Identification and characterization of mercaptopyrimidine‐based small molecules as inhibitors of nonhomologous DNA end joining

Deleterious Point Mutations in T‐cell Acute Lymphoblastic Leukemia: Mechanistic Insights into Leukemogenesis

(2021) Urbi Roy et al.   INTERNATIONAL JOURNAL OF CANCER

SCR7, an inhibitor of NHEJ can sensitize tumor cells to ionization radiation

(2021) Vidya Gopalakrishnan et al.   MOLECULAR CARCINOGENESIS

Nonhomologous end joining: new accessory factors fine tune the machinery

(2021) Dipayan Ghosh et al.   TRENDS IN GENETICS

MicroRNA miR-29c regulates RAG1 expression and modulates V(D)J recombination during B cell development

(2021) Rupa Kumari et al.   Cell Reports

Drug resistance to nelarabine in leukemia cell lines might be caused by reduced expression of deoxycytidine kinase through epigenetic mechanisms

(2021) Keishi Yoshida et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Pharmacologic Inhibitor of DNA-PK, M3814, Potentiates Radiotherapy and Regresses Human Tumors in Mouse Models

(2020) Frank T. Zenke et al.   MOLECULAR CANCER THERAPEUTICS

Identification and characterization of novel SCR7‐based small‐molecule inhibitor of DNA end‐joining, SCR130 and its relevance in cancer therapeutics

(2020) Ujjayinee Ray et al.   MOLECULAR CARCINOGENESIS

Response of Breast Cancer Cells to PARP Inhibitors Is Independent of BRCA Status

(2020) Man Yee Keung et al.   Journal of Clinical Medicine

Inhibitors of DNA Double-Strand Break Repair at the Crossroads of Cancer Therapy and Genome Editing

(2020) Ujjayinee Ray et al.   BIOCHEMICAL PHARMACOLOGY

NHEJ Inhibitor SCR7 and its Different Forms: Promising CRISPR Tools for Genome Engineering

(2020) Ujjayinee Ray et al.   GENE

Modulation of DNA double-strand break repair as a strategy to improve precise genome editing

(2020) Ujjayinee Ray et al.   ONCOGENE

A historical reflection on our understanding of radiation-induced DNA double strand break repair in somatic mammalian cells; interfacing the past with the present

(2019) Atsushi Shibata et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

PrankWeb: a web server for ligand binding site prediction and visualization

(2019) Lukas Jendele et al.   NUCLEIC ACIDS RESEARCH

DNA-PK as an Emerging Therapeutic Target in Cancer

(2019) Ismail S. Mohiuddin et al.   Frontiers in Oncology

Harnessing DNA Double-Strand Break Repair for Cancer Treatment

(2019) Anika Trenner et al.   Frontiers in Oncology

MRN complex-dependent recruitment of ubiquitylated BLM helicase to DSBs negatively regulates DNA repair pathways

(2018) Vivek Tripathi et al.   Nature Communications

Autocyclized and Oxidized Forms of SCR7 Induce Cancer Cell Death by Inhibiting Nonhomologous DNA End joining in a Ligase IV Dependent Manner

(2018) Supriya V. Vartak et al.   FEBS Journal

HSP110 translocates to the nucleus upon genotoxic chemotherapy and promotes DNA repair in colorectal cancer cells

(2018) Sebastien Z. Causse et al.   ONCOGENE

Green synthesis palladium nanoparticles mediated by white tea (Camellia sinensis) extract with antioxidant, antibacterial, and antiproliferative activities toward the human leukemia (MOLT-4) cell line

(2017) Susan Azizi et al.   International Journal of Nanomedicine

The Role of the Core Non-Homologous End Joining Factors in Carcinogenesis and Cancer

(2017) et al.   Cancers

A novel inhibitor of BCL2, Disarib abrogates tumor growth while sparing platelets, by activating intrinsic pathway of apoptosis

(2016) Supriya V. Vartak et al.   BIOCHEMICAL PHARMACOLOGY

DNA repair of myeloma plasma cells correlates with clinical outcome: the effect of the nonhomologous end-joining inhibitor SCR7

(2016) M. Gkotzamanidou et al.   BLOOD

The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models

(2016) L. Oplustil O'Connor et al.   CANCER RESEARCH

Induction of DNA damage and erroneous repair can explain genomic instability caused by endosulfan

(2016) Robin Sebastian et al.   CARCINOGENESIS

A novel small molecule inhibitor of the DNA repair protein Ku70/80

(2016) Eric Weterings et al.   DNA REPAIR

Identification of a novel BCL2-specific inhibitor that binds predominantly to the BH1 domain

(2016) Divyaanka Iyer et al.   FEBS Journal

Different DNA End Configurations Dictate Which NHEJ Components Are Most Important for Joining Efficiency

(2016) Howard H. Y. Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and characterization of novel ligase I inhibitors

(2016) Monica Pandey et al.   MOLECULAR CARCINOGENESIS

DNA Double-Strand Break Repair Inhibitors as Cancer Therapeutics

(2015) Mrinal Srivastava et al.   CHEMISTRY & BIOLOGY

Pluronic copolymer encapsulated SCR7 as a potential anticancer agent

(2015) Franklin John et al.   FARADAY DISCUSSIONS

Inhibition of nonhomologous end joining to increase the specificity of CRISPR/Cas9 genome editing

