Detecting retinal cell stress and apoptosis with DARC: Progression from lab to clinic

Artificial intelligence in OCT angiography

(2021) Tristan T. Hormel et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Risk factors for progression of age‐related macular degeneration

(2020) Thomas J Heesterbeek et al.   OPHTHALMIC AND PHYSIOLOGICAL OPTICS

MS optic neuritis-induced long-term structural changes within the visual pathway

(2020) Marc Pawlitzki et al.   Neurology-Neuroimmunology & Neuroinflammation

Near-Infrared Reflectance Imaging for Quantification of Atrophy Associated with Age-Related Macular Degeneration

(2020) Nizar Saleh Abdelfattah et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

A CNN-aided method to predict glaucoma progression using DARC (Detection of Apoptosing Retinal Cells)

(2020) Eduardo M. Normando et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration

(2020) Kai Kaarniranta et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Diagnostic and prognostic value of circular RNA CDR1as/ciRS‐7 for solid tumours: A systematic review and meta‐analysis

(2020) Yutian Zou et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Clinical and biomarker changes of Alzheimer's disease in adults with Down syndrome: a cross-sectional study

(2020) Juan Fortea et al.   LANCET

Discovery and clinical translation of novel glaucoma biomarkers

(2020) Gala Beykin et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Incomplete response to Anti-VEGF therapy in neovascular AMD: Exploring disease mechanisms and therapeutic opportunities

(2020) Priyatham S. Mettu et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Extraocular, periocular, and intraocular routes for sustained drug delivery for glaucoma

(2020) Uday B. Kompella et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Retinal changes in Alzheimer's disease— integrated prospects of imaging, functional and molecular advances

(2020) Veer B. Gupta et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Recent advances in the development of activatable multifunctional probes for in vivo imaging of caspase-3

(2020) Pengzhan Wang et al.   CHINESE CHEMICAL LETTERS

Optic nerve head anatomy in myopia and glaucoma, including parapapillary zones alpha, beta, gamma and delta: Histology and clinical features

(2020) Ya Xing Wang et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Dynamic changes in cell size and corresponding cell fate after optic nerve injury

(2020) Benjamin M. Davis et al.   Scientific Reports

Assessing retinal ganglion cell death and neuroprotective agents using real time imaging

(2019) Azusa Ito et al.   BRAIN RESEARCH

OCT Structural Abnormality Detection in Glaucoma using Topographically Correspondent Rim and Retinal Nerve Fiber Layer Criteria

(2019) Hongli Yang et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Noninvasive evaluation of cerebrospinal fluid pressure in ocular hypertension: a preliminary study

(2018) Xiaobin Xie et al.   ACTA OPHTHALMOLOGICA

Forecasting the prevalence of preclinical and clinical Alzheimer's disease in the United States

(2018) Ron Brookmeyer et al.   Alzheimers & Dementia

LDL-Cholesterol Is Not the Only Clinically Relevant Biomarker for Coronary Artery Disease or Acute Coronary Syndrome

(2018) Patrick A. Field et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Therapeutic Potential of Annexin A1 in Ischemia Reperfusion Injury

(2018) Junaid Ansari et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Annexins in Glaucoma

(2018) Timothy Yap et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

OCT is an alternative to MRI for monitoring MS – YES

(2018) Elias S Sotirchos et al.   Multiple Sclerosis Journal

Towards the application of precision medicine in Age-Related Macular Degeneration

(2018) Raffaella Cascella et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Neuroprotective strategies for retinal disease

(2018) Machelle T. Pardue et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Inflammation, neurodegeneration and protein aggregation in the retina as ocular biomarkers for Alzheimer’s disease in the 3xTg-AD mouse model

(2018) Alfonso Grimaldi et al.   Cell Death & Disease

In vivo imaging of adeno-associated viral vector labelled retinal ganglion cells

(2018) Corey A. Smith et al.   Scientific Reports

OCT is an alternative to MRI for monitoring MS – YES

(2018) Elias S Sotirchos et al.   Multiple Sclerosis Journal

Clinically applicable deep learning for diagnosis and referral in retinal disease

(2018) Jeffrey De Fauw et al.   NATURE MEDICINE

Retinal thinning associates with nigral dopaminergic loss in de novo Parkinson disease

(2018) Jeeyun Ahn et al.   NEUROLOGY

Did you choose appropriate tracer for retrograde tracing of retinal ganglion cells? The differences between cholera toxin subunit B and Fluorogold

