Training vs. Tolerance: The Yin/Yang of the Innate Immune System

Involvement of the Innate Immune System in the Pathogenesis of Chronic Obstructive Pulmonary Disease

(2022) Stanislav Kotlyarov   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Reply to: ‘Lack of evidence for intergenerational inheritance of immune resistance to infections’

(2022) Natalie Katzmarski et al.   NATURE IMMUNOLOGY

Lack of evidence for intergenerational inheritance of immune resistance to infections

(2022) Eva Kaufmann et al.   NATURE IMMUNOLOGY

Caloric restriction in humans reveals immunometabolic regulators of health span

(2022) O. Spadaro et al.   SCIENCE

TLR4 is a regulator of trained immunity in a murine model of Duchenne muscular dystrophy

(2022) Salyan Bhattarai et al.   Nature Communications

The induction of peripheral trained immunity in the pancreas incites anti-tumor activity to control pancreatic cancer progression

(2022) Anne E. Geller et al.   Nature Communications

Dynamic increase of M2 macrophages is associated with disease progression of colorectal cancers following cetuximab-based treatment

(2022) Hyung-Don Kim et al.   Scientific Reports

LPS Guides Distinct Patterns of Training and Tolerance in Mast Cells

(2022) Marco De Zuani et al.   Frontiers in Immunology

Regulating trained immunity with nanomedicine

(2022) Mandy M. T. van Leent et al.   Nature Reviews Materials

Gut Microbiota-Derived Small Extracellular Vesicles Endorse Memory-like Inflammatory Responses in Murine Neutrophils

(2022) Trim Lajqi et al.   Biomedicines

Maladaptive innate immune training of myelopoiesis links inflammatory comorbidities

(2022) Xiaofei Li et al.   CELL

Gram-positive Staphylococcus aureus LTA promotes distinct memory-like effects in murine bone marrow neutrophils

(2022) Trim Lajqi et al.   CELLULAR IMMUNOLOGY

Epigenetic regulation of innate immune memory in microglia

(2022) Xiaoming Zhang et al.   Journal of Neuroinflammation

Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses

(2022) Lei-Lei Chen et al.   NATURE CELL BIOLOGY

Non-specific effects of BCG and DTP vaccination on infant mortality: An analysis of birth cohorts in Ghana and Tanzania

(2022) MK Quinn et al.   VACCINE

Functional in-vitro evaluation of the non-specific effects of BCG vaccination in a randomised controlled clinical study

(2022) Morven Wilkie et al.   Scientific Reports

Extracellular trap can be trained as a memory response

(2022) Yu Gao et al.   Virulence

Prophylactic and therapeutic insights into trained immunity: A renewed concept of innate immune memory

(2022) Suresh Bindu et al.   Human Vaccines & Immunotherapeutics

Trained Immunity Contribution to Autoimmune and Inflammatory Disorders

(2022) Samanta C. Funes et al.   Frontiers in Immunology

Trained Immunity Enhances Human Monocyte Function in Aging and Sepsis

(2022) P. Spencer Gill et al.   Frontiers in Immunology

Gut commensal Limosilactobacillus reuteri induces atypical memory-like phenotype in human dendritic cells in vitro

(2022) Gintare Lasaviciute et al.   Gut Microbes

Macrophages as tools and targets in cancer therapy

(2022) Alberto Mantovani et al.   NATURE REVIEWS DRUG DISCOVERY

Critical appraisal of serum urate targets in the management of gout

(2022) Lisa K. Stamp et al.   Nature Reviews Rheumatology

The future clinical implications of trained immunity

(2022) Valentin Nica et al.   Expert Review of Clinical Immunology

The role of neutrophils in trained immunity

(2022) Lydia Kalafati et al.   IMMUNOLOGICAL REVIEWS

NLRC3 expression in macrophage impairs glycolysis and host immune defense by modulating the NF-κB-NFAT5 complex during septic immunosuppression

