Nonhomologous end joining: new accessory factors fine tune the machinery

53BP1: a DSB escort

(2020) Zachary Mirman et al.   GENES & DEVELOPMENT

ERCC6L2 promotes DNA orientation-specific recombination in mammalian cells

(2020) Xiaojing Liu et al.   CELL RESEARCH

Identification and characterization of novel SCR7‐based small‐molecule inhibitor of DNA end‐joining, SCR130 and its relevance in cancer therapeutics

(2020) Ujjayinee Ray et al.   MOLECULAR CARCINOGENESIS

FOXL2 directs DNA double-strand break repair pathways by differentially interacting with Ku

(2020) Hanyong Jin et al.   Nature Communications

The rise and rise of mitochondrial DNA mutations

(2020) Conor Lawless et al.   Open Biology

Inhibitors of DNA Double-Strand Break Repair at the Crossroads of Cancer Therapy and Genome Editing

(2020) Ujjayinee Ray et al.   BIOCHEMICAL PHARMACOLOGY

A Genetic Map of the Response to DNA Damage in Human Cells

(2020) Michele Olivieri et al.   CELL

Impaired NHEJ repair in amyotrophic lateral sclerosis is associated with TDP-43 mutations

(2020) Anna Konopka et al.   Molecular Neurodegeneration

End Processing Factor APLF Promotes NHEJ Efficiency and Contributes to TMZ- and Ionizing Radiation-Resistance in Glioblastoma Cells

(2020) Wei Dong et al.   OncoTargets and Therapy

Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining

(2020) Paola Francica et al.   Cell Reports

Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects

(2019) Joy Mitra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ERCC6L2 defines a novel entity within inherited acute myeloid leukemia

(2019) Suvi P. M. Douglas et al.   BLOOD

Amyotrophic lateral sclerosis-associated TDP-43 mutation Q331K prevents nuclear translocation of XRCC4-DNA ligase 4 complex and is linked to genome damage-mediated neuronal apoptosis

(2019) Erika N Guerrero et al.   HUMAN MOLECULAR GENETICS

The nucleoskeleton protein IFFO1 immobilizes broken DNA and suppresses chromosome translocation during tumorigenesis

(2019) Wen Li et al.   NATURE CELL BIOLOGY

AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity

(2019) Jacqueline H. L. Fok et al.   Nature Communications

Generation of a Mouse Model Lacking the Non-Homologous End-Joining Factor Mri/Cyren

(2019) Sergio Castañeda-Zegarra et al.   Biomolecules

MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining

(2018) Putzer J. Hung et al.   MOLECULAR CELL

Microhomology-mediated end joining: Good, bad and ugly

(2018) Ja-Hwan Seol et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

ERCC6L2 -associated inherited bone marrow failure syndrome

(2018) Iren Shabanova et al.   Molecular Genetics & Genomic Medicine

Autocyclized and Oxidized Forms of SCR7 Induce Cancer Cell Death by Inhibiting Nonhomologous DNA End joining in a Ligase IV Dependent Manner

(2018) Supriya V. Vartak et al.   FEBS Journal

CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions

(2018) Michal Zimmermann et al.   NATURE

Ribonucleotide incorporation enables repair of chromosome breaks by nonhomologous end joining

(2018) John M. Pryor et al.   SCIENCE

PAXX and its paralogs synergistically direct DNA polymerase λ activity in DNA repair

(2018) Andrew Craxton et al.   Nature Communications

Characterization of DNA double-strand break repair pathways in diffuse large B cell lymphoma

(2018) Vidya Gopalakrishnan et al.   MOLECULAR CARCINOGENESIS

DNA Repair in Drosophila : Mutagens, Models, and Missing Genes

(2017) Jeff Sekelsky   GENETICS

Autoinhibition of the Nuclease ARTEMIS Is Mediated by a Physical Interaction between Its Catalytic and C-terminal Domains

(2017) Doris Niewolik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN

(2017) Nausica Arnoult et al.   NATURE

Non-homologous DNA end joining and alternative pathways to double-strand break repair

(2017) Howard H. Y. Chang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice

(2017) Xiangyu Liu et al.   Nature Communications

DNA Repair in Drosophila : Mutagens, Models, and Missing Genes

(2017) Jeff Sekelsky   GENETICS

Induction of DNA damage and erroneous repair can explain genomic instability caused by endosulfan

(2016) Robin Sebastian et al.   CARCINOGENESIS

A novel small molecule inhibitor of the DNA repair protein Ku70/80

(2016) Eric Weterings et al.   DNA REPAIR

Synthetic lethality between PAXX and XLF in mammalian development

(2016) Gabriel Balmus et al.   GENES & DEVELOPMENT

Different DNA End Configurations Dictate Which NHEJ Components Are Most Important for Joining Efficiency

