The future clinical implications of trained immunity

Trained immunity induction by the inactivated mucosal vaccine MV130 protects against experimental viral respiratory infections

(2022) Paola Brandi et al.   Cell Reports

Rheumatoid arthritis CD14 + monocytes display metabolic and inflammatory dysfunction, a phenotype that precedes clinical manifestation of disease

(2021) Trudy McGarry et al.   Clinical & Translational Immunology

A modular approach toward producing nanotherapeutics targeting the innate immune system

(2021) Mandy M. T. van Leent et al.   Science Advances

Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis

(2021) Laurienne Edgar et al.   CIRCULATION

MTBVAC, a live TB vaccine poised to initiate efficacy trials 100 years after BCG

(2021) Carlos Martín et al.   VACCINE

MyD88-dependent BCG immunotherapy reduces tumor and regulates tumor microenvironment in bladder cancer murine model

(2021) Nina M. G. P. de Queiroz et al.   Scientific Reports

Induction of Protective Immunity by a Single Low Dose of a Master Cell Bank cGMP-rBCG-P Vaccine Against the Human Metapneumovirus in Mice

(2021) Jorge A. Soto et al.   Frontiers in Cellular and Infection Microbiology

Endothelial Immunity Trained by Coronavirus Infections, DAMP Stimulations and Regulated by Anti-Oxidant NRF2 May Contribute to Inflammations, Myelopoiesis, COVID-19 Cytokine Storms and Thromboembolism

(2021) Ying Shao et al.   Frontiers in Immunology

An integrative genomics approach identifies KDM4 as a modulator of trained immunity

(2021) Simone J.C.F.M. Moorlag et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Induction of trained immunity by influenza vaccination - impact on COVID-19

(2021) Priya A. Debisarun et al.   PLoS Pathogens

The Bacterial Mucosal Immunotherapy MV130 Protects Against SARS-CoV-2 Infection and Improves COVID-19 Vaccines Immunogenicity

(2021) Carlos del Fresno et al.   Frontiers in Immunology

Clinical and molecular insights into BCG immunotherapy for melanoma

(2020) M. Kremenovic et al.   JOURNAL OF INTERNAL MEDICINE

The Set7 Lysine Methyltransferase Regulates Plasticity in Oxidative Phosphorylation Necessary for Trained Immunity Induced by β-Glucan

(2020) Samuel T. Keating et al.   Cell Reports

New live attenuated tuberculosis vaccine MTBVAC induces trained immunity and confers protection against experimental lethal pneumonia

(2020) Raquel Tarancón et al.   PLoS Pathogens

BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment

(2020) Branko Cirovic et al.   Cell Host & Microbe

Soluble Uric Acid Is an Intrinsic Negative Regulator of Monocyte Activation in Monosodium Urate Crystal–Induced Tissue Inflammation

(2020) Qiuyue Ma et al.   JOURNAL OF IMMUNOLOGY

Trained immunity as a molecular mechanism for BCG immunotherapy in bladder cancer

(2020) Jelmer H. van Puffelen et al.   Nature Reviews Urology

Bacterial Lysates as Immunotherapies for Respiratory Infections: Methods of Preparation

(2020) Norma Suárez et al.   Frontiers in Bioengineering and Biotechnology

Mechanisms of BCG in the treatment of bladder cancer-current understanding and the prospect

(2020) Jiansong Han et al.   BIOMEDICINE & PHARMACOTHERAPY

Disease-Specific Autoantibodies Induce Trained Immunity in RA Synovial Tissues and Its Gene Signature Correlates with the Response to Clinical Therapy

(2020) Xiaoli Dai et al.   MEDIATORS OF INFLAMMATION

Immunometabolic control of trained immunity

(2020) Niels P. Riksen et al.   MOLECULAR ASPECTS OF MEDICINE

Efficacy of intravesical therapies on the prevention of recurrence and progression of non‐muscle‐invasive bladder cancer: A systematic review and network meta‐analysis

(2020) Jun‐Lin Lu et al.   Cancer Medicine

Lactate Suppresses Macrophage Pro-Inflammatory Response to LPS Stimulation by Inhibition of YAP and NF-κB Activation via GPR81-Mediated Signaling

(2020) Kun Yang et al.   Frontiers in Immunology

The Intersection of Epigenetics and Metabolism in Trained Immunity

(2020) Stephanie Fanucchi et al.   IMMUNITY

The Role of Cell Metabolism in Innate Immune Memory

(2020) Anaisa Valido Ferreira et al.   Journal of Innate Immunity

Designing the Next Generation of Vaccines: Relevance for Future Pandemics

(2020) Jorge Domínguez-Andrés et al.   mBio

Trained Immunity Carried by Non-immune Cells

(2019) Attoumani Hamada et al.   Frontiers in Microbiology

Mechanisms of Trained Innate Immunity in oxLDL Primed Human Coronary Smooth Muscle Cells