(2018) Fei Yao et al.   PLoS One

OPTICAL COHERENCE TOMOGRAPHY, FLUORESCEIN ANGIOGRAPHY, AND DIAGNOSIS OF CHOROIDAL NEOVASCULARIZATION IN AGE-RELATED MACULAR DEGENERATION

(2018) Vincent Gualino et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Artificial intelligence and deep learning in ophthalmology

(2018) Daniel Shu Wei Ting et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

To the edge of cell death and back

(2018) Yi-Nan Gong et al.   FEBS Journal

Optical Coherence Tomography Reveals Retinal Neuroaxonal Thinning in Frontotemporal Dementia as in Alzheimer’s Disease

(2017) Laura Ferrari et al.   JOURNAL OF ALZHEIMERS DISEASE

Glaucoma

(2017) Jost B Jonas et al.   LANCET

Retinal layer segmentation in multiple sclerosis: a systematic review and meta-analysis

(2017) Axel Petzold et al.   LANCET NEUROLOGY

Topical Coenzyme Q10 demonstrates mitochondrial-mediated neuroprotection in a rodent model of ocular hypertension

(2017) Benjamin Michael Davis et al.   MITOCHONDRION

Detecting Structural Progression in Glaucoma with Optical Coherence Tomography

(2017) Andrew J. Tatham et al.   OPHTHALMOLOGY

Imaging and quantifying ganglion cells and other transparent neurons in the living human retina

(2017) Zhuolin Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adaptive optics optical coherence tomography in glaucoma

(2017) Zachary M. Dong et al.   PROGRESS IN RETINAL AND EYE RESEARCH

The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD

(2017) Sayantan Datta et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Primary angle closure glaucoma: What we know and what we don’t know

(2017) Xinghuai Sun et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Detection and measurement of clinically meaningful visual field progression in clinical trials for glaucoma

(2017) C. Gustavo De Moraes et al.   PROGRESS IN RETINAL AND EYE RESEARCH

THE PATHOPHYSIOLOGY OF GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION AND THE COMPLEMENT PATHWAY AS A THERAPEUTIC TARGET

(2017) David S. Boyer et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

An enhanced bioluminescence-based Annexin V probe for apoptosis detection in vitro and in vivo

(2017) Trajen Head et al.   Cell Death & Disease

Glaucoma: the retina and beyond

(2016) Benjamin Michael Davis et al.   ACTA NEUROPATHOLOGICA

Gold nanoparticles-based SPECT/CT imaging probe targeting for vulnerable atherosclerosis plaques

(2016) Xiao Li et al.   BIOMATERIALS

Exposure of phosphatidylserine on the cell surface

(2016) S Nagata et al.   CELL DEATH AND DIFFERENTIATION

Annexin A5 Increases Survival in Murine Sepsis Model by Inhibiting HMGB1-Mediated Proinflammation and Coagulation

(2016) Jung Hwa Park et al.   MOLECULAR MEDICINE

Risk of Visual Field Progression in Glaucoma Patients with Progressive Retinal Nerve Fiber Layer Thinning

(2016) Marco Yu et al.   OPHTHALMOLOGY

Risk factors and biomarkers of age-related macular degeneration

(2016) Nathan G. Lambert et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Non-amyloidogenic effects of α2 adrenergic agonists: implications for brimonidine-mediated neuroprotection

(2016) Shereen Nizari et al.   Cell Death & Disease

Robust high-throughput kinetic analysis of apoptosis with real-time high-content live-cell imaging

(2016) Jesse D Gelles et al.   Cell Death & Disease

The retina as an early biomarker of neurodegeneration in a rotenone-induced model of Parkinson’s disease: evidence for a neuroprotective effect of rosiglitazone in the eye and brain

(2016) Eduardo Maria Normando et al.   Acta Neuropathologica Communications

Anesthesia-Induced Neuronal Apoptosis in the Developing Retina

(2015) Ying Cheng et al.   ANESTHESIA AND ANALGESIA

Optical coherence tomography reflects brain atrophy in multiple sclerosis: A four-year study

(2015) Shiv Saidha et al.   ANNALS OF NEUROLOGY

The Diagnosis and Treatment of Optic Neuritis

(2015) Helmut Wilhelm et al.   Deutsches Arzteblatt International

99mTc-Annexin A5 quantification of apoptotic tumor response: a systematic review and meta-analysis of clinical imaging trials

(2015) Tarik Z. Belhocine et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Neuroprotective effect of memantine on the retinal ganglion cells of APPswe/PS1ΔE9 mice and its immunomodulatory mechanisms

(2015) Lixiong Gao et al.   EXPERIMENTAL EYE RESEARCH

Adenosine A 3 receptor activation is neuroprotective against retinal neurodegeneration

