Pathological alteration and therapeutic implications of sepsis-induced immune cell apoptosis

B-cell dynamics during experimental endotoxemia in humans

(2019) Alexandra Brinkhoff et al.   BIOSCIENCE REPORTS

Toll-like receptor 4 deficiency increases resistance in sepsis-induced immune dysfunction

(2018) Chao Cao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Dendritic cells in sepsis: Potential immunoregulatory cells with therapeutic potential

(2018) V. Kumar   MOLECULAR IMMUNOLOGY

Protective Effect of Tubastatin A in CLP-Induced Lethal Sepsis

(2018) Qiufang Deng et al.   INFLAMMATION

Ulinastatin mediates suppression of regulatory T cells through TLR4/NF-κB signaling pathway in murine sepsis

(2018) Chao Cao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Contribution of NK cells to immunotherapy mediated by PD-1/PD-L1 blockade

(2018) Joy Hsu et al.   JOURNAL OF CLINICAL INVESTIGATION

Natural killer cells in sepsis: Underprivileged innate immune cells

(2018) Vijay Kumar   EUROPEAN JOURNAL OF CELL BIOLOGY

The biology of natural killer cells during sepsis

(2017) Yin Guo et al.   IMMUNOLOGY

Fluid administration in severe sepsis and septic shock, patterns and outcomes: an analysis of a large national database

(2017) Paul E. Marik et al.   INTENSIVE CARE MEDICINE

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

(2017) Andrew Rhodes et al.   INTENSIVE CARE MEDICINE

Targeting Immune Cell Checkpoints during Sepsis

(2017) Naeem Patil et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phenotypic Changes and Impaired Function of Peripheral γδ T Cells in Patients With Sepsis

(2017) Xue-Lian Liao et al.   SHOCK

Monocyte Function and Clinical Outcomes in Febrile and Afebrile Patients with Severe Sepsis

(2017) Anne M. Drewry et al.   SHOCK

Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations

(2016) Carolin Fleischmann et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The immune system's role in sepsis progression, resolution, and long-term outcome

(2016) Matthew J. Delano et al.   IMMUNOLOGICAL REVIEWS

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Sepsis-induced immune dysfunction: can immune therapies reduce mortality?

(2016) Matthew J. Delano et al.   JOURNAL OF CLINICAL INVESTIGATION

Polymicrobial Sepsis Diminishes Dendritic Cell Numbers and Function Directly Contributing to Impaired Primary CD8 T Cell Responses In Vivo

(2016) Robert K. Strother et al.   JOURNAL OF IMMUNOLOGY

Frontline Science: Defects in immune function in patients with sepsis are associated with PD-1 or PD-L1 expression and can be restored by antibodies targeting PD-1 or PD-L1

(2016) Andriani C. Patera et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Sepsis and septic shock

(2016) Richard S. Hotchkiss et al.   Nature Reviews Disease Primers

Imaging Apoptosis in Sepsis—A Technology We Would Die for!*

(2015) Richard S. Hotchkiss et al.   CRITICAL CARE MEDICINE

The Epidemiology of Chronic Critical Illness in the United States*

(2015) Jeremy M. Kahn et al.   CRITICAL CARE MEDICINE

Homeostatic NF-κB Signaling in Steady-State Migratory Dendritic Cells Regulates Immune Homeostasis and Tolerance

(2015) Myriam Baratin et al.   IMMUNITY

Inhibition of MicroRNA 195 Prevents Apoptosis and Multiple-Organ Injury in Mouse Models of Sepsis

(2015) Dong Zheng et al.   JOURNAL OF INFECTIOUS DISEASES

Insights into the Apoptotic Death of Immune Cells in Sepsis

(2015) Ying-yi Luan et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Sepsis: a roadmap for future research

