Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction

When Is a Control Not a Control? Reactive Microglia Occur Throughout the Control Contralateral Pathway of Retinal Ganglion Cell Projections in Experimental Glaucoma

(2021) James R. Tribble et al.   Translational Vision Science & Technology

Retinal Ganglion Cell Degeneration in a Rat Magnetic Bead Model of Ocular Hypertensive Glaucoma

(2021) James R. Tribble et al.   Translational Vision Science & Technology

Niacin Cures Systemic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy

(2020) Eija Pirinen et al.   Cell Metabolism

Neuroprotection: A versatile approach to combat glaucoma

(2020) Santoshi Naik et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Programmed axon degeneration: from mouse to mechanism to medicine

(2020) Michael P. Coleman et al.   NATURE REVIEWS NEUROSCIENCE

Improvement in inner retinal function in glaucoma with nicotinamide (vitamin B3 ) supplementation: A crossover randomized clinical trial

(2020) Flora Hui et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Nicotinamide-Rich Diet in DBA/2J Mice Preserves Retinal Ganglion Cell Metabolic Function as Assessed by PERG Adaptation to Flicker

(2020) Tsung-Han Chou et al.   Nutrients

Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity

(2019) Kathryn Cimdins et al.   MOLECULAR NEUROBIOLOGY

Extracellular ATP and β-NAD alter electrical properties and cholinergic effects in the rat heart in age-specific manner

(2019) Ksenia B. Pustovit et al.   Purinergic Signalling

Lactate-Mediated Protection of Retinal Ganglion Cells

(2019) Rupali Vohra et al.   JOURNAL OF MOLECULAR BIOLOGY

Hyperhomocysteinemia-induced death of retinal ganglion cells: The role of Müller glial cells and NRF2

(2019) Soumya Navneet et al.   Redox Biology

Insulin signalling promotes dendrite and synapse regeneration and restores circuit function after axonal injury

(2018) Jessica Agostinone et al.   BRAIN

NAD+supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

(2018) Yujun Hou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The coma in glaucoma: Retinal ganglion cell dysfunction and recovery

(2018) Lewis E. Fry et al.   PROGRESS IN RETINAL AND EYE RESEARCH

The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson’s Disease

(2018) David C. Schöndorf et al.   Cell Reports

Pharmacological bypass of NAD+ salvage pathway protects neurons from chemotherapy-induced degeneration

(2018) Hui-wen Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vitamin B3 forms as precursors to NAD+: Are they safe?

(2018) B. Poljsak et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Glaucoma as a Metabolic Optic Neuropathy

(2017) Pete A. Williams et al.   JOURNAL OF GLAUCOMA

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

(2017) Vincenzo Sorrentino et al.   NATURE

Vitamin B 3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice

(2017) Pete A. Williams et al.   SCIENCE

NAD+ Attenuates Bilirubin-Induced Hyperexcitation in the Ventral Cochlear Nucleus by Inhibiting Excitatory Neurotransmission and Neuronal Excitability

(2017) Min Liang et al.   Frontiers in Cellular Neuroscience

Nicotinamide and WLDS Act Together to Prevent Neurodegeneration in Glaucoma

(2017) Pete A. Williams et al.   Frontiers in Neuroscience

Mitochondrial Dynamics Is Linked to Longevity and Protects from End-Organ Injury: The Emerging Role of Sirtuin 3

(2016) Ariela Benigni et al.   ANTIOXIDANTS & REDOX SIGNALING

Effects of Nicotinamide Adenine Dinucleotide (NAD+) and Diadenosine Tetraphosphate (Ap4A) on Electrical Activity of Working and Pacemaker Atrial Myocardium in Guinea Pigs

(2016) K. B. Pustovit et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma

(2016) Pete A. Williams et al.   Molecular Neurodegeneration

KymoAnalyzer: a software tool for the quantitative analysis of intracellular transport in neurons

