Deficiency of ligase IV leads to reduced NHEJ, accumulation of DNA damage, and can sensitize cells to cancer therapeutics

Depletion of RNASEH2 Activity Leads to Accumulation of DNA Double-strand Breaks and Reduced Cellular Survivability in T Cell Leukemia

(2022) Dipayan Ghosh et al.   JOURNAL OF MOLECULAR BIOLOGY

Novel CRISPR/Cas9-mediated knockout of LIG4 increases efficiency of site-specific integration in Chinese hamster ovary cell line

(2022) Chuanjie Wang et al.   BIOTECHNOLOGY LETTERS

Identification and characterization of mercaptopyrimidine‐based small molecules as inhibitors of nonhomologous DNA end joining

(2022) Ujjayinee Ray et al.   FEBS Journal

Catalytically inactive DNA ligase IV promotes DNA repair in living cells

(2022) Noah J Goff et al.   NUCLEIC ACIDS RESEARCH

Nonamer dependent RAG cleavage at CpGs can explain mechanism of chromosomal translocations associated to lymphoid cancers

(2022) Amita M. Paranjape et al.   PLoS Genetics

A novel KU70-mutant human leukemic cell line generated using CRISPR-Cas9 shows increased sensitivity to DSB inducing agents and reduced NHEJ activity

(2022) Dipayan Ghosh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Unleashing a novel function of Endonuclease G in mitochondrial genome instability

(2022) Sumedha Dahal et al.   eLife

20 years of DNA Polymerase μ, the polymerase that still surprises

(2021) Dipayan Ghosh et al.   FEBS Journal

G4 DNA present at human telomeric DNA contributes toward reduced sensitivity to γ-radiation induced oxidative damage, but not bulky adduct formation

(2021) Ujjayinee Ray et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

SCR7, an inhibitor of NHEJ can sensitize tumor cells to ionization radiation

(2021) Vidya Gopalakrishnan et al.   MOLECULAR CARCINOGENESIS

Nonhomologous end joining: new accessory factors fine tune the machinery

(2021) Dipayan Ghosh et al.   TRENDS IN GENETICS

MicroRNA miR-29c regulates RAG1 expression and modulates V(D)J recombination during B cell development

(2021) Rupa Kumari et al.   Cell Reports

Understanding the DNA double-strand break repair and its therapeutic implications

(2021) Ujjayinee Ray et al.   DNA REPAIR

Identification and characterization of novel SCR7‐based small‐molecule inhibitor of DNA end‐joining, SCR130 and its relevance in cancer therapeutics

(2020) Ujjayinee Ray et al.   MOLECULAR CARCINOGENESIS

Inhibition of DNA ligase IV enhances the CRISPR/Cas9-mediated knock-in efficiency in mouse brain neurons

(2020) Xueshan Cao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterization of G-quadruplex antibody reveals differential specificity for G4 DNA forms

(2020) Saniya M Javadekar et al.   DNA RESEARCH

Inhibition of DNA Repair in Cancer Therapy: Toward a Multi-Target Approach

(2020) Samuele Lodovichi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Modulation of DNA double-strand break repair as a strategy to improve precise genome editing

(2020) Ujjayinee Ray et al.   ONCOGENE

Whole-exome sequencing of cervical carcinomas identifies activating ERBB2 and PIK3CA mutations as targets for combination therapy

(2019) Luca Zammataro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular targeted therapy: treating cancer with specificity

(2018) Yeuan Ting Lee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

MRN complex-dependent recruitment of ubiquitylated BLM helicase to DSBs negatively regulates DNA repair pathways

(2018) Vivek Tripathi et al.   Nature Communications

Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis

(2018) Andrea M. Kaminski et al.   Nature Communications

Autocyclized and Oxidized Forms of SCR7 Induce Cancer Cell Death by Inhibiting Nonhomologous DNA End joining in a Ligase IV Dependent Manner

(2018) Supriya V. Vartak et al.   FEBS Journal

Ribonucleotide incorporation enables repair of chromosome breaks by nonhomologous end joining

(2018) John M. Pryor et al.   SCIENCE

Characterization of DNA double-strand break repair pathways in diffuse large B cell lymphoma

(2018) Vidya Gopalakrishnan et al.   MOLECULAR CARCINOGENESIS

Bilirubin-Induced Oxidative Stress Leads to DNA Damage in the Cerebellum of Hyperbilirubinemic Neonatal Mice and Activates DNA Double-Strand Break Repair Pathways in Human Cells

(2018) Vipin Rawat et al.   Oxidative Medicine and Cellular Longevity

Non-homologous DNA end joining and alternative pathways to double-strand break repair