(2015) Joana Galvao et al.   EXPERIMENTAL EYE RESEARCH

Optical coherence tomography as a tool to evaluate retinal changes in Parkinson's disease

(2015) Pooja Mailankody et al.   PARKINSONISM & RELATED DISORDERS

Hyperspectral Imaging Signatures Detect Amyloidopathy in Alzheimer’s Mouse Retina Well before Onset of Cognitive Decline

(2014) Swati S. More et al.   ACS Chemical Neuroscience

Correlation of Retinal Nerve Fiber Layer Thickness and Visual Fields in Glaucoma: A Broken Stick Model

(2014) Tarek Alasil et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

α-synuclein in the inner retina in parkinson disease

(2014) Ivan Bodis-Wollner et al.   ANNALS OF NEUROLOGY

Relations of low contrast visual acuity, quality of life and multiple sclerosis functional composite: a cross-sectional analysis

(2014) Johann Schinzel et al.   BMC Neurology

Intraocular pressure variations: Causes and clinical significance

(2014) Arthur J. Sit   CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE

Brain PET in the Diagnosis of Alzheimer’s Disease

(2014) Charles Marcus et al.   CLINICAL NUCLEAR MEDICINE

The Pathophysiology and Treatment of Glaucoma

(2014) Robert N. Weinreb et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A Dual-Labeled Annexin A5 is not Suited for SPECT Imaging of Brain Cell Death in Experimental Murine Stroke

(2014) Marietta Zille et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Effect of the Aβ Aggregation Modulator MRZ-99030 on Retinal Damage in an Animal Model of Glaucoma

(2014) T. E. Salt et al.   NEUROTOXICITY RESEARCH

γ-Synuclein Antibodies Have Neuroprotective Potential on Neuroretinal Cells via Proteins of the Mitochondrial Apoptosis Pathway

(2014) Corina Wilding et al.   PLoS One

Role of Flippases, Scramblases and Transfer Proteins in Phosphatidylserine Subcellular Distribution

(2014) Hannah M. Hankins et al.   TRAFFIC

High-Resolution Imaging of Retinal Nerve Fiber Bundles in Glaucoma Using Adaptive Optics Scanning Laser Ophthalmoscopy

(2013) Kohei Takayama et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Beta-Amyloid, Phospho-Tau and Alpha-Synuclein Deposits Similar to Those in the Brain Are Not Identified in the Eyes of Alzheimer's and Parkinson's Disease Patients

(2013) Cheng-Ying Ho et al.   BRAIN PATHOLOGY

The potential of annexin-labelling for the diagnosis and follow-up of glaucoma

(2013) Eduardo M. Normando et al.   CELL AND TISSUE RESEARCH

Unexpected low-dose toxicity of the universal solvent DMSO

(2013) Joana Galvao et al.   FASEB JOURNAL

Inflammatory demyelination induces glia alterations and ganglion cell loss in the retina of an experimental autoimmune encephalomyelitis model

(2013) Lioba Horstmann et al.   Journal of Neuroinflammation

Progress on retinal image analysis for age related macular degeneration

(2013) Yogesan Kanagasingam et al.   PROGRESS IN RETINAL AND EYE RESEARCH

The attenuation of retinal nerve fiber layer thickness and cognitive deterioration

(2013) Yuan Shen et al.   Frontiers in Cellular Neuroscience

Delay to Treatment and Visual Outcomes in Patients Treated With Anti-Vascular Endothelial Growth Factor for Age-Related Macular Degeneration

(2012) Jonathan H. Lim et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Protection of the Membrane Permeability Barrier by Annexins

(2012) Carl E. Creutz et al.   BIOCHEMISTRY

Improved resistance to ischemia and reperfusion, but impaired protection by ischemic preconditioning in patients with type 1 diabetes mellitus: a pilot study

(2012) Richard Engbersen et al.   Cardiovascular Diabetology

Annexin A2 and A5 Serve as New Ligands for C1q on Apoptotic Cells

(2012) Myriam Martin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Annexin A5 stimulates autophagy and inhibits endocytosis

(2012) G. Ghislat et al.   JOURNAL OF CELL SCIENCE

Alzheimer’s Disease in the Retina: Imaging Retinal Aß Plaques for Early Diagnosis and Therapy Assessment

(2012) Yosef Koronyo et al.   Neurodegenerative Diseases

Mechanisms of Age-Related Macular Degeneration

(2012) Jayakrishna Ambati et al.   NEURON

Ganglion Cell Loss in Relation to Visual Disability in Multiple Sclerosis

(2012) Scott D. Walter et al.   OPHTHALMOLOGY

The Age-related Eye Disease Study 2 (AREDS2)