(2016) Howard H. Y. Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microhomology-mediated end joining is the principal mediator of double-strand break repair during mitochondrial DNA lesions

(2016) Satish Kumar Tadi et al.   MOLECULAR BIOLOGY OF THE CELL

Risky business: Microhomology-mediated end joining

(2016) Supriya Sinha et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Sliding sleeves of XRCC4–XLF bridge DNA and connect fragments of broken DNA

(2016) Ineke Brouwer et al.   NATURE

Repair Pathway Choices and Consequences at the Double-Strand Break

(2016) Raphael Ceccaldi et al.   TRENDS IN CELL BIOLOGY

The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins

(2016) Gabrielle J. Grundy et al.   Nature Communications

WRN regulates pathway choice between classical and alternative non-homologous end joining

(2016) Raghavendra A. Shamanna et al.   Nature Communications

PAXX Is an Accessory c-NHEJ Factor that Associates with Ku70 and Has Overlapping Functions with XLF

(2016) Satish K. Tadi et al.   Cell Reports

XLS (c9orf142) is a new component of mammalian DNA double-stranded break repair

(2015) A Craxton et al.   CELL DEATH AND DIFFERENTIATION

DNA Double-Strand Break Repair Inhibitors as Cancer Therapeutics

(2015) Mrinal Srivastava et al.   CHEMISTRY & BIOLOGY

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination

(2015) Pedro A. Mateos-Gomez et al.   NATURE

Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ

(2015) Tatiana Kent et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phosphorylation of Ku dictates DNA double-strand break (DSB) repair pathway choice in S phase

(2015) Kyung-Jong Lee et al.   NUCLEIC ACIDS RESEARCH

Essential role for polymerase specialization in cellular nonhomologous end joining

(2015) John M. Pryor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair

(2015) T. Ochi et al.   SCIENCE

Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?

(2015) Agnel Sfeir et al.   TRENDS IN BIOCHEMICAL SCIENCES

Homology and enzymatic requirements of microhomology-dependent alternative end joining

(2015) S Sharma et al.   Cell Death & Disease

Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway

(2015) Mengtan Xing et al.   Nature Communications

Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ

(2015) Tatiana Kent et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ERCC6L2 Mutations Link a Distinct Bone-Marrow-Failure Syndrome to DNA Repair and Mitochondrial Function

(2014) Hemanth Tummala et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Structure–Function Studies of DNA Polymerase λ

(2014) Katarzyna Bebenek et al.   BIOCHEMISTRY

The clinical impact of deficiency in DNA non-homologous end-joining

(2014) Lisa Woodbine et al.   DNA REPAIR

A Human Short Open Reading Frame (sORF)-encoded Polypeptide That Stimulates DNA End Joining

(2014) Sarah A. Slavoff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolutionarily Conserved Heterogeneous Nuclear Ribonucleoprotein (hnRNP) A/B Proteins Functionally Interact with Human andDrosophilaTAR DNA-binding Protein 43 (TDP-43)

(2014) Maurizio Romano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RPA antagonizes microhomology-mediated repair of DNA double-strand breaks

(2014) Sarah K Deng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sustained active site rigidity during synthesis by human DNA polymerase μ

(2014) Andrea F Moon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA Damage and Its Links to Neurodegeneration

(2014) Ram Madabhushi et al.   NEURON

Sources of DNA Double-Strand Breaks and Models of Recombinational DNA Repair

(2014) A. Mehta et al.   Cold Spring Harbor Perspectives in Biology

Modernizing the Nonhomologous End-Joining Repertoire: Alternative and Classical NHEJ Share the Stage

(2013) Ludovic Deriano et al.   Annual Review of Genetics

Mechanism of Homologous Recombination and Implications for Aging-Related Deletions in Mitochondrial DNA

(2013) X. J. Chen   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice

(2013) Cristina Escribano-Díaz et al.   MOLECULAR CELL

Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells

(2013) L. N. Truong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Inhibitor of Nonhomologous End-Joining Abrogates Double-Strand Break Repair and Impedes Cancer Progression

(2012) Mrinal Srivastava et al.   CELL

Chromosomal translocations among the healthy human population: implications in oncogenesis

(2012) Mridula Nambiar et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Persistently bound Ku at DNA ends attenuates DNA end resection and homologous recombination

(2012) Zhengping Shao et al.   DNA REPAIR

Role of recombination activating genes in the generation of antigen receptor diversity and beyond