(2022) Jiqian Xu et al.   MOLECULAR THERAPY

Trained immunity in type 2 immune responses

(2022) Franziska Hartung et al.   Mucosal Immunology

Trained immunity — basic concepts and contributions to immunopathology

(2022) Jordi Ochando et al.   Nature Reviews Nephrology

Plasma metabolome predicts trained immunity responses after antituberculosis BCG vaccination

(2022) Valerie A. C. M. Koeken et al.   PLOS BIOLOGY

Enriched dietary saturated fatty acids induce trained immunity via ceramide production that enhances severity of endotoxemia and clearance of infection

(2022) Amy L Seufert et al.   eLife

Trained immunity: adaptation within innate immune mechanisms

(2022) Jorge Domínguez-Andrés et al.   PHYSIOLOGICAL REVIEWS

Extracellular vesicles carrying HIV-1 Nef induce long-term hyperreactivity of myeloid cells

(2022) Larisa Dubrovsky et al.   Cell Reports

Sexual Dimorphism in Innate Immunity: The Role of Sex Hormones and Epigenetics

(2021) Rebecca Shepherd et al.   Frontiers in Immunology

Rheumatoid arthritis CD14 + monocytes display metabolic and inflammatory dysfunction, a phenotype that precedes clinical manifestation of disease

(2021) Trudy McGarry et al.   Clinical & Translational Immunology

LPS Tolerance Inhibits Cellular Respiration and Induces Global Changes in the Macrophage Secretome

(2021) Joseph Gillen et al.   Biomolecules

Diabetes and Metabolic Drivers of Trained Immunity

(2021) Robin P. Choudhury et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The Role of the Pathogen Dose and PI3Kγ in Immunometabolic Reprogramming of Microglia for Innate Immune Memory

(2021) Trim Lajqi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Systemic administration of β-glucan induces immune training in microglia

(2021) Yang Heng et al.   Journal of Neuroinflammation

BCG-induced non-specific effects on heterologous infectious disease in Ugandan neonates: an investigator-blind randomised controlled trial

(2021) Sarah Prentice et al.   LANCET INFECTIOUS DISEASES

Crosstalk Between Staphylococcus aureus and Innate Immunity: Focus on Immunometabolism

(2021) Christopher M. Horn et al.   Frontiers in Immunology

The Regulatory Role of α-Ketoglutarate Metabolism in Macrophages

(2021) Shaojuan Liu et al.   MEDIATORS OF INFLAMMATION

Targeting inflammation in atherosclerosis — from experimental insights to the clinic

(2021) Oliver Soehnlein et al.   NATURE REVIEWS DRUG DISCOVERY

How to Train Your Dragon: Harnessing Gamma Delta T Cells Antiviral Functions and Trained Immunity in a Pandemic Era

(2021) Jonathan Caron et al.   Frontiers in Immunology

Glutathione Metabolism Contributes to the Induction of Trained Immunity

(2021) Anaisa V. Ferreira et al.   Cells

miR–9-5p regulates immunometabolic and epigenetic pathways in β-glucan–trained immunity via IDH3α

(2021) Haibo Su et al.   JCI Insight

Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis

(2021) Laurienne Edgar et al.   CIRCULATION

LPS Induces Opposing Memory-like Inflammatory Responses in Mouse Bone Marrow Neutrophils

(2021) Trim Lajqi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Allergoid–mannan conjugates reprogram monocytes into tolerogenic dendritic cells via epigenetic and metabolic rewiring

(2021) Cristina Benito-Villalvilla et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Trained Immunity Confers Prolonged Protection From Listeriosis

(2021) Charlotte Théroude et al.   Frontiers in Immunology

Continuous Exposure to Non-Soluble β-Glucans Induces Trained Immunity in M-CSF-Differentiated Macrophages

