Interaction between microbiota and immunity in health and disease

Microbiota-targeted maternal antibodies protect neonates from enteric infection

(2020) Wen Zheng et al.   NATURE

Separating the signal from the noise in metagenomic cell-free DNA sequencing

(2020) Philip Burnham et al.   Microbiome

Gut microbial metabolite trimethylamine N-oxide aggravates GVHD by inducing M1 macrophage polarization in mice

(2020) Kunpeng Wu et al.   BLOOD

Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt+ Regulatory T Cells and Exacerbate Colitis in Mice

(2019) Graham J. Britton et al.   IMMUNITY

Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis

(2019) Nobuhiro Nakamoto et al.   Nature Microbiology

Dysbiosis of Skin Microbiota in Psoriatic Patients: Co-occurrence of Fungal and Bacterial Communities

(2019) Zuzana Stehlikova et al.   Frontiers in Microbiology

Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology

(2019) Priya Rangan et al.   Cell Reports

Paneth cell α-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments

(2019) D. Ehmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A defined commensal consortium elicits CD8 T cells and anti-cancer immunity

(2019) Takeshi Tanoue et al.   NATURE

The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages

(2019) Julie Schulthess et al.   IMMUNITY

Dysregulated Lung Commensal Bacteria Drive Interleukin-17B Production to Promote Pulmonary Fibrosis through Their Outer Membrane Vesicles

(2019) Daping Yang et al.   IMMUNITY

Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis

(2019) Tomas Castro-Dopico et al.   IMMUNITY

Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity

(2019) María Martínez-López et al.   IMMUNITY

Gut mucosal virome alterations in ulcerative colitis

(2019) Tao Zuo et al.   GUT

Malassezia Is Associated with Crohn’s Disease and Exacerbates Colitis in Mouse Models

(2019) Jose J. Limon et al.   Cell Host & Microbe

Maternal Immunization Confers Protection to the Offspring against an Attaching and Effacing Pathogen through Delivery of IgG in Breast Milk

(2019) Gustavo Caballero-Flores et al.   Cell Host & Microbe

Commensal Microbiota Promote Lung Cancer Development via γδ T Cells

(2019) Chengcheng Jin et al.   CELL

Data-driven multiple-level analysis of gut-microbiome-immune-joint interactions in rheumatoid arthritis

(2019) QuanQiu Wang et al.   BMC GENOMICS

Prevotella copri in individuals at risk for rheumatoid arthritis

(2019) Deshire Alpizar-Rodriguez et al.   ANNALS OF THE RHEUMATIC DISEASES

A Forward Chemical Genetic Screen Reveals Gut Microbiota Metabolites That Modulate Host Physiology

(2019) Haiwei Chen et al.   CELL

Infants born to mothers with IBD present with altered gut microbiome that transfers abnormalities of the adaptive immune system to germ-free mice

(2019) Joana Torres et al.   GUT

The Integrative Human Microbiome Project

(2019)   NATURE

Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases

(2019) Jason Lloyd-Price et al.   NATURE

Alterations of the bile microbiome in primary sclerosing cholangitis

(2019) Timur Liwinski et al.   GUT

Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells

(2019) Annabell Bachem et al.   IMMUNITY

The Intestine Harbors Functionally Distinct Homeostatic Tissue-Resident and Inflammatory Th17 Cells

(2019) Sara Omenetti et al.   IMMUNITY

Human placenta has no microbiome but can contain potential pathogens

(2019) Marcus C. de Goffau et al.   NATURE

Laboratory mice born to wild mice have natural microbiota and model human immune responses

(2019) Stephan P. Rosshart et al.   SCIENCE

The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs

(2019) Anthony T. Virtue et al.   Science Translational Medicine

Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis

(2019) Chandran Ramakrishna et al.   Nature Communications

Controlling for Contaminants in Low-Biomass 16S rRNA Gene Sequencing Experiments

(2019) Lisa Karstens et al.   mSystems

A specific gene-microbe interaction drives the development of Crohn’s disease–like colitis in mice