(2012) Emily Y. Chew et al.   OPHTHALMOLOGY

Glaucoma 2.0: Neuroprotection, Neuroregeneration, Neuroenhancement

(2012) Elma E. Chang et al.   OPHTHALMOLOGY

Orbital Cerebrospinal Fluid Space in Glaucoma: The Beijing Intracranial and Intraocular Pressure (iCOP) Study

(2012) Ningli Wang et al.   OPHTHALMOLOGY

Critical pathogenic events underlying progression of neurodegeneration in glaucoma

(2012) David J. Calkins   PROGRESS IN RETINAL AND EYE RESEARCH

Optical coherence tomography segmentation reveals ganglion cell layer pathology after optic neuritis

(2011) Stephanie B. Syc et al.   BRAIN

Retinal thickness in patients with mild cognitive impairment and Alzheimer's disease

(2011) Anat Kesler et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Angiotensin II Type 1 Receptor Blockade Does Not Enhance Apoptotic Cell Death During Ischemia and Reperfusion in Humans In Vivo

(2011) Patrick Meijer et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Rotenone induces degeneration of photoreceptors and impairs the dopaminergic system in the rat retina

(2011) Julián Esteve-Rudd et al.   NEUROBIOLOGY OF DISEASE

Enhanced Depth Imaging Detects Lamina Cribrosa Thickness Differences in Normal Tension Glaucoma and Primary Open-Angle Glaucoma

(2011) Hae-Young Lopilly Park et al.   OPHTHALMOLOGY

Association of Retinal and Macular Damage with Brain Atrophy in Multiple Sclerosis

(2011) Jan Dörr et al.   PLoS One

Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration

(2011) J.-D. Ding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Superoxide is an associated signal for apoptosis in axonal injury

(2010) A. Kanamori et al.   BRAIN

Evidence of outer retinal changes in glaucoma patients as revealed by ultrahigh-resolution in vivo retinal imaging

(2010) S. S. Choi et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Reproducibility of Retinal Nerve Fiber Layer Thickness Measurements Using Spectral Domain Optical Coherence Tomography

(2010) Huijuan Wu et al.   JOURNAL OF GLAUCOMA

Characterisation of neuronal cell death in acute and delayed in vitro ischemia (oxygen–glucose deprivation) models

(2010) Bruno P. Meloni et al.   JOURNAL OF NEUROSCIENCE METHODS

Annexin A5 Uptake in Ischemic Myocardium: Demonstration of Reversible Phosphatidylserine Externalization and Feasibility of Radionuclide Imaging

(2010) H. Kenis et al.   JOURNAL OF NUCLEAR MEDICINE

Identification of amyloid plaques in retinas from Alzheimer's patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model

(2010) Maya Koronyo-Hamaoui et al.   NEUROIMAGE

Mitochondrial optic neuropathies – Disease mechanisms and therapeutic strategies

(2010) Patrick Yu-Wai-Man et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Imaging of apoptosis in the heart with nanoparticle technology

(2010) Howard H. Chen et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Imaging multiple phases of neurodegeneration: a novel approach to assessing cell death in vivo

(2010) M F Cordeiro et al.   Cell Death & Disease

Rosuvastatin Increases Extracellular Adenosine Formation in Humans In Vivo

(2009) Patrick Meijer et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The annexins: spatial and temporal coordination of signaling events during cellular stress

(2009) Katia Monastyrskaya et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Clinical use and research applications of Heidelberg retinal angiography and spectral-domain optical coherence tomography - a review

(2009) Andrea Hassenstein et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

99mTc-HYNIC-rh-annexin-V scintigraphy: visual and quantitative evaluation of early treatment-induced apoptosis to predict treatment outcome

(2009) Marina S. Kartachova et al.   NUCLEAR MEDICINE COMMUNICATIONS

In-vivo-Imaging retinaler Zellapoptose nach akuter Lichtexposition

(2009) S. Schmitz-Valckenberg et al.   OPHTHALMOLOGE

Imaging and dosimetry of 99mTc EC annexin V: Preliminary clinical study targeting apoptosis in breast tumors

(2008) Hiroaki Kurihara et al.   APPLIED RADIATION AND ISOTOPES

Inflammatory demyelination induces axonal injury and retinal ganglion cell apoptosis in experimental optic neuritis

(2008) Kenneth S. Shindler et al.   EXPERIMENTAL EYE RESEARCH