(2021) Bart G. J. Moerings et al.   Frontiers in Immunology

A Synergy Between Endotoxin and (1→3)-Beta-D-Glucan Enhanced Neutrophil Extracellular Traps in Candida Administered Dextran Sulfate Solution Induced Colitis in FcGRIIB-/- Lupus Mice, an Impact of Intestinal Fungi in Lupus

(2021) Supichcha Saithong et al.   Journal of Inflammation Research

Brain innate immune response via miRNA-TLR7 sensing in polymicrobial sepsis

(2021) Lin Zou et al.   BRAIN BEHAVIOR AND IMMUNITY

Immune Memory in Aging: a Wide Perspective Covering Microbiota, Brain, Metabolism, and Epigenetics

(2021) Ozlem Bulut et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Adipose tissue induces trained innate immunity in patients with obesity

(2021) J Van Tuijl et al.   EUROPEAN HEART JOURNAL

Transmission of trained immunity and heterologous resistance to infections across generations

(2021) Natalie Katzmarski et al.   NATURE IMMUNOLOGY

Liver ischaemia–reperfusion injury: a new understanding of the role of innate immunity

(2021) Hirofumi Hirao et al.   Nature Reviews Gastroenterology & Hepatology

Trained innate immunity, long-lasting epigenetic modulation, and skewed myelopoiesis by heme

(2021) Elisa Jentho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytokine-induced memory-like natural killer cells for cancer immunotherapy

(2021) Mubin Tarannum et al.   Stem Cell Research & Therapy

Molecular and Cellular Mechanisms Modulating Trained Immunity by Various Cell Types in Response to Pathogen Encounter

(2021) Orlando A. Acevedo et al.   Frontiers in Immunology

Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging

(2020) Shuai Ma et al.   CELL

AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control

(2020) Asier González et al.   Cell Metabolism

Targeting immunometabolism as an anti-inflammatory strategy

(2020) Eva M. Pålsson-McDermott et al.   CELL RESEARCH

Trained Immunity: Linking Obesity and Cardiovascular Disease across the Life-Course?

(2020) Siroon Bekkering et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Trained Immunity: An Underlying Driver of Inflammatory Atherosclerosis

(2020) Chao Zhong et al.   Frontiers in Immunology

Pseudomonas aeruginosa Utilizes Host-Derived Itaconate to Redirect Its Metabolism to Promote Biofilm Formation

(2020) Sebastián A. Riquelme et al.   Cell Metabolism

Interaction between microbiota and immunity in health and disease

(2020) Danping Zheng et al.   CELL RESEARCH

Cytokine-like Roles for Metabolites in Immunity

(2020) Zbigniew Zasłona et al.   MOLECULAR CELL

β-Glucan Induces Protective Trained Immunity against Mycobacterium tuberculosis Infection: A Key Role for IL-1

(2020) Simone J.C.F.M. Moorlag et al.   Cell Reports

The Set7 Lysine Methyltransferase Regulates Plasticity in Oxidative Phosphorylation Necessary for Trained Immunity Induced by β-Glucan

(2020) Samuel T. Keating et al.   Cell Reports

BCG vaccine protection from severe coronavirus disease 2019 (COVID-19)

(2020) Luis E. Escobar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resident macrophages acquire innate immune memory in staphylococcal skin infection

(2020) Reinhild Feuerstein et al.   eLife

BCG-Induced Trained Immunity in Healthy Individuals: The Effect of Plasma Muramyl Dipeptide Concentrations

(2020) Vera P. Mourits et al.   Journal of Immunology Research

Dysregulation of Lipid Metabolism in Macrophages Is Responsible for Severe Endotoxin Tolerance in FcgRIIB-Deficient Lupus Mice

(2020) Thiranut Jaroonwitchawan et al.   Frontiers in Immunology

Characterizing the BCG Induced Macrophage and Neutrophil Mechanisms for Defense Against Mycobacterium tuberculosis

(2020) Thomas E. Bickett et al.   Frontiers in Immunology

Polarization of Low-Grade Inflammatory Monocytes Through TRAM-Mediated Up-Regulation of Keap1 by Super-Low Dose Endotoxin