(2019) R. Caruso et al.   Science Immunology

Deep microbial analysis of multiple placentas shows no evidence for a placental microbiome

(2019) AA Kuperman et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Antibiotics-Driven Gut Microbiome Perturbation Alters Immunity to Vaccines in Humans

(2019) Thomas Hagan et al.   CELL

Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes

(2019) Erick Riquelme et al.   CELL

Microbiomes as sources of emergent host phenotypes

(2019) J. B. Lynch et al.   SCIENCE

Re‐assessing microbiomes in the low‐biomass reproductive niche

(2019) JL O’Callaghan et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Metabolite-Sensing Receptor Ffar2 Regulates Colonic Group 3 Innate Lymphoid Cells and Gut Immunity

(2019) Eunyoung Chun et al.   IMMUNITY

Western Diet and the Immune System: An Inflammatory Connection

(2019) Anette Christ et al.   IMMUNITY

A Specific Mutation in Muc2 Determines Early Dysbiosis in Colitis-Prone Winnie Mice

(2019) Marina Liso et al.   INFLAMMATORY BOWEL DISEASES

Dichotomous regulation of group 3 innate lymphoid cells by nongastric Helicobacter species

(2019) John W. Bostick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Celiac Disease and the Microbiome

(2019) Valitutti et al.   Nutrients

Cutaneous Immune Cell-Microbiota Interactions Are Controlled by Epidermal JunB/AP-1

(2019) Özge Uluçkan et al.   Cell Reports

Host–microbiota interactions in rheumatoid arthritis

(2019) Yuichi Maeda et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Human IgA binds a diverse array of commensal bacteria

(2019) Delphine Sterlin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis

(2019) Xinyang Song et al.   NATURE

IL-17a promotes sociability in mouse models of neurodevelopmental disorders

(2019) Michael Douglas Reed et al.   NATURE

Symbionts exploit complex signaling to educate the immune system

(2019) Deniz Erturk-Hasdemir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy

(2018) Vancheswaran Gopalakrishnan et al.   CANCER CELL

Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner

(2018) Morgane Sonia Thion et al.   CELL

Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair

(2018) Jonathan L. Linehan et al.   CELL

Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota

(2018) Francesca Cignarella et al.   Cell Metabolism

Intestinal Dysbiosis Featuring Abundance of Ruminococcus gnavus Associates With Allergic Diseases in Infants

(2018) Huey-Huey Chua et al.   GASTROENTEROLOGY

Dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus

(2018) Jinfeng Wang et al.   GUT

Dietary Fiber Confers Protection against Flu by Shaping Ly6c − Patrolling Monocyte Hematopoiesis and CD8 + T Cell Metabolism

(2018) Aurélien Trompette et al.   IMMUNITY

Critical Role for the Microbiota in CX 3 CR1 + Intestinal Mononuclear Phagocyte Regulation of Intestinal T Cell Responses

(2018) Myunghoo Kim et al.   IMMUNITY

The Artificial Sweetener Splenda Promotes Gut Proteobacteria, Dysbiosis, and Myeloperoxidase Reactivity in Crohn’s Disease–Like Ileitis

(2018) Alexander Rodriguez-Palacios et al.   INFLAMMATORY BOWEL DISEASES

Gut microbiome–mediated bile acid metabolism regulates liver cancer via NKT cells

(2018) Chi Ma et al.   SCIENCE

The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients

(2018) Vyara Matson et al.   SCIENCE

The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression

(2018) Smruti Pushalkar et al.   Cancer Discovery

The Inhibitory Innate Immune Sensor NLRP12 Maintains a Threshold against Obesity by Regulating Gut Microbiota Homeostasis

(2018) Agnieszka D. Truax et al.   Cell Host & Microbe

A Map of Toll-like Receptor Expression in the Intestinal Epithelium Reveals Distinct Spatial, Cell Type-Specific, and Temporal Patterns

