Nonamer dependent RAG cleavage at CpGs can explain mechanism of chromosomal translocations associated to lymphoid cancers

MiRAGDB: A Knowledgebase of RAG Regulators

(2022) Sagar Sanjiv Desai et al.   Frontiers in Immunology

Deleterious Point Mutations in T‐cell Acute Lymphoblastic Leukemia: Mechanistic Insights into Leukemogenesis

(2021) Urbi Roy et al.   INTERNATIONAL JOURNAL OF CANCER

MicroRNA miR-29c regulates RAG1 expression and modulates V(D)J recombination during B cell development

(2021) Rupa Kumari et al.   Cell Reports

Biochemical activity of RAGs is impeded by Dolutegravir, an HIV integrase inhibitor

(2020) Namrata M. Nilavar et al.   Cell Death Discovery

Znc2 module of RAG1 contributes towards structure-specific nuclease activity of RAGs

(2020) Namrata M. Nilavar et al.   BIOCHEMICAL JOURNAL

Cut-and-Run: A Distinct Mechanism by which V(D)J Recombination Causes Genome Instability

(2019) Christopher M. Kirkham et al.   MOLECULAR CELL

MRN complex-dependent recruitment of ubiquitylated BLM helicase to DSBs negatively regulates DNA repair pathways

(2018) Vivek Tripathi et al.   Nature Communications

HIV integrase inhibitor, Elvitegravir, impairs RAG functions and inhibits V(D)J recombination

(2017) Mayilaadumveettil Nishana et al.   Cell Death & Disease

Biochemical Characterization of Nonamer Binding Domain of RAG1 Reveals its Thymine Preference with Respect to Length and Position

(2016) Deepthi Raveendran et al.   Scientific Reports

AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature

(2015) Henrik Sahlin Pettersen et al.   DNA REPAIR

Crystal structure of the V(D)J recombinase RAG1–RAG2

(2015) Min-Sung Kim et al.   NATURE

Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia

(2015) Srividya Swaminathan et al.   NATURE IMMUNOLOGY

Detection of G-Quadruplex DNA Using Primer Extension as a Tool

(2015) Rupa Kumari et al.   PLoS One

Structure-specific nuclease activity of RAGs is modulated by sequence, length and phase position of flanking double-stranded DNA

(2014) Rupa Kumari et al.   FEBS Journal

Synapsis Alters RAG-Mediated Nicking at Tcrb Recombination Signal Sequences: Implications for the "Beyond 12/23" Rule

(2014) J. K. Banerjee et al.   MOLECULAR AND CELLULAR BIOLOGY

G-Quadruplex Structures Formed at the HOX11 Breakpoint Region Contribute to Its Fragility during t(10;14) Translocation in T-Cell Leukemia

(2013) M. Nambiar et al.   MOLECULAR AND CELLULAR BIOLOGY

Cooperative recruitment of HMGB1 during V(D)J recombination through interactions with RAG1 and DNA

(2013) Alicia J. Little et al.   NUCLEIC ACIDS RESEARCH

RAG and HMGB1 create a large bend in the 23RSS in the V(D)J recombination synaptic complexes

(2013) Mihai Ciubotaru et al.   NUCLEIC ACIDS RESEARCH

A non-B DNA can replace heptamer of V(D)J recombination when present along with a nonamer: implications in chromosomal translocations and cancer

(2012) Mayilaadumveettil Nishana et al.   BIOCHEMICAL JOURNAL

IgH partner breakpoint sequences provide evidence that AID initiates t(11;14) and t(8;14) chromosomal breaks in mantle cell and Burkitt lymphomas

(2012) H. A. Greisman et al.   BLOOD

An Inhibitor of Nonhomologous End-Joining Abrogates Double-Strand Break Repair and Impedes Cancer Progression

(2012) Mrinal Srivastava et al.   CELL

Chromosomal translocations among the healthy human population: implications in oncogenesis

(2012) Mridula Nambiar et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Potential G-quadruplex formation at breakpoint regions of chromosomal translocations in cancer may explain their fragility

(2012) Vijeth K. Katapadi et al.   GENOMICS

Role of recombination activating genes in the generation of antigen receptor diversity and beyond

(2012) Mayilaadumveettil Nishana et al.   IMMUNOLOGY

Mechanism of Fragility atBCL2Gene Minor Breakpoint Cluster Region during t(14;18) Chromosomal Translocation

(2012) Mridula Nambiar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

Translocation-Capture Sequencing Reveals the Extent and Nature of Chromosomal Rearrangements in B Lymphocytes

(2011) Isaac A. Klein et al.   CELL

Genome-wide Translocation Sequencing Reveals Mechanisms of Chromosome Breaks and Rearrangements in B Cells

(2011) Roberto Chiarle et al.   CELL

Differential Reaction Kinetics, Cleavage Complex Formation, and Nonamer Binding Domain Dependence Dictate the Structure-Specific and Sequence-Specific Nuclease Activity of RAGs

(2011) Abani Kanta Naik et al.   JOURNAL OF MOLECULAR BIOLOGY

How does DNA break during chromosomal translocations?

(2011) M. Nambiar et al.   NUCLEIC ACIDS RESEARCH

The t(14;18)(q32;q21)/IGH-MALT1 translocation in MALT lymphomas is a CpG-type translocation, but the t(11;18)(q21;q21)/API2-MALT1 translocation in MALT lymphomas is not

(2010) A. G. Tsai et al.   BLOOD

Cytosines, but Not Purines, Determine Recombination Activating Gene (RAG)-induced Breaks on Heteroduplex DNA Structures

(2010) Abani Kanta Naik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-apoptotic Protein BCL2 Down-regulates DNA End Joining in Cancer Cells

(2010) Tadi Satish Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions

(2010) Robert W Maul et al.   NATURE IMMUNOLOGY

Formation of a G-quadruplex at the BCL2 major breakpoint region of the t(14;18) translocation in follicular lymphoma

(2010) Mridula Nambiar et al.   NUCLEIC ACIDS RESEARCH

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

(2010) S. A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis

(2009) Fang Fang Yin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

COSMIC (the Catalogue of Somatic Mutations in Cancer): a resource to investigate acquired mutations in human cancer

(2009) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

The Biochemistry of Somatic Hypermutation

(2008) Jonathan U. Peled et al.   Annual Review of Immunology

Chromosomal translocations in cancer

(2008) Mridula Nambiar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Human Chromosomal Translocations at CpG Sites and a Theoretical Basis for Their Lineage and Stage Specificity

(2008) Albert G. Tsai et al.   CELL

AID Is Required for the Chromosomal Breaks in c-myc that Lead to c-myc/IgH Translocations

(2008) Davide F. Robbiani et al.   CELL

V(D)J Recombinase Binding and Cleavage of Cryptic Recombination Signal Sequences Identified from Lymphoid Malignancies

(2008) Ming Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY