MRN complex-dependent recruitment of ubiquitylated BLM helicase to DSBs negatively regulates DNA repair pathways

BLM helicase regulates DNA repair by counteracting RAD51 loading at DNA double-strand break sites

(2017) Dharm S. Patel et al.   JOURNAL OF CELL BIOLOGY

A single double-strand break system reveals repair dynamics and mechanisms in heterochromatin and euchromatin

(2016) Aniek Janssen et al.   GENES & DEVELOPMENT

Mitotic phosphorylation of Bloom helicase at Thr182 is required for its proteasomal degradation and maintenance of chromosomal stability

(2015) S S Kharat et al.   ONCOGENE

Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks

(2015) Pierre Caron et al.   Cell Reports

The role of post-translational modifications in fine-tuning BLM helicase function during DNA repair

(2014) Stefanie Böhm et al.   DNA REPAIR

Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks

(2014) François Aymard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Small Molecule Inhibitor of the BLM Helicase Modulates Chromosome Stability in Human Cells

(2013) Giang Huong Nguyen et al.   CHEMISTRY & BIOLOGY

Ubiquitin-dependent recruitment of the Bloom Syndrome helicase upon replication stress is required to suppress homologous recombination

(2013) Shweta Tikoo et al.   EMBO JOURNAL

Enhancement of microhomology-mediated genomic rearrangements by transient loss of mouse Bloom syndrome helicase

(2013) A. Yamanishi et al.   GENOME RESEARCH

RIF1 Counteracts BRCA1-mediated End Resection during DNA Repair

(2013) Lin Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TopBP1 Controls BLM Protein Level to Maintain Genome Stability

(2013) Jiadong Wang et al.   MOLECULAR CELL

A Role for BLM in Double-Strand Break Repair Pathway Choice: Prevention of CtIP/Mre11-Mediated Alternative Nonhomologous End-Joining

(2013) Anastazja Grabarz et al.   Cell Reports

The Interaction of CtIP and Nbs1 Connects CDK and ATM to Regulate HR–Mediated Double-Strand Break Repair

(2013) Hailong Wang et al.   PLoS Genetics

An Inhibitor of Nonhomologous End-Joining Abrogates Double-Strand Break Repair and Impedes Cancer Progression

(2012) Mrinal Srivastava et al.   CELL

Inhibition of Homologous Recombination in Human Cells by Targeting RAD51 Recombinase

(2012) Fei Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

(2011) A. V. Nimonkar et al.   GENES & DEVELOPMENT

High-resolution profiling of γH2AX around DNA double strand breaks in the mammalian genome

(2010) Jason S Iacovoni et al.   EMBO JOURNAL

Chk1-Dependent Constitutive Phosphorylation of BLM Helicase at Serine 646 Decreases after DNA Damage

(2010) S. Kaur et al.   MOLECULAR CANCER RESEARCH

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Genomic instability and cancer: lessons from analysis of Bloom's syndrome

(2009) Miranda Payne et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

BLM helicase stimulates the ATPase and chromatin-remodeling activities of RAD54

(2009) V. Srivastava et al.   JOURNAL OF CELL SCIENCE

SUMO Modification Regulates BLM and RAD51 Interaction at Damaged Replication Forks

(2009) Karen J. Ouyang et al.   PLOS BIOLOGY

Small Ubiquitin-related Modifier (SUMO) Binding Determines Substrate Recognition and Paralog-selective SUMO Modification

(2008) Jianmei Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair

(2008) Nicole Bennardo et al.   PLoS Genetics