(2012) Mayilaadumveettil Nishana et al.   IMMUNOLOGY

Time-Dependent Predominance of Nonhomologous DNA End-Joining Pathways during Embryonic Development in Mice

(2012) Kishore K. Chiruvella et al.   JOURNAL OF MOLECULAR BIOLOGY

Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

(2012) J. Ross Chapman et al.   MOLECULAR CELL

Ribonucleotides and manganese ions improve non-homologous end joining by human Polµ

(2012) Maria Jose Martin et al.   NUCLEIC ACIDS RESEARCH

Microhomology Directs Diverse DNA Break Repair Pathways and Chromosomal Translocations

(2012) Diana D. Villarreal et al.   PLoS Genetics

DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells

(2011) Zhiyong Mao et al.   CELL CYCLE

Human Mre11/Human Rad50/Nbs1 and DNA Ligase IIIα/XRCC1 Protein Complexes Act Together in an Alternative Nonhomologous End Joining Pathway

(2011) Julie Della-Maria et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mgm101 Is a Rad52-related Protein Required for Mitochondrial DNA Recombination

(2011) MacMillan Mbantenkhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polynucleotide Kinase and Aprataxin-like Forkhead-associated Protein (PALF) Acts as Both a Single-stranded DNA Endonuclease and a Single-Stranded DNA 3′ Exonuclease and Can Participate in DNA End Joining in a Biochemical System

(2011) Sicong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How does DNA break during chromosomal translocations?

(2011) M. Nambiar et al.   NUCLEIC ACIDS RESEARCH

Structural characterization of filaments formed by human Xrcc4-Cernunnos/XLF complex involved in nonhomologous DNA end-joining

(2011) V. Ropars et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TDP-43 functions and pathogenic mechanisms implicated in TDP-43 proteinopathies

(2011) Todd J. Cohen et al.   TRENDS IN MOLECULAR MEDICINE

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

(2010) Samuel F. Bunting et al.   CELL

Efficiency of nonhomologous DNA end joining varies among somatic tissues, despite similarity in mechanism

(2010) Sheetal Sharma et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Purification and characterization of exonuclease-free Artemis: Implications for DNA-PK-dependent processing of DNA termini in NHEJ-catalyzed DSB repair

(2010) Katherine S. Pawelczak et al.   DNA REPAIR

Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2

(2010) Eleni P Mimitou et al.   EMBO JOURNAL

The Structural and Biochemical Characterization of Human RNase H2 Complex Reveals the Molecular Basis for Substrate Recognition and Aicardi-Goutières Syndrome Defects

(2010) Małgorzata Figiel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-apoptotic Protein BCL2 Down-regulates DNA End Joining in Cancer Cells

(2010) Tadi Satish Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Structure of the Human RNase H2 Complex Defines Key Interaction Interfaces Relevant to Enzyme Function and Human Disease

(2010) Martin A. M. Reijns et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of TRF1, TRF2, TIN2, TERT, KU70, and BRCA1 proteins is associated with telomere shortening and may contribute to multistage carcinogenesis of gastric cancer

(2010) Hua Hu et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

CtIP promotes microhomology-mediated alternative end joining during class-switch recombination

(2010) Mieun Lee-Theilen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dual Roles for DNA Polymerase Theta in Alternative End-Joining Repair of Double-Strand Breaks in Drosophila

(2010) Sze Ham Chan et al.   PLoS Genetics

Radioresistant cervical cancer shows upregulation of the NHEJ proteins DNA-PKcs, Ku70 and Ku86

(2009) C Beskow et al.   BRITISH JOURNAL OF CANCER

Global Analysis of TDP-43 Interacting Proteins Reveals Strong Association with RNA Splicing and Translation Machinery

(2009) Brian D. Freibaum et al.   JOURNAL OF PROTEOME RESEARCH

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Backup pathways of NHEJ in cells of higher eukaryotes: Cell cycle dependence

(2009) George Iliakis   RADIOTHERAPY AND ONCOLOGY

DNA helicases Sgs1 and BLM promote DNA double-strand break resection

(2008) S. Gravel et al.   GENES & DEVELOPMENT

Recruitment and Dissociation of Nonhomologous End Joining Proteins at a DNA Double-Strand Break in Saccharomyces cerevisiae

(2008) D. Wu et al.   GENETICS

Bacterial Nonhomologous End Joining Ligases Preferentially Seal Breaks with a 3′-OH Monoribonucleotide

(2008) Hui Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ERCC1-XPF Endonuclease Facilitates DNA Double-Strand Break Repair

(2008) A. Ahmad et al.   MOLECULAR AND CELLULAR BIOLOGY

Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair

(2008) Nicole Bennardo et al.   PLoS Genetics