(2020) Allison Rahtes et al.   Frontiers in Immunology

17β-Estradiol Promotes Trained Immunity in Females Against Sepsis via Regulating Nucleus Translocation of RelB

(2020) Zhiheng Sun et al.   Frontiers in Immunology

Mitochondrial Signature in Human Monocytes and Resistance to Infection in C. elegans During Fumarate-Induced Innate Immune Training

(2020) C. Angélica Pérez-Hernández et al.   Frontiers in Immunology

Innate immunity drives pathogenesis of rheumatoid arthritis

(2020) Maria I. Edilova et al.   Biomedical Journal

Trained immunity and tolerance in innate lymphoid cells, monocytes, and dendritic cells during allergen-specific immunotherapy

(2020) Andrzej Eljaszewicz et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Trained Innate Immunity by Repeated Low-Dose Lipopolysaccharide Injections Displays Long-Term Neuroprotective Effects

(2020) Xiao-yan Zhou et al.   MEDIATORS OF INFLAMMATION

Disease-Specific Autoantibodies Induce Trained Immunity in RA Synovial Tissues and Its Gene Signature Correlates with the Response to Clinical Therapy

(2020) Xiaoli Dai et al.   MEDIATORS OF INFLAMMATION

Immunometabolic control of trained immunity

(2020) Niels P. Riksen et al.   MOLECULAR ASPECTS OF MEDICINE

Trained Innate Immunity, Epigenetics, and Covid-19

(2020) Alberto Mantovani et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Role of Microbiota in Neutrophil Regulation and Adaptation in Newborns

(2020) Trim Lajqi et al.   Frontiers in Immunology

Memory-Like Responses of Brain Microglia Are Controlled by Developmental State and Pathogen Dose

(2020) Trim Lajqi et al.   Frontiers in Immunology

Lactate Suppresses Macrophage Pro-Inflammatory Response to LPS Stimulation by Inhibition of YAP and NF-κB Activation via GPR81-Mediated Signaling

(2020) Kun Yang et al.   Frontiers in Immunology

Updates in infection risk and management in acute leukemia

(2020) C. Logan et al.   Hematology-American Society of Hematology Education Program

Trained innate lymphoid cells in allergic diseases

(2020) Takashi Ebihara et al.   ALLERGOLOGY INTERNATIONAL

Tumor-Associated Macrophages in Tumor Immunity

(2020) Yueyun Pan et al.   Frontiers in Immunology

Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes

(2020) Hyuk Sung Kwon et al.   Translational Neurodegeneration

Immunity and Inflammation in Atherosclerosis

(2019) Dennis Wolf et al.   CIRCULATION RESEARCH

Mechanisms of Trained Innate Immunity in oxLDL Primed Human Coronary Smooth Muscle Cells

(2019) Lucia Schnack et al.   Frontiers in Immunology

Toxin-induced hormesis may restrain aging

(2019) Trim Lajqi et al.   BIOGERONTOLOGY

Identification of DNA methylation patterns predisposing for an efficient response to BCG vaccination in healthy BCG-naïve subjects

(2019) Jyotirmoy Das et al.   Epigenetics

Priming Microglia for Innate Immune Memory in the Brain

(2019) Jonas J. Neher et al.   TRENDS IN IMMUNOLOGY

Endotoxin tolerance modulates TREG and TH17 lymphocytes protecting septic mice

(2019) Mariana M.C. Andrade et al.   Oncotarget

Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia

(2019) Siroon Bekkering et al.   Cell Metabolism

Lactic Acid Inhibits Lipopolysaccharide-Induced Mast Cell Function by Limiting Glycolysis and ATP Availability

(2019) Heather L. Caslin et al.   JOURNAL OF IMMUNOLOGY

Endotoxin‐induced immunotolerance is associated with loss of monocyte metabolic plasticity and reduction of oxidative burst