(2016) Sylvia Neumann et al.   TRAFFIC

NAMPT-Mediated NAD + Biosynthesis Is Essential for Vision In Mice

(2016) Jonathan B. Lin et al.   Cell Reports

Glia-Neuron Interactions in the Retina Can Be Studied in Cocultures of Müller Cells and Retinal Ganglion Cells

(2016) D. M. Skytt et al.   Biomed Research International

Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer’s disease-relevant murine model

(2015) Aaron N Long et al.   BMC Neurology

SARM1 activation triggers axon degeneration locally via NAD+ destruction

(2015) J. Gerdts et al.   SCIENCE

NAD+ in aging, metabolism, and neurodegeneration

(2015) E. Verdin   SCIENCE

circlize implements and enhances circular visualization in R

(2014) Zuguang Gu et al.   BIOINFORMATICS

A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

(2014) M Di Stefano et al.   CELL DEATH AND DIFFERENTIATION

Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3

(2014) Nahid A Khan et al.   EMBO Molecular Medicine

Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040

(2014) Yih-Chung Tham et al.   OPHTHALMOLOGY

Factors associated with lifetime risk of open-angle glaucoma blindness

(2013) Dorothea Peters et al.   ACTA OPHTHALMOLOGICA

VEGF-A Is Necessary and Sufficient for Retinal Neuroprotection in Models of Experimental Glaucoma

(2013) Richard H. Foxton et al.   AMERICAN JOURNAL OF PATHOLOGY

Dual control of mitochondrial biogenesis by sirtuin 1 and sirtuin 3

(2013) Julia Brenmoehl et al.   MITOCHONDRION

Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models

(2013) Bing Gong et al.   NEUROBIOLOGY OF AGING

Retina ganglion cell degeneration in glaucoma: an opportunity missed? A review

(2012) James E Morgan   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Oxidative stress and mitochondrial dysfunction in glaucoma

(2012) Vicki Chrysostomou et al.   CURRENT OPINION IN PHARMACOLOGY

Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma

(2012) Gareth R. Howell et al.   JOURNAL OF CLINICAL INVESTIGATION

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Web-based inference of biological patterns, functions and pathways from metabolomic data using MetaboAnalyst

(2011) Jianguo Xia et al.   Nature Protocols

Synthesis and transport of creatine in the CNS: importance for cerebral functions

(2010) Elidie Béard et al.   JOURNAL OF NEUROCHEMISTRY

Targeting NMNAT1 to Axons and Synapses Transforms Its Neuroprotective Potency In Vivo

(2010) E. Babetto et al.   JOURNAL OF NEUROSCIENCE

Metabolic Vulnerability Disposes Retinal Ganglion Cell Axons to Dysfunction in a Model of Glaucomatous Degeneration

(2010) S. Baltan et al.   JOURNAL OF NEUROSCIENCE

Overexpression of Wldsor Nmnat2 in mauthner cells by single-cell electroporation delays axon degeneration in live zebrafish

(2010) Yan Feng et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Neurodegeneration in glaucoma: progression and calcium-dependent intracellular mechanisms

(2010) S.D. Crish et al.   NEUROSCIENCE

Endogenous Nmnat2 Is an Essential Survival Factor for Maintenance of Healthy Axons

(2010) Jonathan Gilley et al.   PLOS BIOLOGY

Cellular Regulation of SIRT1

(2009) Jo Milner   CURRENT PHARMACEUTICAL DESIGN

Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases

(2009) H. Chen et al.   HUMAN MOLECULAR GENETICS

MetaboAnalyst: a web server for metabolomic data analysis and interpretation

(2009) J. Xia et al.   NUCLEIC ACIDS RESEARCH

High doses of nicotinamide prevent oxidative mitochondrial dysfunction in a cellular model and improve motor deficit in aDrosophilamodel of Parkinson's disease

(2008) Haiqun Jia et al.   JOURNAL OF NEUROSCIENCE RESEARCH