Inhibition of DNA Repair in Cancer Therapy: Toward a Multi-Target Approach

Targeted brain tumor radiotherapy using an Auger emitter

(2020) Giacomo Pirovano et al.   CLINICAL CANCER RESEARCH

The kinase polypharmacology landscape of clinical PARP inhibitors

(2020) Albert A. Antolin et al.   Scientific Reports

Poly(ADP-Ribose)Polymerase (PARP) Inhibitors and Radiation Therapy

(2020) Stephen A. Jannetti et al.   Frontiers in Pharmacology

Molecular Mechanisms of Radiation-Induced Cancer Cell Death: A Primer

(2020) Joseph Sia et al.   Frontiers in Cell and Developmental Biology

Exploiting the Microhomology-Mediated End-Joining Pathway in Cancer Therapy

(2020) Jeffrey Patterson-Fortin et al.   CANCER RESEARCH

DNA polymerase beta modulates cancer progression via enhancing CDH13 expression by promoter demethylation

(2020) Meina Wang et al.   ONCOGENE

Rad9/53BP1 promotes DNA repair via crossover recombination by limiting the Sgs1 and Mph1 helicases

(2020) Matteo Ferrari et al.   Nature Communications

DNA Polymerase theta (POLQ) is important for repair of DNA double-strand breaks caused by fork collapse

(2019) Zi Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN)

(2019) Joshua A. Sommers et al.   PLoS One

ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks

(2019) Gabriel Balmus et al.   Nature Communications

Current strategies for the targeted treatment of high-grade serous epithelial ovarian cancer and relevance of BRCA mutational status

(2019) Angiolo Gadducci et al.   Journal of Ovarian Research

Tyrosine kinase c-Abl couples RNA polymerase II transcription to DNA double-strand breaks

(2019) Kaspar Burger et al.   NUCLEIC ACIDS RESEARCH

Dynamic Processing of Displacement Loops during Recombinational DNA Repair

(2019) Aurèle Piazza et al.   MOLECULAR CELL

Rad51/BRCA2 disruptors inhibit homologous recombination and synergize with olaparib in pancreatic cancer cells

(2019) Marinella Roberti et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Downregulation of APE1 potentiates breast cancer cells to olaparib by inhibiting PARP-1 expression

(2019) Xiaobin Ma et al.   BREAST CANCER RESEARCH AND TREATMENT

53BP1 as a potential predictor of response in PARP inhibitor-treated homologous recombination-deficient ovarian cancer

(2019) Rachel M. Hurley et al.   GYNECOLOGIC ONCOLOGY

Targeting PARP-1 with alpha-particles is potently cytotoxic to human neuroblastoma in pre-clinical models

(2019) Mehran Makvandi et al.   MOLECULAR CANCER THERAPEUTICS

Computational analysis of data from a genome-wide screening identifies new PARP1 functional interactors as potential therapeutic targets

(2019) Samuele Lodovichi et al.   Oncotarget

Eukaryotic Base Excision Repair: New Approaches Shine Light on Mechanism

(2019) William A. Beard et al.   Annual Review of Biochemistry

Radiation-induced synthetic lethality: combination of poly(ADP-ribose) polymerase and RAD51 inhibitors to sensitize cells to proton irradiation

(2019) Anne-Catherine Wéra et al.   CELL CYCLE

A comprehensive review of topoisomerase inhibitors as anticancer agents in the past decade

(2019) Xiaoxia Liang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

APE1 and NPM1 protect cancer cells from platinum compounds cytotoxicity and their expression pattern has a prognostic value in TNBC

(2019) Matilde Clarissa Malfatti et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Synthetic lethality between BRCA1 deficiency and poly(ADP-ribose) polymerase inhibition is modulated by processing of endogenous oxidative DNA damage

(2019) Sara Giovannini et al.   NUCLEIC ACIDS RESEARCH

DNA‑PKcs inhibitor increases the sensitivity of gastric cancer cells to radiotherapy

(2019) Wei Geng et al.   ONCOLOGY REPORTS

ATM in DNA repair in cancer

(2019) Mei Hua Jin et al.   PHARMACOLOGY & THERAPEUTICS

Novel variants of unknown significance in the PMS2 gene identified in patients with hereditary colon cancer

(2019) Raffaella Liccardo et al.   Cancer Management and Research

DNA-PK as an Emerging Therapeutic Target in Cancer

(2019) Ismail S. Mohiuddin et al.   Frontiers in Oncology

Pharmacology of the ATM inhibitor AZD0156: potentiation of irradiation and olaparib responses pre-clinically.