(2015) Jonathan Cohen et al.   LANCET INFECTIOUS DISEASES

Systemic Inflammatory Response Syndrome Criteria in Defining Severe Sepsis

(2015) Kirsi-Maija Kaukonen et al.   NEW ENGLAND JOURNAL OF MEDICINE

A walk across a quantum lattice

(2015) A. Widera   SCIENCE

Monocyte-mediated defense against bacteria, fungi, and parasites

(2015) Grégoire Lauvau et al.   SEMINARS IN IMMUNOLOGY

Interleukin-7 and Anti–Programmed Cell Death 1 Antibody Have Differing Effects to Reverse Sepsis-Induced Immunosuppression

(2015) Yuichiro Shindo et al.   SHOCK

Analysis of circulating plasmacytoid dendritic cells during the course of sepsis

(2015) Georg F. Weber et al.   SURGERY

Activated Neutrophils Induce Epithelial Cell Apoptosis Through Oxidant-Dependent Tyrosine Dephosphorylation of Caspase-8

(2014) Song Hui Jia et al.   AMERICAN JOURNAL OF PATHOLOGY

Sepsis lethality via exacerbated tissue infiltration and TLR-induced cytokine production by neutrophils is integrin  3 1-dependent

(2014) Y. V. Lerman et al.   BLOOD

Blockade of the T cell immunoglobulin and mucin domain protein 3 pathway exacerbates sepsis-induced immune deviation and immunosuppression

(2014) Z. Zhao et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Natural Killer Cells in Sepsis

(2014) Evangelos J. Giamarellos-Bourboulis   CRITICAL CARE MEDICINE

Development and Function of Dendritic Cell Subsets

(2014) Alexander Mildner et al.   IMMUNITY

Enhanced Dendritic Cell Survival Attenuates Lipopolysaccharide-Induced Immunosuppression and Increases Resistance to Lethal Endotoxic Shock

(2014) E. L. Gautier et al.   JOURNAL OF IMMUNOLOGY

NKG2D Is Critical for NK Cell Activation in Host Defense against Pseudomonas aeruginosa Respiratory Infection

(2014) S. C. Wesselkamper et al.   JOURNAL OF IMMUNOLOGY

Macrophage Polarization in Bacterial Infections

(2014) M. Benoit et al.   JOURNAL OF IMMUNOLOGY

Microbe-Specific Unconventional T Cells Induce Human Neutrophil Differentiation into Antigen Cross-Presenting Cells

(2014) Martin S. Davey et al.   JOURNAL OF IMMUNOLOGY

Persistent Neutrophil Dysfunction and Suppression of Acute Lung Injury in Mice following Cecal Ligation and Puncture Sepsis

(2014) Jamison J. Grailer et al.   Journal of Innate Immunity

Strategies to improve drug development for sepsis

(2014) Mitchell P. Fink et al.   NATURE REVIEWS DRUG DISCOVERY

Persistent Lymphopenia After Diagnosis of Sepsis Predicts Mortality

(2014) Anne M. Drewry et al.   SHOCK

The new normal: immunomodulatory agents against sepsis immune suppression

(2014) Noelle A. Hutchins et al.   TRENDS IN MOLECULAR MEDICINE

Why have clinical trials in sepsis failed?

(2014) John C. Marshall   TRENDS IN MOLECULAR MEDICINE

Immune Effects of Interferon Gamma in Persistent Staphylococcal Sepsis

(2013) Marek Nalos et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Association of γδ T Cells with Disease Severity and Mortality in Septic Patients

(2013) Juan C. Andreu-Ballester et al.   Clinical and Vaccine Immunology

Reduction of Immunocompetent T Cells Followed by Prolonged Lymphopenia in Severe Sepsis in the Elderly*

(2013) Shigeaki Inoue et al.   CRITICAL CARE MEDICINE

Monitoring the immune response in sepsis: a rational approach to administration of immunoadjuvant therapies

(2013) Fabienne Venet et al.   CURRENT OPINION IN IMMUNOLOGY

A divergent response of innate regulatory T-cells to sepsis in humans: Circulating invariant natural killer T-cells are preserved

