SCR7, an inhibitor of NHEJ can sensitize tumor cells to ionization radiation

G-quadruplex DNA structures and their relevance in radioprotection

(2021) Nitu Kumari et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

20 years of DNA Polymerase μ, the polymerase that still surprises

(2021) Dipayan Ghosh et al.   FEBS Journal

Nonhomologous end joining: new accessory factors fine tune the machinery

(2021) Dipayan Ghosh et al.   TRENDS IN GENETICS

Identification and characterization of novel SCR7‐based small‐molecule inhibitor of DNA end‐joining, SCR130 and its relevance in cancer therapeutics

(2020) Ujjayinee Ray et al.   MOLECULAR CARCINOGENESIS

Inhibitors of DNA Double-Strand Break Repair at the Crossroads of Cancer Therapy and Genome Editing

(2020) Ujjayinee Ray et al.   BIOCHEMICAL PHARMACOLOGY

NHEJ Inhibitor SCR7 and its Different Forms: Promising CRISPR Tools for Genome Engineering

(2020) Ujjayinee Ray et al.   GENE

Modulation of DNA double-strand break repair as a strategy to improve precise genome editing

(2020) Ujjayinee Ray et al.   ONCOGENE

Acute toxicity analysis of Disarib, an inhibitor of BCL2

(2020) Shivangi Sharma et al.   Scientific Reports

Autocyclized and Oxidized Forms of SCR7 Induce Cancer Cell Death by Inhibiting Nonhomologous DNA End joining in a Ligase IV Dependent Manner

(2018) Supriya V. Vartak et al.   FEBS Journal

Characterization of DNA double-strand break repair pathways in diffuse large B cell lymphoma

(2018) Vidya Gopalakrishnan et al.   MOLECULAR CARCINOGENESIS

A Benzothiazole Derivative (5g) Induces DNA Damage And Potent G2/M Arrest In Cancer Cells

(2017) Mahesh Hegde et al.   Scientific Reports

A novel inhibitor of BCL2, Disarib abrogates tumor growth while sparing platelets, by activating intrinsic pathway of apoptosis

(2016) Supriya V. Vartak et al.   BIOCHEMICAL PHARMACOLOGY

Induction of DNA damage and erroneous repair can explain genomic instability caused by endosulfan

(2016) Robin Sebastian et al.   CARCINOGENESIS

Identification of a novel BCL2-specific inhibitor that binds predominantly to the BH1 domain

(2016) Divyaanka Iyer et al.   FEBS Journal

US Intergroup Trial of Response-Adapted Therapy for Stage III to IV Hodgkin Lymphoma Using Early Interim Fluorodeoxyglucose–Positron Emission Tomography Imaging: Southwest Oncology Group S0816

(2016) Oliver W. Press et al.   JOURNAL OF CLINICAL ONCOLOGY

Mathematical models of radiation action on living cells: From the target theory to the modern approaches. A historical and critical review

(2016) Larry Bodgi et al.   JOURNAL OF THEORETICAL BIOLOGY

Radiotherapy for Non-Hodgkin’s lymphoma: still standard practice and not an outdated treatment option

(2016) Michel Zimmermann et al.   Radiation Oncology

Combinatorial Study of a Novel Poly (ADP-ribose) Polymerase Inhibitor and an HDAC Inhibitor, SAHA, in Leukemic Cell Lines

(2016) Mahesh Hegde et al.   Targeted Oncology

Extract of Vernonia condensata, Inhibits Tumor Progression and Improves Survival of Tumor-allograft Bearing Mouse

(2016) Elizabeth Thomas et al.   Scientific Reports

Quercetin, a Natural Flavonoid Interacts with DNA, Arrests Cell Cycle and Causes Tumor Regression by Activating Mitochondrial Pathway of Apoptosis

(2016) Shikha Srivastava et al.   Scientific Reports

A Novel Resveratrol Based Tubulin Inhibitor Induces Mitotic Arrest and Activates Apoptosis in Cancer Cells

(2016) Elizabeth Thomas et al.   Scientific Reports

Antiproliferative and tumor inhibitory studies of 2,3 disubstituted 4-thiazolidinone derivatives

(2015) Kothanahally S. Sharath Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

DNA Double-Strand Break Repair Inhibitors as Cancer Therapeutics

(2015) Mrinal Srivastava et al.   CHEMISTRY & BIOLOGY

Inhibition of nonhomologous end joining to increase the specificity of CRISPR/Cas9 genome editing

(2015) Supriya V. Vartak et al.   FEBS Journal

Mechanisms and Consequences of Double-Strand DNA Break Formation in Chromatin

(2015) Wendy J. Cannan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Targeting the DNA Damage Response in Cancer

(2015) Mark J. O’Connor   MOLECULAR CELL

PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair

(2015) T. Ochi et al.   SCIENCE

Endosulfan induces male infertility

(2015) R Sebastian et al.   Cell Death & Disease

Homology and enzymatic requirements of microhomology-dependent alternative end joining

(2015) S Sharma et al.   Cell Death & Disease

The Role of Radiotherapy in Hodgkin’s Lymphoma: What Has Been Achieved during the Last 50 Years?