(2019) Lucy C. Riches et al.   MOLECULAR CANCER THERAPEUTICS

Inhibition of APE1-endonuclease activity affects cell metabolism in colon cancer cells via a p53-dependent pathway

(2019) Marta Codrich et al.   DNA REPAIR

MRE11-RAD50-NBS1 complex alterations and DNA damage response: implications for cancer treatment

(2019) Lei Bian et al.   Molecular Cancer

The novel ATR inhibitor BAY 1895344 is efficacious as monotherapy and combined with DNA damage-inducing or repair-compromising therapies in preclinical cancer models

(2019) Antje M. Wengner et al.   MOLECULAR CANCER THERAPEUTICS

Synthetic lethality as an engine for cancer drug target discovery

(2019) Alan Huang et al.   NATURE REVIEWS DRUG DISCOVERY

Genetic determinants of cellular addiction to DNA polymerase theta

(2019) Wanjuan Feng et al.   Nature Communications

Identification Of Natural Compound Derivative For Inhibition Of XLF And Overcoming Chemoresistance In Colorectal Cancer Cells

(2019) Zhuo Liu et al.   Drug Design Development and Therapy

RAD52 as a Potential Target for Synthetic Lethality-Based Anticancer Therapies

(2019) Toma et al.   Cancers

RAD52 Functions in Homologous Recombination and Its Importance on Genomic Integrity Maintenance and Cancer Therapy

(2019) Augusto Nogueira et al.   Cancers

Clinical significance of MLH1/MSH2 for stage II/III sporadic colorectal cancer

(2019) Shui-Ming Wang et al.   World Journal of Gastrointestinal Oncology

DNA Oxidation and Excision Repair Pathways

(2019) Tae-Hee Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Activity of M3814, an Oral DNA-PK Inhibitor, In Combination with Topoisomerase II Inhibitors in Ovarian Cancer Models

(2019) Hannah C. Wise et al.   Scientific Reports

The Enigmatic Function of PARP1: From PARylation Activity to PAR Readers

(2019) Tatiana Kamaletdinova et al.   Cells

Inhibition of Ubiquitin Specific Protease 1 Sensitizes Colorectal Cancer Cells to DNA-Damaging Chemotherapeutics

(2019) Xin Xu et al.   Frontiers in Oncology

Harnessing DNA Double-Strand Break Repair for Cancer Treatment

(2019) Anika Trenner et al.   Frontiers in Oncology

Genetic testing for hereditary prostate cancer: Current status and limitations

(2018) Jun Tu Zhen et al.   CANCER

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

(2018) Katherine A. Hoadley et al.   CELL

Non-canonical functions of microRNA pathway enzymes - Drosha, DGCR8, Dicer and Ago proteins

(2018) Sheng Kai Pong et al.   FEBS LETTERS

MSH6 and PMS2 germ-line pathogenic variants implicated in Lynch syndrome are associated with breast cancer

(2018) Maegan E Roberts et al.   GENETICS IN MEDICINE

Homologous recombination and the repair of DNA double-strand breaks

(2018) William Douglass Wright et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The DNA-PK Inhibitor VX-984 Enhances the Radiosensitivity of Glioblastoma Cells GrownIn Vitroand as Orthotopic Xenografts

(2018) Cindy R. Timme et al.   MOLECULAR CANCER THERAPEUTICS

A Short BRCA2-Derived Cell-Penetrating Peptide Targets RAD51 Function and Confers Hypersensitivity toward PARP Inhibition

(2018) Anika Trenner et al.   MOLECULAR CANCER THERAPEUTICS

Super-resolution imaging identifies PARP1 and the Ku complex acting as DNA double-strand break sensors

(2018) Guang Yang et al.   NUCLEIC ACIDS RESEARCH

MRN complex-dependent recruitment of ubiquitylated BLM helicase to DSBs negatively regulates DNA repair pathways

(2018) Vivek Tripathi et al.   Nature Communications

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas

(2018) Theo A. Knijnenburg et al.   Cell Reports

Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Tumor Cells

(2018) Katherine Sullivan-Reed et al.   Cell Reports

Combined Inhibition of ATR and WEE1 as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer

(2018) Juan Jin et al.   NEOPLASIA

The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models

(2018) Stephen T. Durant et al.   Science Advances

Expressional analysis of MLH1 and MSH2 in breast cancer

(2018) Saima Shakil Malik et al.   CURRENT PROBLEMS IN CANCER

Mechanisms of PARP inhibitor sensitivity and resistance

(2018) Alan D. D’Andrea   DNA REPAIR

MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors

(2018) Marialaura Petroni et al.   Cell Death & Disease

Functional Interaction Between BRCA1 and DNA Repair in Yeast May Uncover a Role of RAD50, RAD51, MRE11A, and MSH6 Somatic Variants in Cancer Development

(2018) Luisa Maresca et al.   Frontiers in Genetics

Nucleotide Excision Repair Factor XPC Ameliorates Prognosis by Increasing the Susceptibility of Human Colorectal Cancer to Chemotherapy and Ionizing Radiation

(2018) Liang-Bo Hu et al.   Frontiers in Oncology

Genomic analysis of DNA repair genes and androgen signaling in prostate cancer

(2018) Kasey Jividen et al.   BMC CANCER

Aneuploid acute myeloid leukemia exhibits a signature of genomic alterations in the cell cycle and protein degradation machinery

(2018) Giorgia Simonetti et al.   CANCER

53BP1: A key player of DNA damage response with critical functions in cancer

(2018) Mohammad Mirza-Aghazadeh-Attari et al.   DNA REPAIR

Function and Interactions of ERCC1-XPF in DNA Damage Response

(2018) Maryam Faridounnia et al.   MOLECULES

XPA, XPC, and XPD Modulate Sensitivity in Gastric Cisplatin Resistance Cancer Cells

(2018) Natalia Pajuelo-Lozano et al.   Frontiers in Pharmacology

PARP inhibition enhances tumor cell–intrinsic immunity in ERCC1-deficient non–small cell lung cancer

(2018) Roman M. Chabanon et al.   JOURNAL OF CLINICAL INVESTIGATION

Physiological protein blocks direct the Mre11–Rad50–Xrs2 and Sae2 nuclease complex to initiate DNA end resection

(2017) Giordano Reginato et al.   GENES & DEVELOPMENT

RAD51 as a potential surrogate marker for DNA repair capacity in solid malignancies

(2017) Mariam Gachechiladze et al.   INTERNATIONAL JOURNAL OF CANCER

Chromatin remodelling and DNA repair genes are frequently mutated in endometrioid endometrial carcinoma

(2017) Pablo García-Sanz et al.   INTERNATIONAL JOURNAL OF CANCER

DNA2—An Important Player in DNA Damage Response or Just Another DNA Maintenance Protein?

(2017) Elzbieta Pawłowska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Drugging the Cancers Addicted to DNA Repair

(2017) Jac A. Nickoloff et al.   JNCI-Journal of the National Cancer Institute

Loss of DNA Damage Response in Neuroblastoma and Utility of a PARP Inhibitor

(2017) Masatoshi Takagi et al.   JNCI-Journal of the National Cancer Institute

Identifying synthetic lethal targets using CRISPR/Cas9 system

(2017) Jaspreet Kaur Dhanjal et al.   METHODS

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

(2017) Andrew N. Blackford et al.   MOLECULAR CELL

DNA mismatch repair and its many roles in eukaryotic cells

(2017) Dekang Liu et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR–Cas9 genome-editing efficiency

(2017) Marella D Canny et al.   NATURE BIOTECHNOLOGY

Synthetic lethality and cancer

(2017) Nigel J. O'Neil et al.   NATURE REVIEWS GENETICS

The essential kinase ATR: ensuring faithful duplication of a challenging genome

(2017) Joshua C. Saldivar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The multifaceted roles of PARP1 in DNA repair and chromatin remodelling

(2017) Arnab Ray Chaudhuri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The homologous recombination protein RAD51 is a promising therapeutic target for cervical carcinoma

(2017) Qian Chen et al.   ONCOLOGY REPORTS

Poly(ADP-ribose) polymerase 1 escorts XPC to UV-induced DNA lesions during nucleotide excision repair

(2017) Mihaela Robu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An analysis of the gene interaction networks identifying the role of PARP1 in metastasis of non-small cell lung cancer

(2017) Kai Chen et al.   Oncotarget

Improving radiotherapy in cancer treatment: Promises and challenges

(2017) Helen H.W. Chen et al.   Oncotarget

APE1 overexpression is associated with poor survival in patients with solid tumors: a meta-analysis

