Whole-exome sequencing of cervical carcinomas identifies activating ERBB2 and PIK3CA mutations as targets for combination therapy
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Whole-exome sequencing of cervical carcinomas identifies activating ERBB2 and PIK3CA mutations as targets for combination therapy
Authors
Keywords
-
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 116, Issue 45, Pages 22730-22736
Publisher
Proceedings of the National Academy of Sciences
Online
2019-10-18
DOI
10.1073/pnas.1911385116
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Cancer statistics, 2019
- (2019) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Challenges for the Clinical Development of PI3K Inhibitors: Strategies to Improve Their Impact in Solid Tumors
- (2019) Ariella B. Hanker et al. Cancer Discovery
- Prevalence and role of HER2 mutations in cancer
- (2019) Emiliano Cocco et al. PHARMACOLOGY & THERAPEUTICS
- Safety and Efficacy of Pembrolizumab in Advanced, Programmed Death Ligand 1–Positive Cervical Cancer: Results From the Phase Ib KEYNOTE-028 Trial
- (2017) Jean-Sebastien Frenel et al. JOURNAL OF CLINICAL ONCOLOGY
- An Autism-Linked Mutation Disables Phosphorylation Control of UBE3A
- (2015) Jason J. Yi et al. CELL
- Lobular Endocervical Glandular Hyperplasia Is a Neoplastic Entity With Frequent Activating GNAS Mutations
- (2013) Akiko Matsubara et al. AMERICAN JOURNAL OF SURGICAL PATHOLOGY
- Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15
- (2013) S. Inoue et al. GENES & DEVELOPMENT
- Landscape of genomic alterations in cervical carcinomas
- (2013) Akinyemi I. Ojesina et al. NATURE
- Signatures of mutational processes in human cancer
- (2013) Ludmil B. Alexandrov et al. NATURE
- Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples
- (2013) Kristian Cibulskis et al. NATURE BIOTECHNOLOGY
- IntOGen-mutations identifies cancer drivers across tumor types
- (2013) Abel Gonzalez-Perez et al. NATURE METHODS
- Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma
- (2013) S. Zhao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3
- (2013) Hari B Kamadurai et al. eLife
- EXCAVATOR: detecting copy number variants from whole-exome sequencing data
- (2013) Alberto Magi et al. GENOME BIOLOGY
- Two sides of the story? Smad4 loss in pancreatic cancer versus head-and-neck cancer
- (2012) Stephen P. Malkoski et al. FEBS LETTERS
- Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2
- (2012) H. Greulich et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Activating HER2 Mutations in HER2 Gene Amplification Negative Breast Cancer
- (2012) Ron Bose et al. Cancer Discovery
- Recurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development
- (2011) J. Wu et al. Science Translational Medicine
- Fragile X-related protein FXR1 controls post-transcriptional suppression of lipopolysaccharide-induced tumour necrosis factor-α production by transforming growth factor-β1
- (2010) Tarnjit K. Khera et al. FEBS Journal
- The Sequence Alignment/Map format and SAMtools
- (2009) H. Li et al. BIOINFORMATICS
- Fast and accurate short read alignment with Burrows-Wheeler transform
- (2009) H. Li et al. BIOINFORMATICS
- A Structural Element within the HUWE1 HECT Domain Modulates Self-ubiquitination and Substrate Ubiquitination Activities
- (2009) Renuka K. Pandya et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Insights into Ubiquitin Transfer Cascades from a Structure of a UbcH5B∼Ubiquitin-HECTNEDD4L Complex
- (2009) Hari B. Kamadurai et al. MOLECULAR CELL
- A comprehensive catalogue of somatic mutations from a human cancer genome
- (2009) Erin D. Pleasance et al. NATURE
- Somatic LKB1 Mutations Promote Cervical Cancer Progression
- (2009) Shana N. Wingo et al. PLoS One
- Genetic diagnosis by whole exome capture and massively parallel DNA sequencing
- (2009) Murim Choi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Expression of Smad2 and Smad4 in cervical cancer: absent nuclear Smad4 expression correlates with poor survival
- (2008) Judith N Kloth et al. MODERN PATHOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started