(2019) Lucia Schnack et al.   Frontiers in Immunology

mTOR-Dependent Oxidative Stress Regulates oxLDL-Induced Trained Innate Immunity in Human Monocytes

(2019) Yahya Sohrabi et al.   Frontiers in Immunology

Heterologous effects of vaccination and trained immunity

(2019) I.C. Gyssens et al.   CLINICAL MICROBIOLOGY AND INFECTION

Innate Immune Cells' Contribution to Systemic Lupus Erythematosus

(2019) Andrés A. Herrada et al.   Frontiers in Immunology

MTBVAC-Based TB-HIV Vaccine Is Safe, Elicits HIV-T Cell Responses, and Protects against Mycobacterium tuberculosis in Mice

(2019) Esther Broset et al.   Molecular Therapy-Methods & Clinical Development

DZNep-mediated apoptosis in B-cell lymphoma is independent of the lymphoma type, EZH2 mutation status and MYC, BCL2 or BCL6 translocations

(2019) Chidimma Agatha Akpa et al.   PLoS One

Transcriptome reprogramming and myeloid skewing in haematopoietic stem and progenitor cells in systemic lupus erythematosus

(2019) Maria Grigoriou et al.   ANNALS OF THE RHEUMATIC DISEASES

Impaired Alanine Transport or Exposure to d-Cycloserine Increases the Susceptibility of MRSA to β-lactam Antibiotics

(2019) Laura A Gallagher et al.   JOURNAL OF INFECTIOUS DISEASES

Advances in systemic lupus erythematosus pathogenesis via mTOR signaling pathway

(2019) Jingjing He et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming

(2018) Anette Christ et al.   CELL

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

(2018) Ioannis Mitroulis et al.   CELL

BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity

(2018) Rob J.W. Arts et al.   Cell Host & Microbe

Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses

(2018) Olivier B. Bakker et al.   NATURE IMMUNOLOGY

Toll-Like Receptors Drive Specific Patterns of Tolerance and Training on Restimulation of Macrophages

(2018) Suzanne K. Butcher et al.   Frontiers in Immunology

The Potential Role of Trained Immunity in Autoimmune and Autoinflammatory Disorders

(2018) Rob J. W. Arts et al.   Frontiers in Immunology

Bridging the gap between vaccination with Bacille Calmette-Guérin (BCG) and immunological tolerance: the cases of type 1 diabetes and multiple sclerosis

(2018) Giovanni Ristori et al.   CURRENT OPINION IN IMMUNOLOGY

Inhibiting Inflammation with Myeloid Cell-Specific Nanobiologics Promotes Organ Transplant Acceptance

(2018) Mounia S. Braza et al.   IMMUNITY

Application of BCG-CWS as a Systemic Adjuvant by Using Nanoparticulation Technology

(2018) Hideyuki Masuda et al.   MOLECULAR PHARMACEUTICS

Immune genes are primed for robust transcription by proximal long noncoding RNAs located in nuclear compartments

(2018) Stephanie Fanucchi et al.   NATURE GENETICS

Trained Immunity-Based Vaccines: A New Paradigm for the Development of Broad-Spectrum Anti-infectious Formulations

(2018) Silvia Sánchez-Ramón et al.   Frontiers in Immunology

In vitro and in vivo Effects of Lactate on Metabolism and Cytokine Production of Human Primary PBMCs and Monocytes

(2018) Jacqueline M. Ratter et al.   Frontiers in Immunology

Sepsis Induces a Long-Lasting State of Trained Immunity in Bone Marrow Monocytes

(2018) Katharina Bomans et al.   Frontiers in Immunology

Inflammatory genes TNFα and IL6 display no signs of increased H3K4me3 in circulating monocytes from untreated rheumatoid arthritis patients

(2017) T C Messemaker et al.   GENES AND IMMUNITY

Modulation of the immune response in rheumatoid arthritis with strategically released rapamycin

(2017) Ping Shao et al.   Molecular Medicine Reports

Uric acid priming in human monocytes is driven by the AKT–PRAS40 autophagy pathway

(2017) Tania O. Crişan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetics and Trained Immunity

(2017) Charlotte D.C.C. van der Heijden et al.   ANTIOXIDANTS & REDOX SIGNALING

Early vaccination protects against childhood leukemia: A systematic review and meta-analysis