(2013) Daithi S. Heffernan et al.   HUMAN IMMUNOLOGY

Sepsis and the innate-like response

(2013) James J. Douglas et al.   INTENSIVE CARE MEDICINE

Antiinflammatory effects of apoptotic cells

(2013) Peter M. Henson et al.   JOURNAL OF CLINICAL INVESTIGATION

Dendritic cells in childhood sepsis

(2013) Khalid I. Elsayh et al.   JOURNAL OF CRITICAL CARE

T Cell Ig Mucin-3 Promotes Homeostasis of Sepsis by Negatively Regulating the TLR Response

(2013) X. Yang et al.   JOURNAL OF IMMUNOLOGY

Inhibiting the Programmed Death 1 Pathway Rescues Mycobacterium tuberculosis–Specific Interferon γ–Producing T Cells From Apoptosis in Patients With Pulmonary Tuberculosis

(2013) Amar Singh et al.   JOURNAL OF INFECTIOUS DISEASES

Sepsis definitions: time for change

(2013) Jean-Louis Vincent et al.   LANCET

Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach

(2013) Richard S Hotchkiss et al.   LANCET INFECTIOUS DISEASES

Granulocyte–macrophage colony-stimulating factor: not just another haematopoietic growth factor

(2013) Alejandro Francisco-Cruz et al.   MEDICAL ONCOLOGY

Downregulation of Mcl-1 has anti-inflammatory pro-resolution effects and enhances bacterial clearance from the lung

(2013) C D Lucas et al.   Mucosal Immunology

Use of Oral Fluconazole during Pregnancy and the Risk of Birth Defects

(2013) Ditte Mølgaard-Nielsen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reduced frequency of CD56dim CD16pos natural killer cells in pediatric systemic inflammatory response syndrome/sepsis patients

(2013) E. Scott Halstead et al.   PEDIATRIC RESEARCH

Inflammatory Mechanisms in Sepsis

(2013) Daithi S. Heffernan et al.   SHOCK

Glutamine Administration Modulates Lung γδ T Lymphocyte Expression in Mice With Polymicrobial Sepsis

(2013) Ya-Mei Hu et al.   SHOCK

Immune Regulatory Function of B Cells

(2012) Claudia Mauri et al.   Annual Review of Immunology

Cyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription and their inhibition drives apoptosis to promote resolution of inflammation

(2012) A E Leitch et al.   CELL DEATH AND DIFFERENTIATION

γδ-T cells: an unpolished sword in human anti-infection immunity

(2012) Jian Zheng et al.   Cellular & Molecular Immunology

Interferon-γ production by natural killer cells and cytomegalovirus in critically ill patients*

(2012) Laurent Chiche et al.   CRITICAL CARE MEDICINE

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Classical dendritic cells as a unique immune cell lineage: Figure 1.

(2012) Boris Reizis   JOURNAL OF EXPERIMENTAL MEDICINE

Increased apoptosis of peripheral blood neutrophils is associated with reduced incidence of infection in trauma patients with hemorrhagic shock

(2012) C. Anne Morrison et al.   JOURNAL OF INFECTION

Increased proportion of CD4+CD25+Foxp3+ regulatory T cells during early-stage sepsis in ICU patients

(2012) Feng-Ying Leng et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Transcriptome Kinetics of Circulating Neutrophils during Human Experimental Endotoxemia

(2012) Stan de Kleijn et al.   PLoS One

Phenotype and Functions of Natural Killer Cells in Critically-Ill Septic Patients

(2012) Jean-Marie Forel et al.   PLoS One

Human Monocytes Differentiate into Dendritic Cells Subsets that Induce Anergic and Regulatory T Cells in Sepsis

(2012) Valérie Faivre et al.   PLoS One

Innate Response Activator B Cells Protect Against Microbial Sepsis

(2012) P. J. Rauch et al.   SCIENCE

Delta Neutrophil Index

(2012) Yoonmi Seok et al.   SHOCK

C5a-mediated neutrophil dysfunction is RhoA-dependent and predicts infection in critically ill patients

