Unleashing a novel function of Endonuclease G in mitochondrial genome instability

Depletion of RNASEH2 Activity Leads to Accumulation of DNA Double-strand Breaks and Reduced Cellular Survivability in T Cell Leukemia

(2022) Dipayan Ghosh et al.   JOURNAL OF MOLECULAR BIOLOGY

Characterization of G4 DNA formation in mitochondrial DNA and their potential role in mitochondrial genome instability

(2021) Sumedha Dahal et al.   FEBS Journal

MicroRNA miR-29c regulates RAG1 expression and modulates V(D)J recombination during B cell development

(2021) Rupa Kumari et al.   Cell Reports

Mitochondrial genetic variation is enriched in G-quadruplex regions that stall DNA synthesis in vitro

(2020) Thomas J Butler et al.   HUMAN MOLECULAR GENETICS

Identification and characterization of novel SCR7‐based small‐molecule inhibitor of DNA end‐joining, SCR130 and its relevance in cancer therapeutics

(2020) Ujjayinee Ray et al.   MOLECULAR CARCINOGENESIS

Characterization of G-quadruplex antibody reveals differential specificity for G4 DNA forms

(2020) Saniya M Javadekar et al.   DNA RESEARCH

G-quadruplex dynamics contribute to regulation of mitochondrial gene expression

(2019) M. Falabella et al.   Scientific Reports

A guide to computational methods for G-quadruplex prediction

(2019) Emilia Puig Lombardi et al.   NUCLEIC ACIDS RESEARCH

DNA Polymerase θ Increases Mutational Rates in Mitochondrial DNA

(2018) Simon Wisnovsky et al.   ACS Chemical Biology

Potential roles for G-quadruplexes in mitochondria

(2018) Micol Falabella et al.   CURRENT MEDICINAL CHEMISTRY

Endonuclease G promotes mitochondrial genome cleavage and replication

(2018) Rahel Stefanie Wiehe et al.   Oncotarget

Structural insights into DNA degradation by human mitochondrial nuclease MGME1

(2018) Chun Yang et al.   NUCLEIC ACIDS RESEARCH

G-quadruplex formation by single-base mutation or deletion of mitochondrial DNA sequences

(2018) I-Te Chu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Single-Molecule Analysis of mtDNA Replication Uncovers the Basis of the Common Deletion

(2017) Aaron F. Phillips et al.   MOLECULAR CELL

Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells

(2017) Lan-Feng Dong et al.   eLife

Role of endonuclease G in exogenous DNA stability in HeLa cells

(2016) V. Misic et al.   BIOCHEMISTRY-MOSCOW

Microhomology-mediated end joining is the principal mediator of double-strand break repair during mitochondrial DNA lesions

(2016) Satish Kumar Tadi et al.   MOLECULAR BIOLOGY OF THE CELL

GNG Motifs Can Replace a GGG Stretch during G-Quadruplex Formation in a Context Dependent Manner

(2016) Kohal Das et al.   PLoS One

Mitochondrial endonuclease G mediates breakdown of paternal mitochondria upon fertilization

(2016) Q. Zhou et al.   SCIENCE

A Novel Resveratrol Based Tubulin Inhibitor Induces Mitotic Arrest and Activates Apoptosis in Cancer Cells

(2016) Elizabeth Thomas et al.   Scientific Reports

Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA

(2015) An S. Tan et al.   Cell Metabolism

High-throughput sequencing of DNA G-quadruplex structures in the human genome

(2015) Vicki S Chambers et al.   NATURE BIOTECHNOLOGY

Homology and enzymatic requirements of microhomology-dependent alternative end joining

(2015) S Sharma et al.   Cell Death & Disease

Detection of G-Quadruplex DNA Using Primer Extension as a Tool

(2015) Rupa Kumari et al.   PLoS One

Association of G-quadruplex forming sequences with human mtDNA deletion breakpoints

(2014) Dawei W Dong et al.   BMC GENOMICS

DNA Sequences Proximal to Human Mitochondrial DNA Deletion Breakpoints Prevalent in Human Disease Form G-quadruplexes, a Class of DNA Structures Inefficiently Unwound by the Mitochondrial Replicative Twinkle Helicase

(2014) Sanjay Kumar Bharti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity

(2013) Weiqiang Lin et al.   EMBO JOURNAL

Mitochondrial Nucleases ENDOG and EXOG Participate in Mitochondrial DNA Depletion Initiated by Herpes Simplex Virus 1 UL12.5

(2013) B. A. Duguay et al.   JOURNAL OF VIROLOGY

G-Quadruplex Structures Formed at the HOX11 Breakpoint Region Contribute to Its Fragility during t(10;14) Translocation in T-Cell Leukemia

(2013) M. Nambiar et al.   MOLECULAR AND CELLULAR BIOLOGY

Pif1 family helicases suppress genome instability at G-quadruplex motifs

(2013) Katrin Paeschke et al.   NATURE

Quantitative visualization of DNA G-quadruplex structures in human cells

(2013) Giulia Biffi et al.   Nature Chemistry

An Appraisal of Human Mitochondrial DNA Instability: New Insights into the Role of Non-Canonical DNA Structures and Sequence Motifs