(2019) Inge Grondman et al.   JOURNAL OF LEUKOCYTE BIOLOGY

S-glycosylation-based cysteine profiling reveals regulation of glycolysis by itaconate

(2019) Wei Qin et al.   Nature Chemical Biology

Hematopoietic progenitor cells as integrative hubs for adaptation to and fine-tuning of inflammation

(2019) Triantafyllos Chavakis et al.   NATURE IMMUNOLOGY

Tumour-associated neutrophils in patients with cancer

(2019) Merav E. Shaul et al.   Nature Reviews Clinical Oncology

Innate Immune Cells' Contribution to Systemic Lupus Erythematosus

(2019) Andrés A. Herrada et al.   Frontiers in Immunology

MicroRNAs as Molecular Switches in Macrophage Activation

(2019) Graziella Curtale et al.   Frontiers in Immunology

Trained Immunity in Organ Transplantation

(2019) Jordi Ochando et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The roles of microRNAs in epigenetic regulation

(2019) Qian Yao et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

β-Glucan-Induced Trained Immunity Protects against Leishmania braziliensis Infection: a Crucial Role for IL-32

(2019) Jéssica Cristina dos Santos et al.   Cell Reports

Western Diet and the Immune System: An Inflammatory Connection

(2019) Anette Christ et al.   IMMUNITY

Pathological alteration and therapeutic implications of sepsis-induced immune cell apoptosis

(2019) Chao Cao et al.   Cell Death & Disease

Systemic acquired resistance networks amplify airborne defense cues

(2019) Marion Wenig et al.   Nature Communications

Memory-Like Inflammatory Responses of Microglia to Rising Doses of LPS: Key Role of PI3Kγ

(2019) Trim Lajqi et al.   Frontiers in Immunology

Macrophages in Atherosclerosis Regression

(2019) Tessa J. Barrett   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Urate‐induced immune programming: Consequences for gouty arthritis and hyperuricemia

(2019) Georgiana Cabău et al.   IMMUNOLOGICAL REVIEWS

Trained Immunity Confers Broad-Spectrum Protection Against Bacterial Infections

(2019) Eleonora Ciarlo et al.   JOURNAL OF INFECTIOUS DISEASES

Trained immunity modulates inflammation-induced fibrosis

(2019) Mohamed Jeljeli et al.   Nature Communications

H3K4me1 Supports Memory-like NK Cells Induced by Systemic Inflammation

(2019) Orhan Rasid et al.   Cell Reports

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming

(2018) Anette Christ et al.   CELL

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

(2018) Ioannis Mitroulis et al.   CELL

BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis

(2018) Eva Kaufmann et al.   CELL

Metabolic Induction of Trained Immunity through the Mevalonate Pathway

(2018) Siroon Bekkering et al.   CELL

Trained Innate Immunity as a Novel Mechanism Linking Infection and the Development of AtherosclerosisNovelty and Significance

(2018) Jenneke Leentjens et al.   CIRCULATION RESEARCH

Innate immune memory: An evolutionary perspective

(2018) Benjamin Gourbal et al.   IMMUNOLOGICAL REVIEWS

Remembering Pathogen Dose: Long-Term Adaptation in Innate Immunity

(2018) Michael Bauer et al.   TRENDS IN IMMUNOLOGY

The immune system as a victim and aggressor in chronic obstructive pulmonary disease

(2018) Joshua J. C. McGrath et al.   Journal of Thoracic Disease

Enhancing and Extending Biological Performance and Resilience

(2018) Rehana K. Leak et al.   Dose-Response

Induction of innate immune memory via microRNA targeting of chromatin remodelling factors

(2018) John J. Seeley et al.   NATURE

Innate immune memory in the brain shapes neurological disease hallmarks

(2018) Ann-Christin Wendeln et al.   NATURE

Induction of Trained Innate Immunity in Human Monocytes by Bovine Milk and Milk-Derived Immunoglobulin G