(2018) April E. Price et al.   IMMUNITY

ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS–STING

(2018) Konrad Aden et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition

(2018) Marcus Fulde et al.   NATURE

Precision editing of the gut microbiota ameliorates colitis

(2018) Wenhan Zhu et al.   NATURE

Environment dominates over host genetics in shaping human gut microbiota

(2018) Daphna Rothschild et al.   NATURE

NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis

(2018) Zuliang Jie et al.   NATURE IMMUNOLOGY

Microglial signatures and their role in health and disease

(2018) Oleg Butovsky et al.   NATURE REVIEWS NEUROSCIENCE

Early-Life Formation of the Microbial and Immunological Environment of the Human Airways

(2018) Céline Pattaroni et al.   Cell Host & Microbe

The role of the microbiome in NAFLD and NASH

(2018) Aleksandra A Kolodziejczyk et al.   EMBO Molecular Medicine

l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans

(2018) Robert A. Koeth et al.   JOURNAL OF CLINICAL INVESTIGATION

Microbiome–microglia connections via the gut–brain axis

(2018) Reem Abdel-Haq et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gut Microbiome Dysbiosis and Immunometabolism: New Frontiers for Treatment of Metabolic Diseases

(2018) José E. Belizário et al.   MEDIATORS OF INFLAMMATION

Commensal bacteria contribute to insulin resistance in aging by activating innate B1a cells

(2018) Monica Bodogai et al.   Science Translational Medicine

Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis

(2018) Nicholas A. Scott et al.   Science Translational Medicine

Interactions between Bacteriophage, Bacteria, and the Mammalian Immune System

(2018) Jonas Van Belleghem et al.   Viruses-Basel

Gut microbiome structure and metabolic activity in inflammatory bowel disease

(2018) Eric A. Franzosa et al.   Nature Microbiology

Contamination in Low Microbial Biomass Microbiome Studies: Issues and Recommendations

(2018) Raphael Eisenhofer et al.   TRENDS IN MICROBIOLOGY

Circulating and Tissue-Resident CD4 + T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation

(2017) Ahmed N. Hegazy et al.   GASTROENTEROLOGY

On-going Mechanical Damage from Mastication Drives Homeostatic Th17 Cell Responses at the Oral Barrier

(2017) Nicolas Dutzan et al.   IMMUNITY

Homeostatic Immunity and the Microbiota

(2017) Yasmine Belkaid et al.   IMMUNITY

RNA virus receptor Rig-I monitors gut microbiota and inhibits colitis-associated colorectal cancer

(2017) Houbao Zhu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring

(2017) Sangdoo Kim et al.   NATURE

Inflammation, metaflammation and immunometabolic disorders

(2017) Gökhan S. Hotamisligil   NATURE

Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine

(2017) Leore T. Geller et al.   SCIENCE

Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation

(2017) Koji Atarashi et al.   SCIENCE

The microbial metabolite desaminotyrosine protects from influenza through type I interferon

(2017) Ashley L. Steed et al.   SCIENCE

Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients

(2017) V. Gopalakrishnan et al.   SCIENCE

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

(2017) Bertrand Routy et al.   SCIENCE

Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis

(2017) Teruaki Nakatsuji et al.   Science Translational Medicine

Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE 2 -Mediated Suppression of Antitumor Immunity

(2017) Tze Mun Loo et al.   Cancer Discovery

NLRP6 Protects Il10 −/− Mice from Colitis by Limiting Colonization of Akkermansia muciniphila

(2017) Sergey S. Seregin et al.   Cell Reports

Shaping of Intestinal Microbiota in Nlrp6- and Rag2-Deficient Mice Depends on Community Structure

(2017) Eric J.C. Gálvez et al.   Cell Reports

Endogenous Antimicrobial Peptide Expression in Response to Bacterial Epidermal Colonization