(2011) A. C. Morris et al.   BLOOD

IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology

(2011) Marc Pellegrini et al.   CELL

Peculiarities of cell death mechanisms in neutrophils

(2011) B Geering et al.   CELL DEATH AND DIFFERENTIATION

Improving long-term outcomes after discharge from intensive care unit

(2011) Dale M. Needham et al.   CRITICAL CARE MEDICINE

Profound and persistent decrease of circulating dendritic cells is associated with ICU-acquired infection in patients with septic shock

(2011) D. Grimaldi et al.   INTENSIVE CARE MEDICINE

Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure

(2011) Jonathan S. Boomer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Role of Natural Killer Cells in Sepsis

(2011) Laurent Chiche et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Evolution of neutrophil apoptosis in septic shock survivors and nonsurvivors

(2011) Eduardo Tamayo et al.   JOURNAL OF CRITICAL CARE

B cells enhance early innate immune responses during bacterial sepsis

(2011) Kindra M. Kelly-Scumpia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophil Mobilization from the Bone Marrow during Polymicrobial Sepsis Is Dependent on CXCL12 Signaling

(2011) M. J. Delano et al.   JOURNAL OF IMMUNOLOGY

Unknown

(2011) Jochen Grommes et al.   MOLECULAR MEDICINE

Origins of CD4+ effector and central memory T cells

(2011) Marion Pepper et al.   NATURE IMMUNOLOGY

Innate or Adaptive Immunity? The Example of Natural Killer Cells

(2011) E. Vivier et al.   SCIENCE

Dose-Dependent Effect of Anti-CTLA-4 on Survival in Sepsis

(2011) Shigeaki Inoue et al.   SHOCK

Neutrophils are significant producers of IL-10 during sepsis

(2010) Kevin R. Kasten et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The post sepsis-induced expansion and enhanced function of regulatory T cells create an environment to potentiate tumor growth

(2010) K. A. Cavassani et al.   BLOOD

Neutrophils, from Marrow to Microbes

(2010) Niels Borregaard   IMMUNITY

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Measurement of monocytic HLA-DR (mHLA-DR) expression in patients with severe sepsis and septic shock: assessment of immune organ failure

(2010) Joerg C. Schefold   INTENSIVE CARE MEDICINE

Immunoparalysis and nosocomial infection in children with multiple organ dysfunction syndrome

(2010) Mark W. Hall et al.   INTENSIVE CARE MEDICINE

B cells—Masters of the immunoverse

(2010) Andrew T. Vaughan et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow

(2010) Kyle J. Eash et al.   JOURNAL OF CLINICAL INVESTIGATION

Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus

(2010) Niklas K. Björkström et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Modulation of Dendritic Cell Differentiation in the Bone Marrow Mediates Sustained Immunosuppression after Polymicrobial Sepsis

(2010) E. Pastille et al.   JOURNAL OF IMMUNOLOGY

Dendritic Cell Modification of Neutrophil Responses to Infection after Burn Injury

(2010) J. Bohannon et al.   JOURNAL OF IMMUNOLOGY

Sepsis Induces Early Alterations in Innate Immunity That Impact Mortality to Secondary Infection

(2010) M. J. Delano et al.   JOURNAL OF IMMUNOLOGY

IL-7 Promotes T Cell Viability, Trafficking, and Functionality and Improves Survival in Sepsis

(2010) J. Unsinger et al.   JOURNAL OF IMMUNOLOGY

Monocytes and Macrophages Regulate Immunity through Dynamic Networks of Survival and Cell Death

(2010) Arti Parihar et al.   Journal of Innate Immunity

Insights Into Sepsis Therapeutic Design Based on the Apoptotic Death Pathway

(2010) Yuichi Hattori et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Immunotherapy for Sepsis — A New Approach against an Ancient Foe

