Depletion of RNASEH2 Activity Leads to Accumulation of DNA Double-strand Breaks and Reduced Cellular Survivability in T Cell Leukemia

Ribonucleotide incorporation into DNA during DNA replication and its consequences

(2021) Zhi-Xiong Zhou et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Deleterious Point Mutations in T‐cell Acute Lymphoblastic Leukemia: Mechanistic Insights into Leukemogenesis

(2021) Urbi Roy et al.   INTERNATIONAL JOURNAL OF CANCER

20 years of DNA Polymerase μ, the polymerase that still surprises

(2021) Dipayan Ghosh et al.   FEBS Journal

G4 DNA present at human telomeric DNA contributes toward reduced sensitivity to γ-radiation induced oxidative damage, but not bulky adduct formation

(2021) Ujjayinee Ray et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Nonhomologous end joining: new accessory factors fine tune the machinery

(2021) Dipayan Ghosh et al.   TRENDS IN GENETICS

MicroRNA miR-29c regulates RAG1 expression and modulates V(D)J recombination during B cell development

(2021) Rupa Kumari et al.   Cell Reports

Identification of hub genes in hepatocellular carcinoma using integrated bioinformatic analysis

(2020) Shengni Hua et al.   Aging-US

Identification and characterization of novel SCR7‐based small‐molecule inhibitor of DNA end‐joining, SCR130 and its relevance in cancer therapeutics

(2020) Ujjayinee Ray et al.   MOLECULAR CARCINOGENESIS

Znc2 module of RAG1 contributes towards structure-specific nuclease activity of RAGs

(2020) Namrata M. Nilavar et al.   BIOCHEMICAL JOURNAL

The molecular basis and disease relevance of non-homologous DNA end joining

(2020) Bailin Zhao et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Aicardi-Goutières syndrome gene Rnaseh2c is a metastasis susceptibility gene in breast cancer

(2019) Sarah K. Deasy et al.   PLoS Genetics

Molecular and physiological consequences of faulty eukaryotic ribonucleotide excision repair

(2019) Vanessa Kellner et al.   EMBO JOURNAL

Identification of Common Genes Refers to Colorectal Carcinogenesis with Paired Cancer and Noncancer Samples

(2018) Lihua Zhang et al.   DISEASE MARKERS

CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions

(2018) Michal Zimmermann et al.   NATURE

Ribonucleotide incorporation enables repair of chromosome breaks by nonhomologous end joining

(2018) John M. Pryor et al.   SCIENCE

Characterization of DNA double-strand break repair pathways in diffuse large B cell lymphoma

(2018) Vidya Gopalakrishnan et al.   MOLECULAR CARCINOGENESIS

Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition

(2018) Chao Wang et al.   ONCOGENE

Integrative analysis of lncRNAs and miRNAs with coding RNAs associated with ceRNA crosstalk network in triple negative breast cancer

(2017) Naijun Yuan et al.   OncoTargets and Therapy

Induction of DNA damage and erroneous repair can explain genomic instability caused by endosulfan

(2016) Robin Sebastian et al.   CARCINOGENESIS

Identification of a novel BCL2-specific inhibitor that binds predominantly to the BH1 domain

(2016) Divyaanka Iyer et al.   FEBS Journal

Identification and characterization of novel ligase I inhibitors

(2016) Monica Pandey et al.   MOLECULAR CARCINOGENESIS

DNA-Sensing and Nuclease Gene Expressions as Markers for Colorectal Cancer Progression

(2016) Chin-An Yang et al.   ONCOLOGY

RNaseH2A is involved in human gliomagenesis through the regulation of cell proliferation and apoptosis

(2016) BIN DAI et al.   ONCOLOGY REPORTS

Combinatorial Study of a Novel Poly (ADP-ribose) Polymerase Inhibitor and an HDAC Inhibitor, SAHA, in Leukemic Cell Lines

(2016) Mahesh Hegde et al.   Targeted Oncology

Extract of Vernonia condensata, Inhibits Tumor Progression and Improves Survival of Tumor-allograft Bearing Mouse

(2016) Elizabeth Thomas et al.   Scientific Reports

A Novel Resveratrol Based Tubulin Inhibitor Induces Mitotic Arrest and Activates Apoptosis in Cancer Cells

(2016) Elizabeth Thomas et al.   Scientific Reports

Homology and enzymatic requirements of microhomology-dependent alternative end joining