(2017) Chun-Ling Yuan et al.   Oncotarget

Single nucleotide polymorphisms of nucleotide excision repair pathway are significantly associated with outcomes of platinum-based chemotherapy in lung cancer

(2017) Xiao Song et al.   Scientific Reports

ATR Mutations Promote the Growth of Melanoma Tumors by Modulating the Immune Microenvironment

(2017) Chi-Fen Chen et al.   Cell Reports

Enhancement of BLM-DNA2-Mediated Long-Range DNA End Resection by CtIP

(2017) James M. Daley et al.   Cell Reports

Drugging the Cancers Addicted to DNA Repair

(2017) Jac A. Nickoloff et al.   JNCI-Journal of the National Cancer Institute

Loss of DNA Damage Response in Neuroblastoma and Utility of a PARP Inhibitor

(2017) Masatoshi Takagi et al.   JNCI-Journal of the National Cancer Institute

The Role of the Core Non-Homologous End Joining Factors in Carcinogenesis and Cancer

(2017) et al.   Cancers

Targeting the ATR-CHK1 Axis in Cancer Therapy

(2017) Stuart Rundle et al.   Cancers

Suppression of the FA pathway combined with CHK1 inhibitor hypersensitize lung cancer cells to gemcitabine

(2017) Chun-Hua Dai et al.   Scientific Reports

Non-homologous end joining: advances and frontiers

(2016) Kai Yang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

An open-label, dose-escalation study to evaluate the safety and pharmacokinetics of CEP-9722 (a PARP-1 and PARP-2 inhibitor) in combination with gemcitabine and cisplatin in patients with advanced solid tumors

(2016) Ahmad Awada et al.   ANTI-CANCER DRUGS

53BP1 depletion causes PARP inhibitor resistance in ATM-deficient breast cancer cells

(2016) Ruoxi Hong et al.   BMC CANCER

Women at high risk of breast cancer: Molecular characteristics, clinical presentation and management

(2016) Zdenek Kleibl et al.   BREAST

Targeting the ATR/CHK1 Axis with PARP Inhibition Results in Tumor Regression in BRCA -Mutant Ovarian Cancer Models

(2016) Hyoung Kim et al.   CLINICAL CANCER RESEARCH

A novel small molecule inhibitor of the DNA repair protein Ku70/80

(2016) Eric Weterings et al.   DNA REPAIR

XPA: A key scaffold for human nucleotide excision repair

(2016) Norie Sugitani et al.   DNA REPAIR

DNA polymerase θ (POLQ), double-strand break repair, and cancer

(2016) Richard D. Wood et al.   DNA REPAIR

Interplay between Fanconi anemia and homologous recombination pathways in genome integrity

(2016) Johanna Michl et al.   EMBO JOURNAL

53BP1 loss induces chemoresistance of colorectal cancer cells to 5-fluorouracil by inhibiting the ATM–CHK2–P53 pathway

(2016) Jing Yao et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

WRN-targeted therapy using inhibitors NSC 19630 and NSC 617145 induce apoptosis in HTLV-1-transformed adult T-cell leukemia cells

(2016) R. Moles et al.   Journal of Hematology & Oncology

Biochemical and cell biological assays to identify and characterize DNA helicase inhibitors

(2016) Taraswi Banerjee et al.   METHODS

ATM Mutations in Cancer: Therapeutic Implications

(2016) M. Choi et al.   MOLECULAR CANCER THERAPEUTICS

The Fanconi anaemia pathway: new players and new functions

(2016) Raphael Ceccaldi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Overlapping roles for PARP1 and PARP2 in the recruitment of endogenous XRCC1 and PNKP into oxidized chromatin

(2016) Hana Hanzlikova et al.   NUCLEIC ACIDS RESEARCH

Targeting BRCA1- and BRCA2-deficient cells with RAD52 small molecule inhibitors

(2016) Fei Huang et al.   NUCLEIC ACIDS RESEARCH

DNA repair targeted therapy: The past or future of cancer treatment?