(2010) Richard S. Hotchkiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

T-CELL ACTIVATION DIFFERENTIALLY MEDIATES THE HOST RESPONSE TO SEPSIS

(2010) Kevin R. Kasten et al.   SHOCK

EARLY ASSESSMENT OF LEUKOCYTE ALTERATIONS AT DIAGNOSIS OF SEPTIC SHOCK

(2010) Fabienne Venet et al.   SHOCK

Neutrophil kinetics in health and disease

(2010) Charlotte Summers et al.   TRENDS IN IMMUNOLOGY

Granulocyte–Macrophage Colony-stimulating Factor to Reverse Sepsis-associated Immunosuppression

(2009) Christian Meisel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Macroscopic Postmortem Findings in 235 Surgical Intensive Care Patients with Sepsis

(2009) Christian Torgersen et al.   ANESTHESIA AND ANALGESIA

Toll-Like Receptors 2 and 4 Contribute to Sepsis-Induced Depletion of Spleen Dendritic Cells

(2009) F. Pene et al.   INFECTION AND IMMUNITY

IL-15 Prevents Apoptosis, Reverses Innate and Adaptive Immune Dysfunction, and Improves Survival in Sepsis

(2009) S. Inoue et al.   JOURNAL OF IMMUNOLOGY

Cell Death

(2009) Richard S. Hotchkiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis

(2009) X. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DIFFERENT PATTERNS OF SIGLEC-9-MEDIATED NEUTROPHIL DEATH RESPONSES IN SEPTIC SHOCK

(2009) Stephan von Gunten et al.   SHOCK

MODULATION OF THE BCL-2 FAMILY BLOCKS SEPSIS-INDUCED DEPLETION OF DENDRITIC CELLS AND MACROPHAGES

(2009) Octavia M. Peck-Palmer et al.   SHOCK

Endotoxin tolerance: new mechanisms, molecules and clinical significance

(2009) Subhra K. Biswas et al.   TRENDS IN IMMUNOLOGY

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Downregulation of CD40 Ligand Response in Monocytes from Sepsis Patients

(2008) A. Sinistro et al.   Clinical and Vaccine Immunology

Apoptosis in Sepsis: Mechanisms, Clinical Impact and Potential Therapeutic Targets

(2008) Alfred Ayala et al.   CURRENT PHARMACEUTICAL DESIGN

Depletion of natural CD4+CD25+ T regulatory cells with anti-CD25 antibody does not change the course of Pseudomonas aeruginosa-induced acute lung infection in mice

(2008) Svetlana O. Carrigan et al.   IMMUNOBIOLOGY

CD56brightnatural killer (NK) cells: an important NK cell subset

(2008) Aurélie Poli et al.   IMMUNOLOGY

Increased circulating regulatory T cells (CD4+CD25+CD127−) contribute to lymphocyte anergy in septic shock patients

(2008) Fabienne Venet et al.   INTENSIVE CARE MEDICINE

Reactivation of Cytomegalovirus Infection in Critically Ill Immunocompetent Patients—Reply

(2008) Ajit P. Limaye   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Deletion of MyD88 markedly attenuates sepsis-induced T and B lymphocyte apoptosis but worsens survival

(2008) O. M. Peck-Palmer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Molecular and cellular aspects of sepsis-induced immunosuppression

(2008) Tisha S. Wang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Neutrophil Depletion Causes a Fatal Defect in Murine Pulmonary Staphylococcus aureus clearance

(2008) Charles M. Robertson et al.   JOURNAL OF SURGICAL RESEARCH

Unknown

(2008) Guillaume Monneret et al.   MOLECULAR MEDICINE

Dendritic cell PAR1–S1P3 signalling couples coagulation and inflammation

(2008) Frank Niessen et al.   NATURE

Functions of natural killer cells

(2008) Eric Vivier et al.   NATURE IMMUNOLOGY