(2018) Marloes van Splunter et al.   Nutrients

Trained Immunity and Local Innate Immune Memory in the Lung

(2018) Mihai G. Netea et al.   CELL

The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity

(2018) Jorge Domínguez-Andrés et al.   Cell Metabolism

Inhibiting Inflammation with Myeloid Cell-Specific Nanobiologics Promotes Organ Transplant Acceptance

(2018) Mounia S. Braza et al.   IMMUNITY

Immune genes are primed for robust transcription by proximal long noncoding RNAs located in nuclear compartments

(2018) Stephanie Fanucchi et al.   NATURE GENETICS

Protective immunity in recurrent Staphylococcus aureus infection reflects localized immune signatures and macrophage-conferred memory

(2018) Liana C. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting SHIP-1 in Myeloid Cells Enhances Trained Immunity and Boosts Response to Infection

(2018) Paula Saz-Leal et al.   Cell Reports

Trained Immunity-Based Vaccines: A New Paradigm for the Development of Broad-Spectrum Anti-infectious Formulations

(2018) Silvia Sánchez-Ramón et al.   Frontiers in Immunology

In vitro and in vivo Effects of Lactate on Metabolism and Cytokine Production of Human Primary PBMCs and Monocytes

(2018) Jacqueline M. Ratter et al.   Frontiers in Immunology

Regulation of Endotoxin Tolerance and Compensatory Anti-inflammatory Response Syndrome by Non-coding RNAs

(2018) Eleni Vergadi et al.   Frontiers in Immunology

Rusty Microglia: Trainers of Innate Immunity in Alzheimer's Disease

(2018) Adonis Sfera et al.   Frontiers in Neurology

Inflammatory genes TNFα and IL6 display no signs of increased H3K4me3 in circulating monocytes from untreated rheumatoid arthritis patients

(2017) T C Messemaker et al.   GENES AND IMMUNITY

Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity

(2017) Jutamas Suwanpradid et al.   JOURNAL OF IMMUNOLOGY

Rapid Protective Effects of Early BCG on Neonatal Mortality Among Low Birth Weight Boys: Observations From Randomized Trials

(2017) Sofie Biering-Sørensen et al.   JOURNAL OF INFECTIOUS DISEASES

AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

(2017) Daniel Garcia et al.   MOLECULAR CELL

Modulation of the immune response in rheumatoid arthritis with strategically released rapamycin

(2017) Ping Shao et al.   Molecular Medicine Reports

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metabolic regulation of inflammation

(2017) Timo Gaber et al.   Nature Reviews Rheumatology

Uric acid priming in human monocytes is driven by the AKT–PRAS40 autophagy pathway

(2017) Tania O. Crişan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

(2017) W. K. Eddie Ip et al.   SCIENCE

Cancer Inflammation and Cytokines

(2017) Maria Rosaria Galdiero et al.   Cold Spring Harbor Perspectives in Biology

Reprogramming of Tumor-Associated Macrophages with Anticancer Therapies: Radiotherapy versus Chemo- and Immunotherapies

(2017) Géraldine Genard et al.   Frontiers in Immunology

Comorbidity of periodontal disease: two sides of the same coin? An introduction for the clinician

(2017) Palle Holmstrup et al.   Journal of Oral Microbiology

Scientific research on animal biodiversity is systematically biased towards vertebrates and temperate regions

(2017) Mark A. Titley et al.   PLoS One

Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans

(2016) Simin N. Meydani et al.   Aging-US

The Role of Neutrophils in Transplanted Organs

(2016) D. Scozzi et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Innate immune cell activation and epigenetic remodeling in symptomatic and asymptomatic atherosclerosis in humans in vivo

(2016) Siroon Bekkering et al.   ATHEROSCLEROSIS

Aged neutrophils contribute to the first line of defense in the acute inflammatory response

(2016) B. Uhl et al.   BLOOD

Neurons and astroglia govern microglial endotoxin tolerance through macrophage colony-stimulating factor receptor-mediated ERK1/2 signals