(2015) Magdalena Witkowska et al.   Biomed Research International

Enhanced Efficacy of Pluronic Copolymer Micelle Encapsulated SCR7 against Cancer Cell Proliferation

(2014) Franklin John et al.   MACROMOLECULAR BIOSCIENCE

Sources of DNA Double-Strand Breaks and Models of Recombinational DNA Repair

(2014) A. Mehta et al.   Cold Spring Harbor Perspectives in Biology

Sapodilla Plum (Achras sapota) Induces Apoptosis in Cancer Cell Lines and Inhibits Tumor Progression in Mice

(2014) Mrinal Srivastava et al.   Scientific Reports

Modernizing the Nonhomologous End-Joining Repertoire: Alternative and Classical NHEJ Share the Stage

(2013) Ludovic Deriano et al.   Annual Review of Genetics

Propyl-2-(8-(3,4-Difluorobenzyl)-2′,5′-Dioxo-8-Azaspiro[Bicyclo[3.2.1] Octane-3,4′-Imidazolidine]-1′-yl) Acetate Induces Apoptosis in Human Leukemia Cells through Mitochondrial Pathway following Cell Cycle Arrest

(2013) Chandagirikoppal V. Kavitha et al.   PLoS One

Ionizing-radiation induced DNA double-strand breaks: A direct and indirect lighting up

(2013) Julien Vignard et al.   RADIOTHERAPY AND ONCOLOGY

An Inhibitor of Nonhomologous End-Joining Abrogates Double-Strand Break Repair and Impedes Cancer Progression

(2012) Mrinal Srivastava et al.   CELL

Chromosomal translocations among the healthy human population: implications in oncogenesis

(2012) Mridula Nambiar et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Role of recombination activating genes in the generation of antigen receptor diversity and beyond

(2012) Mayilaadumveettil Nishana et al.   IMMUNOLOGY

Radiation-Induced c-Jun Activation Depends on MEK1-ERK1/2 Signaling Pathway in Microglial Cells

(2012) Zhiyong Deng et al.   PLoS One

Extracts of Strawberry Fruits Induce Intrinsic Pathway of Apoptosis in Breast Cancer Cells and Inhibits Tumor Progression in Mice

(2012) Ranganatha R. Somasagara et al.   PLoS One

A novel DNA intercalator, 8-methoxy pyrimido[4′,5′:4,5]thieno (2,3-b)quinoline-4(3H)-one induces apoptosis in cancer cells, inhibits the tumor progression and enhances lifespan in mice with tumor

(2011) Sheetal Sharma et al.   MOLECULAR CARCINOGENESIS

Role of oxidative stress and DNA damage in human carcinogenesis

(2011) Thomas B. Kryston et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

How does DNA break during chromosomal translocations?

(2011) M. Nambiar et al.   NUCLEIC ACIDS RESEARCH

Inhibition of p38 MAPK Attenuates Ionizing Radiation-Induced Hematopoietic Cell Senescence and Residual Bone Marrow Injury

(2011) Yong Wang et al.   RADIATION RESEARCH

Analysis of White Blood Cell Counts in Mice after Gamma- or Proton-Radiation Exposure

(2011) Casey J. Maks et al.   RADIATION RESEARCH

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

Efficiency of nonhomologous DNA end joining varies among somatic tissues, despite similarity in mechanism

(2010) Sheetal Sharma et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A novel structural derivative of natural alkaloid ellipticine, MDPSQ, induces necrosis in leukemic cells

(2010) M. S. Shahabuddin et al.   INVESTIGATIONAL NEW DRUGS

Anti-apoptotic Protein BCL2 Down-regulates DNA End Joining in Cancer Cells

(2010) Tadi Satish Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of Proton Radiation Dose, Dose Rate and Dose Fractionation on Hematopoietic Cells in Mice

(2010) J. H. Ware et al.   RADIATION RESEARCH

Backup pathways of NHEJ in cells of higher eukaryotes: Cell cycle dependence

(2009) George Iliakis   RADIOTHERAPY AND ONCOLOGY

Assembly of checkpoint and repair machineries at DNA damage sites

(2009) Michael S.Y. Huen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Chromosomal translocations in cancer

(2008) Mridula Nambiar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

The Effect of Radiation Dose and Chemotherapy on Overall Survival in 237 Patients With Stage III Non–Small-Cell Lung Cancer

(2008) Li Wang et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

The Linear-Quadratic Model Is an Appropriate Methodology for Determining Isoeffective Doses at Large Doses Per Fraction

(2008) David J. Brenner   SEMINARS IN RADIATION ONCOLOGY