(2013) Pedro H. Oliveira et al.   PLoS One

A non-B DNA can replace heptamer of V(D)J recombination when present along with a nonamer: implications in chromosomal translocations and cancer

(2012) Mayilaadumveettil Nishana et al.   BIOCHEMICAL JOURNAL

An Inhibitor of Nonhomologous End-Joining Abrogates Double-Strand Break Repair and Impedes Cancer Progression

(2012) Mrinal Srivastava et al.   CELL

The Mitochondrial DNA 9-bp Deletion Polymorphism Is a Risk Factor for Hepatocellular Carcinoma in the Chinese Population

(2012) Yiqi Jin et al.   Genetic Testing and Molecular Biomarkers

Mechanism of Fragility atBCL2Gene Minor Breakpoint Cluster Region during t(14;18) Chromosomal Translocation

(2012) Mridula Nambiar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Time-Dependent Predominance of Nonhomologous DNA End-Joining Pathways during Embryonic Development in Mice

(2012) Kishore K. Chiruvella et al.   JOURNAL OF MOLECULAR BIOLOGY

Non-B DB v2.0: a database of predicted non-B DNA-forming motifs and its associated tools

(2012) Regina Z. Cer et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial DNA deletions are associated with non-B DNA conformations

(2012) Joana Damas et al.   NUCLEIC ACIDS RESEARCH

The mitochondrial DNA 4,977-bp deletion and its implication in copy number alteration in colorectal cancer

(2011) Tao Chen et al.   BMC Medical Genetics

RNA processing in human mitochondria

(2011) Maria I.G. Lopez Sanchez et al.   CELL CYCLE

Mitochondrial Insertion–Deletion Polymorphism: Role in Disease Pathology

(2011) Sreelatha Komandur et al.   Genetic Testing and Molecular Biomarkers

A simplified polyethylenimine-mediated transfection process for large-scale and high-throughput applications

(2011) Céline Raymond et al.   METHODS

Non-apoptotic role of BID in inflammation and innate immunity

(2011) Garabet Yeretssian et al.   NATURE

Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function

(2011) Chris McDermott-Roe et al.   NATURE

G4 Resolvase 1 tightly binds and unwinds unimolecular G4-DNA

(2011) Banabihari Giri et al.   NUCLEIC ACIDS RESEARCH

Efficiency of nonhomologous DNA end joining varies among somatic tissues, despite similarity in mechanism

(2010) Sheetal Sharma et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

DNA Instability at Chromosomal Fragile Sites in Cancer

(2010) Laura W. Dillon et al.   CURRENT GENOMICS

Mitochondrial DNA and genetic disease

(2010) Kim J. Krishnan et al.   Essays in Biochemistry

Role of Magmas in protein transport and human mitochondria biogenesis

(2010) D. Sinha et al.   HUMAN MOLECULAR GENETICS

Cytosines, but Not Purines, Determine Recombination Activating Gene (RAG)-induced Breaks on Heteroduplex DNA Structures

(2010) Abani Kanta Naik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-apoptotic Protein BCL2 Down-regulates DNA End Joining in Cancer Cells

(2010) Tadi Satish Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The human Pat1b protein: a novel mRNA deadenylation factor identified by a new immunoprecipitation technique

(2010) Antonio Totaro et al.   NUCLEIC ACIDS RESEARCH

Formation of a G-quadruplex at the BCL2 major breakpoint region of the t(14;18) translocation in follicular lymphoma

(2010) Mridula Nambiar et al.   NUCLEIC ACIDS RESEARCH

A 9-bp Deletion Homoplasmy in Women with Polycystic Ovary Syndrome Revealed by Mitochondrial Genome-Mutation Screen

(2009) Guangchao Zhuo et al.   BIOCHEMICAL GENETICS

Evidence for a role of FEN1 in maintaining mitochondrial DNA integrity

(2009) Lidza Kalifa et al.   DNA REPAIR

Novel DNA mismatch-repair activity involving YB-1 in human mitochondria

(2009) Nadja C. de Souza-Pinto et al.   DNA REPAIR

Spectroscopic studies of position-specific DNA "breathing" fluctuations at replication forks and primer-template junctions

(2009) D. Jose et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis

(2008) Mansour Akbari et al.   DNA REPAIR

Methyl angolensate, a natural tetranortriterpenoid induces intrinsic apoptotic pathway in leukemic cells

(2008) Kishore K. Chiruvella et al.   FEBS LETTERS

Processing of G4 DNA by Dna2 Helicase/Nuclease and Replication Protein A (RPA) Provides Insights into the Mechanism of Dna2/RPA Substrate Recognition

(2008) Taro Masuda-Sasa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of the Role of Non-B DNA Structures in Mutagenesis and Human Genomic Disorders

(2008) Robert D. Wells   JOURNAL OF BIOLOGICAL CHEMISTRY

Removal of Oxidative DNA Damage via FEN1-Dependent Long-Patch Base Excision Repair in Human Cell Mitochondria

(2008) P. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

Replication stalling at unstable inverted repeats: Interplay between DNA hairpins and fork stabilizing proteins

(2008) I. Voineagu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conservation of the pro-apoptotic nuclease activity of endonuclease G in unicellular trypanosomatid parasites

(2007) S. Gannavaram et al.   JOURNAL OF CELL SCIENCE