(2016) Chun-Hsien Chu et al.   BRAIN BEHAVIOR AND IMMUNITY

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

(2016) Rob J.W. Arts et al.   Cell Metabolism

Phagocytosis: An Immunobiologic Process

(2016) Siamon Gordon   IMMUNITY

Lactic Acid Suppresses IL-33–Mediated Mast Cell Inflammatory Responses via Hypoxia-Inducible Factor-1α–Dependent miR-155 Suppression

(2016) Daniel Abebayehu et al.   JOURNAL OF IMMUNOLOGY

Rheumatoid arthritis

(2016) Josef S Smolen et al.   LANCET

Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

(2016) Shih-Chin Cheng et al.   NATURE IMMUNOLOGY

Fatty acid oxidation in macrophage polarization

(2016) Mitsunori Nomura et al.   NATURE IMMUNOLOGY

Microglia Priming with Aging and Stress

(2016) Anzela Niraula et al.   NEUROPSYCHOPHARMACOLOGY

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

Trained immunity: A program of innate immune memory in health and disease

(2016) M. G. Netea et al.   SCIENCE

Immunometabolic circuits in trained immunity

(2016) Rob J.W. Arts et al.   SEMINARS IN IMMUNOLOGY

Immunometabolic Pathways in BCG-Induced Trained Immunity

(2016) Rob J.W. Arts et al.   Cell Reports

Several Critical Cell Types, Tissues, and Pathways Are Implicated in Genome-Wide Association Studies for Systemic Lupus Erythematosus

(2016) Lu Liu et al.   G3-Genes Genomes Genetics

Molecular Mechanisms That Underlie the Dynamic Adaptation of Innate Monocyte Memory to Varying Stimulant Strength of TLR Ligands

(2016) Ruoxi Yuan et al.   Frontiers in Immunology

CD16+ Monocyte Subset Was Enriched and Functionally Exacerbated in Driving T-Cell Activation and B-Cell Response in Systemic Lupus Erythematosus

(2016) Huaqun Zhu et al.   Frontiers in Immunology

Sepsis and septic shock

(2016) Richard S. Hotchkiss et al.   Nature Reviews Disease Primers

The physiology and habitat of the last universal common ancestor

(2016) Madeline C. Weiss et al.   Nature Microbiology

Soluble uric acid primes TLR-induced proinflammatory cytokine production by human primary cells via inhibition of IL-1Ra

(2015) Tania O Crișan et al.   ANNALS OF THE RHEUMATIC DISEASES

Long-lasting pro-inflammatory suppression of microglia by LPS-preconditioning is mediated by RelB-dependent epigenetic silencing

(2015) W. Schaafsma et al.   BRAIN BEHAVIOR AND IMMUNITY

The Selective Sirtuin 1 Activator SRT2104 Reduces Endotoxin-Induced Cytokine Release and Coagulation Activation in Humans*

(2015) Anne J. van der Meer et al.   CRITICAL CARE MEDICINE

Global epidemiology of gout: prevalence, incidence and risk factors

(2015) Chang-Fu Kuo et al.   Nature Reviews Rheumatology

Super-low Dose Endotoxin Pre-conditioning Exacerbates Sepsis Mortality

(2015) Keqiang Chen et al.   EBioMedicine

Oxidized Low-Density Lipoprotein Induces Long-Term Proinflammatory Cytokine Production and Foam Cell Formation via Epigenetic Reprogramming of Monocytes

(2014) Siroon Bekkering et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role of the Microbiota in Immunity and Inflammation

(2014) Yasmine Belkaid et al.   CELL

The RAG Recombinase Dictates Functional Heterogeneity and Cellular Fitness in Natural Killer Cells

(2014) Jenny M. Karo et al.   CELL

Trained Immunity or Tolerance: Opposing Functional Programs Induced in Human Monocytes after Engagement of Various Pattern Recognition Receptors