(2017) Michael Brandwein et al.   Frontiers in Immunology

Interactions between Intestinal Microbiota and Host Immune Response in Inflammatory Bowel Disease

(2017) Ming Zhang et al.   Frontiers in Immunology

Aberrant intestinal microbiota due to IL-1 receptor antagonist deficiency promotes IL-17- and TLR4-dependent arthritis

(2017) Rebecca Rogier et al.   Microbiome

Microbiota Promotes Chronic Pulmonary Inflammation by Enhancing IL-17A and Autoantibodies

(2016) Koshika Yadava et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Genetics and Pathogenesis of Inflammatory Bowel Disease

(2016) Ta-Chiang Liu et al.   Annual Review of Pathology-Mechanisms of Disease

Dietary Emulsifier–Induced Low-Grade Inflammation Promotes Colon Carcinogenesis

(2016) Emilie Viennois et al.   CANCER RESEARCH

Microbiome and Anticancer Immunosurveillance

(2016) Laurence Zitvogel et al.   CELL

Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans

(2016) Ron Sender et al.   CELL

Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome

(2016) Aleksey Chudnovskiy et al.   CELL

The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the Microbiome

(2016) Meital Gury-BenAri et al.   CELL

The Central Nervous System and the Gut Microbiome

(2016) Gil Sharon et al.   CELL

Temporal Stability of the Human Skin Microbiome

(2016) Julia Oh et al.   CELL

The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway

(2016) Rojo A Ratsimandresy et al.   Cellular & Molecular Immunology

Antibiotics Suppress Activation of Intestinal Mucosal Mast Cells and Reduce Dietary Lipid Absorption in Sprague-Dawley Rats

(2016) Hirokazu Sato et al.   GASTROENTEROLOGY

Metabolites: messengers between the microbiota and the immune system

(2016) Maayan Levy et al.   GENES & DEVELOPMENT

Fungal microbiota dysbiosis in IBD

(2016) Harry Sokol et al.   GUT

Gut Microbiota Drive Autoimmune Arthritis by Promoting Differentiation and Migration of Peyer’s Patch T Follicular Helper Cells

(2016) Fei Teng et al.   IMMUNITY

Fostering of advanced mutualism with gut microbiota by Immunoglobulin A

(2016) Duncan B. Sutherland et al.   IMMUNOLOGICAL REVIEWS

CD4+ T-cell help amplifies innate signals for primary CD8+ T-cell immunity

(2016) Sammy Bedoui et al.   IMMUNOLOGICAL REVIEWS

High fat diet exacerbates dextran sulfate sodium induced colitis through disturbing mucosal dendritic cell homeostasis

(2016) Lu Cheng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Resetting microbiota byLactobacillus reuteriinhibits T reg deficiency–induced autoimmunity via adenosine A2Areceptors

(2016) Baokun He et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells

(2016) Corinne Benakis et al.   NATURE MEDICINE

Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice

(2016) Tze Guan Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The maternal microbiota drives early postnatal innate immune development

(2016) M. Gomez de Aguero et al.   SCIENCE

How colonization by microbiota in early life shapes the immune system

(2016) Thomas Gensollen et al.   SCIENCE

Microglia development follows a stepwise program to regulate brain homeostasis

(2016) O. Matcovitch-Natan et al.   SCIENCE

A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion

(2016) G. M. H. Birchenough et al.   SCIENCE

Antibiotic-Induced Changes in the Intestinal Microbiota and Disease

(2016) Simone Becattini et al.   TRENDS IN MOLECULAR MEDICINE

Dysbiosis Contributes to Arthritis Development via Activation of Autoreactive T Cells in the Intestine

(2016) Yuichi Maeda et al.   Arthritis & Rheumatology

Enrichment of the lung microbiome with oral taxa is associated with lung inflammation of a Th17 phenotype