(2015) S Sharma et al.   Cell Death & Disease

Identification of novel genes involved in gastric carcinogenesis by suppression subtractive hybridization

(2014) N Mottaghi-Dastjerdi et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Reduction of hRNase H2 activity in Aicardi–Goutières syndrome cells leads to replication stress and genome instability

(2014) Sara Pizzi et al.   HUMAN MOLECULAR GENETICS

Defective removal of ribonucleotides from DNA promotes systemic autoimmunity

(2014) Claudia Günther et al.   JOURNAL OF CLINICAL INVESTIGATION

A Systems Genetics Approach Identifies CXCL14, ITGAX, and LPCAT2 as Novel Aggressive Prostate Cancer Susceptibility Genes

(2014) Kendra A. Williams et al.   PLoS Genetics

Identification of two HIV inhibitors that also inhibit human RNaseH2

(2013) Junghwan Kim et al.   MOLECULES AND CELLS

Double-strand break repair: 53BP1 comes into focus

(2013) Stephanie Panier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Propyl-2-(8-(3,4-Difluorobenzyl)-2′,5′-Dioxo-8-Azaspiro[Bicyclo[3.2.1] Octane-3,4′-Imidazolidine]-1′-yl) Acetate Induces Apoptosis in Human Leukemia Cells through Mitochondrial Pathway following Cell Cycle Arrest

(2013) Chandagirikoppal V. Kavitha et al.   PLoS One

The Efficiency of Homologous Recombination and Non-Homologous End Joining Systems in Repairing Double-Strand Breaks during Cell Cycle Progression

(2013) Leonardo Bee et al.   PLoS One

An Inhibitor of Nonhomologous End-Joining Abrogates Double-Strand Break Repair and Impedes Cancer Progression

(2012) Mrinal Srivastava et al.   CELL

Enzymatic Removal of Ribonucleotides from DNA Is Essential for Mammalian Genome Integrity and Development

(2012) Martin A.M. Reijns et al.   CELL

Chromosomal translocations among the healthy human population: implications in oncogenesis

(2012) Mridula Nambiar et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mechanism of Fragility atBCL2Gene Minor Breakpoint Cluster Region during t(14;18) Chromosomal Translocation

(2012) Mridula Nambiar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity

(2012) Bjoern Hiller et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Time-Dependent Predominance of Nonhomologous DNA End-Joining Pathways during Embryonic Development in Mice

(2012) Kishore K. Chiruvella et al.   JOURNAL OF MOLECULAR BIOLOGY

RNase H2-Initiated Ribonucleotide Excision Repair

(2012) Justin L. Sparks et al.   MOLECULAR CELL

Mutagenic Processing of Ribonucleotides in DNA by Yeast Topoisomerase I

(2011) N. Kim et al.   SCIENCE

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

Efficiency of nonhomologous DNA end joining varies among somatic tissues, despite similarity in mechanism

(2010) Sheetal Sharma et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cytosines, but Not Purines, Determine Recombination Activating Gene (RAG)-induced Breaks on Heteroduplex DNA Structures

(2010) Abani Kanta Naik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Structural and Biochemical Characterization of Human RNase H2 Complex Reveals the Molecular Basis for Substrate Recognition and Aicardi-Goutières Syndrome Defects

(2010) Małgorzata Figiel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-apoptotic Protein BCL2 Down-regulates DNA End Joining in Cancer Cells

(2010) Tadi Satish Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Structure of the Human RNase H2 Complex Defines Key Interaction Interfaces Relevant to Enzyme Function and Human Disease

(2010) Martin A. M. Reijns et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ribonuclease H: the enzymes in eukaryotes

(2009) Susana M. Cerritelli et al.   FEBS Journal

Genomics screen in transformed stem cells reveals RNASEH2A, PPAP2C, and ADARB1 as putative anticancer drug targets

(2009) J. M. Flanagan et al.   MOLECULAR CANCER THERAPEUTICS

Methyl angolensate, a natural tetranortriterpenoid induces intrinsic apoptotic pathway in leukemic cells

(2008) Kishore K. Chiruvella et al.   FEBS LETTERS

Contributions of the two accessory subunits, RNASEH2B and RNASEH2C, to the activity and properties of the human RNase H2 complex

(2008) Hyongi Chon et al.   NUCLEIC ACIDS RESEARCH