Trained immunity: A program of innate immune memory in health and disease

Innate immune memory via ATF7-dependent epigenetic changes

(2015) Keisuke Yoshida et al.   CELL CYCLE

Defective trained immunity in patients with STAT-1-dependent chronic mucocutaneaous candidiasis

(2015) D. C. Ifrim et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Atherosclerotic Vascular Disease in the Autoimmune Rheumatologic Patient

(2015) Rekha Mankad   Current Atherosclerosis Reports

Cytomegalovirus Infection Drives Adaptive Epigenetic Diversification of NK Cells with Altered Signaling and Effector Function

(2015) Heinrich Schlums et al.   IMMUNITY

Epigenetic Modification and Antibody-Dependent Expansion of Memory-like NK Cells in Human Cytomegalovirus-Infected Individuals

(2015) Jaewon Lee et al.   IMMUNITY

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

IL-33 Receptor ST2 Amplifies the Expansion of NK Cells and Enhances Host Defense during Mouse Cytomegalovirus Infection

(2015) Tsukasa Nabekura et al.   JOURNAL OF IMMUNOLOGY

Antigen-specific NK cell memory in rhesus macaques

(2015) R Keith Reeves et al.   NATURE IMMUNOLOGY

The transcription factor ATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory

(2015) Keisuke Yoshida et al.   NATURE IMMUNOLOGY

Trained immunity in newborn infants of HBV-infected mothers

(2015) Michelle Hong et al.   Nature Communications

Chromatin Contributions to the Regulation of Innate Immunity

(2014) Stephen T. Smale et al.   Annual Review of Immunology

Metabolic Regulation of Immune Responses

(2014) Kirthana Ganeshan et al.   Annual Review of Immunology

Oxidized Low-Density Lipoprotein Induces Long-Term Proinflammatory Cytokine Production and Foam Cell Formation via Epigenetic Reprogramming of Monocytes

(2014) Siroon Bekkering et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities

(2014) David Gosselin et al.   CELL

BCG-induced trained immunity in NK cells: Role for non-specific protection to infection

(2014) Johanneke Kleinnijenhuis et al.   CLINICAL IMMUNOLOGY

Innate immune memory: towards a better understanding of host defense mechanisms

(2014) Jessica Quintin et al.   CURRENT OPINION IN IMMUNOLOGY

Live attenuated vaccines against pertussis

(2014) Camille Locht et al.   Expert Review of Vaccines

Costimulatory Molecule DNAM-1 Is Essential for Optimal Differentiation of Memory Natural Killer Cells during Mouse Cytomegalovirus Infection

(2014) Tsukasa Nabekura et al.   IMMUNITY

Cytomegalovirus generates long-lived antigen-specific NK cells with diminished bystander activation to heterologous infection

(2014) Gundula Min-Oo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: NKG2ChiCD57+ NK Cells Respond Specifically to Acute Infection with Cytomegalovirus and Not Epstein-Barr Virus

(2014) D. W. Hendricks et al.   JOURNAL OF IMMUNOLOGY

Heterologous Immunological Effects of Early BCG Vaccination in Low-Birth-Weight Infants in Guinea-Bissau: A Randomized-controlled Trial

(2014) Kristoffer Jarlov Jensen et al.   JOURNAL OF INFECTIOUS DISEASES

Intraperitoneal prophylaxis with CpG oligodeoxynucleotides protects neutropenic mice against intracerebral Escherichia coli K1 infection

(2014) Sandra Ribes et al.   Journal of Neuroinflammation

Coregulation of Transcription Factor Binding and Nucleosome Occupancy through DNA Features of Mammalian Enhancers

(2014) Iros Barozzi et al.   MOLECULAR CELL

Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion

(2014) Fei Chen et al.   NATURE IMMUNOLOGY

The mechanism of action of BCG therapy for bladder cancer—a current perspective

(2014) Gil Redelman-Sidi et al.   Nature Reviews Urology

Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18

(2014) B. Zhang et al.   SCIENCE

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

(2014) S. Saeed et al.   SCIENCE

Bone Marrow Dendritic Cells from Mice with an Altered Microbiota Provide Interleukin 17A-Dependent Protection against Entamoeba histolytica Colitis

(2014) Stacey L. Burgess et al.   mBio

Transcriptional Control of Inflammatory Responses

(2014) S. T. Smale et al.   Cold Spring Harbor Perspectives in Biology

Microbial Programming of Systemic Innate Immunity and Resistance to Infection

(2014) Thomas B. Clarke   PLoS Pathogens

Autophagy Controls BCG-Induced Trained Immunity and the Response to Intravesical BCG Therapy for Bladder Cancer

(2014) Kathrin Buffen et al.   PLoS Pathogens

Malaria-Induced NLRP12/NLRP3-Dependent Caspase-1 Activation Mediates Inflammation and Hypersensitivity to Bacterial Superinfection

(2014) Marco A. Ataide et al.   PLoS Pathogens

Human Cytomegalovirus Drives Epigenetic Imprinting of the IFNG Locus in NKG2Chi Natural Killer Cells

(2014) Merlin Luetke-Eversloh et al.   PLoS Pathogens

Latent Enhancers Activated by Stimulation in Differentiated Cells

(2013) Renato Ostuni et al.   CELL

Systemic signaling during plant defense

(2013) Aardra Kachroo et al.   CURRENT OPINION IN PLANT BIOLOGY

Detection of a TLR2 agonist by hematopoietic stem and progenitor cells impacts the function of the macrophages they produce

(2013) Alberto Yáñez et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Altered Immunity and Dendritic Cell Activity in the Periphery of Mice after Long-Term Engraftment with Bone Marrow from Ultraviolet-Irradiated Mice