(2017) Mostafa Ebraheem Morra et al.   Scientific Reports

Innate immune cell activation and epigenetic remodeling in symptomatic and asymptomatic atherosclerosis in humans in vivo

(2016) Siroon Bekkering et al.   ATHEROSCLEROSIS

In VitroExperimental Model of Trained Innate Immunity in Human Primary Monocytes

(2016) Siroon Bekkering et al.   Clinical and Vaccine Immunology

Fungal Chitin Induces Trained Immunity in Human Monocytes during Cross-talk of the Host withSaccharomyces cerevisiae

(2016) Lisa Rizzetto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immunometabolic Pathways in BCG-Induced Trained Immunity

(2016) Rob J.W. Arts et al.   Cell Reports

H3K4 tri-methylation breadth at transcription start sites impacts the transcriptome of systemic lupus erythematosus

(2016) Zhe Zhang et al.   Clinical Epigenetics

Soluble uric acid primes TLR-induced proinflammatory cytokine production by human primary cells via inhibition of IL-1Ra

(2015) Tania O Crișan et al.   ANNALS OF THE RHEUMATIC DISEASES

Child survival and BCG vaccination: a community based prospective cohort study in Uganda

(2015) Victoria Nankabirwa et al.   BMC PUBLIC HEALTH

Trained innate immunity as underlying mechanism for the long-term, nonspecific effects of vaccines

(2015) Bastiaan A. Blok et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Monosodium Urate Crystals Promote Innate Anti-Mycobacterial Immunity and Improve BCG Efficacy as a Vaccine against Tuberculosis

(2015) Francesco Taus et al.   PLoS One

Trained Immunity or Tolerance: Opposing Functional Programs Induced in Human Monocytes after Engagement of Various Pattern Recognition Receptors

(2014) Daniela C. Ifrim et al.   Clinical and Vaccine Immunology

Hypercholesterolemia-induced priming of hematopoietic stem and progenitor cells aggravates atherosclerosis

(2014) Tom Seijkens et al.   FASEB JOURNAL

Nanoparticulation of BCG-CWS for application to bladder cancer therapy

(2014) Takashi Nakamura et al.   JOURNAL OF CONTROLLED RELEASE

Diet-induced (epigenetic) changes in bone marrow augment atherosclerosis

(2014) Erik van Kampen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

3-Deazaneplanocin A (DZNep), an Inhibitor of the Histone Methyltransferase EZH2, Induces Apoptosis and Reduces Cell Migration in Chondrosarcoma Cells

(2014) Nicolas Girard et al.   PLoS One

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

Autophagy Controls BCG-Induced Trained Immunity and the Response to Intravesical BCG Therapy for Bladder Cancer

(2014) Kathrin Buffen et al.   PLoS Pathogens

Long-Lasting Effects of BCG Vaccination on Both Heterologous Th1/Th17 Responses and Innate Trained Immunity

(2013) Johanneke Kleinnijenhuis et al.   Journal of Innate Immunity

Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes

(2012) Jessica Quintin et al.   Cell Host & Microbe

Innate NK Cells and Macrophages Recognize and Reject Allogeneic Nonself In Vivo via Different Mechanisms

(2012) W. Liu et al.   JOURNAL OF IMMUNOLOGY

Treatment of Common and Plane Warts in Children with Topical Viable Bacillus Calmette-Guerin

(2012) Ahmed Salem et al.   PEDIATRIC DERMATOLOGY

Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

(2012) J. Kleinnijenhuis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trained Immunity: A Memory for Innate Host Defense

(2011) Mihai G. Netea et al.   Cell Host & Microbe

NF-κB in immunobiology

(2011) Matthew S Hayden et al.   CELL RESEARCH

Acetyl-CoA Induces Cell Growth and Proliferation by Promoting the Acetylation of Histones at Growth Genes

(2011) Ling Cai et al.   MOLECULAR CELL

Uric acid promotes an acute inflammatory response to sterile cell death in mice

(2010) Hajime Kono et al.   JOURNAL OF CLINICAL INVESTIGATION

Global H4 acetylation analysis by ChIP-chip in systemic lupus erythematosus monocytes

(2009) Z Zhang et al.   GENES AND IMMUNITY

The effects of β-glucan on human immune and cancer cells

(2009) Godfrey Chan et al.   Journal of Hematology & Oncology

Endotoxin tolerance: new mechanisms, molecules and clinical significance

(2009) Subhra K. Biswas et al.   TRENDS IN IMMUNOLOGY

Risk of lymphoma and leukaemia after bacille Calmette-Guérin and smallpox vaccination: A Danish case-cohort study

(2009) Marie Villumsen et al.   VACCINE