(2015) Supriya V. Vartak et al.   FEBS Journal

Mechanisms and Consequences of Double-Strand DNA Break Formation in Chromatin

(2015) Wendy J. Cannan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining

(2015) Takeshi Maruyama et al.   NATURE BIOTECHNOLOGY

Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells

(2015) Van Trung Chu et al.   NATURE BIOTECHNOLOGY

Pluronic copolymer encapsulated SCR7 as a potential anticancer agent

(2015) Franklin John et al.   FARADAY DISCUSSIONS

A Mouse Geneticist's Practical Guide to CRISPR Applications

(2014) P. Singh et al.   GENETICS

Enhanced Efficacy of Pluronic Copolymer Micelle Encapsulated SCR7 against Cancer Cell Proliferation

(2014) Franklin John et al.   MACROMOLECULAR BIOSCIENCE

Targeting mTORC1-Mediated Metabolic Addiction Overcomes Fludarabine Resistance in Malignant B Cells

(2014) A. Sharma et al.   MOLECULAR CANCER RESEARCH

Sources of DNA Double-Strand Breaks and Models of Recombinational DNA Repair

(2014) A. Mehta et al.   Cold Spring Harbor Perspectives in Biology

Chemotherapeutic Compounds Targeting the DNA Double-Strand Break Repair Pathways: The Good, the Bad, and the Promising

(2014) Christian Jekimovs et al.   Frontiers in Oncology

Propyl-2-(8-(3,4-Difluorobenzyl)-2′,5′-Dioxo-8-Azaspiro[Bicyclo[3.2.1] Octane-3,4′-Imidazolidine]-1′-yl) Acetate Induces Apoptosis in Human Leukemia Cells through Mitochondrial Pathway following Cell Cycle Arrest

(2013) Chandagirikoppal V. Kavitha et al.   PLoS One

Structure of the Catalytic Region of DNA Ligase IV in Complex with an Artemis Fragment Sheds Light on Double-Strand Break Repair

(2013) Takashi Ochi et al.   STRUCTURE

Small Molecules, Inhibitors of DNA-PK, Targeting DNA Repair, and Beyond

(2013) David Davidson et al.   Frontiers in Pharmacology

An Inhibitor of Nonhomologous End-Joining Abrogates Double-Strand Break Repair and Impedes Cancer Progression

(2012) Mrinal Srivastava et al.   CELL

Role of recombination activating genes in the generation of antigen receptor diversity and beyond

(2012) Mayilaadumveettil Nishana et al.   IMMUNOLOGY

Development of artemisinin compounds for cancer treatment

(2012) Henry C. Lai et al.   INVESTIGATIONAL NEW DRUGS

Mechanism of Fragility atBCL2Gene Minor Breakpoint Cluster Region during t(14;18) Chromosomal Translocation

(2012) Mridula Nambiar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Time-Dependent Predominance of Nonhomologous DNA End-Joining Pathways during Embryonic Development in Mice

(2012) Kishore K. Chiruvella et al.   JOURNAL OF MOLECULAR BIOLOGY

V(D)J Recombination: Mechanisms of Initiation

(2011) David G. Schatz et al.   Annual Review of Genetics

Irinotecan and DNA-PKcs inhibitors synergize in killing of colon cancer cells

(2011) David Davidson et al.   INVESTIGATIONAL NEW DRUGS

Alkylation Base Damage Is Converted into Repairable Double-Strand Breaks and Complex Intermediates in G2 Cells Lacking AP Endonuclease

(2011) Wenjian Ma et al.   PLoS Genetics

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

(2010) Samuel F. Bunting et al.   CELL

Efficiency of nonhomologous DNA end joining varies among somatic tissues, despite similarity in mechanism

(2010) Sheetal Sharma et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Anti-apoptotic Protein BCL2 Down-regulates DNA End Joining in Cancer Cells

(2010) Tadi Satish Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Radioresistant cervical cancer shows upregulation of the NHEJ proteins DNA-PKcs, Ku70 and Ku86

(2009) C Beskow et al.   BRITISH JOURNAL OF CANCER

Impaired DNA damage response — An Achilles' heel sensitizing cancer to chemotherapy and radiotherapy

(2009) Zbigniew Darzynkiewicz et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A novel DNA intercalator, butylamino-pyrimido[4′,5′:4,5]selenolo(2,3-b)quinoline, induces cell cycle arrest and apoptosis in leukemic cells

(2009) M. S. Shahabuddin et al.   INVESTIGATIONAL NEW DRUGS

Synthesis and cytotoxic activities of chloropyridylimineplatinum(II) and chloropyridyliminecopper(II) surface-functionalized poly(amidoamine) dendrimers

(2009) Xinxin Zhao et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Rational Design of Human DNA Ligase Inhibitors that Target Cellular DNA Replication and Repair

(2008) X. Chen et al.   CANCER RESEARCH

Methyl angolensate, a natural tetranortriterpenoid induces intrinsic apoptotic pathway in leukemic cells

(2008) Kishore K. Chiruvella et al.   FEBS LETTERS