation by suppressing microglial activation and protecting dopaminergic neurons.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Jing Dai, Xue Li, Cai Wang, Shuxin Gu, Lei Dai, Jingyun Zhang, Yunxia Fan, Jing Wu
Summary: The study revealed that repeated sevoflurane exposure in developing rats may induce neuroinflammation and neurocognitive impairment through NF-kappa B-mediated pyroptosis activation. This suggests a potential therapeutic target in treating neuroinflammation following neonatal anesthesia.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Multidisciplinary Sciences
Rukiye Aydin, Mine Baris, Ceren Durmaz-Engin, Lama A. Al-Aswad, Dana M. Blumberg, George A. Cioffi, Jeffrey M. Liebmann, Tongalp H. Tezel, Gulgun Tezel
Summary: Glaucoma is a chronic neurodegenerative disease of the optic nerve and a leading cause of irreversible blindness worldwide. Experimental research using animal models provides information about cellular and molecular processes, while the analysis of the clinical presentation accelerates progress towards improved understanding, treatment, and clinical testing of glaucoma. Early localized alterations in the inner plexiform layer (IPL) are associated with progressing visual field defects in glaucomatous eyes.
Letter
Ophthalmology
Mine Esen Baris, Mukaddes Damla Ciftci, Melis Palamar, Suzan Guven Yilmaz
Summary: This case report describes a 45-day-old infant with iris juvenile xanthogranuloma presenting with hypopyon, which regressed after treatment. Two months later, the patient developed spontaneous hyphema, which was resolved with topical medication. Ocular involvement should be considered in young children with hypopyon and/or hyphema, as it may be a manifestation of juvenile xanthogranuloma.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)
Article
Ophthalmology
Jale Mentes, Mine Esen Baris
Summary: This case report highlights the presence of bilateral quiescent type 1 neovascularizations in a patient with BVMD, emphasizing the superiority of OCTA in detecting them.
TURK OFTALMOLOJI DERGISI-TURKISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Pelin Kiyat, Jale Mentes, Serhad Nalcaci, Filiz Afrashi, Mine Baris
Summary: The study evaluated the functional and anatomical responses to IVA treatment in newly diagnosed and untreated nvAMD cases, finding successful outcomes with 3 or 6 doses of IVA. Among baseline characteristics, the presence of pigment epithelial detachment and serous pigment epithelial detachment were identified as negative factors affecting treatment response.
TURK OFTALMOLOJI DERGISI-TURKISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Mine Esen Baris, Suzan Guven Yilmaz, Melis Palamar
Summary: This study evaluated the impact of prolonged surgical mask wearing on dry eye symptoms and tear film break-up time in healthcare professionals. The results showed that wearing a mask for the entire work-day worsened tear film break-up time and increased dry eye symptoms.
INTERNATIONAL OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Seray Sahin, Onur Furundaoturan, Mine Esen Baris, Elif Demirkilinc Biler
Summary: A 29-year-old man experienced sudden vision loss after a closed-globe injury. Examination revealed an excavation at the optic nerve head, indicating optic nerve avulsion. Magnetic resonance imaging confirmed optic nerve avulsion without damage to the optic nerve sheath. Four months later, the patient's visual acuity remained unchanged with gliosis at the avulsion site. Closed-globe injuries can result in severe posterior damage and should be carefully examined with appropriate imaging to confirm the diagnosis.
TURK OFTALMOLOJI DERGISI-TURKISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Genetics & Heredity
Onur Furundaoturan, Mine Esen Baris, Durdugul Ayyildiz Emecen, Elif Demirkilinc Biler
OPHTHALMIC GENETICS
(2023)
Article
Ophthalmology
Jale Mentes, Mine Esen Baris
Summary: The objective of this study was to determine the prevalence of polypoidal choroidal vasculopathy (PCV) in intravitreal anti-vascular endothelial growth factor (anti-VEGF)-resistant neovascular age-related macular degeneration (nvAMD) cases. The study found that the prevalence rate of PCV was quite high (63.9%) among eyes with intravitreal anti-VEGF treatment-resistant nvAMD in Turkey. It is recommended to conduct indocyanine angiography (ICGA) evaluation for all nvAMD cases that are non-responsive to intravitreal anti-VEGF treatment to understand the reason for resistance and modify the treatment as necessary.
TURK OFTALMOLOJI DERGISI-TURKISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Mine Esen Baris, Funda Kuscu Akdeniz, Idil Unal, Suzan Guven Yilmaz
Summary: The purpose of this study was to evaluate changes in retinal vascularity in patients with severe psoriasis. Detailed ophthalmological examinations were performed on both severe psoriasis patients and control group, and it was found that the vessel densities in the superficial and deep capillary plexus were lower in psoriasis group. Psoriasis patients with psoriatic arthritis also had lower foveal vessel density in the retina.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Ophthalmology
Mohammad Avarand, Mine Esen Baris, Leila Taheri, Suzan Guven Yilmaz
Summary: This study reports the efficacy of pegylated interferon alpha-2a in uveitic macular edema refractory to biologic agents.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Ophthalmology
Mine Esen Baris, Jale Mentes, Filiz Afrashi, Serhad Nalcaci, Cezmi Akkin
TURK OFTALMOLOJI DERGISI-TURKISH JOURNAL OF OPHTHALMOLOGY
(2020)
Meeting Abstract
Ophthalmology
Xiangjun Yang, Jian Cai, Mine Baris, Jon B. Klein, Gulgun Tezel
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2019)
Meeting Abstract
Ophthalmology
Gulgun Tezel, Xiangjun Yang, Jian Cai, Mine Baris, Jon B. Klein
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2019)
Meeting Abstract
Ophthalmology
Mine Baris, Lama Al-Aswad, Dana Blumberg, George Cioffi, Jeffrey M. Liebmann, Tongalp H. Tezel, Gulgun Tezel
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2019)