(2016) Leopoldo N. Segal et al.   Nature Microbiology

Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling

(2015) Maayan Levy et al.   CELL

Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease

(2015) Jason M. Norman et al.   CELL

Personalized Nutrition by Prediction of Glycemic Responses

(2015) David Zeevi et al.   CELL

Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells

(2015) Koji Atarashi et al.   CELL

MyD88 Signaling in T Cells Directs IgA-Mediated Control of the Microbiota to Promote Health

(2015) Jason L. Kubinak et al.   Cell Host & Microbe

Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life

(2015) Fredrik Bäckhed et al.   Cell Host & Microbe

Microbiota and Host Nutrition across Plant and Animal Kingdoms

(2015) Stéphane Hacquard et al.   Cell Host & Microbe

Inhibition of Dectin-1 Signaling Ameliorates Colitis by Inducing Lactobacillus-Mediated Regulatory T Cell Expansion in the Intestine

(2015) Ce Tang et al.   Cell Host & Microbe

Dysbiotic gut microbiota causes transmissible Crohn's disease-like ileitis independent of failure in antimicrobial defence

(2015) Monika Schaubeck et al.   GUT

Distinct Commensals Induce Interleukin-1β via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury

(2015) Sang-Uk Seo et al.   IMMUNITY

A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes

(2015) Tiffany C. Scharschmidt et al.   IMMUNITY

MyD88 Adaptor-Dependent Microbial Sensing by Regulatory T Cells Promotes Mucosal Tolerance and Enforces Commensalism

(2015) Sen Wang et al.   IMMUNITY

Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine

(2015) Aiden Haghikia et al.   IMMUNITY

Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack

(2015) Chamutal Gur et al.   IMMUNITY

Innate Lymphoid Cells Control Early Colonization Resistance against Intestinal Pathogens through ID2-Dependent Regulation of the Microbiota

(2015) Xiaohuan Guo et al.   IMMUNITY

Chronic obstructive pulmonary disease and asthma-associated Proteobacteria, but not commensalPrevotellaspp., promote Toll-like receptor 2-independent lung inflammation and pathology

(2015) Jeppe M. Larsen et al.   IMMUNOLOGY

Commensal–dendritic-cell interaction specifies a unique protective skin immune signature

(2015) Shruti Naik et al.   NATURE

Complementarity and redundancy of IL-22-producing innate lymphoid cells

(2015) Lucille C Rankin et al.   NATURE IMMUNOLOGY

The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment

(2015) Xuan Zhang et al.   NATURE MEDICINE

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

The global burden of IBD: from 2015 to 2025

(2015) Gilaad G. Kaplan   Nature Reviews Gastroenterology & Hepatology

Immunopathogenesis of IBD: current state of the art

(2015) Heitor S. P. de Souza et al.   Nature Reviews Gastroenterology & Hepatology

Nlrp6 regulates intestinal antiviral innate immunity

(2015) Penghua Wang et al.   SCIENCE

Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy

(2015) A. Sivan et al.   SCIENCE

The microbiota regulates type 2 immunity through ROR t+ T cells

(2015) C. Ohnmacht et al.   SCIENCE

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

(2015) M. Vetizou et al.   SCIENCE

Fusobacterium nucleatumand T Cells in Colorectal Carcinoma

(2015) Kosuke Mima et al.   JAMA Oncology

Reagent and laboratory contamination can critically impact sequence-based microbiome analyses

(2014) Susannah J Salter et al.   BMC BIOLOGY

Immunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease

(2014) Noah W. Palm et al.   CELL

Sphingolipids from a Symbiotic Microbe Regulate Homeostasis of Host Intestinal Natural Killer T Cells

(2014) Dingding An et al.   CELL

Role of the Microbiota in Immunity and Inflammation

(2014) Yasmine Belkaid et al.   CELL

NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion

(2014) Marta Wlodarska et al.   CELL

The Cytosolic Bacterial Peptidoglycan Sensor Nod2 Affords Stem Cell Protection and Links Microbes to Gut Epithelial Regeneration