(2016) Navnath S. Gavande et al.   PHARMACOLOGY & THERAPEUTICS

ATR inhibition rewires cellular signaling networks induced by replication stress

(2016) Sebastian A. Wagner et al.   PROTEOMICS

Regulation of Single-Strand Annealing and its Role in Genome Maintenance

(2016) Ragini Bhargava et al.   TRENDS IN GENETICS

High PARP-1 expression is associated with tumor invasion and poor prognosis in gastric cancer

(2016) Ying Liu et al.   Oncology Letters

High ERCC1 expression is associated with platinum-resistance, but not survival in patients with epithelial ovarian cancer

(2016) Pei Du et al.   Oncology Letters

WRN regulates pathway choice between classical and alternative non-homologous end joining

(2016) Raghavendra A. Shamanna et al.   Nature Communications

The DNA resection protein CtIP promotes mammary tumorigenesis

(2016) Colleen R. Reczek et al.   Oncotarget

R152C DNA Pol β mutation impairs base excision repair and induces cellular transformation

(2016) Ting Zhou et al.   Oncotarget

Identification of small molecule inhibitors of ERCC1-XPF that inhibit DNA repair and potentiate cisplatin efficacy in cancer cells

(2016) Sanjeevani Arora et al.   Oncotarget

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities

(2016) Kumar Sanjiv et al.   Cell Reports

Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation

(2016) Max A Horlbeck et al.   eLife

A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to Chemotherapy

(2016) Wenpeng Liu et al.   EBioMedicine

Identification of a Fragment-like Small Molecule Ligand for the Methyl-lysine Binding Protein, 53BP1

(2015) Michael T. Perfetti et al.   ACS Chemical Biology

Eukaryotic Mismatch Repair in Relation to DNA Replication

(2015) Thomas A. Kunkel et al.   Annual Review of Genetics

Innate Immune Recognition of Cancer

(2015) Seng-Ryong Woo et al.   Annual Review of Immunology

How cancer cells hijack DNA double-strand break repair pathways to gain genomic instability

(2015) P. A. Jeggo et al.   BIOCHEMICAL JOURNAL

ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53- or ATM-defective chronic lymphocytic leukemia cells

(2015) M. Kwok et al.   BLOOD

Yet another job for Dna2: Checkpoint activation

(2015) Paulina H. Wanrooij et al.   DNA REPAIR

Inhibition of the ERCC1–XPF structure-specific endonuclease to overcome cancer chemoresistance

(2015) Ewan M. McNeil et al.   DNA REPAIR

Nucleotide excision repair in humans

(2015) Graciela Spivak   DNA REPAIR

MSH2 role in BRCA1-driven tumorigenesis: A preliminary study in yeast and in human tumors from BRCA1-VUS carriers

(2015) Luisa Maresca et al.   European Journal of Medical Genetics

Synthesis, molecular modeling, and biological evaluation of novel RAD51 inhibitors

(2015) Jiewen Zhu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Error-Prone Repair of DNA Double-Strand Breaks

(2015) Kasey Rodgers et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Inhibitors of the apurinic/apyrimidinic endonuclease 1 (APE1)/nucleophosmin (NPM1) interaction that display anti-tumor properties

(2015) Mattia Poletto et al.   MOLECULAR CARCINOGENESIS

Exploiting the Fanconi Anemia Pathway for Targeted Anti-Cancer Therapy

(2015) Ukhyun Jo et al.   MOLECULES AND CELLS

Expression of human poly (ADP-ribose) polymerase 1 in Saccharomyces cerevisiae: Effect on survival, homologous recombination and identification of genes involved in intracellular localization

(2015) Marco La Ferla et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

(2015) Raphael Ceccaldi et al.   NATURE

The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice

(2015) Ismail Hassan Ismail et al.   NATURE CELL BIOLOGY

The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function

(2015) Claire Breslin et al.   NUCLEIC ACIDS RESEARCH

NSC666715 and Its Analogs Inhibit Strand-Displacement Activity of DNA Polymerase β and Potentiate Temozolomide-Induced DNA Damage, Senescence and Apoptosis in Colorectal Cancer Cells

(2015) Aruna S. Jaiswal et al.   PLoS One

Heterozygous p.I171V mutation of the NBN gene as a risk factor for lung cancer development

(2015) EWELINA MARIA KAŁUŻNA et al.   Oncology Letters

The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo

(2015) Frank P. Vendetti et al.   Oncotarget

A Synthetic Lethal Screen Identifies DNA Repair Pathways that Sensitize Cancer Cells to Combined ATR Inhibition and Cisplatin Treatments

(2015) Kareem N. Mohni et al.   PLoS One

Fanconi anemia and the development of leukemia

(2014) Blanche P. Alter   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

Effect of DNA Repair Deficiencies on the Cytotoxicity of Drugs Used in Cancer Therapy - A Review