(2014) Daniela C. Ifrim et al.   Clinical and Vaccine Immunology

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

Dynamic Modulation of Innate Immune Response by Varying Dosages of Lipopolysaccharide (LPS) in Human Monocytic Cells

(2014) Matthew C. Morris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metformin Suppresses Lipopolysaccharide (LPS)-induced Inflammatory Response in Murine Macrophages via Activating Transcription Factor-3 (ATF-3) Induction

(2014) Juyoung Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phagocytosis of Microglia in the Central Nervous System Diseases

(2014) Ruying Fu et al.   MOLECULAR NEUROBIOLOGY

Microglial priming in neurodegenerative disease

(2014) V. Hugh Perry et al.   Nature Reviews Neurology

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

(2014) S. Saeed et al.   SCIENCE

Tissue damage control in disease tolerance

(2014) Miguel P. Soares et al.   TRENDS IN IMMUNOLOGY

Human Cytomegalovirus Drives Epigenetic Imprinting of the IFNG Locus in NKG2Chi Natural Killer Cells

(2014) Merlin Luetke-Eversloh et al.   PLoS Pathogens

Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes

(2014) Deborah Chiabrando et al.   Frontiers in Pharmacology

An Endotoxin Tolerance Signature Predicts Sepsis and Organ Dysfunction at Initial Clinical Presentation

(2014) Olga M. Pena et al.   EBioMedicine

Causes, consequences, and reversal of immune system aging

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Long-Lasting Effects of BCG Vaccination on Both Heterologous Th1/Th17 Responses and Innate Trained Immunity

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Toll-Like Receptors in Antiviral Innate Immunity

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The Contribution of Non-Conventional T Cells and NK Cells in the Mycobacterial-Specific IFNγ Response in Bacille Calmette-Guérin (BCG)-Immunized Infants

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Endotoxin Tolerance Attenuates Liver Ischemia/Reperfusion Injury by Down-Regulation of Interleukin-1 Receptor-Associated Kinase 4 in Kupffer Cells

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Phenotypic and functional heterogeneity of human NK cells developing after umbilical cord blood transplantation: a role for human cytomegalovirus?

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Randomized Trial of BCG Vaccination at Birth to Low-Birth-Weight Children: Beneficial Nonspecific Effects in the Neonatal Period?

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miR-212 Increases Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Sensitivity in Non–Small Cell Lung Cancer by Targeting the Antiapoptotic Protein PED

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miR-146a Mediates Protective Innate Immune Tolerance in the Neonate Intestine

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Molecular Imaging of Innate Immune Cell Function in Transplant Rejection

(2009) Thomas Christen et al.   CIRCULATION

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The Kinase Akt1 Controls Macrophage Response to Lipopolysaccharide by Regulating MicroRNAs

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MicroRNA-132 Potentiates Cholinergic Anti-Inflammatory Signaling by Targeting Acetylcholinesterase

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The NF-κB Factor RelB and Histone H3 Lysine Methyltransferase G9a Directly Interact to Generate Epigenetic Silencing in Endotoxin Tolerance

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miR-146a Is Critical for Endotoxin-induced Tolerance

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Chromatin-Specific Remodeling by HMGB1 and Linker Histone H1 Silences Proinflammatory Genes during Endotoxin Tolerance

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The role of innate immunity in the induction of autoimmunity

(2008) David S. Pisetsky   AUTOIMMUNITY REVIEWS

Neutrophils recruited to the site ofMycobacterium bovisBCG infection undergo apoptosis and modulate lipid body biogenesis and prostaglandin E2production by macrophages

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Epigenetic Regulation of Gene Expression in the Inflammatory Response and Relevance to Common Diseases

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MicroRNAs: new regulators of immune cell development and function

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INDUCTION OF ENDOTOXIN TOLERANCE ENHANCES BACTERIAL CLEARANCE AND SURVIVAL IN MURINE POLYMICROBIAL SEPSIS

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NKG2D ligands: key targets of the immune response

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