(2014) Giulia Nigro et al.   Cell Host & Microbe

Gut Dysbiosis Promotes M2 Macrophage Polarization and Allergic Airway Inflammation via Fungi-Induced PGE2

(2014) Yun-Gi Kim et al.   Cell Host & Microbe

The Treatment-Naive Microbiome in New-Onset Crohn’s Disease

(2014) Dirk Gevers et al.   Cell Host & Microbe

The Microbiome in Inflammatory Bowel Disease: Current Status and the Future Ahead

(2014) Aleksandar D. Kostic et al.   GASTROENTEROLOGY

Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis

(2014) Shimpei Kawamoto et al.   IMMUNITY

Bacterial Sensor Nod2 Prevents Inflammation of the Small Intestine by Restricting the Expansion of the Commensal Bacteroides vulgatus

(2014) Deepshika Ramanan et al.   IMMUNITY

ATP-Gated Ionotropic P2X7 Receptor Controls Follicular T Helper Cell Numbers in Peyer’s Patches to Promote Host-Microbiota Mutualism

(2014) Michele Proietti et al.   IMMUNITY

T Follicular Helper Cell Differentiation, Function, and Roles in Disease

(2014) Shane Crotty   IMMUNITY

Probiotic antigens stimulate hepatic natural killer T cells

(2014) Shuwen Liang et al.   IMMUNOLOGY

Peptidoglycan Recognition Protein 3 and Nod2 Synergistically Protect Mice from Dextran Sodium Sulfate–Induced Colitis

(2014) Xuefang Jing et al.   JOURNAL OF IMMUNOLOGY

Periodontal Pathogens Directly Promote Autoimmune Experimental Arthritis by Inducing a TLR2- and IL-1-Driven Th17 Response

(2014) S. G. de Aquino et al.   JOURNAL OF IMMUNOLOGY

The role of the microbiome in exacerbations of chronic lung diseases

(2014) Robert P Dickson et al.   LANCET

Biogeography and individuality shape function in the human skin metagenome

(2014) Julia Oh et al.   NATURE

A committed precursor to innate lymphoid cells

(2014) Michael G. Constantinides et al.   NATURE

Lung microbiota promotes tolerance to allergens in neonates via PD-L1

(2014) Eva S Gollwitzer et al.   NATURE MEDICINE

Dialogue between skin microbiota and immunity

(2014) Y. Belkaid et al.   SCIENCE

Intestinal Microbial Diversity during Early-Life Colonization Shapes Long-Term IgE Levels

(2013) Julia Cahenzli et al.   Cell Host & Microbe

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

(2013) Shin Yoshimoto et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Staphylococcus δ-toxin induces allergic skin disease by activating mast cells

(2013) Yuumi Nakamura et al.   NATURE

Microbial colonization influences early B-lineage development in the gut lamina propria

(2013) Duane R. Wesemann et al.   NATURE

Compartmentalized and systemic control of tissue immunity by commensals

(2013) Yasmine Belkaid et al.   NATURE IMMUNOLOGY

Innate immune recognition of the microbiota promotes host-microbial symbiosis

(2013) Hiutung Chu et al.   NATURE IMMUNOLOGY

Global Maternal, Newborn, and Child Health — So Near and Yet So Far

(2013) Zulfiqar A. Bhutta et al.   NEW ENGLAND JOURNAL OF MEDICINE

Complement modulates the cutaneous microbiome and inflammatory milieu

(2013) C. Chehoud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals

(2013) M. Shan et al.   SCIENCE

The Intestinal Microbiota Modulates the Anticancer Immune Effects of Cyclophosphamide

(2013) S. Viaud et al.   SCIENCE

Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis

(2013) Jose U Scher et al.   eLife

Gut Bacteria Drive Kupffer Cell Expansion via MAMP-Mediated ICAM-1 Induction on Sinusoidal Endothelium and Influence Preservation-Reperfusion Injury after Orthotopic Liver Transplantation