(2013) R. L. X. Ng et al.   JOURNAL OF IMMUNOLOGY

Long-Lasting Effects of BCG Vaccination on Both Heterologous Th1/Th17 Responses and Innate Trained Immunity

(2013) Johanneke Kleinnijenhuis et al.   Journal of Innate Immunity

Dectin-1 plays a redundant role in the immunomodulatory activities of β-glucan-rich ligands in vivo

(2013) Mohlopheni J. Marakalala et al.   MICROBES AND INFECTION

Remodeling of the Enhancer Landscape during Macrophage Activation Is Coupled to Enhancer Transcription

(2013) Minna U. Kaikkonen et al.   MOLECULAR CELL

The nexus of chromatin regulation and intermediary metabolism

(2013) Philipp Gut et al.   NATURE

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Short-term memory of danger signals and environmental stimuli in immune cells

(2013) Silvia Monticelli et al.   NATURE IMMUNOLOGY

A Role for SIRT2-Dependent Histone H3K18 Deacetylation in Bacterial Infection

(2013) H. A. Eskandarian et al.   SCIENCE

A small jab – a big effect: nonspecific immunomodulation by vaccines

(2013) Christine S. Benn et al.   TRENDS IN IMMUNOLOGY

Epigenetics and Bacterial Infections

(2013) H. Bierne et al.   Cold Spring Harbor Perspectives in Medicine

Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes

(2012) Jessica Quintin et al.   Cell Host & Microbe

Priming of Natural Killer Cells by Nonmucosal Mononuclear Phagocytes Requires Instructive Signals from Commensal Microbiota

(2012) Stephanie C. Ganal et al.   IMMUNITY

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

NAD+-dependent Sirtuin 1 and 6 Proteins Coordinate a Switch from Glucose to Fatty Acid Oxidation during the Acute Inflammatory Response

(2012) Tie Fu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metaboloepigenetics: Interrelationships between energy metabolism and epigenetic control of gene expression

(2012) Dallas R. Donohoe et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Proinflammatory cytokine signaling required for the generation of natural killer cell memory

(2012) Joseph C. Sun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

β-Glucan Derived from Aureobasidium pullulans Is Effective for the Prevention of Influenza in Mice

(2012) Daisuke Muramatsu et al.   PLoS One

Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

(2012) J. Kleinnijenhuis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trained Immunity: A Memory for Innate Host Defense

(2011) Mihai G. Netea et al.   Cell Host & Microbe

Epigenetic regulation of immune cell functions during post-septic immunosuppression

(2011) William F. Carson et al.   Epigenetics

Role of bacillus Calmette–Guérin in the treatment of advanced melanoma

(2011) John H Stewart et al.   Expert Review of Anticancer Therapy

Thy1+ Nk Cells from Vaccinia Virus-Primed Mice Confer Protection against Vaccinia Virus Challenge in the Absence of Adaptive Lymphocytes

(2011) Geoffrey O. Gillard et al.   PLoS Pathogens

Identification and Characterization of Enhancers Controlling the Inflammatory Gene Expression Program in Macrophages

(2010) Serena Ghisletti et al.   IMMUNITY

Mucosal Administration of Flagellin Protects Mice from Streptococcus pneumoniae Lung Infection

(2010) N. Munoz et al.   INFECTION AND IMMUNITY

Ultraviolet Irradiation of Mice Reduces the Competency of Bone Marrow-Derived CD11c+ Cells via an Indomethacin-Inhibitable Pathway

(2010) R. L. X. Ng et al.   JOURNAL OF IMMUNOLOGY

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

Suppression of inflammation by a synthetic histone mimic

(2010) Edwige Nicodeme et al.   NATURE

Critical role for the chemokine receptor CXCR6 in NK cell–mediated antigen-specific memory of haptens and viruses

(2010) Silke Paust et al.   NATURE IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

The widespread regulation of microRNA biogenesis, function and decay

(2010) Jacek Krol et al.   NATURE REVIEWS GENETICS

Hemocyte Differentiation Mediates Innate Immune Memory in Anopheles gambiae Mosquitoes

(2010) Janneth Rodrigues et al.   SCIENCE

Epigenetic regulation of the alternatively activated macrophage phenotype

(2009) M. Ishii et al.   BLOOD

A Unifying Model for the Selective Regulation of Inducible Transcription by CpG Islands and Nucleosome Remodeling

(2009) Vladimir R. Ramirez-Carrozzi et al.   CELL

Hyperglycemia Induces a Dynamic Cooperativity of Histone Methylase and Demethylase Enzymes Associated With Gene-Activating Epigenetic Marks That Coexist on the Lysine Tail

(2009) D. Brasacchio et al.   DIABETES

Adaptive immune features of natural killer cells

(2009) Joseph C. Sun et al.   NATURE

Inositol phosphatase SHIP1 is a primary target of miR-155

(2009) R. M. O'Connell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Risk of lymphoma and leukaemia after bacille Calmette-Guérin and smallpox vaccination: A Danish case-cohort study

(2009) Marie Villumsen et al.   VACCINE

Histone Modifications and Chromatin Remodeling during Bacterial Infections

(2008) Mélanie Anne Hamon et al.   Cell Host & Microbe

Osteosarcoma: The Addition of Muramyl Tripeptide to Chemotherapy Improves Overall Survival—A Report From the Children's Oncology Group

(2008) Paul A. Meyers et al.   JOURNAL OF CLINICAL ONCOLOGY

Host–pathogen interactions in sepsis

(2007) Tom van der Poll et al.   LANCET INFECTIOUS DISEASES