(2014) Jose Calderon-Montano et al.   CURRENT MEDICINAL CHEMISTRY

XPF-ERCC1 Acts in Unhooking DNA Interstrand Crosslinks in Cooperation with FANCD2 and FANCP/SLX4

(2014) Daisy Klein Douwel et al.   MOLECULAR CELL

DNA polymerase β deficiency is linked to aggressive breast cancer: A comprehensive analysis of gene copy number, mRNA and protein expression in multiple cohorts

(2014) Tarek M.A. Abdel-Fatah et al.   Molecular Oncology

A selective USP1–UAF1 inhibitor links deubiquitination to DNA damage responses

(2014) Qin Liang et al.   Nature Chemical Biology

Novel Developments in the Use of Antimetabolites

(2014) Godefridus J. Peters   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

A Small Molecule Inhibitor of Human RAD51 Potentiates Breast Cancer Cell Killing by Therapeutic Agents in Mouse Xenografts

(2014) Fei Huang et al.   PLoS One

CHK2 kinase in the DNA damage response and beyond

(2014) L. Zannini et al.   Journal of Molecular Cell Biology

Beyond DNA Repair: DNA-PK Function in Cancer

(2014) J. F. Goodwin et al.   Cancer Discovery

A Small-Molecule Inhibitor of RAD51 Reduces Homologous Recombination and Sensitizes Multiple Myeloma Cells to Doxorubicin

(2014) David A. Alagpulinsa et al.   Frontiers in Oncology

Targeting an Achilles’ heel of cancer with a WRN helicase inhibitor

(2013) Monika Aggarwal et al.   CELL CYCLE

Roles of Chk1 in cell biology and cancer therapy

(2013) Youwei Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells

(2013) L. N. Truong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of 53BP1 in the Regulation of DNA Double-Strand Break Repair Pathway Choice

(2013) Arun Gupta et al.   RADIATION RESEARCH

Germline Mutation in ATR in Autosomal- Dominant Oropharyngeal Cancer Syndrome

(2012) Akio Tanaka et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Inhibition of BRCT(BRCA1)-phosphoprotein interaction enhances the cytotoxic effect of olaparib in breast cancer cells: a proof of concept study for synthetic lethal therapeutic option

(2012) Ziyan Yuan Pessetto et al.   BREAST CANCER RESEARCH AND TREATMENT

The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy

(2012) Remko Prevo et al.   CANCER BIOLOGY & THERAPY

PARP inhibition selectively increases sensitivity to cisplatin in ERCC1-low non-small cell lung cancer cells

(2012) H. Cheng et al.   CARCINOGENESIS

Inhibition of the Nedd8 System Sensitizes Cells to DNA Interstrand Cross-linking Agents

(2012) Y. Kee et al.   MOLECULAR CANCER RESEARCH

Activation of DSB Processing Requires Phosphorylation of CtIP by ATR

(2012) Shaun E. Peterson et al.   MOLECULAR CELL

PALB2 self-interaction controls homologous recombination

(2012) Rémi Buisson et al.   NUCLEIC ACIDS RESEARCH

Tyrosine phosphorylation enhances RAD52-mediated annealing by modulating its DNA binding

(2011) Masayoshi Honda et al.   EMBO JOURNAL

Mitotic catastrophe: a mechanism for avoiding genomic instability

(2011) Ilio Vitale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SnapShot: DNA Mismatch Repair

(2010) Andres A. Larrea et al.   CELL

Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA

(2010) Jie Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA ligase IV as a new molecular target for temozolomide

(2009) Natsuko Kondo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

In vitro and In vivo Radiosensitization of Glioblastoma Cells by the Poly (ADP-Ribose) Polymerase Inhibitor E7016

(2009) A. L. Russo et al.   CLINICAL CANCER RESEARCH

Functional Interaction between the Fanconi Anemia D2 Protein and Proliferating Cell Nuclear Antigen (PCNA) via a Conserved Putative PCNA Interaction Motif

(2009) Niall G. Howlett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance

(2009) L. S. Waters et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Up-regulation of WRN and DNA ligase III  in chronic myeloid leukemia: consequences for the repair of DNA double-strand breaks

(2008) A. Sallmyr et al.   BLOOD

Phenylbutyrate interferes with the Fanconi anemia and BRCA pathway and sensitizes head and neck cancer cells to cisplatin

(2008) Kyunghee Burkitt et al.   Molecular Cancer

MMEJ repair of double-strand breaks (director’s cut): deleted sequences and alternative endings

(2008) Mitch McVey et al.   TRENDS IN GENETICS