Bilirubin-Induced Oxidative Stress Leads to DNA Damage in the Cerebellum of Hyperbilirubinemic Neonatal Mice and Activates DNA Double-Strand Break Repair Pathways in Human Cells

Inflammatory signature of cerebellar neurodegeneration during neonatal hyperbilirubinemia in Ugt1 -/- mouse model

(2017) Simone Vodret et al.   Journal of Neuroinflammation

Bilirubin-induced ER stress contributes to the inflammatory response and apoptosis in neuronal cells

(2016) Mohammed Qaisiya et al.   ARCHIVES OF TOXICOLOGY

Bilirubin, platelet activation and heart disease: A missing link to cardiovascular protection in Gilbert's syndrome?

(2015) Avinash R. Kundur et al.   ATHEROSCLEROSIS

Jaundice, phototherapy and DNA damage in full-term neonates

(2015) N Ramy et al.   Journal of Perinatology

Impairment of enzymatic antioxidant defenses is associated with bilirubin-induced neuronal cell death in the cerebellum of Ugt1 KO mice

(2015) G Bortolussi et al.   Cell Death & Disease

Albumin administration prevents neurological damage and death in a mouse model of severe neonatal hyperbilirubinemia

(2015) Simone Vodret et al.   Scientific Reports

Age-dependent pattern of cerebellar susceptibility to bilirubin neurotoxicity in vivo in mice

(2014) G. Bortolussi et al.   Disease Models & Mechanisms

Influence of hyperbilirubinemia and phototherapy on markers of genotoxicity and apoptosis in full-term infants

(2014) Sohier Yahia et al.   EUROPEAN JOURNAL OF PEDIATRICS

Life-Long Correction of Hyperbilirubinemia with a Neonatal Liver-Specific AAV-Mediated Gene Transfer in a Lethal Mouse Model of Crigler–Najjar Syndrome

(2014) Giulia Bortolussi et al.   HUMAN GENE THERAPY

Developmental Onset of Bilirubin-induced Neurotoxicity Involves Toll-like Receptor 2-dependent Signaling in HumanizedUDP-glucuronosyltransferase1Mice

(2014) Mei-Fei Yueh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-Genotoxic Potential of Bilirubin In Vivo: Damage to DNA in Hyperbilirubinemic Human and Animal Models

(2013) M. Wallner et al.   Cancer Prevention Research

Bilirubin mediated oxidative stress involves antioxidant response activation via Nrf2 pathway

(2013) Mohammed Qaisiya et al.   CELLULAR SIGNALLING

The molecular basis for the immunomodulatory activities of unconjugated bilirubin

(2013) Sushrut Jangi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Gilbert's syndrome and the risk of death: a population-based cohort study

(2013) Laura J. Horsfall et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Bilirubin and Related Tetrapyrroles Inhibit Food-Borne Mutagenesis: A Mechanism for Antigenotoxic Action against a Model Epoxide

(2013) Christine Mölzer et al.   JOURNAL OF NATURAL PRODUCTS

Bilirubin-Induced Neurologic Damage — Mechanisms and Management Approaches

(2013) Jon F. Watchko et al.   NEW ENGLAND JOURNAL OF MEDICINE

Alterations in the Cell Cycle in the Cerebellum of Hyperbilirubinemic Gunn Rat: A Possible Link with Apoptosis?

(2013) María Celeste Robert et al.   PLoS One

PARP-1: Friend or Foe of DNA Damage and Repair in Tumorigenesis?

(2013) Amanda Swindall et al.   Cancers

Cardiovascular Events as a Function of Serum Bilirubin Levels in a Large, Statin-Treated Cohort

(2012) Laura J. Horsfall et al.   CIRCULATION

Lipid peroxidation is not the primary mechanism of bilirubin-induced neurologic dysfunction in jaundiced Gunn rat pups

(2012) Monica J. Daood et al.   PEDIATRIC RESEARCH

Bilirubin and beyond: A review of lipid status in Gilbert’s syndrome and its relevance to cardiovascular disease protection

(2012) A.C. Bulmer et al.   PROGRESS IN LIPID RESEARCH

The Evolving Landscape of Neurotoxicity by Unconjugated Bilirubin: Role of Glial Cells and Inflammation

(2012) Dora Brites   Frontiers in Pharmacology

Rescue of bilirubin-induced neonatal lethality in a mouse model of Crigler-Najjar syndrome type I by AAV9-mediated gene transfer

(2011) Giulia Bortolussi et al.   FASEB JOURNAL

Role of oxidative stress and DNA damage in human carcinogenesis

(2011) Thomas B. Kryston et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Functional Induction of the Cystine-Glutamate Exchanger System Xc- Activity in SH-SY5Y Cells by Unconjugated Bilirubin

(2011) Pablo J. Giraudi et al.   PLoS One

γH2AX: a sensitive molecular marker of DNA damage and repair

(2010) L-J Mah et al.   LEUKEMIA

Phototherapy, Hyperbilirubinemia and Genotoxicity in Newborns

(2010) Ahmet Karadag et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

A proteomic approach to the bilirubin-induced toxicity in neuronal cells reveals a protective function of DJ-1 protein

(2010) Marta Deganuto et al.   PROTEOMICS

A transcriptome analysis identifies molecular effectors of unconjugated bilirubin in human neuroblastoma SH-SY5Y cells

(2009) Raffaella Calligaris et al.   BMC GENOMICS

Bilirubin Chemistry and Metabolism; Harmful and Protective Aspects

(2009) Libor Vitek et al.   CURRENT PHARMACEUTICAL DESIGN

Assessment of DNA damage and plasma catalase activity in healthy term hyperbilirubinemic infants receiving phototherapy

(2009) Cigdem Karakukcu et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Serum Total Bilirubin Level, Prevalent Stroke, and Stroke Outcomes: NHANES 1999–2004

(2008) Todd S. Perlstein et al.   AMERICAN JOURNAL OF MEDICINE

Mechanism of Eukaryotic Homologous Recombination

(2008) Joseph San Filippo et al.   Annual Review of Biochemistry

Improved resistance to serum oxidation in Gilbert's syndrome: A mechanism for cardiovascular protection

(2008) Andrew C. Bulmer et al.   ATHEROSCLEROSIS

Phototherapy increases DNA damage in lymphocytes of hyperbilirubinemic neonates

(2008) Mustafa Mansur Tatli et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair

(2008) Nicole Bennardo et al.   PLoS Genetics

Bilirubin encephalopathy: A study of neuronal subpopulations and neurodegenerative mechanisms in 12 autopsy cases

(2007) Yasuo Hachiya et al.   BRAIN & DEVELOPMENT

Unconjugated bilirubin differentially affects the redox status of neuronal and astroglial cells

(2007) Maria A. Brito et al.   NEUROBIOLOGY OF DISEASE

Bilirubin injury to neurons: Contribution of oxidative stress and rescue by glycoursodeoxycholic acid

(2007) M BRITO   NEUROTOXICOLOGY