(2017) Howard H. Y. Chang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Small molecules enhance CRISPR/Cas9-mediated homology-directed genome editing in primary cells

(2017) Guoling Li et al.   Scientific Reports

Induction of DNA damage and erroneous repair can explain genomic instability caused by endosulfan

(2016) Robin Sebastian et al.   CARCINOGENESIS

Microhomology-mediated end joining is the principal mediator of double-strand break repair during mitochondrial DNA lesions

(2016) Satish Kumar Tadi et al.   MOLECULAR BIOLOGY OF THE CELL

DNA ligase IV syndrome; a review

(2016) Thomas Altmann et al.   Orphanet Journal of Rare Diseases

Genomic landscape of DNA repair genes in cancer

(2016) Young Kwang Chae et al.   Oncotarget

PAXX Is an Accessory c-NHEJ Factor that Associates with Ku70 and Has Overlapping Functions with XLF

(2016) Satish K. Tadi et al.   Cell Reports

Enrichment of G2/M cell cycle phase in human pluripotent stem cells enhances HDR-mediated gene repair with customizable endonucleases

(2016) Diane Yang et al.   Scientific Reports

DNA Double-Strand Break Repair Inhibitors as Cancer Therapeutics

(2015) Mrinal Srivastava et al.   CHEMISTRY & BIOLOGY

Snaps and mends: DNA breaks and chromosomal translocations

(2015) Saniya M. Javadekar et al.   FEBS Journal

Whole genomes redefine the mutational landscape of pancreatic cancer

(2015) Nicola Waddell et al.   NATURE

Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining

(2015) Takeshi Maruyama et al.   NATURE BIOTECHNOLOGY

Homology and enzymatic requirements of microhomology-dependent alternative end joining

(2015) S Sharma et al.   Cell Death & Disease

Mitochondrial DNA Ligase Is Dispensable for the Viability of Cultured Cells but Essential for mtDNA Maintenance

(2013) Inna N. Shokolenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA Ligases I and III Cooperate in Alternative Non-Homologous End-Joining in Vertebrates

(2013) Katja Paul et al.   PLoS One

Propyl-2-(8-(3,4-Difluorobenzyl)-2′,5′-Dioxo-8-Azaspiro[Bicyclo[3.2.1] Octane-3,4′-Imidazolidine]-1′-yl) Acetate Induces Apoptosis in Human Leukemia Cells through Mitochondrial Pathway following Cell Cycle Arrest

(2013) Chandagirikoppal V. Kavitha et al.   PLoS One

An Inhibitor of Nonhomologous End-Joining Abrogates Double-Strand Break Repair and Impedes Cancer Progression

(2012) Mrinal Srivastava et al.   CELL

Chromosomal translocations among the healthy human population: implications in oncogenesis

(2012) Mridula Nambiar et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mechanism of Fragility atBCL2Gene Minor Breakpoint Cluster Region during t(14;18) Chromosomal Translocation

(2012) Mridula Nambiar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Time-Dependent Predominance of Nonhomologous DNA End-Joining Pathways during Embryonic Development in Mice

(2012) Kishore K. Chiruvella et al.   JOURNAL OF MOLECULAR BIOLOGY

The biology of personalized cancer medicine: Facing individual complexities underlying hallmark capabilities

(2012) Michele De Palma et al.   Molecular Oncology

Human LIGIV is synthetically lethal with the loss of Rad54B-dependent recombination and is required for certain chromosome fusion events induced by telomere dysfunction

(2012) Sehyun Oh et al.   NUCLEIC ACIDS RESEARCH

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

Polymerases in Nonhomologous End Joining: Building a Bridge over Broken Chromosomes

(2010) Dale A. Ramsden   ANTIOXIDANTS & REDOX SIGNALING

Efficiency of nonhomologous DNA end joining varies among somatic tissues, despite similarity in mechanism

(2010) Sheetal Sharma et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cytosines, but Not Purines, Determine Recombination Activating Gene (RAG)-induced Breaks on Heteroduplex DNA Structures

(2010) Abani Kanta Naik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Dealing with DNA damage: Relationships between checkpoint and repair pathways

(2009) Daniël O. Warmerdam et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

Rational Design of Human DNA Ligase Inhibitors that Target Cellular DNA Replication and Repair

(2008) X. Chen et al.   CANCER RESEARCH

DNA and RNA ligases: structural variations and shared mechanisms

(2008) John M Pascal   CURRENT OPINION IN STRUCTURAL BIOLOGY

P1 nuclease cleavage is dependent on length of the mismatches in DNA

(2008) Abani Kanta Naik et al.   DNA REPAIR

Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair

(2008) Nicole Bennardo et al.   PLoS Genetics