(2012) Natasha Corbitt et al.   AMERICAN JOURNAL OF PATHOLOGY

Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4

(2012) Dianne H. Dapito et al.   CANCER CELL

Transient Inability to Manage Proteobacteria Promotes Chronic Gut Inflammation in TLR5-Deficient Mice

(2012) Frederic A. Carvalho et al.   Cell Host & Microbe

Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma

(2012) Shannon L Russell et al.   EMBO REPORTS

Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis

(2012) H. H. Kong et al.   GENOME RESEARCH

Gut microbiome composition is linked to whole grain-induced immunological improvements

(2012) Inés Martínez et al.   ISME Journal

Familial transmission rather than defective innate immunity shapes the distinct intestinal microbiota of TLR-deficient mice

(2012) Carles Ubeda et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophilic Granulocytes Modulate Invariant NKT Cell Function in Mice and Humans

(2012) G. Wingender et al.   JOURNAL OF IMMUNOLOGY

Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10 −/− mice

(2012) Suzanne Devkota et al.   NATURE

Reciprocal interactions of the intestinal microbiota and immune system

(2012) Craig L. Maynard et al.   NATURE

Human gut microbiome viewed across age and geography

(2012) Tanya Yatsunenko et al.   NATURE

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

(2012) Jorge Henao-Mejia et al.   NATURE

Targeting IL-17 and TH17 cells in chronic inflammation

(2012) Pierre Miossec et al.   NATURE REVIEWS DRUG DISCOVERY

The Inhibitory Receptor PD-1 Regulates IgA Selection and Bacterial Composition in the Gut

(2012) S. Kawamoto et al.   SCIENCE

Compartmentalized Control of Skin Immunity by Resident Commensals

(2012) S. Naik et al.   SCIENCE

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

(2011) Eran Elinav et al.   CELL

Transient TLR Activation Restores Inflammatory Response and Ability To Control Pulmonary Bacterial Infection in Germfree Mice

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Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut

(2011) Natalia Shulzhenko et al.   NATURE MEDICINE

Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis

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Necrotizing Enterocolitis

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Microbiota regulates immune defense against respiratory tract influenza A virus infection

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The Antibacterial Lectin RegIII  Promotes the Spatial Segregation of Microbiota and Host in the Intestine

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Peptidoglycan Recognition Proteins Protect Mice from Experimental Colitis by Promoting Normal Gut Flora and Preventing Induction of Interferon-γ

(2010) Sukumar Saha et al.   Cell Host & Microbe

Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells

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Succession of microbial consortia in the developing infant gut microbiome

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Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns

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Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5

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Reversible Microbial Colonization of Germ-Free Mice Reveals the Dynamics of IgA Immune Responses

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Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

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Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

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Role of Gut Commensal Microflora in the Development of Experimental Autoimmune Encephalomyelitis

(2009) J. Ochoa-Reparaz et al.   JOURNAL OF IMMUNOLOGY

Commensal bacteria regulate Toll-like receptor 3–dependent inflammation after skin injury

(2009) Yuping Lai et al.   NATURE MEDICINE

Nod2 is required for the regulation of commensal microbiota in the intestine

(2009) T. Petnicki-Ocwieja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation

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Topographical and Temporal Diversity of the Human Skin Microbiome

(2009) E. A. Grice et al.   SCIENCE

Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine

(2008) Ivaylo I. Ivanov et al.   Cell Host & Microbe

Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis

(2008) Shahla Abdollahi-Roodsaz et al.   JOURNAL OF CLINICAL INVESTIGATION

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

A microbial symbiosis factor prevents intestinal inflammatory disease

(2008) Sarkis K. Mazmanian et al.   NATURE

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis

(2008) Djahida Bouskra et al.   NATURE

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

(2008) Li Wen et al.   NATURE